Nano-technological advancements in multimodal diagnosis and treatment by Dinesh Bhatia, Tania Acharjee, Shruti Shukla, Monika Bhatia

“…Beyond imaging, NPs offer a “one-two punch” in the treatment of complicated disorders by enabling photothermal (PTT), photodynamic (PDT), and multimodal therapies (MMT), as well as nano drug delivery systems (NDDS). This nanotechnology-based technique personalizes medicines for diseases such as tuberculosis (TB) and cardiovascular disease (CVD), focusing on damaged tissues to improve therapeutic response. …”
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Cationic Polymers Inhibit the Conductance of Lysenin Channels by Daniel Fologea, Eric Krueger, Steve Rossland, Sheenah Bryant, Wylie Foss, Tyler Clark

“…These findings reveal key structural characteristics which may provide insight into lysenin’s functionality while opening innovative approaches for the development of applications such as transient cell permeabilization and advanced drug delivery systems.…”
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Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies by Amirata Mohseni, Fatemeh Salehi, Samaneh Rostami, Kaveh Hadiloo, Mehrdad Hashemi, Zahra Baridjavadi, Fatemeh Ahangari, Najibeh Karami, Fatemeh Samani, Safa Tahmasebi, Najma Farahani, Afshin Taheriazam

“…Due to their small size and ability to reach tumor microenvironments, exosomes are also used as carriers for chemotherapeutic drugs in drug delivery systems. Furthermore, evidence indicates that malignant cells release exosomes into the tumor microenvironment, influencing immune cells in a paracrine manner. …”
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Oral colon-targeted responsive chitosan/pectin-based nanoparticles propels the application of tofacitinib in colitis therapy by Chunfei Wu, Chuanlin Bi, Geun-soo Kim, Zizhen Yang, Shuao Li, Tong Dai, Xiaoyu Wu, Jiaojiao Tan, Ningning He, Shangyong Li

“…The present study aims to develop an efficient oral colon-targeted drug delivery systems using prebiotic pectin (Pcn) and chitosan (Csn) polysaccharides as a shell, with Tof loaded into a Bovine Serum Albumin (BSA) core, and improving it with chondroitin sulfate (Chs), thus constructing Tof@BSA-Chs-CP nanoparticles (NPs). …”
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Quality by Design-Based Methodology for Development of Titanate Nanotubes Specified for Pharmaceutical Applications Based on Risk Assessment and Artificial Neural Network Modeling by Ranim Saker, Géza Regdon, Krisztina Ludasi, Tamás Sovány

“…Methods: In the present work, a risk assessment-based procedure was developed and completed using ANN-based modeling to enable the design and fabrication of titanate nanotube-based drug delivery systems with desired properties, based on the critical analysis and evaluation of data collected from published articles regarding titanate nanotube preparation using the hydrothermal treatment method. …”
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Tuning gut microbiota by advanced nanotechnology by Yue Qi, Yueyi Wang, Xiaofei Wang, Hao Zheng, Yuan Lu

“…This review will focus on research progress in nanotechnology to modulate gut microbiota, including the direct use of nanomaterials as antimicrobials, nano-drug delivery systems, and stimulus-responsive nanotechnology. …”
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PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“…Also, when PROTACs are incorporated into sophisticated drug delivery systems, their desirability and selectivity are further improved beyond existing issues related to small-molecule inhibitors. …”
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Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications by Hai Jiang, Ranil Vikraman Kumarasamy, JinJin Pei, Kamaraj Raju, Gopalakrishnan Velliyur Kanniappan, Chella Perumal Palanisamy, Ion Dan Mironescu

“…This comprehensive review explores the integration of engineered nanomaterials with EVs to advance drug delivery systems. It covers various aspects of this integration, including techniques for synthesizing, loading, characterizing, and applying nanomaterials within EVs. …”
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Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications by Sorina Dinescu, Simona Rebeca Ignat, Andreea Daniela Lazar, Ștefania Marin, Elena Danilă, Maria M. Marin, Denisa Ioana Udeanu, Mihaela Violeta Ghica, Mădălina G. Albu-Kaya, Marieta Costache

“…In this work, we have characterized the properties and biocompatibility of these multiparticulate drug delivery systems (MDDS) and we have demonstrated their efficiency against burns and soft tissue lesions, particularly when the drug was microencapsulated, and thus with a controlled release. …”
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Synthesis and crystal structure of piperidinyl propanenitrile towards the preparation of piperidine based bioactive films for drug delivery applications by Reham A. Mohamed-Ezzat, Mohamed S. Hasanin, Benson M. Kariuki, Sawsan Dacrory

“…Thus, they are promising in developing drug delivery systems essential in the pharmaceutical industry. …”
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Synthesis and Characterization of 5-Fluoroacil Loaded Calcium Carbonate Nanoparticles for Targeted Cancer Therapy by Kshidan Marim Abdullah Salem, Mohamed Ahmed Ibrahim, Kim Wei Chan, Md Zuki Abu Bakar, Noorjahan Banu Alitheen, Mohammed Alsubbi, Ahmad Faizal Abdull Razis, Norsharina Ismail

“…1736142025"> Chemotherapy is often limited by its systemic toxicity and lack of specificity, necessitating the development of targeted drug delivery systems that can enhance therapeutic efficacy while minimizing adverse effects. …”
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Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier by Hitaishi Sharma, Kannan Badri Narayanan, Shampa Ghosh, Krishna Kumar Singh, Prarthana Rehan, Aparajita Dasgupta Amist, Rakesh Bhaskar, Jitendra Kumar Sinha

“…Despite their potential, more studies are needed to ensure the safety and efficacy of NP-based drug delivery systems focusing on critical aspects such as toxicity, immunogenicity, and pharmacokinetics. …”
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Nanoparticles assisted drug delivery for effective management of Glioblastoma by Mansi Damani, Nagesh Nilawar, Munira Momin, Raghumani Singh Ningthoujham, Tabassum Khan

“…The integration of nanotechnology in GBM treatment highlights the potential for nanoparticles to revolutionize drug delivery systems, overcoming the inherent challenges posed by the BBB and the tumor microenvironment. …”
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Synthesis and release profile of ibuprofen-loaded zein and gelatin nanofiber scaffolds for potential transdermal application in burn wound treatment by umaima saleem memon, Murk saleem memon, Abdul Wahab Memon, Mehwish Shahzad, Murk Rehman, Farooq Ahmed, Zeeshan Khatri

“…Fibrous mats based on nanotechnology have been extensively researched for their potential as drug delivery systems. The fabrication of electrospun polymeric nanofibrous mats containing non-steroidal anti-inflammatory medications (NSAIDs) and antibacterial agents has been discussed in this article. …”
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Navigating large-volume subcutaneous injections of biopharmaceuticals: a systematic review of clinical pipelines and approved products by Philip Green, Andreas Schneider, Jakob Lange

“…These findings highlight the importance of developing large-volume drug delivery systems and novel formulations to reduce injection volumes. …”
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A comprehensive review on alpha-lipoic acid delivery by nanoparticles by Navid Mosallaei, Amirhossein Malaekeh-Nikouei, Setayesh Sarraf Shirazi, Javad Behmadi, Bizhan Malaekeh-Nikouei

“…To overcome these limitations and enhance ALA's therapeutic efficacy, various nanoparticulate drug delivery systems have been explored. This comprehensive review evaluates the application of different nanoparticulate carriers, including lipid-based nanoparticles (solid lipid nanoparticles, niosomes, liposomes, nanostructured lipid carriers (NLCs), and micelles), nanoemulsions, polymeric nanoparticles (nanocapsules, PEGylated nanoparticles, and polycaprolactone nanoparticles), films, nanofibers, and gold nanoparticles, for ALA delivery. …”
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Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer by Yixiang Gu, Ruifeng Yang, Yang Zhang, Miaomiao Guo, Kyle Takehiro, Ming Zhan, Linhua Yang, Hui Wang

“…Finally, we discuss current strategies aiming at overcoming chemotherapy resistance, such as combination therapies, targeted treatments, and novel drug delivery systems, while proposing future directions for research in this evolving field. …”
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Mechanistic insights into endosomal escape by sodium oleate-modified liposomes by Ebrahim Sadaqa, Satrialdi, Fransiska Kurniawan, Diky Mudhakir

“…Endosomal entrapment significantly limits the efficacy of drug delivery systems. This study investigates sodium oleate-modified liposomes (SO-Lipo) as an innovative strategy to enhance endosomal escape and improve cytosolic delivery in 4T1 triple-negative breast cancer cells. …”
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Immunotherapy versus targeted therapy in management of recurrent squamous cell carcinoma of oral tongue by Nadimul Hoda, Aastha Moza, K.P. Amith, K.S. Sabitha

“…Based on the targeted drug delivery systems with specific physiochemical properties and tailored structure, carriers can load anti-cancer drugs to target the malignant cells.…”
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Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

“…To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes.MethodsThis study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. …”
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