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Discovery of novel TACE inhibitors using graph convolutional network, molecular docking, molecular dynamics simulation, and Biological evaluation.
Published 2024-01-01“…From these predictions, Vorinostat was identified as a potential TACE inhibitor. Moreover, molecular docking and molecular dynamics simulation were conducted to validate these findings, using BMS-561392 as a reference TACE inhibitor. …”
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122
Failure Mechanism and Stability Control of Surrounding Rock of Docking Roadway under Multiple Dynamic Pressures in Extrathick Coal Seam
Published 2020-01-01“…Under the geological environment of No. 16 extrathick coal seam in the Laoshidan coal mine and taking the working face 031604 as the research background, the reasonable docking position selection of the withdrawal roadway and the docking roadway in the middle mining period and the surrounding rock stability control problems of the withdrawal roadway and the docking roadway during the final mining period were studied by using the methods of field theoretical analysis, numerical simulation, and field measurement. …”
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Synthesis, DFT Analysis, and Evaluation of Antibacterial and Antioxidant Activities of Sulfathiazole Derivatives Combined with In Silico Molecular Docking and ADMET Predictions
Published 2021-01-01“…The synthesized compounds were evaluated for their in silico molecular docking analysis using S. aureus gyrase (PDB ID: 2XCT) and human myeloperoxidase (PDB ID: 1DNU) and were found to have minimum binding energy ranging from −7.8 to −10.0 kcal/mol with 2XCT and −7.5 to −9.7 with 1DNU. …”
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125
Exploring the Anti-depression Mechanism of Polygonatum ordoratum Based on GEO Database Combined with Network Pharmacology and Molecular Docking Technology
Published 2025-01-01“…GO and KEGG enrichment analyses were performed using the DAVID database. Molecular docking verification of the main active components and targets was performed using SYBYL-X 2.0 software. …”
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126
Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach
Published 2025-02-01Subjects: Get full text
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127
Exploring the inhibitory effect and mechanism of isorhamnetin therapy on oral squamous cell carcinoma based on network pharmacology and molecular docking
Published 2025-01-01Subjects: “…isorhamnetin|oral squamous cell carcinoma|pi3k/akt signaling pathway|src tyrosine kinase|estrogen receptor-1|network pharmacology|molecular docking|experimental verification <i>in vitro</i>…”
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128
Design, Synthesis, enzyme inhibitory activity and molecular docking studies of new 1,2,3-triazole linked nucleobases
Published 2025-01-01“…Interestingly, four compounds, including 5d, 5h, 5k and 5m displayed excellent potent level of enzyme inhibitory activity at 10−7 M concentration. Further, molecular docking analysis revealed that some compounds shown significant binding interactions with target sites. …”
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129
Screening and Characterizing Tyrosinase Inhibitors from Salvia miltiorrhiza and Carthamus tinctorius by Spectrum-Effect Relationship Analysis and Molecular Docking
Published 2018-01-01“…Therefore, the developed methods (spectrum-effect relationship analysis and molecular docking) could be used to effectively screen TYR inhibitors in complex mixtures such as natural products.…”
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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi
Published 2024-01-01“…Conversely, the in silico molecular docking studies were attained via a Biovia Discovery Studio Visualizer 2021 in combination with the AutoDock Vina software. …”
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Identification of musk compounds as inhibitors of the main SARS-CoV-2 protease by molecular docking and molecular dynamics studies
Published 2024-01-01Subjects: Get full text
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Nano-Azo Ligand and Its Superhydrophobic Complexes: Synthesis, Characterization, DFT, Contact Angle, Molecular Docking, and Antimicrobial Studies
Published 2020-01-01“…The binding between H2L and its Cd(II) complex with receptors of the crystal structure of S. aureus (PDB ID: 3Q8U), crystal structure of protein phosphatase (PPZ1) of Candida albicans (PDB ID: 5JPE), receptors of breast cancer mutant oxidoreductase (PDB ID: 3HB5), and crystal structure of Escherichia coli (PDB ID: 3T88) was predicted and given in detail using molecular docking.…”
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Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking
Published 2016-09-01Subjects: Get full text
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Structural design, accuracy analysis, and mechanical calibration of a small two-component docking mechanism for large loads in space
Published 2025-02-01Subjects: “…Space docking mechanism…”
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138
Screening and evaluation of novel DPP-IV inhibitory peptides in goat milk based on molecular docking and molecular dynamics simulation
Published 2025-01-01“…This study aimed to screen DPP-IV inhibitor peptides in goat milk after simulated digestion in vitro combined with molecular docking and dynamics simulations. By evaluating the docking energy and active sites, and by analyzing RMSD, RMSF, and Rg values, two novel peptides, GPFPLL and LPYPY, were successfully screened and identified. …”
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NMR, Novel Pharmacological and In Silico Docking Studies of Oxyacanthine and Tetrandrine: Bisbenzylisoquinoline Alkaloids Isolated from Berberis glaucocarpa Roots
Published 2018-01-01“…The antiurease nature and possible mode of action for compounds 1 and 2 were verified and explained through their molecular docking studies against jack-bean urease enzyme. Half-maximum inhibitory concentration (IC50) was calculated for compounds 1 and 2. …”
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