Metabolic dysfunction-associated fatty liver disease and risk of nephrolithiasis: a sizeable cross-sectional study by Shengqi Zheng, Tianchi Hua, Guicao Yin, Wei Zhang, Xiaoxiang Wang, Lezhong Qi, Xiayong Jing, Qibing Fan, Xiaoping Yu, Yifan Li

“…Based on ultrasound examination, participants were divided into MAFLD and non-MAFLD groups, and the severity of liver steatosis was determined based on ultrasound images. The relationship between MAFLD and nephrolithiasis was analyzed using a multivariate logistic regression model and subgroup analysis was performed.ResultsThe proportion of participants with MAFLD was significantly higher in the nephrolithiasis group compared to the non-nephrolithiasis group (47.70% vs. 30.45%, P < 0.001). …”
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Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5+CD8+ T Cells by Jason M. Zimmerer, PhD, Sachi Chaudhari, BS, Kavya Koneru, BS, Jing L. Han, MD, PhD, Mahmoud Abdel-Rasoul, MA, Hope Uwase, MA, Tai Yi, MD, Christopher K. Breuer, MD, Ginny L. Bumgardner, MD, PhD

“…The purpose of this investigation was to determine which immune-cell subsets are susceptible to CD8+ TAb-supp cell–mediated cytotoxicity or noncytotoxic suppression. …”
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Impact of a two-way short message service (SMS) to support maternally administered childhood mid-upper arm circumference monitoring and expand malnutrition screening in Kenya: the... by Jennifer A Unger, Barbra A Richardson, Kirkby D Tickell, Mareme M Diakhate, Jeanne L Goodman, Arianna Rubin Means, Keshet Ronen, Carol Levin, Esther M Choo, Catherine Achieng, Mary Masheti, Benson O Singa, Christine J McGrath

“…Secondary outcomes will assess the accuracy of maternal versus health worker MUAC measurements and determinants of acute malnutrition among children 6–18 months of age. …”
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Clinical depression prevalence and associated factors among adolescents with sickle cell anemia in dar es salaam, tanzania: a cross-sectional study by Linda Paul Athman, Agnes Jonathan, Fatima Musa, Honesta John Kipasika, Isihaka Mahawi, Florence Urio, Mwashungi Ally, Ritah Mutagonda, Lulu Chirande, Julie Makani, Emmanuel Balandya

“…Univariate and multivariate regression models were used to determine factors associated with clinical depression. …”
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High-speed centrifugation reduces immune rejection by removing bone marrow elements from fresh osteochondral allografts by Yongsheng Ma, Wenming Yang, Qitai Lin, Meiming Li, Zehao Li, Yugang Xing, Lei Wei, Wangping Duan, Xiaochun Wei

“…The effect of HSC on OCAs preservation was determined in vitro using microbiological testing, live/dead cell staining, and histological staining. …”
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Genomic interrogation of invasive group A Streptococcus (iGAS) epidemiology and COVID-19 impacts in Victoria, Australia: a 6-year retrospective studyResearch in context by Jacqueline M. Morris, Jake A. Lacey, Kerrie Stevens, Lamali Sadeesh Kumar, Mathilda Wilmot, Janet Strachan, Marion Easton, Daneeta Hennessy, Tony M. Korman, Andrew J. Daley, Katherine B. Gibney, Adam W.J. Jenney, Steven Y.C. Tong, Benjamin P. Howden, Norelle L. Sherry

“…Genomic analyses were conducted to determine the epidemiology, genetic diversity, and population dynamics of iGAS. …”
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Neurofilament light chain (Nf-L) in cerebrospinal fluid and serum as a potential biomarker in the differential diagnosis of neurological diseases in cattle by Giorgia Di Muro, Carlotta Tessarolo, Giulia Cagnotti, Alessandra Favole, Sara Ferrini, Ugo Ala, Claudio Bellino, Giuliano Borriello, Marina Gallo, Giulia Iamone, Barbara Iulini, Marzia Pezzolato, Cristina Casalone, Maria Caramelli, Lorenzo Capucci, Patrizia Cavadini, Cristiano Corona, Antonio D’Angelo

“…With this study we wanted to determine Nf-L stability at two different storage temperatures and Nf-L levels in healthy cattle and the relationship with age, evaluate whether Nf-L holds diagnostic potential for neurological disorders, and whether an association exists between Nf-L in serum and in cerebrospinal fluid (CSF). …”
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Foliar Application and Translocation of Radiolabeled Zinc Oxide Suspension vs. Zinc Sulfate Solution by Soybean Plants by Anita Beltrame, João Paulo Rodrigues Marques, Mariana Ayres Rodrigues, Eduardo de Almeida, Márcio Arruda Bacchi, Elisabete Aparecida De Nadai Fernandes, Rafael Otto, Hudson Wallace Pereira de Carvalho

“…The radioactivity of ⁶⁵Zn in the leaves, roots, stems, and pods was determined using γ-ray spectrometry. After the first foliar spray, V4, the partition of radiolabeled Zn in plants treated with ZnO and ZnSO₄ was 99.22% and 98.12% in treated leaves, 0.15% and 0.39% in stems, 0.16% and 0.29% in roots, and 0.47% and 1.19% in newly expanded non-treated leaves, respectively. …”
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PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands by Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan Ozerov, Everett E. Vokes, Grayson Cole, Frank W. Pun, Le Shen, Yuxuan Miao, Alexander T. Pearson, Mark W. Lingen, Bruce Ruggeri, Ari J. Rosenberg, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko

“…Identifying protein arginine methyl transferase 5 (PRMT5) as a putative candidate with the top-scored druggability, we next determined the applicability of PRMT5 inhibitors (PRT543 and PRT811) using ACC cell lines, organoids, and patient derived xenograft (PDX) models. …”
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Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol by Yue Wang, Xin Li, Ying Wang, Hongmei Zhao, Qian Lu, Yujie Zhou, Liyuan Zhang, Aomei Shen, Jingru Bian, Wanmin Qiang, Jingming Ye, Hongmeng Zhao, Yubei Huang, Zhongning Zhang, Peipei Wu

“…Survival analysis using the Kaplan-Meier estimate will determine the incidence of BCRL. Risk factors of BCRL will be analysed using log-rank test and COX-LASSO regression. …”
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Protocol for an adaptive platform trial of intended service user-derived interventions to equitably reduce non-attendance in eye screening programmes in Botswana, India, Kenya and... by Min Kim, David Macleod, Michael Gichangi, Andrew Bastawrous, Matthew J Burton, Jacqueline Ramke, Oathokwa Nkomazana, James R Carpenter, Sailesh Mishra, Shalinder Sabherwal, Luke Allen, Sarah Karanja, Ari Ho-Foster, Nigel Bolster, Malebogo Tlhajoane, Bakgaki Ratshaa

“…The specific design of cluster RCTs will be determined by our research team once the intervention is known, but the population and outcome will be the same across all trials.This adaptive platform trial will be used to identify effective service modifications, driving continuous improvements in access.Ethics and dissemination This trial has been approved by the research ethics committee at the London School of Hygiene & Tropical Medicine (ref: 29549). …”
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The effect of lavender inhalation aromatherapy on systolic and diastolic blood pressure in patients with prehypertension by Amir Musarezaie, Mohammad Javad Tarrahi, Masoumeh Sadeghi, Sedigheh Farzi, Tahere Momeni-Ghale Ghasemi, Amir Hossein Saeidi, Maryam Sadat Shahshahani

“…Background & Aim: The evidence shows that prehypertension is related to an increased risk of cardiovascular complications. This study aims to determine the effect of lavender inhalation aromatherapy on systolic and diastolic blood pressure (SBP & DBP) in people with prehypertension in Isfahan. …”
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Multimodal Imaging of Patients With Gliomas Confirms C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy by Kai R. Laukamp MD, Florian Lindemann PhD, Matthias Weckesser MD, Volker Hesselmann MD, Sandra Ligges PhD, Johannes Wölfer MD, Astrid Jeibmann MD, Bastian Zinnhardt PhD, Thomas Viel PhD, Michael Schäfers MD, Werner Paulus MD, Walter Stummer MD, Otmar Schober PhD, MD, Andreas H. Jacobs MD

“…Tumor sizes as defined by thresholding based on tumor-to-background ratios were significantly different as determined by MET-PET (21.6 ± 36.8 cm 3 ), T1w-Gd-MRI (3.9 ± 7.8 cm 3 ), and FLAIR/T2-MRI (64.8 ± 60.4 cm 3 ; P < .001). …”
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Catheter ablation versus antiarrhythmic drugs with risk factor modification for treatment of atrial fibrillation: a protocol of a randomised controlled trial (PRAGUE-25 trial) by Stepan Havranek, Jiri Jarkovsky, Otakar Jiravský, Pavel Osmancik, Veronika Bulková, Jan Chovančík, Tomáš Roubíček, Dalibor Heřman, Zuzana Čarná, Vladimír Tuka, Martin Matoulek, Martin Fiala, Sylvie Stregl-Hruskova, Adam Latiňák, Jiřina Kotryová

“…An AF freedom of 65% in the RFM+AAD and of 60% in the CA is expected; therefore, 202 patients will be enrolled to achieve the non-inferiority with 80% power, 5% one-sided alpha and a non-inferiority margin of 12%.Ethics and dissemination The PRAGUE-25 trial will determine if modern non-invasive AF treatment strategies are non-inferior to CA. …”
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HDAC10 and its implications in Sézary syndrome pathogenesis by Monika Pieniawska, Karolina Rassek, Bogumiła Skwara, Magdalena Żurawek, Iwona Ziółkowska-Suchanek, Lydia Visser, Monique Lodewijk, Małgorzata Sokołowska-Wojdyło, Małgorzata Sokołowska-Wojdyło, Berenika Olszewska, Roman J. Nowicki, Roman J. Nowicki, Tomasz Stein, Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Marta Szymoniak-Lipska, Natalia Rozwadowska, Katarzyna Iżykowska

“…In this study we aimed to determine the role of HDAC10 in SS, focusing on its cellular localization, role in cell growth, and therapeutic potential. …”
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Antimicrobial susceptibilities of oral Neisseria from men on HIV pre-exposure prophylaxis in Hanoi, Vietnam by Huan Vinh Dong, Paul Adamson, Dieu Hoa Pham, Quynh Hoa Pham, Hai Ha Long Le, Loc Quang Pham, Hao Thi Minh Bui, Giang Minh Le, Jeffrey D. Klausner

“…Minimum inhibitory concentrations (MICs) to azithromycin, ceftriaxone, cefixime, and doxycycline were determined using Etests. Results: There were 42 male participants, the median age was 26 years and 29% (n = 12) reported using antibiotics in the past 6 months. …”
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Predicting the risk of heart failure after acute myocardial infarction using an interpretable machine learning model by Qingqing Lin, Qingqing Lin, Wenxiang Zhao, Wenxiang Zhao, Hailin Zhang, Hailin Zhang, Wenhao Chen, Sheng Lian, Qinyun Ruan, Qinyun Ruan, Zhaoyang Qu, Zhaoyang Qu, Yimin Lin, Yimin Lin, Dajun Chai, Dajun Chai, Dajun Chai, Dajun Chai, Xiaoyan Lin, Xiaoyan Lin, Xiaoyan Lin, Xiaoyan Lin

“…In addition, we used the Shapley Additive Explanations (SHAP) value to determine the importance of the selected features and interpret the optimal model.ResultsA total of 1220 AMI patients were included and 244 (20%) patients developed HF during follow-up. …”
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Genetic Association and Expression Correlation between Colony-Stimulating Factor 1 Gene Encoding M-CSF and Adult-Onset Still’s Disease by Yi-Ming Chen, Wei-Ting Hung, Wan-Chun Chang, Chia-Wei Hsieh, Wen-Hung Chung, Joung-Liang Lan, Ning-Rong Gung, Yun-Shien Lee, Der-Yuan Chen, Shuen-Iu Hung

“…The plasma concentrations of associated gene product were determined. The GWAS, replication, and combined sample analysis confirmed that SNP rs11102024 on 5′-upstream of CSF1 encoding macrophage colony-stimulating factor (M-CSF) was associated with AOSD (P=1.20×10-8, OR (95% CI): 3.28 (2.25~4.79)). …”
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Unleashing the potential of geostationary satellite observations in air quality forecasting through artificial intelligence techniques by C. Zhang, X. Niu, H. Wu, Z. Ding, K. L. Chan, J. Kim, T. Wagner, C. Liu, C. Liu, C. Liu

“…Evaluation against ground-based measurements demonstrates that GeoNet accurately predicts diurnal variations and spatial distribution details of next-day NO<span class="inline-formula">₂</span> pollution, yielding a coefficient of determination of 0.68 and a root mean square of error of 12.31 <span class="inline-formula">µg</span> m<span class="inline-formula">⁻³</span>, significantly surpassing traditional air quality model forecasts. …”
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Brain radiotherapy and dorsal vagal complex irradiation: A new organ at risk to decrease radiation-induced nausea and vomiting? by Valentine Caspar, Nicolas Giraud, Thomas Charleux, Arnaud Beddok, Brieuc Bernard, Maelle Martin, Juliette Thariat, Aymeri Huchet, Véronique Vendrely, Charles Dupin

“…The objective of our study was to determine an association between mean dose to the DVC and nausea. …”
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