PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis by Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim

“…This leads to enhanced HBV replication and production of tumor-promoting inflammatory cytokines and IL6 and COX2 via the IRE1-JNK signaling pathway. …”
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Integrated microbiome, transcriptome and metabolome insight into the alleviating mechanisms of sheep milk in a DSS-induced colitis mouse model by Wenna Yao, Ruilin Du, Shuo Yan, Teligun Bao, Huimin Zhang, Fang Yang, Yue Xue, Yulong Zhao, Siqin Bao, Xihe Li, Yongli Song

“…An imbalance between pro-inflammatory and anti-inflammatory cytokines also is a hallmark of IBD. At present, IBD is treated with medicines. …”
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Diagnostic markers of severe diabetic macular edema in patients with type 2 diabetes by S.A. Suk, S.Yu. Mogilevskyy

“…In the pathogenesis of DME, the main role is played by the breakdown of the blood-retinal barrier as a result of an increase in vascular endothelial growth factor and the expression of pro-inflammatory cytokines. This breakdown leads to hyperpermeability of the vessels with subsequent formation of DME. …”
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Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients

“…A marked increase in serum levels of IL-<mml:math alttext="$18$"><mml:mrow><mml:mn>18</mml:mn></mml:mrow></mml:math> as well as the other cytokines evaluated was observed in the moderately burned patients. …”
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Effect and Mechanism of Electroacupuncture at the Affected Side of Quchi （LI 11） and Yanglingquan （GB 34） Acupoints in Rats with Limb Spasms after Cerebral Infarction by ZHAN Sheng, HUANG Linxing, YI Lizhen, CHEN Ruixue, HUANG Huiyuan, YUE Zenghui

“…Compared with the model group, expression level of RFK and NOX2 protein and the transcription level of RFK and NOX2 mRNA in the electroacupuncture group decreased significantly after treatment (<italic>P</italic>&lt;0.05).ConclusionElectroacupuncture can improve neurological impairment and limb spasm in rats with PSS, and its mechanism may be to the reduction down-regulation of Glu content in the cortex, reduction of the secretion of inflammatory cytokines TNF-α and IL-6, the inhibition of RFK and NOX2 expression, and the reduction of oxidative stress levels.…”
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Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflamma... by Chaokai Yang, Enlong Zhao, Hu Zhang, Liqi Duan, Xinyue Han, Hongli Ding, Yan Cheng, Dengkun Wang, Dengkun Wang, Dengkun Wang, Xiaojing Lei, Xiaojing Lei, Xiaojing Lei, Yongchang Diwu, Yongchang Diwu, Yongchang Diwu

“…This process may suppress the activation of the CMPK2/NLRP3 and TLRs/NF-κB pathways, diminish the production of inflammatory cytokines and chemokines, alleviate neuroinflammation associated with microglia in the brain of AD, and ultimately improve AD pathology.…”
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