Applications of piggyBac Transposons for Genome Manipulation in Stem Cells by Yi Sun, Guang Liu, Yue Huang

“…Over the past few decades, forward genetic screens based on PB transposons have been successfully established to identify genes associated with drug resistance and stem cell-related characteristics. …”
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Probiotics Can Boost the Antitumor Immunity of CD8+T Cells in BALB/c Mice and Patients with Colorectal Carcinoma by Jie Mao, Shu-Ze Zhang, Peng Du, Zhi-Bin Cheng, Huan Hu, Shi-Yao Wang

“…Background. The drug resistance and the immune suppression in the tumor microenvironment are important factors affecting tumor progression. …”
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Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…Therefore, covalent bitherapy should be used in drug development for drug resistance mitigation.…”
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Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment by Bassel Alsaed, Linh Lin, Jieun Son, Jiaqi Li, Johannes Smolander, Timothy Lopez, Pinar Ö. Eser, Atsuko Ogino, Chiara Ambrogio, Yoonji Eum, Tran Thai, Haiyun Wang, Eva Sutinen, Hilma Mutanen, Hanna Duàn, Nina Bobik, Kristian Borenius, William W. Feng, Behnam Nabet, Satu Mustjoki, Sanna Laaksonen, Benjamin K. Eschle, Michael J. Poitras, David Barbie, Ilkka Ilonen, Prafulla Gokhale, Pasi A. Jänne, Heidi M. Haikala

“…These findings suggest that intrinsic drug resistance can be prevented or reversed using combination therapies.…”
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A Serious Case of Poisoning Caused by Oral Ingestion of Water-Soluble Fertilizer by Wei Ye, Shirong Lin, Chengquan Zheng, Chunshui Cao

“…Physicians implemented antimicrobial stewardship to reduce antimicrobial drug resistance and the risk of hospital infection, and the patient’s inflammatory response was well controlled. …”
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Using In Silico Methods to Identify Protein Tyrosine Kinase A (PtkA) Homolog in Non-Tuberculous Mycobacteria (NTM) by Swati Jaiswal, Sanjay Kumar

“…Unlike <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causative agent of tuberculosis, NTM species exhibit different pathogenic characteristics and drug resistance mechanisms, making them increasingly relevant in clinical settings. …”
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Family support and adherence to treatment in people affected by tuberculosis by Cesar Raul Castro Galarza, Maritsa Julia Camarena Cristóbal, Ilse Faustina Fernandez Honorio

“…<p><strong>Background</strong>: Adherence to treatment in tuberculosis is relevant, both for its effect to be successful and to limit the emergence of drug resistance.<br /><strong>Objective</strong>: to determine the relationship between family support and adherence to treatment in patients with tuberculosis.…”
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Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures by Ebere C. Anyanwu, Andrew W. Campbell, John E. Ehiri

“…It is most likely that the interactions of mycotoxins with antifungal drugs may, at least in part, contribute to the observable persistent illnesses, antifungal drug resistance, and allergic reactions in patients exposed to chronic toxigenic molds. …”
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Using genomic data and machine learning to predict antibiotic resistance: A tutorial paper. by Faye Orcales, Lucy Moctezuma Tan, Meris Johnson-Hagler, John Matthew Suntay, Jameel Ali, Kristiene Recto, Phelan Glenn, Pleuni Pennings

“…This paper provides a step-by-step tutorial to train 4 different ML models (logistic regression, random forests, extreme gradient-boosted trees, and neural networks) to predict drug resistance for Escherichia coli isolates and to evaluate their performance using different metrics and cross-validation techniques. …”
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Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control by Stephene S. Meena, Benson K. Kosgei, Geofrey F. Soko, Cheng Tingjun, Ramadhani Chambuso, Julius Mwaiselage, Ray P. S. Han

“…TDEs support cancer progression by suppressing anti-tumor immune responses, promoting metastasis, and conferring drug resistance. Thus, targeting TDEs could improve the efficacy of anti-cancer treatments and control metastasis. …”
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Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…Autophagy mechanisms can influence metastasis and drug resistance in glioblastoma, and there is a complex interplay between autophagy and cellular responses to stress like hypoxia and starvation. …”
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HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models by Jing Wu, Jessie L. Norris, Yujiang Jia, Ning Wang

“…Some outcomes of dynamic models were based on unfeasible assumptions, such as no consideration of drug resistance, behavior disinhibition, or economic inputs in poor countries, and unrealistic input variables, for example, overstated initiation time, adherence, coverage, and efficacy of treatment. …”
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Prevalence of Helminthic Infections in the Gastrointestinal Tract of Cattle in Mazandaran Province (Northern Iran) by Nasrollah Vahedi Nouri, Reza Rahmatian, Alireza Salehi

“…In conclusion, the lack of proper implementation of helminthic infection control programs as well as antiparasitic drug resistance in this area can be a key element for the high prevalence of livestock helminthic infection in these areas.…”
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Vector borne disease control interventions in agricultural and irrigation areas in sub-Saharan Africa: A systematic review. by Levi Kalitsilo, Leila Abdullahi, Nyanyiwe Mbeye, Lily Mwandira, Hleziwe Hara, Collins Mitambo, Rose Oronje

“…However, some challenges to these interventions were identified, which include seasonal changes and climate variability, insecticide and drug resistance, and farmers' attitudes toward accepting the interventions. …”
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Recent advances of antibody-drug conjugates in treating breast cancer with different HER2 status by Yue Qiu, Yaqin Shi, Zhujun Chao, Xinyu Zhu, Yan Chen, Linlin Lu

“…Despite the availability of multiple treatment options for breast cancer, challenges such as adverse events, drug resistance, and disease progression persist for patients. …”
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Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy by Niamh Donnellan, Anne M Friel

“…These include lack of selectivity, side effects and drug resistance. The hallmarks of cancer are a fundamental concept which aids the development of new means to treat human cancers through the understanding of the acquisition of these hallmarks from cells. …”
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Cotrimoxazole Prophylaxis Specifically Selects for Cotrimoxazole Resistance in Streptococcus mutans and Streptococcus sobrinus with Varied Polymorphisms in the Target Genes folA an... by Buwembo William, Charles Mugisha Rwenyonyi, Göte Swedberg, Fred Kironde

“…Considerable polymorphisms were found in the folP gene in S. mutans, but this could not be linked to sulfonamide drug resistance. No variation was seen in folP or folA genes of S. sobrinus. …”
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Gene Therapy for Glioblastoma Multiforme by Smit Shah, Joshua Green, Shantelle A. Graff, Qi Li, John D. Heiss

“…Significant limitations to effective GBM treatment include poor drug delivery across the blood–brain barrier, drug resistance, and complex genetic tumor alterations. …”
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Communication-Efficient Modeling with Penalized Quantile Regression for Distributed Data by Aijun Hu, Chujin Li, Jing Wu

“…Especially, it presents extensive experiments on both the numerical simulations and the HIV drug resistance data analysis, which all confirm the significant efficiency of our proposed method in quantile regression for distributed data by comparative and empirical analysis.…”
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Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer by Lixuan Tang, Xiao Yang, Liwen He, Chaogeng Zhu, Qingshan Chen

“…Although traditional treatment methods such as surgery, radiotherapy, and chemotherapy have increased the survival rate of patients, their efficacy remains unsatisfactory owing to the nonspecific distribution of drugs, high toxicity, and drug resistance of tumor tissues. In recent years, the application of nanotechnology in the medical field has opened a new avenue for the treatment of liver cancer. …”
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