Regulation of Immune Function by Polyphenols by Sujuan Ding, Hongmei Jiang, Jun Fang

“…Nutrition may play an essential role in immunity by interfering with proinflammatory cytokine synthesis, immune cell regulation, and gene expression. …”
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Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma by Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang

“…Natural killer cells (NK cells) play a key role in liver immunosurveillance, but in the tumor microenvironment, NK cells are readily depleted, as evidenced by down-regulation of activating receptors, reduced cytokine secretion, and attenuated killing function. …”
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Colorectal Polyposis and Immune-Based Therapies by Pearl Jacobson-Brown, Manuela G Neuman

“…The progression from precancerous (adenomatous) colon polyps to malignant colorectal cancer involves the complex actions of various cytokines on T cell proliferation, cell-cell adhesion, apoptosis and host immunity. …”
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Hemophagocytic Lymphohistiocytosis in an AIDS Patient with Kaposi Sarcoma: A Treatment Dilemma by Oluwadunni E. Emiloju, Sorab Gupta, Vivian Arguello-Guerra, Claudia Dourado

“…Hemophagocytic lymphohistiocytosis (HLH) is a result of an abnormal activation of immune cells (T lymphocytes, natural killer cells, and macrophages) resulting in cytokine overproduction and immune destruction of cells, eventually resulting in multiorgan failure. …”
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Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents by John Scott Baird

“…Systemic inflammation was characterized as cytokine storm syndrome in 2 patients and hemophagocytic lymphohistiocytosis in 2 patients. …”
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Biology of Inflammation in Crohn's Disease: Mechanisms of Action of Anti-TNF-αAlpha Therapy by Stephan R Targan

“…Corresponding in vitro investigation has shown that T helper 1 (Th1) -mediated cytokine production of interferon-gamma is downregulated in the involved mucosa to a level consistent with that seen in uninflamed mucosa. …”
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Induction of Immunological Tolerance by Oral Anti-CD3 by Andre Pires da Cunha, Howard L. Weiner

“…Orally delivered antibody does not have side effects including cytokine release syndromes, thus oral anti-CD3 antibody is clinically applicable for chronic therapy. …”
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Pathogenesis of Chronic Urticaria: An Overview by Sanjiv Jain

“…An increasing recognition of chronic urticaria as an immune mediated inflammatory disorder related to altered cytokine-chemokine network consequent to immune dysregulation resulting from disturbed innate immunity is emerging as yet another pathogenic explanation. …”
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Serum levels of TNF-α, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease by Cem Evereklioglu, Hamdi Er, Yusuf Türköz, Mustafa Çekmen

“…Aim: Behçet's disease (BD) is a systemic immuno-inflammatory disorder and the aetiopathogenesis is to be specified. Cytokines play a role in immune response and in many inflammatory diseases. …”
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Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications by Mario Sznol, Naiyer Rizvi

“…Interleukin-2 has become a prominent focus of preclinical and clinical investigation, because of its known clinical activity, the important role of this cytokine in immune biology, and the ability to engineer variant proteins with potentially improved antitumor immunomodulatory activity and reduced toxicity. …”
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The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases by Shan Guo, Qi Zhang, Yingjie Guo, Xiaoyan Yin, Peng Zhang, Tao Mao, Zibin Tian, Xiaoyu Li

“…CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. …”
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Interleukin-1, Tumour Necrosis Factor and Treatment of the Septic Shock Syndrome by Charles A Dinarello

“…Specific blockade of the pro-inflammatory cytokines interleukin-1 (IL-1) or tumour necrosis factor (TNF) reduces the morbidity and mortality associated with septic shock. …”
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Immunomodulatory Effects of Robinia pseudoacacia Polysaccharides on Live Vaccine against Infectious Bronchitis in Immunosuppressive Chickens by Qiuyan Sun, Fang Li, Caixia Wang, Meiyan Shen

“…The immunomodulatory efficacy of RPPS was determined by the antibody titer, the lymphocyte transformation rate in peripheral blood, the CD4+ and CD8+ T lymphocyte levels in peripheral blood, and the cytokine levels in the serum. The results showed that RPPS could not only enhance the immune effect of IB live vaccine but also improve the immunity of immunosuppressive chickens. …”
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Advances in the Diagnosis of Latent Tuberculosis Infection by Zhang H, Guan W, Zhou J

“…Recently, however, novel skin tests, molecular biology techniques, and cytokine biomarkers have been developed. This review summarizes the latest research on the diagnosis of LTBI, highlighting new tools and methods to improve detection and differentiation from active tuberculosis(ATB).Keywords: latent infection, tuberculosis, diagnosis, public health, review…”
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Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia by Michael Huang, Erin Owen, Scott Myers, Ashok Raj

“…Upon recovery, the patient went on to complete therapy and remains in remission without permanent neurologic or cardiac sequelae. Conclusion. Cytokine release syndrome from rapid cell lysis was the likely cause as infectious workup failed to reveal a definitive etiology and drug hypersensitivity testing to the chemotherapy agents was negative.…”
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De Quervain’s Tenosynovitis Virally Exacerbated by SARS-CoV-2 and Influenza Infections: A Case Report by Maria Gergoudis, Logan Laubach, Glenn E. Lee, Jeffrey R. Donowitz

“…Further studies including cytokine analysis and inflammatory markers are needed to advance this hypothesis.…”
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Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells by Pengju Wang, Yiyi Wang, Xiaojuan Zhao, Rui Zheng, Yiting Zhang, Ruotong Meng, Hao Dong, Sixin Liang, Xinyi He, Yang Song, Haichuan Su, Bo Yan, An-Gang Yang, Lintao Jia

“…Abstract The excessive cytokine release and limited persistence represent major challenges for chimeric antigen receptor T (CAR-T) cell therapy in diverse tumors. …”
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Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice by Carmine Carbone, Roberto De Luca, Emanuele Puca, Antonio Agostini, Alessia Caggiano, Lorenzo Priori, Annachiara Esposito, Serena Ascrizzi, Geny Piro, Lisa Salvatore, Francesco De Sanctis, Stefano Ugel, Vincenzo Corbo, Dario Neri, Giampaolo Tortora

“…This innovative antibody-cytokine fusion protein improves therapeutic outcomes, paving the way for novel targeted treatment strategies in PDAC.…”
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IGF2BP2 Shapes the Tumor Microenvironment by Regulating Monocyte and Macrophage Recruitment in Bladder Cancer by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Lizhao Wang, Quanpeng Qiu, Rundong Song, Yuanchun Pu, Yuanquan Zhang, Nan Mei, Mengzhao Zhang, Jinhai Fan

“…Single‐cell analysis revealed IGF2BP2's high expression in the GE‐9 epithelial subpopulation, characterized by immune evasion features and cytokine‐mediated macrophage recruitment. NicheNet analysis showed that GE‐9 cells interact with monocyte/macrophage populations through cytokine signaling. …”
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The effect of cannabis-derived terpenes on alveolar macrophage function by Patrick M. Greiss, Patrick M. Greiss, Patrick M. Greiss, Jacquelyn D. Rich, Jacquelyn D. Rich, Jacquelyn D. Rich, Geoffrey A. McKay, Dao Nguyen, Dao Nguyen, Dao Nguyen, Dao Nguyen, Mark G. Lefsrud, David H. Eidelman, David H. Eidelman, David H. Eidelman, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole

“…Neither terpene mixture affected inflammatory cytokine production by MH-S cells in response to LPS. …”
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