The absorption of oral morroniside in rats: In vivo, in situ and in vitro studies by Xiong Shan, Li Jinglai, Mu Yanling, Zhang Zhenqing

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MDMA Impairs Response to Water Intake in Healthy Volunteers by Matthew J. Baggott, Kathleen J. Garrison, Jeremy R. Coyle, Gantt P. Galloway, Allan J. Barnes, Marilyn A. Huestis, John E. Mendelson

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Pharmacomicrobiomics: a new field contributing to optimizing drug therapy in Parkinson’s disease by Yi Zhang, Chengjun Mo, Penghui Ai, Xiaoqin He, Qin Xiao, Xiaodong Yang

“…In recent years, a growing body of evidence indicates that the gut microbiota influence drug metabolism and efficacy. Conversely, drugs also exert a substantial influence on the function and composition of the gut microbiota. …”
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Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations by Xenia A. K. Kersting, Nicoletta Momtahen, Klaus Lieb

“…It is well established that immune responses can trigger cytokine cascades affecting drug metabolism, which, in the case of clozapine treatment, can lead to severe intoxication.…”
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Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms by Przemysław J. Danek, Władysława A. Daniel

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Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway by Wang Fengling, Ye Xi, Zhai Dandan, Dai Wenting, Wu Yifan, Chen Jin, Chen Weidong

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Ataxia and Seizures despite Phenytoin: A Case Report Highlighting the Importance of TDM and Genetic Influences by Rachel Manoj, Arpita Meher, Jefry Winner G.

“…This case underscores the significance of TDM, genetic considerations in drug metabolism, and the need to be vigilant in treating epilepsy to prevent such adverse events.…”
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Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics by Guangqing Xiao, Liang-Shang Gan

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The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity by Cong Han, Ran-ran Gao, Le Zhou, Wei Li

“…The six pathways related to energy metabolism driven by L. reuteri, including the citrate cycle, ascorbate and alderate metabolism, proximal tube bicarbonate metabolism, glycolysis/gluconeogenesis, ferroptosis, drug metabolism–cytochrome P450, are important mechanisms.…”
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A case-control genome-wide association study of estimated breeding values for resistance to gastrointestinal nematodes in two local dairy sheep breeds by C. Persichilli, S. Biffani, G. Senczuk, M. Di Civita, M.K. Bitew, A. Bosco, L. Rinaldi, S. Grande, G. Cringoli, F. Pilla

“…Many of these pathways were involved in the regulation of the immune response, drug metabolism and detoxification, and vitamin metabolism. …”
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The controversies of parabens – an overview nowadays by Petric Zvonimir, Ružić Julia, Žuntar Irena

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HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm. by Mengyao Zhou, Mengfan Xu, Xiangling Zhang, Xiaochun Xing, Yang Li, Guanghui Wang, Guiying Yan

“…We first reconstruct a novel angina pectoris drug dataset, which include drug name, drug metabolism, chemical formula, targets and pathways, then construct a comprehensive human pathway network based on the genetic similarity of the pathways which contain information about the targets. …”
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Improving breast cancer treatments using pharmacomicrobiomics by Aswin Anand Pai, Aadra Prashant Bhatt

“…However, a significant proportion of patients experience disease recurrence due to treatment failure attributed to various factors, including disease pathology, genetics, and drug metabolism. Alam et al. introduce gut microbiota as a key factor influencing tamoxifen pharmacokinetics (Y. …”
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Relapsing Malaria: A Case Report of Primaquine Resistance by Christopher Dijanic, Jillian Nickerson, Sunita Shakya, Amanda Dijanic, Marilyn Fabbri

“…However, in patients with repeated treatment failure, we must consider CYP-450 mutations affecting drug metabolism as an important cause of relapse. A 47-year-old man who travelled to a jungle in Venezuela was diagnosed with P. falciparum and P. vivax in July 2015. …”
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Pramipexole Extended Release: A Novel Treatment Option in Parkinson's Disease by Wolfram Eisenreich, Bernd Sommer, Sebastian Hartter, Wolfgang H. Jost

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Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species by Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodríguez

“…Furthermore, transcriptomic evidence is revealing that biological sex is a variable impacting physiology, immune response, drug metabolism, and consequently, the progression of disease. …”
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A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels by Subrata Deb, Prasanth Puthanveetil, Prashant Sakharkar

“…Underlying hepatic pathophysiology from dyslipidemia deserves further exploration due to its potential effects on hepatic drug metabolism/detoxification.…”
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Drugs of Abuse Can Entrain Circadian Rhythms by Ann E. K. Kosobud, Andrea G. Gillman, Joseph K. Leffel, Norman C. Pecoraro, G. V. Rebec, William Timberlake

“…This could be the basis for known daily variations in drug metabolism, tolerance, and sensitivity to drug reward. …”
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The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and me... by Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu

“…The transcriptome data revealed the involvement of many differentially expressed genes in chemical carcinogenesis, drug metabolism, and metabolism of xenobiotics by cytochrome P450. …”
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Untargeted urine metabolomics reveals dynamic metabolic differences and key biomarkers across different stages of Alzheimer’s disease by Xiaoya Feng, Shenglan Zhao

“…Pathway enrichment analysis revealed that Drug metabolism was significantly enriched across all stages, while Retinol metabolism was particularly prominent during the transition stages. …”
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