Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1 by Shen Chen, Kexin Nie, Hongzhan Wang, Yang Gao, Xinyue Jiang, Hao Su, Zhi Wang, Yueheng Tang, Fuer Lu, Hui Dong, Jingbin Li

“…Short-chain fatty acids (SCFAs) in the intestines were measured to determine if WMW’s effects on HSF1 are mediated through SCFAs. …”
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Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis by Lei Xiang, Qingzhou Li, Zhiwei Guan, Guilin Wang, Xiankuo Yu, Xianwen Zhang, Guochen Zhang, Jushan Hu, Xue Yang, Mingrui Li, Xilinqiqige Bao, Yumei Wang, Dong Wang

“…This study aimed to investigate the pharmacological activity and underlying MOA.MethodsThe inhibitory effect of ORes on breast cancer cell growth was confirmed, and the effective concentrations were determined for further experiments. Gene expression profiles (GEPs) were collected from MDA-MB-231 cells treated with ORes at varying concentrations using HTS2. …”
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Comparative peculiarities of genomic diversity in <i>Gallus gallus domesticus</i> chickens with decorative plumage: the muffs and beard phenotype by N. V. Dementieva, Y. S. Shcherbakov, A. E. Ryabova, A. B. Vakhrameev, A. V. Makarova, O. A. Nikolaeva, A. P. Dysin, A. I. Azovtseva, N. R. Reinbah, O. V. Mitrofanova

“…It is an incomplete autosomal dominant phenotype determined by the Mb locus localised on chromosome GGA27. …”
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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…Additionally, meaningful within-patient change (MWPC) thresholds were determined for the domains and summary scores of the QOL-E using anchor-based analyses, supported by distribution-based analyses.ResultsA total of 458 patients were included in the analyses. …”
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Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift by Erica Grasso, Francesco Certo, Mario Ganau, Giulio Bonomo, Giuseppa Fiumanò, Giovanni Buscema, Andrea Maugeri, Antonella Agodi, Giuseppe M. V. Barbagallo

“…Diagnostic specificity and the sensitivity of each tool was determined. The impact of brain shift on residual tumour was statistically analysed. …”
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Tracheostomy Practice in the Italian Intensive Care Units: A Point-Prevalence Survey by Raffaele Merola, Maria Vargas, Filippo Sanfilippo, Marco Vergano, Giovanni Mistraletti, Luigi Vetrugno, Gennaro De Pascale, Elena Giovanna Bignami, Giuseppe Servillo, Denise Battaglini

“…This study aimed to determine the prevalence of tracheostomy among ICU patients, while also evaluating patient characteristics, complication rates, and overall outcomes related to the procedure. …”
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Role of C5aR2 in prognosis of patients with acute respiratory distress syndrome through negative modulation of C5a: A prospective observational study by Muhammed Rashid, Sreedharan Nair, Pooja Gopal Poojari, Vijetha Shenoy Belle, Vijayanarayana Kunhikatta, Daniel A. Vaz, Vishal Shanbhag, Viji Pulikkel Chandran, Shravya Chitrapady, Girish Thunga

“…The serum C5a and C5aR2were determined using ELISA Kit sandwich method. Area under receiver operating characteristic (AUROC) was used to analyse the prognostic performance of C5a, C5R2, and C5a/C5R2 ratio using MedCalc. …”
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Matrine Inhibits Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Regulating the LINC01116/miR-9-5p/ITGB1 Axis by Lili Ren, Ziru Fang, Jiaojiao Xu, Xiaoxiao Wu, Yongjun Zhang, Hu Cai, Zhicun Han

“…The BC cells (MDA-MB-231 and MCF-7) were treated with various concentrations of MAT, and the optimal dose and timing of MAT action were determined using CCK-8 and quantitative real-time polymerase chain reaction assays. …”
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Preliminary Data on <i>Silybum marianum</i> Metabolites: Comprehensive Characterization, Antioxidant, Antidiabetic, Antimicrobial Activities, LC-MS/MS Profiling, and Predicted ADME... by Sabrina Lekmine, Ouided Benslama, Mohammad Shamsul Ola, Nabil Touzout, Hamza Moussa, Hichem Tahraoui, Haroun Hafsa, Jie Zhang, Abdeltif Amrane

“…Antimicrobial activity was determined using the disc diffusion method, and in silico ADMET and drug-likeness analyses were performed for key metabolites. …”
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Leiden mutation (rs6025) in a severe COVID-19 pneumonia patient with Down syndrome: a clinical case by V.I. Pokhylko, Y.I. Cherniavska, L.Y. Fishchuk, Z.I. Rossokha, O.G. Ievseienkova, O.M. Dubitska, O.F. Popova, M.М. Fastovets, O.О. Kaliuzhka, N.G. Gorovenko

“…Numerous theoretical overviews and research articles indicate the need for genetic testing in patients with COVID-19 to determine the genetic profile of proteins involved in thrombophilia. …”
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Metabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya by Isaiah Debrah, Daibin Zhong, Maxwell G. Machani, Godfrey Nattoh, Kevin O. Ochwedo, Collins M. Morang’a, Ming-Chieh Lee, Linda E. Amoah, Andrew K. Githeko, Yaw A. Afrane, Guiyun Yan

“…A synergist assay using piperonyl butoxide (PBO) (4%) was conducted to determine cytochrome P450s’ role in pyrethroid resistance. …”
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Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract by Anuwatchakij Klamrak, Shaikh Shahinur Rahman, Napapuch Nopkuesuk, Jaran Nabnueangsap, Jaraspim Narkpuk, Piyapon Janpan, Yutthakan Saengkun, Thananya Soonkum, Supawadee Sriburin, Samaporn Teeravechyan, Poramet Sitthiwong, Nisachon Jangpromma, Sirinan Kulchat, Kiattawee Choowongkomon, Rina Patramanon, Arunrat Chaveerach, Jureerut Daduang, Sakda Daduang

“…Abstract In a recent study, we used chemical analysis to show that the Caesalpinia mimosoides aqueous extract, which contains a high concentration of simple phenolics, has strong anti-influenza activity. We determined through molecular docking methods that its potential target inhibitor is the neuraminidase. …”
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Enhancing doctor-patient communication using large language models for pathology report interpretation by Xiongwen Yang, Yi Xiao, Di Liu, Yun Zhang, Huiyin Deng, Jian Huang, Huiyou Shi, Dan Liu, Maoli Liang, Xing Jin, Yongpan Sun, Jing Yao, XiaoJiang Zhou, Wankai Guo, Yang He, WeiJuan Tang, Chuan Xu

“…Postoperative pathology reports, which are essential for diagnosing and determining treatment strategies for surgical patients, frequently include complex data that can be challenging for patients to comprehend. …”
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Balancing environmental impact: A sustainability index analysis of sorghum production for food and feed by A. Prabowo, R.N. Hayati, S. Minarsih, B. Haryanto, D.D. Ludfiani, A. Supriyo, S. Subiharta, E. Nurwahyuni, Y. Hindarwati, M.N. Setiapermas, S. Sudarto, S. Samijan, B. Utomo, E. Winarn, N.D. Suretno, W. Wibawa, S. Agustini, A. Prasetyo, F.R.P. Hantoro, W. Hariyanto, V.E. Aristya

“…Therefore, this study aimed to determine sustainability index and potential of sorghum for food and feed by identifying dimensions and attributes that influence sustainability.METHODS: This study was conducted at Raji, Demak, Central Java, Indonesia in 2023. …”
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Valine potentiates cefoperazone-sulbactam to kill methicillin-resistant Staphylococcus aureus by Shao-hua Li, Yuan Tao, Zhi-cheng Yang, Huan-zhe Fu, Hui-yin Lin, Xuan-xian Peng, Hui Li

“…In mouse models, lower bacterial load in liver, spleen, kidney, thigh, and higher survival were determined in the SCF + valine than valine or SCF alone. …”
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Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy by Andraz Cerar, Martina Jaklic, Sabina Frljak, Gregor Poglajen, Gregor Zemljic, Barbara Guzic Salobir, Maja Dolenc Novak, Monika Stalc, Rok Zbacnik, Mirta Kozelj

“…In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. …”
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Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context by Germán Peñalva, Rafael Cantón, María Teresa Pérez-Rodríguez, Juan José González-López, Jesús Rodríguez-Baño, Ester del Barrio-Tofiño, Cristina Kirkegaard-Biosca, Isabel Sánchez-Romero, Andrea Gutiérrez-Villanueva, Teresa Marrodán-Ciordia, José Manuel Guerra-Laso, Cristóbal del Rosario-Quintana, Laura Suárez-Hormiga, Jordi Cámara, Mireia Puig-Asensio, Eva Heredero, María Antonia Sepúlveda, Juan Carlos Rodríguez-Díaz, Esperanza Merino, Emilia Cercenado, Sofia de la Villa, María Siller, Francisco Arnaiz, Cristina Seral, José Antonio Lepe, José Miguel Cisneros, José Ramón Paño-Pardo

“…Summary: Background: Assessing the burden of antimicrobial resistance is essential to determine the magnitude of this problem and to set its priority. …”
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Prevalence, Incidence and Predictors of Anal HPV Infection and HPV-Related Squamous Intraepithelial Lesions in a Cohort of People Living with HIV by Margherita Sambo, Alessandra Bailoni, Federico Mariani, Massimo Granai, Natale Calomino, Virginia Mancini, Anna D’Antiga, Francesca Montagnani, Mario Tumbarello, Stefano Lazzi, Franco Roviello, Massimiliano Fabbiani

“…Whether HPV vaccination may be efficacious in patients already infected by HPV remains to be determined.…”
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Prognostic value of inflammatory markers for all-cause mortality in patients with acute myocardial infarction in the coronary care unit: a retrospective study based on MIMIC-IV dat... by Fen Cao, Jun-jun Jiang, Gui Zhang, Jun Liu, Ping Xiao, Yang Tian, Wei Zhang, Sheng Zhang, Feng Hou, Zhong-Wu Bao, Kun Wu, Yong-zhi Zhu

“…Logistic regression models were employed to determine the correlation between NLR and in-hospital mortality, 30-day mortality, and 90-day mortality. …”
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Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity by Charalampos Voros, Despoina Mavrogianni, Kyriakos Bananis, Alexios Karakasis, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Raphail Mantzioros, Panagiota Kondili, Menelaos Darlas, Regina Sotiropoulou, Diamantis Athanasiou, Dimitris Mathiopoulos, Panagiotis Antsaklis, Dimitrios Loutradis, Georgios Daskalakis

“…Statistical techniques were used to determine changes and relationships. Results: Bariatric surgery led to substantial increases in eNOS expression across all FSHR polymorphism groups (<i>p</i> < 0.0001), with the Ser/Ser group exhibiting the most variability. …”
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