The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies by Liu S, Zhang G, Li N, Wang Z, Lu L

“…Apoptosis, mediated by the JNK pathway, reduces chondrocyte density, while necroptosis and pyroptosis, involving RIPK-1/RIPK-3 and the NLRP3 inflammasome, respectively, amplify inflammation and cartilage destruction. Inflammatory cytokines and damage-associated molecular patterns (DAMPs) further enhance these PANoptotic pathways. …”
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ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis by Jing Bao, Bin Ye, Yuhan Ren

“…Upon TNF-α stimulation in the intestinal epithelia cell line, overexpression of ABIN1 significantly inhibits necroptosis in the intestinal inflammation model along with the reduction expression of pro-inflammatory cytokines such as IL1B, IL6, IL8, and TNF-α. Blocking RIPK1 by Nec-1s in vivo and in vitro dramatically alleviated the colitis and cell death which shares the same phenotype with ABIN1 overexpression. …”
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Deciphering Metabolic Responses in Traumatic Brain Injury Patients With Different Severity Using 1H NMR-Based Serum Metabolomics by Huan Zhou, Dongdong Sun, Dongmei Wang, Zirui Zhu, Xuelian Hong, Rui Fang, Hua Wang, Minghui Li

“…Moreover, our findings suggest an upregulation of the cytokines IL-1β, IL-6, and TNF-α following TBI, displaying correlations with lactate, 5-aminopentanoate, glucose, and creatinine metabolites. …”
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Effect of Every-other-day Fasting on Level of Serum TNF-α in Rats after Acute Spinal Cord Injury by Jiancheng LIU, Wenchun WANG, Shaojie LUO, Yanbo LI, Yunhui ZHAO, Rizhao PANG, Chao DONG, Shanshan ZHANG, Anren ZHANG

“…The mechanism may be related with suppressing expression of inflammatory cytokines TNF-α, inhibiting inflammatory response and reducing secondary injury.…”
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Oral Tolerance: A New Tool for the Treatment of Gastrointestinal Inflammatory Disorders and Liver-Directed Gene Therapy by Yaron Ilan

“…Inflammatory bowel diseases are immune-mediated disorders where an imbalance between proinflammatory (T helper cell type 1) and anti-inflammatory (T helper cell type 2) cytokines are thought to play a role in the pathogenesis. …”
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TLR2 Derangements Likely Play a Significant Role in the Inflammatory Response and Thrombosis in Patients with Ph(−) Classical Myeloproliferative Neoplasm by Jen Chin Wang, Guanfang Shi, Chi Chen, Ching Wong, Vladimir Gotlieb, Gardith Joseph, Kiron V Nair, Lakshmi Boyapati, Enayati Ladan, James T. Symanowski, Lishi Sun

“…Cultured monocyte-derived dendritic cells and plasma assays in TLR2-elevated patients were found to secrete more cytokines than those from TLR2-normal patients. These facts suggest that TLR2 is the major inflammatory pathways in MPN. …”
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JK-1, a useful erythroleukemic cell line model to study a controlled erythroid differentiation from progenitors to terminal erythropoiesis by Sylvain Metral, Sandrine Genetet, Benoît Gamain, Isabelle Mouro-Chanteloup

“…Here, we characterize the JK-1 CML-derived cell line, previously shown to spontaneously differentiate without cytokines. Using an epigenetic differentiation inhibitor that keeps JK-1 in an early differentiation phase, we characterized 2 progenitor stages: BFU-E JK-1 and CFU-E JK-1 with CD34+/CD36− and CD34−/CD36 + phenotypes respectively. …”
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Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation by Chao-Yang Lai, Yu-Wen Su, Kuo-I Lin, Li-Chung Hsu, Tsung-Hsien Chuang

“…The currently approved biological drugs adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, and secukizumab are antibodies against effector cytokines that participate in the initiation and development of psoriasis. …”
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Effect of fecal microbiota transplantation on ulcerative colitis model in rats: The gut–brain axis by Mahdis Morshedbak, Kaveh Rahimi, Mohammad Reza Tabandeh

“…Additionally, it examined the relationship between anxiety-related behaviors and colitis and assessed the pro-inflammatory cytokines in the hippocampus. Results: FMT led to lower disease score index and improved colon tissue pathology findings. …”
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Mesenchymal Stem Cell–Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease by Carl Randall Harrell, Valentin Djonov, Ana Volarevic, Aleksandar Arsenijevic, Vladislav Volarevic

“…MSC-Exos contain a variety of bioactive proteins (growth factors, immunoregulatory molecules, cytokines, and chemokines) lipids, and microRNAs (miRNAs) which affect viability, proliferation, phenotype, and function of eye-infiltrated immune cells. …”
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The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response by Liqian Zhu, Clinton Jones, Gaiping Zhang

“…Equipped with a broad range of receptors, such as Toll-like receptor 4 (TLR4), CD14, and Fc gamma receptors (FcγRs), macrophages can efficiently recognize and phagocytize invading pathogens and secrete cytokines by triggering various secondary signaling pathways. …”
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Circulating levels of osteoprotegerin and sRANKL and the effect of methotrexate in patients with rheumatoid arthritis by Aadhaar Dhooria, Narendhiran Pandurangan, Karthik Vinay Mahesh, Suchet Sachdev, Aman Sharma, Shefali Sharma, Nidhi Gupta, Varun Dhir

“…In RA, their alterations mediated through inflammatory cytokines are responsible for erosions and systemic bone loss. …”
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Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites by Jian Sun, Shiwei Sheng, Gang Zhao

“…Asthma is characterized with infiltration by eosinophils in pulmonary parenchyma, high serum IgE, and cytokines like IL-4, IL-5, and IL-13 secreted by allergen-specific T helper cell-2 (Th2) cells. …”
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Effect of Oral and Vaginal Hormonal Contraceptives on Inflammatory Blood Biomarkers by Afshin A. Divani, Xianghua Luo, Yvonne H. Datta, James D. Flaherty, Angela Panoskaltsis-Mortari

“…We assessed the effect of hormonal contraceptive use on inflammatory cytokines including CRP, monocyte chemotactic protein-1, soluble tumor necrosis factor (sTNF), interleukin-6 (IL-6), and soluble CD40 ligand. …”
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Recent methods for the diagnosis and differentiation of ameloblastoma: a narrative review by Ke Hu, Xudong Zhang, Ruixue Chen, Xiangjun Li

“…Cone-beam computed tomography is the most appropriate radiological technique for the detection of ameloblastoma. 18F-FDG PET/CT showed high diagnostic accuracy in identifying metastatic/recurrent lesions postoperatively. The detection of cytokines and gelatinase in the cyst fluid further aids in the diagnosis. …”
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Clinical features and diagnostic criteria of diseases of esophagogastroduodenal zone in patients with gallstone disease after cholecystectomy by I. V. Kozlova, Ye. V. Graushkina

“…Inflammatory and erosive-ulcerative changes of esophagogastroduodenal mucosa in these patients develop and progress on a background of disbalance of cytokines and metabolites of connective tissue in blood serum, the most severe in terms over 3 years after cholecystectomy. …”
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CRP and TNF-α  Induce PAPP-A Expression in Human Peripheral Blood Mononuclear Cells by Weiping Li, Hongwei Li, Fusheng Gu

“…Analyses were conducted by ultrasensitive ELISA, western blotting, and RT-PCR following stimulation with CRP or TNF-α cytokines. Results. PAPP-A mRNA and protein levels after CRP stimulation peaked at 24 hours, whereas peak PAPP-A mRNA and protein levels were achieved after TNF-α stimulation at only 2 and 8 hours, respectively. …”
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Accumulating the key proteomic signatures associated with delirium: Evidence from systematic review. by Md Parvez Mosharaf, Khorshed Alam, Jeff Gow, Rashidul Alam Mahumud

“…Among the unique proteins, we focused on the top 13 most investigated proteins (IL-6, CRP, IL-8, S100B, IL-10, TNF-a, IL-1b, Cortisol, MCP-1, GFAP, IGF-1, IL-1ra, and NFL) that are significantly associated with delirium. Most of these are cytokines and inflammatory proteins indicating a strong interconnection with delirium. …”
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Unusual Cutaneous Manifestations in a Patient with a History of Hepatitis B: A Case of Scleromyxedema and Literature Review by Gao A, Tian X, Lang D, Chen Y

“…Chronic antigenic stimulation from circulating cytokines and viral infections, such as HBV, may contribute to disease development. …”
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A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects by Joseph Schwager, Nathalie Richard, Rotraut Schoop, Swen Wolfram

“…RH-A and RH-B diminished the secretion of chemokines and cytokines in LPS/IFN-γ-activated PBL, including CCL5/RANTES, CXCL10/IP-10, interleukin- (IL-) 6, and IL-12. …”
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