Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…The main objective of this study was to synthesize and determine the efficacy and safety of antiplasmodial hybrid drug comprising the sarcosine and aniline derivative for management of plasmodial infections. …”
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Clinical outcomes among HIV positive babies below 18 months of age, diagnosed under the Early Infant Diagnosis (EID) programme, India: a mixed-methods studyResearch in context by Suchit Kamble, Nilesh Gawde, Shilpa Bembalkar, Noopur Goel, Mohan Thorwat, Kalyani Nikhare, Sushmita Kamble, Radhika Brahme, Swapna Pawar, Harsh Kubavat, Bhawanisingh Kushwaha, Vinita Verma, Chinmoyee Das, Raman Gangakhedkar

“…Its impact on the clinical outcomes of infants covered under the programme and associated determinants have not been reported. Methods: This was a mixed-methods study. …”
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Integrated Effects of Water and Nitrogen Coupling on Eggplant Productivity, Fruit Quality, and Resource Use Efficiency in a Cold and Arid Environment by Jie Li, Hengjia Zhang, Chenli Zhou, Anguo Teng, Lian Lei, Yuchun Ba, Jiandong Yu, Fuqiang Li

“…Using the EWM-TOPSIS model, we evaluated different water-nitrogen treatments and determined the optimal irrigation-nitrogen application model for eggplants in this region. …”
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A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year by Eman A. Alraddadi, Eman A. Alraddadi, Hashim F. Alotaibi, Hashim F. Alotaibi, Yasser Alatawi, Ahmed Aljabri, Ahmed A. Alghamdi, Ahmed A. Alghamdi, Fahad Alturki, Fahad Alturki, Faisal F. Alamri, Faisal F. Alamri

“…The primary aim was to determine the risk factors associated with recurrent stroke within 365 days. …”
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Hubungan Indeks Masa Tubuh dan Lingkar Perut dengan Low Density Lipoprotein pada Pasien Penyakit Jantung Koroner di Poliklinik Jantung RSUP Dr. M. Djamil Padang by Medika Prasetya, Fadil Oenzil, Yerizal Karani

“…The objective of this study was to determine the relationship of BMI (body mass index) and abdominal circumference (LP) to high levels of low-density lipoproteins (LDL) in patients with CHD in the Heart Clinic Dr M Djamil Padang in May in 2012. …”
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Potential drug targets for asthma identified through mendelian randomization analysis by Xingxuan Chen, Yu Shang, Danting Shen, Si Shi, Zhe Wen, Lijuan Li, Hong Chen

“…Conclusion A causal relationship exists between genetically determined protein levels of IL1R1, IL7R, ECM1, CD200R1, ADAM19, IL-6 sRa, and Layilin (LAYN) and asthma. …”
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The Role of Bronchoalveolar Lavage in Therapeutic Antimicrobial Choices for Hematologic Patients with Pulmonary Infiltrates by Filippo Patrucco, Mattia Bellan, Davide Martinotti, Giuseppe Ielo, Paola Rebecca Iovine, Martina Mascheroni, Francesco Todisco, Martina Ubaldi, Nadia Castaldo, Francesco Gavelli, Alberto Fantin

“…This study aimed to determine the diagnostic yield of BAL in hematological patients for microbiological purposes and its influence on modifying the therapeutic strategy. …”
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Pemeriksaan Laboratorium Cystatin C Untuk Uji Fungsi Ginjal by Rismawati Yaswir, Afrida Maiyesi

“…Urine levels of CysC can be done to determine the presence of proximal tubular dysfunction. …”
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Penerapan Metode Association Rule Mining untuk Asosiasi Ulasan Terhadap Aspek Tempat Wisata Jawa Timur Park 3 by Aisyatul Maulidah, Fitra A. Bachtiar

“…Testing was conducted to determine the minimum support and minimum confidence impact of the established rules. …”
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Ruthenium(II) Complex with 1-Hydroxy-9,10-Anthraquinone Inhibits Cell Cycle Progression at G0/G1 and Induces Apoptosis in Melanoma Cells by Júlia S. M. Dias, Guilherme A. Ferreira-Silva, Rommel B. Viana, João H. de Araujo Neto, Javier Ellena, Rodrigo S. Corrêa, Marília I. F. Barbosa, Marisa Ionta, Antônio C. Doriguetto

“…Results: Compound (<b>2</b>) was determined by single-crystal X-ray diffraction, which confirms the bidentate coordination mode of HQ through the carbonyl and phenolate oxygens. …”
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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…While early-onset AD has well-established genetic determinants, the genetic basis for late-onset AD remains less clear. …”
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Seasonal Trends, Profiles, and Exposure Risk of PM2.5-bound Bisphenol Analogs in Ambient Outdoor Air: A Study in Shanghai, China by Janvier Munyaneza, Fahim A. Qaraah, Qilong Jia, Hanting Cheng, Huajun Zhen, Guangli Xiu

“…The hazard quotient (HQ) which ranged from 8.61 × 10−9 to 7.02 × 10−5 with BPA determined as the major contributor (97.08% for ∑HQ) wasn’t detrimental to the health of Shanghainese. …”
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Impact of a 6-Month Micronutrient-Dense Plant-Rich Nutrition Intervention on Health and Well-Being at the Worksite by Jay T. Sutliffe, Julia C. Gardner, Michelle M. Gorman, Mary Jo Carnot, Wendy S. Wetzel, Tricia Fortin, Chloe A. Sutliffe, Alison Adams

“…This nonrandomized pilot study utilized the health belief model and the theory of planned behavior to assess the effectiveness of perceived behavioral control to determine the impact of a micronutrient-dense plant-rich (mNDPR) dietary intervention on employee health and wellness at the worksite. …”
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Biliary atresia susceptibility gene EFEMP1 regulates extrahepatic bile duct elastic fiber formation and mechanics by Kapish Gupta, Jessica Llewellyn, Emilia Roberts, Chengyang Liu, Ali Naji, Richard K. Assoian, Rebecca G. Wells

“…We also repurposed pressure myography, a technique heretofore applied to the vasculature, to determine the contribution of elastin and fibulin-3 to extrahepatic bile duct mechanics. …”
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Le temple polygonal de la rue Lecointre à Reims/Durocortorum by Sébastien Péchart, Frédéric Poupon

“…Although it is difficult to determine the actual importance of cult or funerary activities carried out on the site during the late La Tène period, the chronological sequence of evidence, in particular the construction of a polygonal temple with a centered plan in the last third of the 1st c. …”
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Effect of Aerobic Treadmill Exercise Regulating Glucose Transporter 9 on Renal Function in Hyperuricemia Rats by LIANG Jiarong, YANG Huan, CUN Yongdan, WANG Lihuan, LI Yijie, YE Bin

“…Hematoxylin-eosin (HE) was used to stain the renal histopathological section, and the microscope (×400) was used to observe the structural changes of renal tubules and glomerulus; the peroxidase method was used to detect the renal function indexes such as uric acid (UA), creatinine (Cre) and urea nitrogen (BUN); enzyme-linked immunosorbent assay (ELISA) method was used to determine the contents of interleukin-1β (IL-1β) in serum and kidney tissues; Western blot was used to detect the expressions of Caspase-1, IL-1β and glucose transporter 9 (GLUT-9) in the kidney tissues.Results① Pathological examination results: there was not obvious pathological changes were observed in the kidney tissues of the Control group; in the Model group, the renal tissue capsule was incomplete, the glomerulus was deformed and atrophic, and the renal tubules were disordered; in the Exercise group, the number of inflammatory cell infiltration was significantly decreased, the renal tubular structure was relatively intact, and the pathological changes such as cytoplasmic vacuolation of renal tubular epithelial cells were significantly decreased. ② UA, Cre and BUN content of serum: compared with the Control group, UA, BUN and Cre content in serum of the Model group and Exercise group was significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, UA, BUN and Cre content in serum of the Exercise group were significantly decreased (<italic>P</italic>&lt;0.05). ③ Serum and kidney IL-1β content: compared with the Control group, the expression of IL-1β in serum and kidney of the Model group and the Exercise group were significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, the expression of IL-1β in serum and kidney of the Exercise group was significantly decreased (<italic>P</italic>&lt;0.05). ④ Expressions of Caspase-1, IL-1β and GLUT-9 protein: compared with the Control group, the expressions of Caspase-1, IL-1β and GLUT-9 protein in kidney tissues of the Model group and the Exercise group were significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, the expressions of Caspase-1, IL-1β, and GLUT-9 protein in kidney tissues of the Exercise group were significantly decreased (<italic>P</italic>&lt;0.05).ConclusionAerobic treadmill exercise can effectively reduce the level of uric acid and inflammatory response of hyperuricemia rats, and improve renal function, which may be related to the regulation of GLUT-9 protein expression.…”
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Choice regularities of antihypertensive therapy regimens of primary open-angle glaucoma in conditions of real clinical practice by Z.M. Nagornova, A.V. Seleznev, P.Ch. Zavadskiy, A.V. Kuroyedov

“…<br> <b>Conclusion</b>: IOP level at the time of POAG diagnostics can determine a stage of the disease and serve as a prognostic sign of a disease course. …”
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Land use variation impacts on trace elements in the tissues and health risks of a commercial fish by N.D. Takarina, O.M. Chuan, T.G. Pin, I. Femnisya, A. Fathinah, A.N.B. Ramadhan, R. Hermawan, A. Adiwibowo

“…The estimated Daily Intake was used to determine the health risk consumption of this species.FINDINGS: All levels of heavy metals are below the World Health Organization’s permissible limits. …”
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Effects of Electroacupuncture at Fengchi Acupoint on Myosatellite Cells and TLR4/MyD88/NF-κB Signaling Pathway in Chronic Cervical Muscle Injury Rats by HUANG Yuting, CHEN Jiayan, KAN Yu, FANG Yanping, WANG Jinwei, ZHENG Linyao, JING Xianghong, LIAO Jun

“…ObjectiveTo observe effects of electroacupuncture at Fengchi acupoint on expression of myosatellite cells, myogenic determining factor (MyoD), proliferating cell nuclear antigen (PCNA), Toll-like receptor 4 (TLR4), myeloid differentiation primary response gene 88 (MyD88) and nuclear factor-kappa B p65 (NF-κBp65) protein in rat with chronic cervical muscle injury, so as to explore possible mechanism of electroacupuncture in promoting the repair of chronic cervical muscle injury.MethodsTen Wistar rats were selected from 45 Wistar rats as blank group, and the remaining rats were divided into model group, electroacupuncture group (EA group) and meloxicam group according to random number table method, with 10 rats in each group (5 rats were unsuccessful in modeling). …”
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Clinical Characteristics and Optimization of Empirical Antimicrobial Therapy for Febrile Neutropenia in Patients With Hematologic Malignancies by Cui Y, Liu X, Feng S

“…Empirical broad-spectrum antibiotics can be safely discontinued in FUO patients after 48 hours of clinical stability and apyrexia.Conclusion: Proper selection of empirical antibiotics and determining optimal treatment duration are essential for reducing antibiotic resistance and improving outcomes in HM patients with FN. …”
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