Molecular identification of pfcytb, pfdhfr, and pvmrp1 mutations in imported malaria cases in Chile by Alan Oyarce, Lizbeth Huaccha, Esteban M. Cordero, Bárbara Parra, Jorge Fernández, Mario E. Soto-Marchant, Natalia T. Santis-Alay, María Isabel Jercic

“…A key challenge in the global effort to combat malaria is the emergence of drug resistance. Malaria-free countries must also address issues such as limited access to antimalarial drugs and treatment failures caused by drug resistance. …”
Get full text

Is Rhodamine 123 an Appropriate Fluorescent Probe to Assess P-Glycoprotein Mediated Multidrug Resistance in Vinblastine-Resistant CHO Cells? by Jordi Pétriz, José Enrique O’Connor, Mercè Carmona, Joan García‐López

“…It has been reported that functional assessment of the cationic dye rhodamine 123 (Rho123) efflux reveals accurately the drug‐resistant phenotype. To study cellular drug resistance, we have obtained a CHO‐K1 derived cell line resistant to vinblastine by means of multistep selection. …”
Get full text

Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists. by Sophie L Collier, Sarah N Farrell, Christopher D Goodman, Geoffrey I McFadden

“…However, mutations within the organellar genomes of mitochondria and plastids can lead to drug resistance. Such mutations ultimately challenge our ability to control and eradicate the diseases caused by these pathogenic protists. …”
Get full text

Nanotechnology in cancer: advancements in treatment and detection—a review by Abhirami K. Parthasarathi, Someshwar S. Karabsanawar, Prajnashree Acharya

“…These nanoscale materials have the potential to reduce side effects and overcome drug resistance, thus boosting the therapeutic effectiveness. …”
Get full text

Emerging trends and new developments in global research on artemisinin and its derivatives by Yu Lai, Huize Zhang, Xi Chen

“…''Antimalarials,'' ''synthesis,'' ''drug resistance,'' and ''Plasmodium vivax'' are areas of intense research. …”
Get full text

Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker by Yaoting Zhang, Sultan Kadasah, Jiaheng Xie, Dongsheng Gu

“…However, the emergence of drug resistance has brought difficulties to clinical treatment, and new immune checkpoint research is imminent. …”
Get full text

Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans by Saif Hameed, Zeeshan Fatima

“…Continuous deployment of antifungals in treating infections caused by dimorphic opportunistic pathogen Candida albicans has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed multidrug resistance (MDR). …”
Get full text

Differential diagnosis of Brown tumors and bone metastases from parathyroid carcinoma using 18F-FDG PET/CT and 99mTc-MIBI SPECT/CT: A case report by Tuo Ma, Xiaoqian Zhao, Jingmian Zhang, Xinming Zhao

Get full text

Strategies to Overcome Antileishmanial Drugs Unresponsiveness by Shyam Sundar, Anup Singh, Om Prakash Singh

“…As the armoury of antileishmanial drugs is limited, strategies should be made to target the emergence of drug resistance. The loss of efficacy of antimonials such as sodium stibogluconate in the Indian subcontinent which has been the mainstay of treatment for more than six decades has raised concern to save the other drugs. …”
Get full text

Prevalence and molecular characterization of Beta-lactamase resistance gene in multidrug resistance bacteria, Proteus spp. by Sabiha S. Salih, Shno J. Mohammed, Imad M Noori, Lana MA Mohammed, Taib A. Hama Soor

“…Existing of drug resistance bacteria in meat is a series of health concern and beta-lactamase is responsible to generate multi drug resistances in bacteria. …”
Get full text

Seven-Year Analysis of Microbial Keratitis Tendency at an Ophthalmology Department in Poland: A Single-Center Study by Klaudia Ulfik, Sławomir Teper, Michał Dembski, Anna Nowińska, Ewa Wróblewska-Czajka, Edward Wylęgała

“…The choice of a targeted drug depends on the culture result and drug resistance of the microorganism. This was a retrospective observation study. …”
Get full text

Advances in Immunotherapy and Targeted Therapy of Malignant Melanoma by Xue Wang, Shanshan Ma, Shuting Zhu, Liucun Zhu, Wenna Guo

“…Traditional treatments such as surgery, chemotherapy, and radiotherapy are unable to achieve the expected results due to MM’s low sensitivity, high drug resistance, and toxic side effects. As treatment advances, immunotherapy and targeted therapy have made significant breakthroughs in the treatment of MM and have demonstrated promising application prospects. …”
Get full text

Application of a macrocyclization strategy in kinase inhibitor development by Kun Xing, Shujun Li, Jinghuan Li, Dan Liu, Min Huang, Linxiang Zhao

“…The macrocyclization strategy is now widely used to enhance kinase inhibitory activity, overcome drug resistance caused by point mutations, improve kinase selectivity, and optimize drug-like properties. …”
Get full text

St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo. by Yanxia Guo, Shikang Wang, Qun Liu, Yan Dong, Yongqing Liu

“…Drug resistance of cancers remains a major obstacle due to limited therapeutics. …”
Get full text

In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead? by Carlotta Mattioda, Claudia Voena, Gianluca Ciardelli, Clara Mattu

“…Currently available therapies, including chemotherapy, immunotherapy, and CAR-T cells, are often associated with important side effects and with the development of drug resistance and, consequently, disease relapse. In the last decades, it was largely demonstrated that the tumor microenvironment significantly affects cancer cell proliferation and tumor response to treatment. …”
Get full text

The Spread of Antibiotic Resistance Genes In Vivo Model by Shuan Tao, Huimin Chen, Na Li, Tong Wang, Wei Liang

“…There is a consensus on the role of mobile genetic elements (MGEs) in the spread of bacterial resistance. Most drug resistance genes are located on plasmids, and the spread of drug resistance genes among microorganisms through plasmid-mediated conjugation transfer is the most common and effective way for the spread of multidrug resistance. …”
Get full text

Rationality of Tuberculosis Treatment for Drug-Susceptible Pulmonary Tuberculosis at a Primary Care in Bandung by Alfi Nurul Islamiyah, Syarifuddin Syarifuddin, Morsalina Akhsa, Iis Rukmawati, Eni Margayani, Linda Purnamawati Suherman, Vina Septiani, Robby Ramdani

“…Ensuring rational TB treatment is crucial for effective disease control and preventing the emergence of drug resistance. This study aimed to evaluate the rationality of TB treatment among newly diagnosed drug-susceptible pulmonary TB patients in a primary care center in Bandung. …”
Get full text

Patterns of biofilm production and antiseptic resistance in multidrug-resistant Acinetobacter baumannii clinical isolates by Ušjak Dušan, Bošković Lidija

“…Predominantly hospital-derived, the isolates showed a high proportion of antimicrobial drug resistance, with 93.75% classified as extensively drug-resistant (XDR), and the rest as multidrug-resistant (MDR). …”
Get full text

Targeting ferroptosis: a promising approach for treating lung carcinoma by Ziyang Wu, Yan Zhang, Wendi Zhong, Kunjian Wu, Tian Zhong, Tao Jiang

“…The efficacy of targeted therapies and immunotherapies is commonly compromised by the emergence of drug resistance and other factors, resulting in a lack of durable therapeutic benefits. …”
Get full text

Diagnosis and Treatment of Childhood Pulmonary Tuberculosis: A Cross-Sectional Study of Practices among Paediatricians in Private Sector, Mumbai by Carolyn Kavita Tauro, Nilesh Chandrakant Gawde

“…Sputum negative TB suspect is always tested with X-ray or tuberculin skin test. 61.4% prescribe regimen as recommended in ISTC and all monitor progress to treatment clinically. Drug-resistance at beginning of treatment is suspected for child in contact with a drug-resistant patient (67.7%) and with prior history of antitubercular treatment (12.9%). …”
Get full text