Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis by Miao-Yan Xu, Jie Zeng, Xin-Hao Han, Duo-Duo Wei, Bing Fan, Xin‑Hui Qu, Shaorong Huang, Xiao-Jian Han

“…Moreover, JNC NPs + Laser can induce immunogenic cell death (ICD) to improve the maturation of dendritic cells (DCs) and present antigens to T cells, which high-effectively eliminate tumor lung metastasis. …”
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Reduced irradiation exposure areas enhanced anti-tumor effect by inducing DNA damage and preserving lymphocytes by Huiqin Chen, Yuan Li, Qiaofeng Shen, Guanqun Guo, Zhigang Wang, Hanyu Pan, Min Wu, Xueqing Yan, Gen Yang

“…The maturation of dendritic cells (DCs) and DNA damage induced by irradiated tumor cells were also assessed in vitro. …”
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Single-Cell RNA Sequencing Reveals Macrophage Dynamics During MASH in <i>Leptin</i>-Deficient Rats by Xiaoming Xin, Yaohua Ni, Jing Wang, Fenglin Wu, Meichen Liu, Lingjuan Wu, Jiaxing Dai, Chenglin Wu, Xiaolei Song, Wang Zhang, Guangrui Yang, Ruling Shen, Xianmin Zhu

“…In the microenvironment, macrophages had an increased number of interactions with hepatocytes, myofibroblasts, T cells, neutrophils, and dendritic cells, while their interaction strengths remained unchanged. …”
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Refining prognostic assessment of diffuse large B-cell lymphoma: insights from multi-omics and single-cell analysis unveil SRM as a key target for regulating immunotherapy by Xiaojie Liang, Jia Guo, Baiwei Luo, Weixiang Lu, Qiumin Chen, Yeling Deng, Yunong Yang, Liang Wang

“…Bulk and scRNA-seq analyses indicated that upregulation of SRM might mediate cold TME in DLBCL, potentially through suppressing immune activation pathways, promoting dendritic cells (DCs) transformation into tolerogenic DCs, and facilitating M2 polarization of macrophages. …”
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Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan

“…Furthermore, conventional dendritic cells (DCs) transformed into LAMP3 + DCs, contributing to an immunosuppressive microenvironment and enabling immune evasion. …”
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Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor by Xiaoqing Han, Xingbo Wang, Jiao Yan, Panpan Song, Yanjing Wang, Yaqing Kang, Abdur Rauf, Haiyuan Zhang

“…Moreover, photothermal and photodynamic effect of IR780 could kill tumor cells and elicit immunogenic cell death to mediate anti-tumor immunity, promoting dendritic cells (DCs) maturation and then activating specific effector T cells to further eliminate tumor cells. …”
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<i>CYP24A1</i> DNA Methylation in Colorectal Cancer as Potential Prognostic and Predictive Markers by Ru-Hua Zhou, Lei Li, Qing-Jian Ou, Yi-Fan Wang, Yu-Jing Fang, Cai-Xia Zhang

“…<i>CYP24A1</i> hypermethylation was positively correlated with infiltration levels of activated CD4 + T cells, activated CD8 + T cells, activated B cells, activated dendritic cells, and macrophages. Taken together, our findings indicate that the methylation levels of specific CpG sites within the <i>CYP24A1</i> promoter region in blood leukocytes and tumors are potential prognostic and predictive markers for overall survival in CRC patients.…”
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TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets by Trudy Straetemans, Mandy van Brakel, Sabine van Steenbergen, Marieke Broertjes, Joost Drexhage, Joost Hegmans, Bart N. Lambrecht, Cor Lamers, Pierre van Der Bruggen, Pierre G. Coulie, Reno Debets

“…The MC2 and MA3 TCR were surface-expressed and mediated CD8 T-cell functions towards melanoma cell lines and CD4 T-cell functions towards dendritic cells, respectively. We intend to start testing these MAGE-specific TCRs in phase I clinical trial.…”
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12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis by Nathalie Deckx, Inez Wens, Amber H. Nuyts, Niel Hens, Benedicte Y. De Winter, Gudrun Koppen, Herman Goossens, Pierre Van Damme, Zwi N. Berneman, Bert O. Eijnde, Nathalie Cools

“…Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. …”
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A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…Biological experiments demonstrate that covalent Pep-TACs can significantly degrade the expression of PD-L1 on tumor cells, dendritic cells and macrophages, especially under acidic conditions, and markedly enhance the function of T cells and tumor phagocytosis by macrophages. …”
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Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells by Jingwei Liu, Jingwei Liu, Tong Shu, Yiheng Mu, Wanlin Zheng, Xiaohuan Lu, Xiaohuan Lu, Hong Tao, Hong Tao

“…Furthermore, curdione and borneol enhance the expression of tumor necrosis factor α (TNF-α) and caspase 1 (CASP1) in macrophages, as well as the expression of interleukin 12 (IL-12) and interleukin 23 (IL-23) in dendritic cells (DCs). The expression of these inflammatory factors effectively promotes the migration and differentiation of T cells to the site of infection, completing the clearance of infected epithelial cells.ConclusionThe main components of Baofukang suppository, curdione and borneol, inhibit the progression of HPV infection and the occurrence of cervical cancer by modulating the communication between innate and adaptive immunity, promoting the recruitment and recognition of CD8+ T cells to eliminate HPV-infected epithelial cells.…”
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DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge by Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

“…DDO268 safely induces local type I interferon production and stimulates dendritic cell activation providing enhanced protection against IAV challenge. …”
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Comprehensive analysis of publications concerning combinations of immunotherapy and targeted therapies for hepatocellular carcinoma: a bibliometric study by Biling Gan, Lei Wu, Shunan Zhou, Zhihong Chen, Fan Wu, Lianqun Xu, Zhenrong Chen, Honghui Ma, Peijia He, Dan Fang, Ning Shi

“…Early research primarily focused on angiogenesis, dendritic cells, and expression markers, while recent trends have shifted towards phase III trials, adverse reactions, and checkpoint inhibitors, underscoring the field’s dynamic progression.ConclusionFuture research will expand on the pathological mechanisms underlying these therapies and novel interventions and combination strategies. …”
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Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses by Liping Liu, Jiayu Zhao, Zichao Huang, Yudi Xu, Hongyu Chen, Ruirui Qiao, Wantong Song, Zhaohui Tang, Thomas P. Davis, Xuesi Chen

“…Mannan-decoration as the shell could significantly enhance the lymph node draining ability of the nanovaccines, especially in CD8+ dendritic cells (DCs). Azole molecule end-capped polylactic acid-polyethylenimine (PLA-PEI-4BImi) with innate stimulating activity was applied as the inner core for coordinating antigen-presenting cell activation and antigen cross-presentation. …”
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Identification and Functional Analysis of PANoptosis‐Associated Genes in the Progression From Sepsis to ARDS by Zhong‐Hua Lu, Yan Tang, Hu Chen, Feng Liu, Mei Liu, Lu Fu, Xian‐Kai Wang, Ming‐Juan Li, Wei‐Li Yu, Yun Sun

“…NDRG1 showed a positive correlation with activated dendritic cells, whereas DDX3X, PTPRC, and TNFSF8 were positively associated with neutrophils and negatively correlated with CD56bright NK cells. …”
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Peripheral Regulatory Cells Immunophenotyping in Kidney Transplant Recipients with Different Clinical Profiles: A Cross-Sectional Study by Janette Furuzawa-Carballeda, Guadalupe Lima, Perla Simancas, Dolores Ramos-Bello, Margaret Simancas, Ian C. Bostock, Mario Vilatobá, Bernardo Gabilondo, Julio Granados, Luis Morales-Buenrostro, Josefina Alberú, Luis Llorente

“…Regulatory Foxp3-expressing T cells (Tregs), IL-10-producing B cells (Bregs), and IDO-expressing dendritic cells (DCregs) downregulate inflammatory processes and induces peripheral tolerance. …”
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Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia by Noran Abdel Wadood, Monika I. Hollenhorst, Mohamed Ibrahem Elhawy, Na Zhao, Clara Englisch, Saskia B. Evers, Mahana Sabachvili, Stephan Maxeiner, Amanda Wyatt, Christian Herr, Ann-Kathrin Burkhart, Elmar Krause, Daniela Yildiz, Anja Beckmann, Soumya Kusumakshi, Dieter Riethmacher, Markus Bischoff, Sandra Iden, Sören L. Becker, Brendan J. Canning, Veit Flockerzi, Thomas Gudermann, Vladimir Chubanov, Robert Bals, Carola Meier, Ulrich Boehm, Gabriela Krasteva-Christ

“…We demonstrate that activated tuft cells recruit dendritic cells to the trachea and lung. ATP released by tuft cells initiates dendritic cell activation, phagocytosis and migration. …”
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Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5+CD8+ T Cells by Jason M. Zimmerer, PhD, Sachi Chaudhari, BS, Kavya Koneru, BS, Jing L. Han, MD, PhD, Mahmoud Abdel-Rasoul, MA, Hope Uwase, MA, Tai Yi, MD, Christopher K. Breuer, MD, Ginny L. Bumgardner, MD, PhD

“…CD8+ TAb-supp cells did not mediate cytotoxicity to alloprimed dendritic cells, macrophages, CD4+ TFH cells, CD4+ T follicular regulatory cells, or CD4+ regulatory T cell. …”
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Bioinformatics analysis of ferroptosis-related hub genes and immunoinfiltration in myocardial ischemia/reperfusion following heart transplantation by Yuxi Zhang, Qiao Tang, Jiahui Cui, Yanan Li, Heng Xu, Zhen Qiu, Shaoqing Lei, Rui Xue, Qian Sun, Zhongyuan Xia

“…In addition, hub genes exhibited significant correlation with Eosinophils, NK cells resting, Dendritic cells resting, NK cells activated and T cells CD4 memory activated. …”
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Reducing the solubility of the major birch pollen allergen Bet v 1 by particle-loading mitigates Th2 responses by Amin Kraiem, Erica Pelamatti, Sophie Grosse-Kathoefer, Hilal Demir, Ute Vollmann, Caroline Ehgartner, Maria Stigler, Benjamin Punz, Litty Johnson, Nicola Hüsing, Barbara Bohle, Lorenz Aglas

“…Alterations in adjuvanticity by particle-loading were investigated by activation of dendritic cells, mast cells and the Toll-like receptor 4 pathway as well as by Th2 polarization in an IL-4 reporter mouse model. …”
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