Inflammatory Response Mechanisms Exacerbating Hypoxemia in Coexistent Pulmonary Fibrosis and Sleep Apnea by Ayodeji Adegunsoye, Jay Balachandran

“…Comorbidities like pulmonary hypertension, obesity, gastroesophageal reflux disease, and hypoxic pulmonary vasoconstriction contribute to chronic hypoxemia leading to the release of proinflammatory cytokines that may propagate clinical deterioration and alter the pulmonary fibrotic pathway. …”
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SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis by Carina Magdaleno, Daniel J. Tschumperlin, Narendiran Rajasekaran, Archana Varadaraj

“…The SOCS (Suppressor Of Cytokine Signaling) domain is a 40 amino acid conserved domain known to form a functional ubiquitin ligase complex targeting the Von Hippel Lindau (VHL) protein for proteasomal degradation. …”
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The Impact of Polyunsaturated Fatty Acid Supplementation on Inflammatory Markers in Preterm Infants – A Literature Review by Larysa Bielecka

“…Research consistently shows that PUFA supplementation lowers IL-6 levels, a cytokine considered a risk factor for sepsis in preterm infants. …”
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Vaccines and Immunotherapeutics for the Treatment of Malignant Disease by Joel F. Aldrich, Devin B. Lowe, Michael H. Shearer, Richard E. Winn, Cynthia A. Jumper, Ronald C. Kennedy

“…A number of immunotherapeutic strategies have arisen for the treatment of malignant disease, including various vaccination schemes, cytokine therapy, adoptive cellular therapy, and monoclonal antibody therapy. …”
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Evaluation of Tumour Necrosis Factor-Alpha and Interleukin-1beta in an Experimental Pyelonephritis Model Induced with Planktonic and Biofilms Cells of Pseudomonas aeruginosa by Rahul Mittal, Saroj Sharma, Sanjay Chhibber, Kusum Harjai

“…The results of the present investigation suggest that exaggerated cytokine production during P aeruginosa-induced pyelonephritis causes tissue damage operative through neutrophil recruitment leading to bacterial persistence in host tissues. …”
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Substance P Increases Cell-Surface Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor): In Vivo Biotinylation of Urothelial Cell-Surface Proteins by Katherine L. Meyer-Siegler, Shen-Ling Xia, Pedro L. Vera

“…Macrophage migration inhibitory factor (MIF), an inflammatory cytokine, and its receptor CD74 are upregulated by bladder inflammation. …”
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Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO by Rupa Biswas, Raymond F. Hamilton, Andrij Holian

“…Silica increased NLRP3 inflammasome activation and release of the proinflammatory cytokine, IL-1β, to a greater extent in MARCO−/− AM compared to wild type (WT) AM. …”
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Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis by Eun Ju Shin, Mi Jeong Sung, Hye Jeong Yang, Myung Sunny Kim, Jin-Taek Hwang

“…In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). …”
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Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage by Bolin Cai, Edwin A. Deitch, Luis Ulloa

“…However, the recognition of inflammatory cytokines as a common lethal pathway has become consent. …”
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Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis by Aijaz Ahmad, Ravineel B. Singh, Kara L. Nickolich, Matthew J. Pilewski, Caden Ngeow, Kwame Frempong-Manso, Keven M. Robinson

“…Interleukin-17 (IL-17) and the Type 17 immune signaling pathway cytokine family are recognized for their pivotal role in fostering protective immunity against various pathogens. …”
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The Role of IL-33 in Gut Mucosal Inflammation by Luca Pastorelli, Carlo De Salvo, Maurizio Vecchi, Theresa T. Pizarro

“…Interleukin (IL)-33 is a recently identified cytokine belonging to the IL-1 family that is widely expressed throughout the body and has the ability to induce Th2 immune responses. …”
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Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer by Yinan Yao, Guangdie Yang, Guohua Lu, Jiani Ye, Luyun Cui, Zhu Zeng, Junjun Chen, Jianying Zhou

“…The interaction of immune cells and cytokines in the tumor microenvironment affects the development and prognosis of tumors with an unclear potential regulatory mechanism. …”
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Nanoporosity of Alumina Surfaces Induces Different Patterns of Activation in Adhering Monocytes/Macrophages by Natalia Ferraz, Jaan Hong, Matteo Santin, Marjam Karlsson Ott

“…Human mononuclear cells cultured on alumina membranes with pore diameters of 20 and 200 nm were evaluated in terms of cell adhesion, viability, morphology, and release of proinflammatory cytokines. After 24 hours, cell adhesion was assessed by means of light microscopy and cell viability by measuring LDH release. …”
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The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course by Jessica Mwinyi, Christa Grete-Wenger, Jyrki J. Eloranta, Gerd A. Kullak-Ublick

“…PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. …”
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The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour by Lynne Sykes, David A. MacIntyre, Xiao J. Yap, Tiong Ghee Teoh, Phillip R. Bennett

“…It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. …”
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Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection by Yung-Chun Chuang, Hong-Ru Chen, Trai-Ming Yeh

“…In this review, we focus on the possible pathogenic effects of a pleiotropic cytokine, macrophage migration inhibitory factor (MIF), on the pathogenesis of DENV infection. …”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…Considerable logistical outlays have been deployed to develop and to translate humanised antibodies targeting immune cells, cytokines, and cytokine receptors to the clinic. Very recent phase III trials with the leading agent, a humanised anti-CD3 antibody, call into question whether further development of these biologics represents a step forward or more of the same. …”
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Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients by Yu Zhou, Deli Ye, Xiaofen Yuan, Yonglie Zhou, Jun Xia

“…Interestingly, HbA1c levels and HOMA-β were found to be correlated with a series of BA species. Proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and anti-inflammatory cytokine (IL-10) were all positively associated with several BA species, especially the conjugated secondary BAs. …”
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Normalization of Deviant Behavior in Muc2+/+ Mice through Dietary Incorporation of Bacillus subtilis Spores by Maryana Morozova, Alexander Alekseev, Arsalan Saeidi, Ekaterina Litvinova

“…The addition of kanamycin-resistant strain Bacillus subtilis BS20 spores to the diet of Muc2+/+ mice for 3 weeks at 107 CFU/g led to a change in behavior and cytokine levels in the gut compared to control C57BL/6 mice. …”
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Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis by Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie

“…Results were compared with the clinical features of s-JIA and serum cytokine levels including interleukin- (IL-) 6, IL-18, and soluble tumor necrosis factor receptors I and II. …”
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