Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation by Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Hye-Sun Choi, Byung-Sam Kim, Teruo Kawada, Tsuyoshi Goto, Taesun Park, Jung Han Yoon Park, Rina Yu

“…Moreover, deficiency of 4-1BB markedly reduced macrophage infiltration and inflammatory cytokine production in the skeletal muscle of mice fed a high-fat diet. …”
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CD163, a novel receptor for TNF, was revealed in situ by proximity ligation assay by Alexandre Cousin, Myriam Oger, Aymar de Jenlis, Audrey Lejart, Laure Barbier, Diane Riccobono, Xavier Holy, Anne-Laure Favier, Krisztina Nikovics

“…Cytokine therapy utilizes cytokines to enhance the immune system to fight diseases. …”
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Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis by Lingxiao Xu, Qiuyue Peng, Wenhua Xuan, Xiaoke Feng, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wang

“…We have recently shown that IL-29 was an important proinflammatory cytokine in pathogenesis of rheumatoid arthritis (RA). …”
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Analysis of cyt0kine gene expression in stimulated T cells of small children by semi-quantitative PCR by H. Koning, M. R. M. Baert, R. de Groot, H. J. Neijens, H. F. J. Savelkoul

“…Therefore, a polymerase chain reaction (PCR) aided analysis of cytokine gene expression by PBMC or T cells is a valuable tool. …”
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Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis by Basit Saleem Qazi, Kai Tang, Asma Qazi

“…It is a proangiogenic cytokine that is overexpressed in many human cancers. …”
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How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? by Muhammad Babar Khawar, Fareeha Azam, Nadeem Sheikh, Khawaja Abdul Mujeeb

“…Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. …”
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Effects of anti-CD4 antibody treatment on calcium ions influx in peanut-sensitized C3H/HeJ mice by Junjuan Wang, Cui Zhou, Shiwen Han, Zainabu Majid, Na Sun, Huilian Che

“…However, administration of anti-CD4 antibodies markedly alleviated allergic symptoms, activated T cells, and reduced Ca2+ inflow, cytokine, histamine, mMcp-1, and the IgHG3, CXCL12, MMP2 and FABP4 gene. …”
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The effect of general versus spinal anesthesia on perioperative innate immune function in patients undergoing total hip arthroplasty by Lotte M. C. Jacobs, Veerle Bijkerk, Lucas T. van Eijk, Leo A. B. Joosten, Christiaan Keijzer, Jetze Visser, Michiel C. Warlé

“…Immune function was assessed by determination of ex vivo cytokine production capacity upon whole blood stimulation with E. coli lipopolysaccharides (LPS) and measurement of plasma cytokines and danger-associated molecular patterns (DAMPs). …”
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A 7-Amino Acid Peptide Mimic from Hepatitis C Virus Hypervariable Region 1 Inhibits Mouse Lung Th9 Cell Differentiation by Blocking CD81 Signaling during Allergic Lung Inflammation by Wanzhou Zhao, Conghao Tan, Xi Yu, Ruihe Yu, Qibing Mei, Yun Cheng

“…Th9 is a novel Th cell subset that mainly produces IL-9, a potent proinflammatory cytokine in asthma. A 7-amino acid peptide (7P) of the hypervariable region 1 (HVR1) of hepatitis C virus has been identified as an important regulator in the type 2 cytokine (IL-4, IL-5, and IL-13) immune response. …”
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Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

“…Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. …”
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High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response by Tianzhu Tao, Lulong Bo, Teng Li, Longbao Shi, Hui Zhang, Bo Ye, Yuhai Xu, Qingqing Ma, Xiaoming Deng, Guorong Zhang

“…The effects of anti-VISTA mAb on the 7-day survival, lymphocyte apoptosis, cytokine expression, bacterial burden, and vital organ damage were determined. …”
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Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial by Ana Belén Fernández-Serrano, Francisco José Moya-Faz, Cesar Augusto Giner Alegría, Juan Carlos Fernández Rodríguez, Jose Francisco Soriano Guilabert, Martín del Toro Mellado

“…But there was a further reduction in measured pro-inflammatory cytokine scores, improving body pain and physical health. …”
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IL-10 in Antilipopolysaccharide Immunity Against Systemic Klebsiella Infections by Tomislav Rukavina, Brigita Ticac, Vanja Vasiljev

“…This study was undertaken in order to determine whether anti-inflammatory cytokine interleukin-10 is responsible for a previously described protection against Klebsiella infection mediated by antilipopolysaccharide antibodies. …”
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C-Reactive Protein Knockout Attenuates Temporomandibular Joint Inflammation in Rats by Yao He, Mengjiao Zhou, Zixiang Jian, Lingli Fang, Lan Huang, Jinlin Song

“…The downregulation of proinflammatory cytokines (interleukin- (IL-) 1β and IL-6) and upregulation of the anti-inflammatory cytokine IL-10 were detected in CRP-/- rats, which also exhibited reduced macrophage activation and osteoclast differentiation. …”
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IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B Streptococcus Infection by Luciana Tissi, Francesco Bistoni, Manuela Puliti

“…IL-4 is an anti-inflammatory cytokine that inhibits the onset and severity in different experimental arthritis models. …”
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Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells by Patrícia S. de Araújo-Souza, Steffi C. H. Hanschke, João P. B. Viola

“…Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. …”
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TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells by L. Kui, G. C. Chan, P. P. W. Lee

“…Proinflammatory cytokines such as TNF-α and type I interferons (IFN) are pathogenic signatures of systemic lupus erythematosus, and plasmacytoid dendritic cells (pDCs) play a major role by predominantly producing IFN-α. …”
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IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis by Song I Lee, Na Young Kim, Chaeuk Chung, Dongil Park, Da Hyun Kang, Duk Ki Kim, Min-Kyung Yeo, Pureum Sun, Jeong Eun Lee

“…Abstract Background Interleukin-6 (IL-6) plays a central role in sepsis-induced cytokine storm involving immune hyperactivation and early neutrophil activation. …”
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Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression by Josephine Diony Nanda, Chiau-Jing Jung, Rahmat Dani Satria, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Tzong-Shiann Ho, Chiou-Feng Lin

“…These are commonly associated with cytokine release syndrome (CRS). The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS’s pathogenic and host defensive effects. …”
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IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever by Lilian Karem Flores-Mendoza, Tania Estrada-Jiménez, Virginia Sedeño-Monge, Margarita Moreno, María del Consuelo Manjarrez, Guadalupe González-Ochoa, Lourdes Millán-Pérez Peña, Julio Reyes-Leyva

“…Background. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs) that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue. …”
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