Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma by Liang Ma, Yuling Li, Jingxian Wu, Yanfei Gao

“…Analysis of somatic copy number alterations in the TCGA (The Cancer Genome Atlas)-UCEC dataset revealed a connection between CDKN2A and drug metabolism in UCEC. Assessment of the relationship between CDKN2A and genes involved in immunotherapy for UCEC patients showed a negative correlation between CDKN2A and CD8+ T cell activity, as well as IL-2 and TP53. …”
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Tumor microbiome: roles in tumor initiation, progression, and therapy by Shengxin Zhang, Jing Huang, Zedong Jiang, Huan Tong, Xuelei Ma, Yang Liu

“…Additionally, tumor microbiome is closely associated with drug resistance and influences therapeutic efficacy by modulating immune responses, drug metabolism, and apoptotic pathways. Furthermore, we explore innovative microbe-based therapeutic strategies, such as engineered bacteria, oncolytic virotherapy, and other modalities aimed at enhancing immunotherapeutic efficacy, paving the way for microbiome-centered cancer treatment frameworks.…”
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Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1 by Xiaowen Hu, Mengsiyu Li, Chunxue Zhang, Shuguang Pang

“…Metformin, as a first-line treatment for diabetes, interacts with many protein kinases and transcription factors which affect the expression of downstream target genes governing drug metabolism. Sulfotransferase, SULT2A1, one phase II metabolic enzyme, sulfonates both xenobiotic and endobiotic compounds to accelerate drug excretion. …”
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Interaction of α-Cembrenediol with Human Serum Albumin Based on Spectroscopic and Computational Analyses by Xian-Kun Su, Zhen-Chun Sun, Chang-You Zhao, Hui Yang, Tian-Ming Zhao, Chao Ma, Guo-Fei Zhu

“…However, knowledge of the absorption, transport, and release of α-cembrenediol in drug metabolism within the body is currently limited. …”
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The AhR pathway regulation in phthalates-induced cancer promotion, progression and metastasis: a scoping review by Mostafa Akbariani, Mahmoud Omidi, Zohreh Shahabi, Hamed Haghi-Aminjan, Amir Shadboorestan

“…Specifically, DEHP activated AhR, leading to elevated expression of EMT markers, increased cancer stem cell populations, and enhanced drug metabolism and resistance. Other phthalates, such as Butyl Benzyl Phthalate (BBP), also activated AhR-mediated pathways, promoting angiogenesis and metastasis. …”
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Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer by Yixiang Gu, Ruifeng Yang, Yang Zhang, Miaomiao Guo, Kyle Takehiro, Ming Zhan, Linhua Yang, Hui Wang

“…This review provides a comprehensive analysis of the key molecular mechanisms underlying chemotherapy resistance, including drug efflux, enhanced DNA damage repair (DDR), apoptosis evasion, epigenetic modifications, altered intracellular drug metabolism, and the role of cancer stem cells (CSCs). …”
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Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease by Tomonori Sugita, Katsushi Amano, Masanori Nakano, Noriko Masubuchi, Masahiro Sugihara, Tomokazu Matsuura

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Comparison of target concentration of propofol during three phases of live donor liver transplant surgery using a target-controlled infusion of propofol total intravenous anaesthes... by Neha Garg, Yatin Kalra, Shivali Panwar, Mahesh K. Arora, Udit Dhingra

“…Background and Aims: Three phases (dissection, anhepatic, and neohepatic) exist for propofol pharmacokinetics during liver transplantation (LT), resulting in varying cardiac output, volume of distribution, and drug metabolism. The primary objective was to compare the mean target concentration of propofol required to maintain the bispectral index (BIS) between 40 and 60 during three phases of LT by using a target-controlled infusion of total intravenous anaesthesia (TCI-TIVA). …”
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Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

“…IntroductionCancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes.MethodsThis study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. …”
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Optimizing Antipsychotic Therapy in Acute Alcoholic Hallucinosis through Pharmacogenetic Testing by Valentin Skryabin, Anton Masyakin, Sergei Pozdniakov, Igor Shatokhin, Svetlana Sokolova, Valentina Ivanchenko

“…Pharmacogenetics, which examines gene variants affecting drug metabolism, may improve treatment outcomes by guiding medication selection and dosage. …”
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A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers by Ghanshyam B. Dudhatra, Shailesh K. Mody, Madhavi M. Awale, Hitesh B. Patel, Chirag M. Modi, Avinash Kumar, Divyesh R. Kamani, Bhavesh N. Chauhan

“…Their mechanism of action is mainly through absorption process, drug metabolism, and action on drug target. This paper clearly indicates that scientific researchers and pharmaceutical industries have to give emphasis on experimental studies to find out novel active principles from such a vast array of unexploited plants having a role as a bioavailability and bioefficacy enhancer. …”
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Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan by Yi Liu, Xiaomu Kong, Yongwei Jiang, Meimei Zhao, Peng Gao, Xiao Cong, Yongtong Cao, Liang Ma

“…The differences in the antihypertensive treatment with angiotensin type II receptor blockers (ARBs) may be attributed to polymorphisms in genes involving drug-targeted receptor and drug metabolism. The present study aimed to investigate whether the antihypertensive effect of the ARB drug valsartan was associated with angiotensin II type 1 receptor (AGTR1) gene polymorphism (A1166 C) and cytochrome P450 enzyme 2C9 (CYP2C9) gene polymorphism (CYP2C9∗3). …”
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Bioinformatics analysis combined with experimental validation reveals the biological role of the ILK gene in prostate cancer by Xiao-xiang Yu, Yi Liu, Rong-jiang Luo, Zi-xuan Song, Wen-kai Chen, Zeng-mi Mo, Feng-jing Wang

“…The protein–protein interaction (PPI) network analysis revealed that MYC was the central regulatory gene, with the intersected genes mainly involved in regulating cell adhesion and drug metabolism in prostate cancer (PCa). Experimental results showed LNCaP cell proliferation was significantly inhibited in the knockdown groups (P < 0.001). …”
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New Insights Into Hepatic Impairment (HI) Trials by Sebastian Haertter, Maximilian Lobmeyer, Brian C. Ferslew, Pallabi Mitra, Thomas Arnhold

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Cytochrome P450 2J2*7 Single-nucleotide Polymorphism and Nocturnal Hypertension in an Elderly Turkish Population by Elif Hilal Vural, Arzu Güneş Granberg, Atiye Çengel, Marja-Liisa Dahl, Hakan Zengil

“…The CYP2J2*7 (G/T) polymorphism was evaluated using a Taqman® Drug Metabolism Genotyping Assay kit and a TAQMAN ABI7900 device. …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…Abstract Cytochrome P450 (CYP) 3A4 plays a major role in drug metabolism. Its activity could be determined by non-invasive and cost-effective assays, such as breath analysis, for the personalised monitoring of drug response. …”
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Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review. by Mahima Joshi, Javed Muneer, Lawrence Mbuagbaw, Ipsita Goswami

“…The proportion of neonates receiving routine sedation-analgesia during TH is center-specific and varies from 40-100% worldwide. TH alters most drugs' metabolic rate and clearance, except for Midazolam. …”
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AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volun... by Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar

“…The role of AKR1D1*36C>T (rs 1872930) allelic variant in interindividual variability of CYP450 mediated drug metabolism was recently elucidated. A total of 27 healthy male subjects, volunteers in IBP single-dose two-way cross-over bioequivalence studies were genotyped for CYP2C9*2, CYP2C9*3 and AKR1D1*36 polymorphisms. …”
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Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…BackgroundPregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone due to ethical and practical constraints. …”
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Advances, challenges and future applications of liver organoids in experimental regenerative medicine by Da Gong, Jiaye Mo, Jiaye Mo, Mei Zhai, Fulin Zhou, Guocai Wang, Shaohua Ma, Xiaoyong Dai, Xiaoyong Dai, Xuesong Deng

“…After several years of refinement, human liver organoids can now accurately replicate the liver’s morphological structure, nutrient and drug metabolism, gene expression, and secretory functions, providing a robust model for liver disease research. …”
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