Clinical and psychosocial context of HIV perinatally infected young mothers in Harare, Zimbabwe: A longitudinal mixed-methods study. by Zivai Mupambireyi, Victoria Simms, Webster Mavhu, Concilia Mutasa, Edward Matsikire, April Ricotta, Margaret Pascoe, Tinei Shamu, Beula Senzanje, Chiara Pierotti, Angela Mushavi, Nicola Willis, Frances M Cowan

“…In 2013, they completed a structured interview, clinical examination, psychological screening and had viral load and drug resistance testing. A subset completed in-depth interviews (n = 10). …”
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Molecular Characterization and Epidemiology of Carbapenem-Resistant Enterobacteriaceae Isolated from Pediatric Patients in Guangzhou, Southern China by Fei Gao, Zhile Xiong, Bingshao Liang, Zhenting Huang, Qiulian Deng, Jielin Wang, Huamin Zhong, Yan Long, Sufei Zhu

“…Therefore, this study aimed to investigate the epidemiology of CRE, drug resistance, and resistance mechanisms in children in Guangzhou, Southern China. …”
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The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells by Sabrina Bimonte, Antonio Barbieri, Maddalena Leongito, Giuseppe Palma, Vitale del Vecchio, Michela Falco, Raffaele Palaia, Vittorio Albino, Mauro Piccirillo, Alfonso Amore, Antonella Petrillo, Vincenza Granata, Francesco Izzo

“…Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. …”
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Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection by Shuji Gao, Shuo Yuan, Yingying Quan, Wenjie Jin, Yamin Shen, Rishun Li, Baobao Liu, Yuxin Wang, Li Yi, Shaohui Wang, Xiaogai Hou, Yang Wang

“…Consequently, targeting AI-2 quorum sensing to inhibit biofilm formation represents a promising strategy for preventing and managing drug resistance and chronic infections caused by S. suis. …”
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Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidity by FANG Zijian, LI Qingchun，XIE Li，SONG Xu，DAI Ruoqi，WU Yifei，JIA Qingjun，CHENG Qinglin

“…The adverse outcomes of PTB are associated with first diagnosed hospitals and drug resistance in urban patients, and are associated with the treatment/observed management and fixed-dose combinations throughout the process in rural patients.…”
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Intratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer by Linsheng Xu, Linsheng Xu, Bingde Hu, Jingli He, Xin Fu, Na Liu

“…Although tumor immunotherapy is widely recognized for treating unresectable CRC, challenges such as ineffective immunotherapy and drug resistance remain prevalent. While intratumor microbiome-derived butyrate has been implicated in promoting lung cancer metastasis, its role in CRC chemoresistance is not well understood. …”
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Case report: A panorama gene profile of ovarian cancer metastasized to axillary lymph node by Yu Xia, Yu Huang, Zheng Liu, Siyuan Song, Yi Wang, Yi Wang, Jing Luo

“…This study unraveled the potential mechanism of genetic mutation for tumor metabolism, drug resistance, and metastasis.…”
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Bacterial isolates and drug susceptibility patterns in infected lesions of cutaneous leishmaniasis patients at ALERT hospital, Addis Ababa, Ethiopia by Gizealew Ayalew, Asegedech Asmamaw, Mistire Wolde, Regasa Diriba, Biruk Zerfu

“…These findings highlight the critical needs of microbial diagnostics and antibiotic susceptibility testing in CL patients due to the rising prevalence of drug-resistance, including the multi-drug resistant bacteria.…”
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Targeting Caveolin‐1 in Multiple Myeloma Cells Enhances Chemotherapy and Natural Killer Cell‐Mediated Immunotherapy by Dewen Zhan, Zhimin Du, Shang Zhang, Juanru Huang, Jian Zhang, Hui Zhang, Zhongrui Liu, Eline Menu, Jinheng Wang

“…Here, it is found that caveolin‐1 (CAV1), a primary component of membrane lipid rafts and caveolae, is highly expressed in MM cells and is associated with MM progression and drug resistance. CAV1 knockdown decreases MM cell adhesion to stromal cells and attenuates cell adhesion‐mediated drug resistance to bortezomib. …”
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SNP rs9364554 Modulates Androgen Receptor Binding and Drug Response in Prostate Cancer by Yuqian Yan, Lei Shi, Tao Ma, Liguo Wang, Haojie Huang

“…The downregulation of SLC22A3 is associated with drug resistance. More importantly, we found that this SNP has different binding affinities with transcription factors, specifically FOXA1 and AR, which significantly affects their regulation of <i>SLC22A3</i> transcription. (4) Conclusions: Our findings highlight the potential of using this SNP as a biomarker for predicting chemotherapeutic outcomes and uncover possible mechanisms underlying drug resistance in advanced prostate cancers. …”
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NT5E Mediates Cisplatin Resistance in NSCLC Through the PI3K-AKT Signaling Pathway by Liangfeng Zheng, Jian Liu, Feiyue Ji, Chunxiang Li, Ye Qian, Lili Shao, Xiaomin Lu

“…This finding provides important insights for a deeper understanding of the mechanism of drug resistance in lung cancer and serves as a theoretical basis for the development of new therapeutic strategies and drugs.…”
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Urinary Tract Infections in Adults by Evan B. Cohn, Anthony J. Schaeffer

“…While there have also been advances in the realm of antimicrobials, there have been numerous problems with multiple drug resistant organisms. Providing economical care while minimizing drug resistance requires appropriate diagnosis, evaluation, and treatment of urinary tract infections.…”
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Antibacterial Potency of Honey by Najla A. Albaridi

“…Despite the developments in controlling infectious disease around the world, they are still the second biggest cause of morbidity and mortality due in part to the increase in drug resistance among large numbers of the bacterial strains. …”
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Resveratrol as a potential broad-spectrum compound for cancer treatment by Li Kar Stella Tan, Chee Wun How, Jhi Biau Foo, Kooi Yeong Khaw, Bey Hing Goh, Yong Sze Ong

“…The severe adverse side effects, drug resistance and unaffordable price plagued with chemotherapeutic drugs has spurred the development of “dirty drug”. …”
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BRAF Inhibitors for BRAF V600E Mutant Colorectal Cancers: Literature Survey and Case Report by Yasar Subutay Peker, Mehmet Fatih Can, Ismail Hakki Ozerhan, Gokhan Yagci, Nazif Zeybek, Kutan Kavakli, Sedat Gurkok, Alper Gozubuyuk, Onur Genc, Gokhan Erdem, Ahmet Ozet, Mustafa Gerek, Yusuf Peker

“…A remarkable response was achieved with vemurafenib treatment in which the drug resistance occurred approximately in the sixth month. …”
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Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer by Jinbao Chen, Chenqi Wu, Kun Yu, Jinpei Liu, Jiahua Yang, Wei Li, Xiaoxia Tang, Yihai Shi, Ke Xu, Yi Chen, Xiaoyu Qin

“…Bufalin has a therapeutic effect on both metastasis and drug resistance, but how bufalin affects chemoresistance-mediated metastasis remains unclear. …”
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Phenotypic identification of Metallo-ß- lactamase resistance Gram negative bacteria from a clinical specimen in Sidama, Ethiopia. by Tsegaye Alemayehu, Wondwesson Abera, Musa Mohammed Ali, Bethelihem Jimma, Henok Ayalew, Limenih Habte, Frezer Teka, Demissie Asegu

“…The rates of multi, extensive and pan-drug resistance bacteria accounted for 128/153 (83.7%), 77 /153(50.3%), and 26/153 (17.0%), respectively. …”
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Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis by Ren Liu, Yang Liu, Jiehui Qiu, Qun Ren, Chunping Wei, Dejin Pan, Jianglong Shi, Peng Liu, DanDan Wei, Tianxin Xiang, Na Cheng

“…Abstract The novel pathogen, Elizabethkingia anophelis, has gained attention due to its high mortality rates and drug resistance facilitated by its inherent metallo-β-lactamases (MBLs) genes. …”
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stilPCR increases the effective sequencing length of Illumina targeted next-generation sequencing. by Jason D Limberis, Roland J Nagel, Soumitesh Chakravorty, Dena Block, Scott Dewell, Alina Nalyvayko, Zach Howard, Grant Theron, Rouxjeane Venter, John Z Metcalfe

“…We have successfully utilized stilPCR on clinical sputum from tuberculosis patients to detect drug resistance mutations.…”
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Efficacy and Safety of Paromomycin for Visceral Leishmaniasis: A Systematic Review by Pashupati Pokharel, Rakesh Ghimire, Pratik Lamichhane

“…Despite limited therapies for visceral leishmaniasis and emerging drug resistance, a proper review on the action of paromomycin for kala-azar is lacking. …”
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