mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier by Shan-Shan Meng, Feng-Mei Guo, Li-Li Huang, Ying-Zi Huang, Jian-Feng Xie, Cong-Shan Yang, Hai-Bo Qiu, Yi Yang

“…Therefore, the aim of this study was to determine whether mTORC2 mediated protective effects of MSC-secreted HGF against LPS-induced pulmonary microvascular endothelial barrier dysfunction activated like mTORC1 activation. …”
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Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions by Hechun Liu, Feng Wang, Hui Xia, Da Pan, Ligang Yang, Shaokang Wang, Feng Zhao, Guiju Sun

“…This study aimed to determine the effects of different sources ω-3 PUFAs on glucolipid metabolism and lipoprotein subfractions in T2DM with dyslipidemia. …”
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Bearberry in the treatment of acute uncomplicated cystitis (BRUMI): protocol of a multicentre, randomised double-blind clinical trial by Péter Hegyi, Noémi Gede, Szilárd Váncsa, Barbara Tóth, András Jávorházy, Péter Nyirády, Boglárka Csupor-Löffler, Péter Birinyi, George Zhanel, Kurt Naber, Reinhard Länger, Nóra Vörhendi, Dezső Csupor

“…At least 504 patients (allocated as 1:1) will need to be enrolled to access non-inferiority with a non-inferiority limit of 14% for the primary endpoint.Improvement of symptoms of uncomplicated cystitis (based on the ACSS score) at day 7 is defined as the primary endpoint, whereas several secondary endpoints such as the number and ratio of patients with bacteriuria at day 7, frequency and severity of side effects; recurrence of urinary tract infection, concurrent use of other over the counter (OTC) medications and food supplements will be determined to elucidate more detailed differences between the groups. …”
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Pt@ZnCo₂O₄ Microspheres as Peroxidase Mimics: Enhanced Catalytic Activity and Application for L-Cysteine Detection by Shuqi Liao, Weisen Deng, Feng Yang, Jutao Zhou, Ling Wu, Donghong Yu, Zhong Cao

“…The sensor possesses good selectivity, reusability, and usage stability, which can be well applied to the determination of L-Cys in health product capsules with recovery rates of 96.9%~103.7% and RSD of 1.07%~6.50%. …”
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Screening Southeast Asian medicinal plants: Clausena lansium, Leea indica, Strobilanthes crispa, Vitex trifolia for anti-platelet aggregation and blood coagulation effects by Sogand Zareisedehizadeh, Fu-Xun Heng, Chay-Hoon Tan, Paul Chi-Lui Ho, Hwee-Ling Koh

“…Anticoagulant activities were evaluated by determining the effects on prothrombin time (PT) and activated partial thromboplastin time (aPTT). …”
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Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O) by Pia Gattinger, Luibov I. Kozlovskaya, Alexander S. Lunin, Olga S. Gancharova, Dina I. Sirazova, Dina I. Sirazova, Vasiliy D. Apolokhov, Egor S. Chekina, Ilya V. Gordeychuk, Ilya V. Gordeychuk, Alexander V. Karaulov, Alexander V. Karaulov, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Aydar A. Ishmukhametov, Aydar A. Ishmukhametov

“…Neutralizing antibody (nAB) titers, weight, lung symptoms, and viral loads, as measured using RT-PCR in the upper and lower respiratory tracts, were determined. In addition, infectious virus titers from the lungs were measured using a plaque-forming assay. …”
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Examining internet use for health information seeking and influencing factors among undergraduate health science students in Southwest Ethiopia by Alex Ayenew Chereka, Fikadu Wake Butta, Addisalem Workie Demsash, Sisay Yitayh Kassie, Adamu Ambachew Shibabaw, Abiy Tasew Dubale, Geleta Nenko Dube, Mekonnen Kenate Hunde, Wubalem Dilie Limeneh, Amare Dagnew Fentahun, Milkias Dugassa Emanu, Mekashaw Tareke Abebe, Gemeda Wakgari Kitil

“…Statistical significance was determined using a P-value of less than 0.05. Result: A total of 423 respondents participated in this study, resulting in a 100 % response rate. …”
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Xi Lei San Attenuates Dextran Sulfate Sodium-Induced Colitis in Rats and TNF-α-Stimulated Colitis in CACO2 Cells: Involvement of the NLRP3 Inflammasome and Autophagy by Zhang Tao, Xiaoqing Zhou, Yan Zhang, Wenfeng Pu, Yi Yang, Fuxia Wei, Qian Zhou, Lin Zhang, Zhonghan Du, Ji Wu

“…A western blot analysis was performed to determine the expression levels of inflammasome-related proteins and autophagy-related proteins, ELISA was performed to analyze IL-1β, IL-18, and IL-33 concentrations, and flow cytometry was used to monitor cell apoptosis and ROS levels. …”
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Advancing presurgical non-invasive spread through air spaces prediction in clinical stage IA lung adenocarcinoma using artificial intelligence and CT signatures by Guanchao Ye, Guangyao Wu, Yiying Li, Chi Zhang, Lili Qin, Lili Qin, Jianlin Wu, Jun Fan, Yu Qi, Fan Yang, Yongde Liao

“…The SHAP algorithm explains the contribution of each feature in the model, visually demonstrating the impact of each feature on the model's decisions.ConclusionThe combined model has the potential to serve as a biomarker for predicting STAS using preoperative CT scans, determining the appropriate surgical strategy, and guiding the extent of resection.…”
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The MBH–M∗ Relation up to z ∼ 2 through Decomposition of COSMOS-Web NIRCam Images by Takumi S. Tanaka, John D. Silverman, Xuheng Ding, Knud Jahnke, Benny Trakhtenbrot, Erini Lambrides, Masafusa Onoue, Irham Taufik Andika, Angela Bongiorno, Andreas L. Faisst, Steven Gillman, Christopher C. Hayward, Michaela Hirschmann, Anton Koekemoer, Vasily Kokorev, Zhaoxuan Liu, Georgios E. Magdis, Alvio Renzini, Caitlin Casey, Nicole E. Drakos, Maximilien Franco, Ghassem Gozaliasl, Jeyhan Kartaltepe, Daizhong Liu, Henry Joy McCracken, Jason Rhodes, Brant Robertson, Sune Toft

“…With host photometry free of AGN emission, we determine the stellar mass of the host galaxies to be $\mathrm{log}\left({M}_{* }/{M}_{\odot }\right)\sim 9.5-11.6$ through spectral energy distribution fitting and measure the evolution of the mass relation between SMBHs and their host galaxies. …”
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Sustainable geopolymer adsorbents utilizing silica fume as a partial replacement for metakaolin in the removal of copper ion from synthesized copper solution by Pilomeena Arokiasamy, Mohd Mustafa Al Bakri Abdullah, Eva Arifi, Noorina Hidayu Jamil, Md Azree Othuman Mydin, Shayfull Zamree Abd Rahim, Andrei Victor Sandu, Shafiq Ishak

“…The concentration of Cu2+ before and after adsorption was determined by Atomic absorption spectroscopy (AAS) and the removal efficiency was calculated. …”
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Impact of Sjögren’s disease on quality of sexual life using the Qualisex score by Eric Hachulla, Xavier Mariette, Jacques-Eric Gottenberg, Philippe Dieude, Aleth Perdriger, Emanuelle Dernis, Marion Couderc, Raphaele Seror, Gaetane Nocturne, Rakiba Belkhir, Valérie Devauchelle-Pensec, Veronique Le Guern, Alexandra Kachaner, Sophie Berville

“…Objective This study aimed to assess the impact of Sjögren disease (SjD) on the quality of sexual life and its determinants using the Qualisex questionnaire.Methods The Qualisex questionnaire was administered to participants within the ASSESS cohort, a French national multicentric prospective cohort of individuals with SjD. …”
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It depends on how you tell: a qualitative diagnostic analysis of the implementation climate for community-wide mass drug administration for soil-transmitted helminth by Judd L Walson, Saravanakumar Puthupalayam Kaliappan, Sitara Swarna Rao Ajjampur, Sarah Lawrence, Khumbo Kalua, Euripide Avokpaho, Amy Roll, Angelin Titus, Yesudoss Jacob, Marie Claire Gwayi-Chore, Félicien Chabi, Comlanvi Innocent Togbevi, Abiguel Belou Elijan, Providence Nindi, Moudachirou Ibikounle, Kumudha Aruldas, Arianna Rubin Means

“…This formative analysis was conducted to evaluate the implementation climate for cMDA and to determine barriers and facilitators to launch.Settings Prior to the launch of a cMDA trial in Benin, India and Malawi.Participants Community members (adult women and men, children, and local leaders), community drug distributors (CDDs) and health facility workers.Design We conducted 48 focus group discussions (FGDs) with community members, 13 FGDs with CDDs and 5 FGDs with health facility workers in twelve randomly selected clusters across the three study countries. …”
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The therapeutic potential of PX-478 in a murine model of pelvic organ prolapse by Wei-Min Fan, Yu-Qi Yang, Li-Wen Zhang, Xiao-Hui Mei, Ke Sun, Duan-Qing Wu, Ying Yang, Chun-Fang Duan, Jun Ye, Ru-Jun Chen

“…Expression levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP-1) were determined through immunohistochemistry and western blot. …”
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Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population by Geng Shen, Yuting Liu, Can Zhou, Wei Luo, Yun-xiao Yang, Shuai Guo, Jiayi Yi, Lin Wang, Wei Li, Zhao-gong Zhi, Xiu-huan Chen, Chen Li, Yanyan Jin, Hai Gao

“…Multivariable Cox proportional hazards regression models were utilized to determine the relationship between NPAR with all-cause mortality and cardiovascular disease (CVD) mortality. …”
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Alpha and Theta Oscillations Associated With Behavioral Phenotypes of Pain–Attention Interaction by Nikou Kelardashti, Benjamin T. Dunkley, Rima El‐Sayed, Vaidhehi Veena Sanmugananthan, Junseok Andrew Kim, Natalie Rae Osborne, Joshua C. Cheng, Anton Rogachov, Rachael L. Bosma, Ariana E. Besik, Karen Deborah Davis

“…Individual IAP scores were determined by assessing mind‐wandering during pain and A/P type was based on interference of pain with cognitive task performance. …”
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Characteristics of Sluggish Cognitive Tempo among adults with ADHD: objective neurocognitive measures align with self-report of executive function by Beth Krone, Lenard A. Adler, Deepti Anbarasan, Terry Leon, Richard Gallagher, Pooja Patel, Stephen V. Faraone, Jeffrey H. Newcorn

“…The variables were treated with Principal Axis Factoring with Promax with Kaiser Normalization to elucidate latent constructs and determine performance profiles associated with SCT among people with ADHD.ResultsEF Deficits and emotional dyscontrol (ED) symptoms significantly differentiated adults with ADHD and SCT whether measured via self or clinician report. …”
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Knowledge of prevention and treatment of infectious diarrhea among parents of children under five with diarrhea in Anhui province: an outpatient-clinic-based questionnaire survey by Yuanfang SUN, Yongkang XIAO, Lei GONG, Hongyuan WEI, Wanwan MA, Shuo FENG, Qiang ZHANG, Linlin LI, Qile WU, Jiabing WU

“…ObjectiveTo assess the status and determinants of knowledge of prevention and treatment of infectious diarrhea among parents of children aged ≤5 years with diarrhea to provide evidence for the development of targeted health intervention strategies. …”
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Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospi... by Bu Wang, Bu Wang, Wei Zhang, Hongxia Zhang, Maochen Li, Zhihua Zhang, Xiaocui Peng, Na Wang, Ning Song

“…Univariate analysis identified potential risk factors for CRKP infections using appropriate statistical methods, followed by multivariable logistic regression to determine independent risk factors. Mortality rates between CRKP and CSKP groups were compared using chi-square tests, and survival curves were generated with the Kaplan–Meier method.ResultsThe study included 283 patients, with 104 (36.7%) infected by CRKP and 179 (63.3%) by CSKP. …”
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To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway by Jia-Rong Gao, Xiu-Juan Qin, Zhao-Hui Fang, Li-Shan, Li-Ping Han, Hui-Jiang, Ming-Fei Guo, Nan-Nan Jiang

“…Complications of the blood pipe are the main cause of disability and death in diabetic patients, including vascular lesions that directly affects the prognosis of patients with diabetes and survival. This study was to determine the influence of high glucose and related mechanism of vascular lesion of type 2 diabetes mellitus pathogenesis. …”
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