Improved Clinical Outcomes with Appropriate Meropenem De-escalation in Patients with Febrile Neutropenia by Tyler Luu, Austin Fan, Reid Shaw, Hina Dalal, Jenna Adams, Maressa Santarossa, Gail Reid, Stephanie Tsai, Nina M. Clark, Fritzie S. Albarillo

“…CDI rate was also lower in the de-escalated group. In addition, consultations by infectious diseases physicians were more common in the de-escalation group. …”
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Opportunity for early de-escalation of antibiotics in Enterobacterales bacteremia with multiplex PCR rapid diagnostic technology by Erin Deja, Adam Greenfield, Sangeeta Sastry, Barry Rittmann

“…Strategies are needed to optimize rapid and effective antimicrobial therapy with early de-escalation. In this brief, we describe the utilization of multiplex polymerase chain reaction rapid diagnostic technology for the early de-escalation of broad-spectrum antimicrobials in patients with Enterobacterales bacteremia.…”
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The Resuscitation, Equilibrium and De-escalation (RED) strategy: a phased, personalized hemodynamic support in children with sepsis by Jaime Fernández-Sarmiento, Sushitra Ranjit, L. Nelson Sanchez-Pinto, Vinay M. Nadkarni, Roberto Jabornisky, Niranjan Kissoon

“…The proposed Resuscitation, Equilibrium and De-escalation (RED) strategy is a simplified phased hemodynamic management approach for patients with sepsis and septic shock. …”
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Neoadjuvant Immunotherapy and De-escalation of Surgery in Locally Advanced Breast Implant-associated Anaplastic Large Cell Lymphoma by Marzia Salgarello, Jaroslaw Krupa, Rebecca Allchin, Simon Pilgrim, Fiona Miall, Arianna Di Napoli, Maurizio Martelli, Giulio Tarantino

“…A literature review and the reported cases suggest the effectiveness of targeted immunotherapy as monotherapy or in combination with chemotherapy in locally advanced BIA-ALCL in disease downstaging, surgical de-escalation, reduction of significant postoperative complications, and an acceptable tolerance profile. …”
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De-escalation of surgical and radiation treatment in elderly luminal breast cancer patients, single institution report and review of the evidence by Yasmin Korzets, Marian Khatib, Hadar Goldvaser, Yehiel Hibshoosh, Alla Nikolaevski-Berlin, Ido Wolf, Viacheslav Soyfer

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Monitoring of Circulating Tumor DNA and Indication of De-Escalation Adjuvant Targeted Therapy for EGFR-Mutated NSCLC After Complete Resection by Song Dong, PhD, Bingfa Yan, PhD, Si-Yang Liu, PhD, Xuan Gao, PhD, Hui-Zhao Hong, MD, Hong-Ji Li, MD, Wei Gao, PhD, Hong-Hong Yan, PhD, Si-Yang Maggie Liu, PhD, Hai-Yan Tu, PhD, Yi Pan, PhD, Qing Zhou, PhD, Xue-Ning Yang, PhD, Xue-Feng Xia, PhD, Xin Yi, PhD, Wen-Zhao Zhong, PhD, Yi-Long Wu, MD, Jia-Tao Zhang, PhD

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Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy? by Pascal Vranckx, Stephan Windecker, Marco Valgimigli, Neil O’Leary, Yoshinobu Onuma, Peter Damman, Eva Christine Ida Woelders, Kai Ninomiya, Denise Adriana Maria Peeters, Arnoud Willem Johannes van 't Hof, Patrick Washington J C Serruys, Robert-Jan Matthijs van Geuns

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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

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Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approved with reservations] by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

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Edoxaban Monotherapy in Nonvalvular Atrial Fibrillation Patients with Coronary Artery Disease by Daisuke Fukamachi, Yasuo Okumura, Naoya Matsumoto, Eizo Tachibana, Koji Oiwa, Makoto Ichikawa, Hironori Haruta, Kazumiki Nomoto, Ken Arima, Atsushi Hirayama

“…It might be possible to shorten the time for de-escalation from a dual therapy to monotherapy, but data regarding de-escalation to an edoxaban monotherapy are lacking. …”
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Conflict and Its Management by James, A. Wall, Jr.

“…Subsequently, we probe into conflict escalation (and de-escalation), contexts, and conflict management. When examining this last topic, we note that conflict can be managed by the disputants themselves, by managers, or by other thirdparties. …”
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Some statements on medical care in the "new normal" post-covid-19 by Alfredo Darío Espinosa Brito

“…Due to the favorable prognoses in relation to the control of the COVID-19 pandemic in Cuba, a stage of "new normality" was announced, with a progressive "de-escalation" of measures that had been implemented to prevent the disease. …”
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Exploring postgraduates’ experiences: A focused group discussion on violence against doctors by Vijayalaxmi Mangasuli, S. B. Vijeth, Bhagyalaxmi Sidenur, A. M. Amrutha

“…Suggested interventions were improved security, training in de-escalation, zero-tolerance policies, and support systems for affected staff. …”
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Cooling down AI regulation controversies: Three closure processes in the Chilean legislative arena by Mónica Humeres, Dusan Cotoras, Renato Moretti, Iñaki Oyarzún-Merino, Teresa Correa, Claudia López

“…Drawing on the framework of sociotechnical controversies, we analyze the de-escalation of contentious discussions observed in the AI legislative process by Chile's National Congress. …”
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A Critique on the Book Ethnicity and Ethnocentrism in Iran: Myth and Reality by Siavash Gholipour

“…In line with the book's themes, the author introduces inclusive government, highlighting cultural commonalities, and de-escalation policies as appropriate strategies for dealing with Iran's multicultural situation. …”
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COVID-19 Pandemic in Brunei Darussalam by Wei Shan Ang, Jodi Woan-Fei Law, Vengadesh Letchumanan, Yong Sze Ong, Yatinesh Kumari, Long Chiau Ming, Loh Teng-Hern Tan

“…National COVID-19 Recovery Plan Framework and a gradual COVID-19 de-escalation plan were implemented to ensure a smoother transition to the new normal. …”
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THE POLITICS OF INSECURITY REPORTAGE IN NORTHERN NIGERIA by ISA SA’IDU

“…It is therefore instructive for Nigerian media to always report insecurity and conflict from a nationalistic perspective, which entails restraint in language use, framing of stories to promote national interest as well as de-escalation of tension. …”
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Surveillance experiences of extinction rebellion activists and police: Unpacking the technologization of Dutch protest policing by Majsa Storbeck, Gabriele Jacobs, Marc Schuilenburg, Robin van den Akker

“…Pervasive suspicion erodes institutional trust among activists and threatens the traditionally communicative and de-escalation-focused approach of Dutch law enforcement. …”
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GEOPOLITICAL VARIATION IN THE REPORTAGE OF SECURITY BY THE NATION AND DAILY TRUST NEWSPAPERS (2010-2020): A PROGNOSIS by M. M. NURUDDEN, M. M. NURUDDEN

“…For the content analysis, front page and editorial columns were identified as units of analysis, whereby five (5) frames tagged by the research as geopoliticization, glorification, escalation, de-escalation and neutral (GEOGLOESDEN) were content analysed. …”
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