Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III... by Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson

“…Patients randomised to the adaptive arm will commence at a dose level determined by their International Myeloma Working Group frailty score. …”
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CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors by Yi Sun, Eduardo Davila, YuJie Guo, Richard D Schulick, Elliott Yee, Yuki Fujiwara, Kaitlyn Dickinson, Zhiwei Sun, Junyi Hu, Yuwen Zhu

“…For mechanistic studies, vascular maturation was determined by immunofluorescent staining and flow cytometry was performed to examine tumor-infiltrating T lymphocytes. …”
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Reactive arthritis incidence in a community cohort following a large waterborne campylobacteriosis outbreak in Havelock North, New Zealand by Nicholas Jones, Rebecca Grainger, Michael G Baker, Tim Wood, Tiffany A Walker, Terence Quirke, Rebekah Roos, Jill Sherwood, Graham Mackereth, Tomasz Kiedrzynski, Rachel Eyre, Shevaun Paine, Anita Jagroop

“…Objectives In August 2016, Campylobacter spp contaminated an untreated reticulated water supply resulting in a large-scale gastroenteritis outbreak affecting an estimated 8320 people. We aimed to determine the incidence of probable reactive arthritis (ReA) cases in individuals with culture-confirmed campylobacteriosis (CC), self-reported probable campylobacteriosis (PC) and those reporting no diarrhoea (ND).Design We conducted a retrospective cohort study to identify incidence of probable ReA cases. …”
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The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia by Lixue Huang, Bingxuan Weng, Yuanqi Wang, Mengyuan Wang, Yin Mei, Wei Chen, Meng Ma, Jingnan Li, Jianzhen Weng, Yang Ju, Xuefeng Zhong, Xunliang Tong, Yanming Li

“…The logistic regression model was used to determine the association between immunosuppression and outcomes. …”
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Wildlife trade at the interface between deeply-rooted animal-based traditional medicine and unregulated harvesting of wild animals in West Africa by Stanislas Zanvo, Samson Dognimon, Chabi A. M. S. Djagoun, Jiroux Akpatchémè, Akomian Fortuné Azihou, Bruno Djossa, Bruno Djossa, Etotépé A. Sogbohossou, Brice Sinsin

“…We used a generalized linear model to determine the drivers underlying the spatial patterns of wildlife markets. …”
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Ice-nucleating particles active below −24 °C in a Finnish boreal forest and their relationship to bioaerosols by F. Vogel, F. Vogel, M. P. Adams, L. Lacher, P. B. Foster, G. C. E. Porter, G. C. E. Porter, B. Bertozzi, B. Bertozzi, K. Höhler, J. Schneider, T. Schorr, N. S. Umo, J. Nadolny, Z. Brasseur, P. Heikkilä, E. S. Thomson, N. Büttner, M. I. Daily, R. Fösig, A. D. Harrison, J. Keskinen, U. Proske, U. Proske, U. Proske, J. Duplissy, J. Duplissy, M. Kulmala, T. Petäjä, O. Möhler, B. J. Murray

“…This study should motivate further work to establish whether the commonality in bioaerosol ice-nucleating properties between spring in Finland and summer in Colorado is more generally applicable to different coniferous forest locations and times and also to determine to what extent these bioaerosols are transported to locations where they may affect clouds.…”
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Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets by Wenyu ZHANG, Xianshu FU, Xue BAI, Shiwen WU, Jiabin LI, Xiaoping YU, Mingzhou ZHANG, Zihong YE

“…In this study, the design of experiment (DOE) scheme was used to determine the optimal ratio of D. officinale, P. sibiricum, and Z. jujuba based on the measured mass fractions of polysaccharides, flavonoids, and polyphenols in the drug. …”
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Hot press sintering of Y2O3-Al2O3 glasses: Impact of particle size on thermal behaviour, sintering ability and mechanical properties of sintered bodies by Melinda Majerová, Anna Prnová, Jana Valúchová, Monika Michálková, Beáta Pecušová, Michal Žitňan, Róbert Klement, Dušan Galusek

“…The work was conducted with the aim of determining the optimal particle size and grinding conditions of glassy powder used for hot-pressing of ceramic and glass-ceramic materials with desired mechanical properties. …”
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Reproductive modes in populations of late-acting self-incompatible and self-compatible polyploid Ludwigia grandiflora subsp. hexapetala in western Europe by Stoeckel, Solenn, Becheler, Ronan, Portillo-Lemus, Luis, Harang, Marilyne, Besnard, Anne-Laure, Lassalle, Gilles, Causse-Védrines, Romain, Michon-Coudouel, Sophie, Park, Daniel J., Pope, Bernard J., Petit, Eric J., Barloy, Dominique

“…., the proportion of individuals produced by clonality, selfing and outcrossing in populations, determines how hereditary material is transmitted through generations. …”
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Multimorbidity is associated with risk of incident venous thromboembolism – A nationwide proof-of-concept study by Jonatan Ahrén, MirNabi Pirouzifard, Björn Holmquist, Jan Sundquist, Kristina Sundquist, Bengt Zöller

“…Further studies will determine the usefulness of multimorbidity for VTE prediction in different clinical settings.…”
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Adult HIV/AIDS patients are more likely to experience anxiety symptoms by Zakir Abdu, Wondwossen Belayneh, Aman Dule, Solomon Seyife Alemu, Lema Fikadu Wedajo, Mohammedamin Hajure, Gebremeskel Mulatu Tesfaye, Yadeta Alemayehu Workneh, Wubishet Gezimu, Mustefa Adem Hussen, Bilisumamulifna Tefera, Sadik Habib

“…Bivariate and multivariable logistic regressions were employed to identify independently associated variables, and statistical significance was determined at a p-value <0.05.ResultsOut of a total of 323 samples, 320 respondents completed all items, resulting in a response rate of 99.07%. …”
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Association between behavioral and sociodemographic factors and high subjective health among adolescents: a nationwide representative study in South Korea by Jaehyun Kong, Seohyun Hong, Seunghwan Lee, Seokjun Kim, Soeun Kim, Jiyeon Oh, Wonwoo Jang, Hanseul Cho, Sooji Lee, Jiseung Kang, Yejun Son, Lee Smith, Selin Woo, Dong Keon Yon

“…A stratification analysis was performed for subgroups to determine variations across different demographic and behavioral groups. …”
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Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study by Yutong Wu, Huiwen Xu, Liping Mao, Rongrong Zhao, Junfeng Chu, Lili Huang, Wendi Zhang, Yiran Liu, Qiong Chen, Xiaobo Tao, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Tian Tian, Lei Zhang, Jiahua Cui, Guangyu Tian, Minjie Chu

“…Enzyme linked immunosorbent assay (ELISA) is used to determine the levels of candidate protein. Results A total of 7 pQTL‐SNPs were significantly associated with altered LUAD risk (p < 0.05). …”
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Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve by Yuanyuan Li, Ruoyao Xu, Muyan Chen, Kaige Zheng, Huimin Nie, Chengyu Yin, Boyu Liu, Yan Tai, Junying Du, Jie Wang, Jianqiao Fang, Boyi Liu

“…Immunostaining, flow cytometry, behavioral assay, in vivo imaging were utilized for effects determination and mechanism exploration. Results EA ameliorated mechanical and cold pain hypersensitivities, reduced sensory neuron damage and improved loss in intra-epidermal nerve fibers (IENFs) in model mice. …”
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A Series of Novel Alleles of <i>Ehd2</i> Modulating Heading and Salt Tolerance in Rice by Peng Xu, Shulei Hao, Xiaoxia Wen, Guifang Ma, Qinqin Yang, Ling Liu, Galal Bakr Anis, Yingxin Zhang, Lianping Sun, Xihong Shen, Qunen Liu, Daibo Chen, Yongbo Hong, Yuyu Chen, Xiaodeng Zhan, Shihua Cheng, Liyong Cao, Weixun Wu

“…Heading date, a critical agronomic trait, determines the regional and seasonal adaptability of rice varieties. …”
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The Impacts of SLC22A1 rs594709 and SLC47A1 rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients by Di Xiao, Yu Guo, Xi Li, Ji-Ye Yin, Wei Zheng, Xin-Wen Qiu, Ling Xiao, Rang-Ru Liu, Sai-Ying Wang, Wei-Jing Gong, Hong-Hao Zhou, Zhao-Qian Liu

“…The distributions of SLC22A1 rs594709 and SLC47A1 rs2289669 polymorphisms were determined in 267 T2DM patients and 182 healthy subjects. …”
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Risk Factors for Hospital Readmission Following Noncardiac Surgery: International Cohort Study by Michael H. McGillion, RN, PhD, Flavia K. Borges, MD, PhD, David Conen, MD, MPH, Daniel I. Sessler, MD, Brenda L. Coleman, RN, PhD, Maura Marcucci, MD, MSc, Carley Ouellette, RN, MSc, Marissa Bird, RN, PhD, Carly Whitmore, RN, PhD, Shaunattonie Henry, RN, PhD, Sandra Ofori, MD, MSc, Shirley M. Pettit, RN, Deborah M. Bedini, RN, MHS, Leslie P. Gauthier, MScT, Jennifer Lounsbury, RN(EC), MN, Nancy M. Carter, RN, PhD, Vikas Tandon, MD, Ameen Patel, MD, Teresa Cafaro, MD, MSc, Marko R. Simunovic, MD, John A. Harlock, MD, Diane Heels-Ansdell, MSc, Fadi Elias, MD, MS, Theodore Rapanos, MD, Shawn Forbes, MD, Elizabeth Peter, RN, PhD, Judy Watt-Watson, RN, PhD, Kelly Metcalfe, RN, PhD, Sandra L. Carroll, RN, PhD, Philip J. Devereaux, MD, PhD

“…Objective:. To determine timing and risk factors associated with readmission within 30 days of discharge following noncardiac surgery. …”
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Dietetic service provision and nutritional interventions provided to patients with head and neck sarcoma: Findings from a national United Kingdom centre five-year audit by Florence Cook, Dimitris Tatsis, Malla Salli, Deepti Sinha, Nicholas Kalavrezos

“…Malnutrition is common in head and neck cancer (HNC) but limited literature exists determining nutritional interventions required in HNS. …”
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Straw return combined with water-saving irrigation increases microbial necromass accumulation by accelerating microbial growth-turnover in Mollisols of paddy fields by Peng Chen, Junzeng Xu, Kechun Wang, Zhongxue Zhang, Zhaoqiang Zhou, Yawei Li, Tiecheng Li, Tangzhe Nie, Qi Wei, Linxian Liao

“…Microbial physiology was determined by a substrate-independent H218O labeling method. …”
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Preparation, Structural Characterization and Antioxidant Activity of Extracellular Nanovesicles from Hericium erinaceus by Xueli YANG, Ben NIU, Hangjun CHEN, Weijie WU, Guannan WANG, Xiangjun FANG, Honglei MU, Haiyan GAO

“…The in vitro antioxidant activity of HEDENVs was evaluated by determining the DPPH, ABTS+, and O2− radical scavenging capacity. …”
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