A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment by Aoling Huang, Haochen Xue, Ting Xie, Lingyan Xiang, Zhengzhuo Chen, Aolong Ma, Honglin Yan, Jingping Yuan

“…However, the heterogeneity, drug resistance, and poor prognosis of breast cancer highlight an urgent need for further exploration of its underlying mechanisms. …”
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EpigenomeViewer: A Shiny Web Application for Visualizing Methylation Patterns Across Biological Samples by Nurul Syakima Ab Mutalib

“…EpigenomeViewer is particularly useful in the study of drug resistance and early stage cancer biomarkers, where understanding methylation differences between tumour and normal samples is vital. …”
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Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf Goats by Oyeduntan A. Adediran, Emmanuel C. Uwalaka

“…Anthelmintic drug resistance has led to the search for alternatives in controlling helminth infections. …”
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Metabolic Analysis of the Mode of Action and Mode of Resistance for Novobiocin in Staphylococcus aureus by Weile Xie, Dan Luo, Zhe Wang

“…Methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin resistant Staphylococcus aureus (VRSA) are critical pathogens identified by the WHO for their significant drug resistance. Targeting of bacterial gyrase, specifically the gyrB subunit, is a promising approach because of this enzyme’s essential role in bacterial DNA replication and its absence in higher eukaryotes. …”
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Dual targeting carbonic anhydrase inhibitors as promising therapeutic approach: a structural overview by Katia D’Ambrosio, Anna Di Fiore, Emma Langella

“…It can enhance therapeutic outcomes, reduce side effects and avoid the emergence of drug resistance, particularly in conditions like cancer, inflammation and neurological disorders, where multiple pathways contribute to disease progression. …”
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CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis by Ying Zhang, Ruiwei Yao, Mingyi Li, Chongkai Fang, Kunliang Feng, Xiuru Chen, Jinan Wang, Rui Luo, Hanqian Shi, Xinqiu Chen, Xilin Zhao, Hanlin Huang, Shuwei Liu, Bing Yin, Chong Zhong

“…Abstract The high mortality rate from hepatocellular carcinoma (HCC) is due primarily to challenges in early diagnosis and the development of drug resistance in advanced stages. Many first-line chemotherapeutic drugs induce ferroptosis, a form of programmed cell death dependent on ferrous iron-mediated oxidative stress, suggesting that drug resistance and ensuing tumor progression may in part stem from reduced ferroptosis. …”
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Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology by Jihao Xu, Minh Duc Pham, Vincenzo Corbo, Mariano Ponz-Sarvise, Tobiloba Oni, Daniel Öhlund, Chang-Il Hwang

“…We explore the applications of pancreatic organoids in dissecting the tumor microenvironment (TME); elucidating cancer progression, metastasis, and drug resistance mechanisms; and personalizing therapeutic strategies. …”
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Modeling critical dosing strategies for stromal-induced resistance to cancer therapy by Anna K. Kraut, Colleen M. Garvey, Carly Strelez, Shannon M. Mumenthaler, Jasmine Foo

“…We propose a mathematical model for a common tumor-stromal interaction motif where stromal cells secrete factors that promote drug resistance. We demonstrate that the presence of this interaction modulates the therapeutic dose window of efficacy and can lead to nonmonotonic treatment response. …”
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Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer by Rabia Hursitoglu, Abdulkadir Yasir Bahar, Sezen Koçarslan, Gökmen Aktaş, Neslihan Kurtul, Emine Kılınç

“…CSCs become dormant in the cell cycle, which is one of the mechanisms of escape in drug resistance. We hypothesized that including Ki67 immunohistochemical staining in our study would increase the specificity in detecting CSCs. …”
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In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae) by Johnson Nyarko Boampong

“…Malaria is an endemic disease globally and the conundrum of drug resistance has led to the search for newer antimalarial agents. …”
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Ovarian Epithelial Cancer Stem Cells by Irena Conic, Irena Dimov, Desanka Tasic-Dimov, Biljana Djordjevic, Vladisav Stefanovic

“…Finally, this review discusses the signaling pathways that are important regulators of candidate EOCSC maintenance and function, their potential role in the distinct pathogenesis of different EOC subtypes, as well as potential mechanisms and clinical relevance of EOCSC involvement in drug resistance.…”
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Synthesis and Antitumor Activity of a GSH Inert Bisphosphonate Platinum (II) Complex by Lu Ma, Hua Liu, Yichun Ju, Kai Chen, Yi Yang, Zhichao Zhou, Zhenqin Zhang, Zheng Cai

“…Traditional platinum chemotherapeutic agents for osteosarcoma inevitably have acquired drug resistance and serious side effects, which have limited their utility. …”
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Application of adoptive cell therapy in malignant melanoma by Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu

“…Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity. …”
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The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases by Nnamdi Ikemefuna Okafor, Omobolanle Ayoyinka Omoteso, Yahya E. Choonara

“…Abstract Some of the most crucial turning points in the treatment strategies for some major infectious diseases including AIDS, malaria, and TB, have been reached with the introduction of antimicrobials and vaccines. Drug resistance and poor effectiveness are key limitations that need to be overcome. …”
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Biomarkers as Key Contributors in Treating Malignant Melanoma Metastases by Camila Ferreira de Souza, Alice Santana Morais, Miriam Galvonas Jasiulionis

“…This is justified because of a subpopulation of cells presenting a remarkable molecular heterogeneity, which is able to explain the drug resistance and the growing mortality rates worldwide. …”
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Assessment of Antiretroviral Treatment Adherence among Children Attending Care at a Tertiary Hospital in Southeastern Nigeria by Cletus Akahara, Emeka Nwolisa, Kelechi Odinaka, Seline Okolo

“…There is need for concerted effort in addressing this barrier to improve adherence and prevent the emergence of drug resistance and treatment failure.…”
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The Hematopoietic Niche in Myeloproliferative Neoplasms by Annette H. Schmitt-Graeff, Roland Nitschke, Robert Zeiser

“…Nonneoplastic MSCs in turn can promote aggressiveness and drug resistance of malignant cells. In the future, strategies to counteract the pathological interaction between the niche and neoplastic HSCs may offer additional treatment strategies for MPN patients.…”
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Trafficked Proteins—Druggable in Plasmodium falciparum? by Jasmin Lindner, Kamila Anna Meissner, Isolmar Schettert, Carsten Wrenger

“…An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy. However, drug resistance is spreading, and the identification of new drug targets as well as the development of new antimalarials is urgently required. …”
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Pyrazinamide Resistance: A Major Cause of Switching Shorter to Longer Bedaquiline-based Regimens in Multidrug-resistant Tuberculosis Patients by Oki Nugraha Putra, Nur Indah, Telly Purnamasari, Adi Larasanti

“…Methods: We conducted a retrospective analysis of medical records from MDR-TB patients treated with STR at Haji Hospital, Surabaya, between January 2022 and January 2023. Data on drug-resistance profiles, determined by drug-susceptibility testing (DST), and line probe assay, as well as adverse effects, were collected. …”
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Optimal Control in Two Strain Pneumonia Transmission Dynamics by Mary C. Swai, Nyimvua Shaban, Theresia Marijani

“…A mathematical model for the transmission dynamics of pneumonia disease in the presence of drug resistance is formulated. Intervention strategies, namely, vaccination, public health education, and treatment are implemented. …”
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