Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Background Successful development of chimeric antigen receptor (CAR) T cell immunotherapy for children and adults with relapsed/refractory acute myeloid leukemia (AML) is highly desired given their poor clinical prognosis and frequent inability to achieve cure with conventional chemotherapy. …”
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Increasing the meaningful involvement of women in HIV cure-related research: a qualitative interview study in the United States by Karine Dubé, Elizabeth Barr, Morgan Philbin, Amaya Perez-Brumer, Brian Minalga, Beth Peterson, Dawn Averitt, Bridgette Picou, Krista Martel, Cecilia Chung, María Mejía, Martha Cameron, Gail Graham, Lynda Dee, Dázon Dixon Diallo, Ebony Gordon, Anastasia Korolkova, Typhanye Dyer, Judith D. Auerbach, Eileen Scully, Krista L. Dong, Sara Gianella

“…They also expressed a desired for women-centered and holistic clinical trial designs that account for intersectionality. …”
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Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting by Martina A. McAteer, Daniel R. McGowan, Gary J. R. Cook, Hing Y. Leung, Tony Ng, James P. B. O’Connor, Luigi Aloj, Anna Barnes, Phil J. Blower, Kevin M. Brindle, John Braun, Craig Buckley, Daniel Darian, Paul Evans, Vicky Goh, David Grainger, Carol Green, Matt G. Hall, Thomas A. Harding, Catherine D. G. Hines, Simon J. Hollingsworth, Penny L. Hubbard Cristinacce, Rowland O. Illing, Martin Lee, Baptiste Leurent, Sue Mallett, Radhouene Neji, Natalia Norori, Nora Pashayan, Neel Patel, Kieran Prior, Thomas Reiner, Adam Retter, Alasdair Taylor, Jasper van der Aart, Joseph Woollcott, Wai-Lup Wong, Jan van der Meulen, Shonit Punwani, Geoff S. Higgins

“…Subsequently, panellists attended a consensus meeting to discuss survey outcomes and readjust scores independently if desired. Survey items with median scores ≥ 7 were considered ‘required/appropriate’, ≤ 3 ‘not required/inappropriate’, and 4–6 indicated ‘uncertainty remained’. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…This engineering approach does not require a priori knowledge of structural and functional mapping of antibody–antigen interaction and thus is generally applicable for therapeutic antibody development when desired ortholog binding is lacking. These findings provide foundational insights as 23ME–00610 advances in clinical studies to gain understanding of the hCD200R1 immune checkpoint as a target in immuno-oncology.…”
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The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team‐based approach to clinically validated, research‐ready electronic health record data by Andrea L. C. Schneider, Jennifer C. Ginestra, Meeta Prasad Kerlin, Michael G. S. Shashaty, Todd A. Miano, Daniel S. Herman, Oscar J. L. Mitchell, Rachel Bennett, Alexander T. Moffett, John Chandler, Atul Kalanuria, Zahra Faraji, Nicholas S. Bishop, Benjamin Schmid, Angela T. Chen, Kathryn H. Bowles, Thomas Joseph, Rachel Kohn, Rachel R. Kelz, George L. Anesi, Monisha Kumar, Ari B. Friedman, Emily Vail, Nuala J. Meyer, Blanca E. Himes, Gary E. Weissman

“…Analysts and clinical researchers jointly iteratively reviewed SQL queries and their output to validate desired data elements. Data from patients aged ≥18 years with at least one encounter at an acute care hospital or hospice occurring since 7/1/2017 were included. …”
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In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

“…Ostrich ESM was prepared from pathogen-free ostrich eggs, sterilized with UV radiation and prepared in desired dimensions before implantation (1.5 × 1 cm). …”
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Long-Term Outcomes of a Health Information System-Based Feedback Intervention Study of Antimicrobial Prescriptions in Primary Care Institutions: Follow-Up of a Randomized Cross-Ove... by Yan Y, Yang J, Lu Y, Cui Z, Chang Y

“…It is reasonable to think that the desired effects will be difficult to maintain without sustained implementation of feedback intervention.Keywords: long-term outcomes, feedback intervention, antimicrobial prescriptions, health information system, primary care institutions…”
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Optimization design of an acoustic cover layer for a cylindrical cavity based on porous materials by Bohan ZHANG, Jili RONG, Xiuyan CHENG

“…The findings indicate that the optimal placement and coverage design of porous materials are essential for achieving the desired protective effects while minimizing material usage and overall mass. …”
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Tools for the Analysis of Quantum Protocols Requiring State Generation Within a Time Window by Bethany Davies, Thomas Beauchamp, Gayane Vardoyan, Stephanie Wehner

“…Let <inline-formula><tex-math notation="LaTeX">$s$</tex-math></inline-formula> be the number of desired resource states required by a protocol. We characterize the probability distribution <inline-formula><tex-math notation="LaTeX">$X_{(w,s)}$</tex-math></inline-formula> of the ages of the quantum resource states, once <inline-formula><tex-math notation="LaTeX">$s$</tex-math></inline-formula> states have been generated in a window <inline-formula><tex-math notation="LaTeX">$w$</tex-math></inline-formula>. …”
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Polish Historiography of Polish - Lithuanian Union of 20th Century by Mečislovas Jučas

“…Halecki) emphasized the Polish nobility's attempts to rule Halič-Volyn territory, which was also desired by Hungary and Lithuania. Until 1370, Poland was looking for a union with Hungary against Lithuania, later with Lithuania against Hungary. …”
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‘Queer Reverence’: Aubrey Beardsley’s Venus and Tannhäuser by Nicole Fluhr

“…Indeed, The Story of Venus and Tannhäuser celebrates neither sin nor shame, but the ‘inexhaustible license’ of a world where all desires are licit; in the Venusberg, taboos cannot be broken, because there are none to break. …”
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Analisis Faktor yang Berpengaruh pada Adopsi E-Commerce dan Dampaknya Bagi Kinerja UKM di Kabupaten Subang by Abu Muna Almaududi Ausat, Endang Siti Astuti, Wilopo Wilopo

“…The existence of services in the form of e-commerce, consumers can access and place orders from various places, then all services desired by consumers can be immediately followed up. …”
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Audit Sistem Informasi pada Sistem Manajemen Layanan Satu Atap (SIMANTAP) Menggunakan Kerangka COBIT 5.0 (Studi Kasus: Bank Indonesia Provinsi Bengkulu) by Arie Vatresia, Pieters N.P Tambunan, Aan Erlanshari

“…Meanwhile, in order for the SIMANTAP information system to achieve the desired level of capability at level 5 (Optimizing Process), the recommendations that need to be made are to make key performance indicators in all SIMANTAP performance assessments, create a SIMANTAP guide book, and document the level of implementation and performance evaluation. …”
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Effect of adding concentrated myofibrillar proteins of silver carp (Hypophthalmichthys molitrix) on the qualitative and nutritional characteristics of pasta by Mahsa Karami Charvadeh, Eshagh Zakipour Rahimabadi, Parva Safari

“…Conclusion: Given the results of sensory analysis with chemical characteristics and quality characteristics of cooking the pasta, it can be concluded that enrichment with up to 10% concentrated myofibrillar fish proteins makes no difference compared to the control group, while enhancing the desired characteristics of the final product.…”
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Delayed completion of pneumococcal conjugate vaccination among children 4–48 months in rural Uganda: a socio-demographic inquiry by Herbert Malemo, Andrew Tamale, Paul Kakwangire, Matthew C. Igwe, Dickens R. Mwine, Isa Asiimwe, Solomon A. Mbina, Mary G. Abalinda

“…Thus, concerted efforts in terms of sensitization are un-doubtfully desired especially among caretakers aged 20–39 years as well as those who are not married.…”
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Comparative- and Cost-Effectiveness Research Determining the Optimal Intervention for Advancing Transgender Women With HIV to Full Viral Suppression (Text Me, Alexis!): Protocol fo... by Cathy J Reback, Thomas Blue, Ali Jalali, Raphael Landovitz, Michael J Li, Raymond P Mata, Danielle Ryan, Philip J Jeng, Sean M Murphy

“…Over the course of the 90 days, participants in the PHN arm will receive unlimited navigation sessions; participants in the SMS text messaging arm will receive 270 theory-based SMS text messages (3 messages daily) that are targeted, tailored, and personalized specifically for transgender women with HIV; and participants in the PHN+SMS text messaging arm will receive a combined PHN and SMS text message intervention. The desired outcome of Text Me, Alexis! is viral suppression and cost-effectiveness. …”
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NEWCOMBO PROBLEMA IR AMERIKIETIŠKAS KLAUSIMAS by Zenonas Norkus

“…This conflict arises in the situations where an actor has to choose between the action bespeaking good news that a desirable state of world obtains upon which the chosen action has no causal influence, and the action bespeaking bad news but causally efficient to produce a small benefit. …”
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NEWCOMBO PROBLEMA IR AMERIKIETIŠKAS KLAUSIMAS by Zenonas Norkus

“…This conflict arises in the situations where an actor has to choose between the action bespeaking good news that a desirable state of world obtains upon which the chosen action has no causal influence, and the action bespeaking bad news but causally efficient to produce a small benefit. …”
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