Conservative treatment for cataract: state-of-the-art by S.Yu. Petrov, I.V. Kozlova, R.P. Poleva

“…Oftan^® Catachrom containts adenosine, nicotinamide, and cytochrome C. Currently, this agent is a well-studied medication used when cataract surgery cannot be performed. …”
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槲皮素诱导耐甲氨蝶呤骨肉瘤细胞系U2-OS/MTX300凋亡

“…【目的】 研究槲皮素对耐甲氨蝶呤骨肉瘤细胞株U2-OS/MTX300的增殖抑制和诱导凋亡作用及相关机制【方法】 以不同浓度槲皮素及甲氨蝶呤处理U2-OS及U2-OS/MTX300采用四甲基偶氮唑蓝(MTT)法及平板克隆检测细胞增殖,流式细胞仪检测细胞周期,Hochest 33258 染色及流式细胞仪检测凋亡,Western blot法检测凋亡相关蛋白cleaved-PARP,Bax,Bak,Bcl-2及Bcl-XL表达【结果】 槲皮素可明显抑制耐甲氨蝶呤骨肉瘤细胞U2-OS/MTX300的增殖,72 h IC50值为(22 ± 4)μmol/L102550μmol/L可显著抑制U2-OS/MTX300克隆形成数量,且随剂量增加抑制作用明显增强槲皮素与甲氨蝶呤之间不存在交叉耐药性槲皮素能诱导U2-OS/MTX300细胞S期阻滞,并可诱导胞内产生典型凋亡小体,流式细胞仪可检测到明显凋亡其作用机制是通过上调Bax,Bak及下调Bcl-2表达,促进cytochrome C释放及诱发PARP等重要胞内蛋白断裂来实现【结论】 槲皮素可显著抑制耐甲氨蝶呤骨肉瘤细胞系U2-OS/MTX300细胞增殖并诱导其凋亡,线粒体途径可能是其诱导凋亡的重要机制…”
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Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway by Attalla Farag El-kott, Ali A. Shati, Mohammed Ali Al-kahtani, Sultan Alqahtani

“…Concomitantly, in both control and Cis-treated cells, AG significantly lowered the protein levels of p53, p-p53 (Ser16), PUMA, cytochrome C, and cleaved caspase-3. Interestingly, pre-incubating the cells with either [D-Lys3]-GHRP-6 or LY294002 completely abolished the above-mentioned effect of AG in both control and Cis-treated cells. …”
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Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability by Mingqi Qiao, Peng Sun, Yang Wang, Sheng Wei, Xia Wei, Chunhong Song, Fushun Wang, Jibiao Wu

“…The hypothalamus and hippocampus of each group modelling PMS displayed the following features: decreased expression of Ulip2, tubulin beta chain 15, α actin, and interleukin 1 receptor accessory protein; increased expression of kappa-B motif-binding phosphoprotein; decreased expression of hydrolase at the end of ubiquitin carboxy, albumin, and aldolase protein; and increased expression of M2 pyruvate kinase, panthenol-cytochrome C reductase core protein I, and calcium-binding protein. …”
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Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation by Aleksandra Jankovic, Aleksandra Korac, Biljana Buzadzic, Vesna Otasevic, Ana Stancic, Milica Vucetic, Milica Markelic, Ksenija Velickovic, Igor Golic, Bato Korac

“…What is more, after an initial decrease on day 1, a sequential increase in pyruvate dehydrogenase, acyl-CoA dehydrogenase, cytochrome c oxidase, and ATP synthase and a decrease in acetyl-CoA carboxylase (from day 3) were observed. …”
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Dietary Supplementation of L-Arginine and N-Carbamylglutamate Attenuated the Hepatic Inflammatory Response and Apoptosis in Suckling Lambs with Intrauterine Growth Retardation by Hao Zhang, Yaotian Fan, Mabrouk Elsabagh, Shuang Guo, Mengzhi Wang, Honghua Jiang

“…Compared with CON lambs, relative protein 53 (P53), apoptosis antigen 1 (Fas), Bcl-2-associated X protein (Bax), caspase-3, cytochrome C, tumor necrosis factor alpha (TNF-α), nuclear factor kappa-B (NF-κB) p65, and NF-κB pp65 protein levels were higher (P<0.05) in liver from IUGR lambs, whereas those in liver from IUGR lambs under Arg or NCG treatment were lower than those in IUGR lambs. …”
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The Differential Expression of Mitochondrial Function-Associated Proteins and Antioxidant Enzymes during Bovine Herpesvirus 1 Infection: A Potential Mechanism for Virus Infection-I... by Xiaotian Fu, Xinyi Jiang, Xinye Chen, Liqian Zhu, Gaiping Zhang

“…The virus infection significantly increased the expression of subunit SDHB (succinate dehydrogenase) and MTCO1 (cytochrome c oxidase subunit I), critical components of RC complexes II and IV, respectively. …”
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Insecticide chlorfenapyr confers induced toxicity in human cells through mitochondria-dependent pathways of apoptosis by Longfei Wang, Zheng Qu, Yifan Xu, Guangqing Yu, Xiangyang Liu, Meizi Wang, Shiheng An, Xinming Yin, Risong Na, Youwu Hao

“…Further research showed that Chl induced mitochondrial damage (the collapse of mitochondrial membrane potential and the opening of mitochondrial permeability transition pore) with up-regulated expression of Bax/Bcl-2 leads to the release of cytochrome c from mitochondria which in turn activated the apoptotic pathway. …”
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DNA Barcoding and Phylogenetic Analysis of Culex and Anopheles Species in Siirt, Türkiye by Halil Dilmen, Behcet İnal, Mehmet Salih Özgökçe, Mustafa Cemal Çiftçi, Hilmi Kara, Sedriye Çatkın, Meryem Özer Dilmen, Gülcihan Koyunçu

“…A 658 bp fragment of the mitochondrial cytochrome c oxidase subunit 1 (COI) gene region was used for molecular diagnosis. …”
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Preparation of Iron Oxide and Titania-Based Composite, Core-Shell Populated, Nanoparticulates Material by Two-Step LASER Ablation in Aqueous Media as Antimicrobial and Anticancer A... by Hasan H. Bahjat, Raid A. Ismail, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Mohsen Al-Omar, Salman A. A. Mohammed, Riaz A. Khan

“…To further confirm the cytotoxic effects and the mechanism of the anticancer activity of the synthesized NPs against the A549 cell lines, several related parameters (cell viability, membrane permeability, nuclear intensity, and cytochrome-C release) were analyzed using the high-content screening (HCS) assay. …”
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Molecular Identification and Traceability of Illegal Trading in Lignobrycon myersi (Teleostei: Characiformes), a Threatened Brazilian Fish Species, Using DNA Barcode by Alexandre dos Santos Rodrigues, José Henrique Souza Galdino Brandão, Jamille de Araújo Bitencourt, Ricardo Jucá-Chagas, Iracilda Sampaio, Horácio Schneider, Paulo Roberto Antunes de Mello Affonso

“…In order to provide a reliable DNA barcode dataset for L. myersi, we compared mitochondrial sequences of cytochrome c oxidase subunit I (COI) from fresh, frozen, and salt-preserved specimens. …”
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漆黄素通过调节Apaf-1,ERK和COX-2信号通路诱导人宫颈癌细胞凋亡

“…滋mol/L时)显著诱导细胞凋亡; 使Caspase-3和Caspase-9的蛋白酶活性分别增加20% ~ 50%和22% ~ 38%;促进Apaf1蛋白的表达;能有效诱导Cytochrome-C的释放;降低 ERK/MAPK信号通路中ERK1/2蛋白的磷酸化水平;与ERK抑制剂或siRNA联合使用可抑制60% ~ 70%细胞增殖;减少COX-2蛋白的表达;明显减少PGE2的产生,仅1800 ~ 2600 pg/mL;减少p300?…”
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Lake Baikal amphipods and their genomes, great and small by P. B. Drozdova, E. V. Madyarova, A. N. Gurkov, A. E. Saranchina, E. V. Romanova, J. V. Petunina, T. E. Peretolchina, D. Y. Sherbakov, M. A. Timofeyev

“…Crossing experiments conducted so far for two morphological species suggest that the differences in the mitochondrial marker (cytochrome c oxidase subunit I gene) can potentially be applied for making predictions about reproductive isolation. …”
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Autophagy-Enhancing Properties of <i>Hedyotis diffusa</i> Extracts in HaCaT Keratinocytes: Potential as an Anti-Photoaging Cosmetic Ingredient by Qiwen Zheng, Xiangji Jin, Trang Thi Minh Nguyen, Eun-Ji Yi, Se-Jig Park, Gyeong-Seon Yi, Su-Jin Yang, Tae-Hoo Yi

“…Our findings indicate that HD promotes autophagy by modulating the PI3K/AKT/mTOR and PINK/PARK2 pathways, which stabilizes mitochondrial quality, maintains MMP and Ca²⁺ balance, and reduces cytochrome c release. These effects relieve cell cycle arrest and prevent apoptosis associated with an increased BAX/BCL-2 ratio. …”
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Trichinella spiralis excretory/secretory proteins mediated larval invasion via inducing gut epithelial apoptosis and barrier disruption. by Qi Qi Lu, Wen Wen Zheng, Zhao Yu Zhang, Pei Kun Cong, Xin Guo, Yao Zhang, Xin Zhuo Zhang, Shao Rong Long, Ruo Dan Liu, Zhong Quan Wang, Jing Cui

“…Besides, flow cytometry revealed an increasing apoptosis rate in Caco-2 cells after the IIL ESP treatment. qPCR and Western blot analysis indicated that IIL ESP activated caspases (Caspase 3, Caspase 9 and Caspase 8), up-regulated the pro-apoptotic factors (Bax and Cytochrome c) and down-regulated the anti-apoptosis molecule Bcl-2. …”
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Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440 by Jakob Grether, Holger Dittmann, Leon Willems, Tabea Schmiegelt, Elvio Henrique Benatto Perino, Philipp Hubel, Lars Lilge, Rudolf Hausmann

“…Of the three promoters tested in fluorescent biosensor assays, the promoter of the oxygen-sensitive cbb3-type cytochrome c oxidase gene showed high oxygen-dependent controllability. …”
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Species classification of Tabanus (Diptera: Tabanidae) in Western Thailand: Integrating DNA barcoding and modern morphometrics by Tanasak Changbunjong, Thekhawet Weluwanarak, Sedthapong Laojun, Tanawat Chaiphongpachara

“…To enhance the reliability of species identification, DNA barcoding was employed to analyze 30 cytochrome c oxidase subunit 1 (cox1) gene sequences from 15 horse fly species, which were then compared with sequences in the GenBank and BOLD databases. …”
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Massive subcutaneous filariosis by Filaria martis in beech marten (Martes foina) in Italy by Giovanni Sgroi, Ranju Ravindran Santhakumar Manoj, Ettore Napoli, Nicola D'Alessio, Maria Gabriella Lucibelli, Claudio de Martinis, Esterina De Carlo, Peyman Khademi, Alireza Sazmand, Vincenzo Veneziano

“…All the filarioids were identified as Filaria martis via morphology and Sanger sequencing of the cytochrome c oxidase subunit I (cox1) gene that revealed a single sequence type (GenBank accession number PQ034642) having 100 % nucleotide identity with those available in the literature. …”
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Roaming the Seas—Assessing Marine Invertebrate Biodiversity Along Salinity Gradients With Zooplankton and eDNA Metabarcoding by Alica Ohnesorge, Uwe John, Lucie Kuczynski, Stefan Neuhaus, Kingsly Chuo Beng, Bernd Krock, Silke Laakmann

“…DNA was extracted from eDNA and ZP samples, amplified using two universal primers that target of the mitochondrial cytochrome c oxidase subunit 1 (COI) and the nuclear ribosomal 18S rRNA genes, and paired‐end sequenced on Illumina Miseq. …”
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Microbiota Landscape of Gut System of Guppy Fish (Poecilia reticulata) Plays an Outstanding Role in Adaptation Mechanisms by Christian Aimé Kayath, Armel Ibala Zamba, Joseph Goma-Tchimbakala, Victor Mamonékéné, Gloire Moniceth Mombo Makanga, Aimé Augustin Lebonguy, Etienne Nguimbi

“…Finally, we showed that cytochrome c oxidase is not interfering in presence of trace metals. …”
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