Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension by Kohei Kotani, Joji Kawabe, Hiroyasu Morikawa, Tomohiko Akahoshi, Makoto Hashizume, Susumu Shiomi

“…Analysis using network-based pathways revealed decreased expression of adenosine deaminase, ectonucleoside triphosphate diphosphohydrolase 4, ATP-binding cassette, subfamily C, member 1, transforming growth factor-β, and prostaglandin E receptor 2; increased expression of cytochrome P450, family 4, subfamily F, polypeptide 3, and glutathione peroxidase 3; and abnormalities in the immune system, nucleic acid metabolism, arachidonic acid/leukotriene pathways, and biological processes. …”
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Resistance of Echinochloa crus-galli Populations to Acetolactate Synthase-Inhibiting Herbicides by Dilpreet S. Riar, Jason K. Norsworthy, Jason A. Bond, Mohammad T. Bararpour, Michael J. Wilson, Robert C. Scott

“…Experiments were conducted to characterize cross-resistance to acetolactate synthase- (ALS-) inhibiting herbicides and determine if malathion, a known cytochrome P450 monooxygenase (CYP) inhibitor, would overcome resistance. …”
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Nanocomposite treatment of hospital wastewater; Prophylaxis toxicity in the freshwater crayfish muscles and hepatopancreas by Hend A. Sabry, Sally M. Salaah, Marwa M. El-Naggar, Elham H.A. Ali, Magdy T. Khalil, Amal A.E. Ibrahim, Amr B. Mostafa

“…This improvement was attained by reducing the HP and muscles' toxicity through lowering nitric oxide contents, lipid peroxidation, protein carbonyl, and 8‑hydroxy- deoxyguanosine, while decreasing total antioxidant capacities, cytochrome P450, adenosine triphosphate, and calcium. …”
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Comparison of clinical and pharmacodynamic features of proton pump inhibitors efficacy in gastroesophageal reflux disease by O. A. Storonova, A. S. Trukhmanov

“…Intensity of acid-suppressive action of PPI depends on drug metabolic pathways and genetically determined features of cytochrome P450 system. Mutations of CYP2C19 alleles allow to divide the studied patients population into groups of rapid, mediun and slow «metabolizers» that it is necessary to take into account at prescription of the certain drug. …”
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Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients by Lara Marques, Nuno Vale

“…Herein, this study aims to analyze how covariates—such as age, weight, gender, body surface area (BSA), cytochrome P450 (CYP) expression, race, and health status—affect the therapeutic regime of orally administered salbutamol using population PK (popPK) modeling. …”
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Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan by Yi Liu, Xiaomu Kong, Yongwei Jiang, Meimei Zhao, Peng Gao, Xiao Cong, Yongtong Cao, Liang Ma

“…The present study aimed to investigate whether the antihypertensive effect of the ARB drug valsartan was associated with angiotensin II type 1 receptor (AGTR1) gene polymorphism (A1166 C) and cytochrome P450 enzyme 2C9 (CYP2C9) gene polymorphism (CYP2C9∗3). …”
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Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats by Yi-Wen Chien, Hsiang-Chi Peng, Ya-Ling Chen, Man-Hui Pai, Hsiao-Yun Wang, Hsiao-Li Chuang, Suh-Ching Yang

“…Hepatic thiobarbituric acid-reactive substance (TBARS) levels, cytochrome P450 2E1 protein expression, and tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, IL-6, and IL-10 levels, as well as intracellular adhesion molecule (ICAM)-1 levels were significantly elevated, whereas plasma adiponectin level was significantly reduced in group E (p<0.05). …”
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Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome, mycobiome, and metabolome by Yue Liu, Ping Ren, Hailong Li, Yingying Liu, Yiting Yang, Wanting Wang, Jiaming Zhou, Ling Su, Lili Guan, Hongxia Ma

“…These altered metabolites are involved in primary bile acid biosynthesis, metabolism of xenobiotics by cytochrome P450, lysine degradation, and other metabolic pathways. …”
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Differential detoxification enzyme profiles in C-corn strain and R-rice strain of Spodoptera frugiperda by comparative genomic analysis: insights into host adaptation by Ping-Hong Yao, Syed Husne Mobarak, Mao-Fa Yang, Chao-Xing Hu

“…Results A total of 1,995 detoxification-related genes, including cytochrome P450 monooxygenases (CYPs), carboxylesterases (COEs), glutathione S-transferases (GSTs), UDP-glucuronosyltransferases (UGTs), and ATP-binding cassette transporters (ABCs), were identified across the genus Spodoptera, including S. littoralis, S. litura, S. picta, S. exigua, and both FAW strains. …”
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Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression by Hwa Young Ahn, Hwan Hee Kim, Ji-Yeon Hwang, Changhun Park, Bo Youn Cho, Young Joo Park

“…Pioglitazone is metabolized by multiple cytochrome P450 (CYP) enzymes, which are regulated by the xenobiotic receptor constitutive androstane receptor (CAR). …”
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Hemoprotein dalam Tubuh Manusia by Husnil Kadri

“…Base on Fe ion state in heme group, hemoproteins are divided into: (1) Hemoproteins have ion Fe2+ state that can bind oxygen, such as hemoglobin, myoglobin, neuroglobin, and cytoglobin. (2) Hemoproteins have ion Fe3+ state that act as oxidoreductase enzymes, such as cytochrome P450, cytochromes in oxidative phosphorylation, catalase, tryptophan pyrolase, and NO synthase. …”
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Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies by Jifeng Gu, Jifeng Gu, Huishan Zhang, Mei Wang, Yuyang Zhou, Yuyang Zhou, Zhipeng Deng, Rong Shi

“…However, the metabolic characteristics of isoflavone aglycones remain unclear.MethodsIn this study, human liver microsomes (HLMs) and Cytochrome P450 (CYP) recombinant enzymes were used to study the metabolic stability, identify the metabolic pathways and enzyme kinetics of these three components, and elucidate their possible binding sites through molecular docking.ResultsWhen tectorigenin, irigenin, and irisflorentin were co-incubated with HLMs and CYP recombinant enzymes, hydroxylation metabolite for tectorigenin, demethylated metabolite for irigenin, and 6,7-dihydroxy-5,3′,4′,5′-tetramethoxy isoflavone originating from irisflorentin were identified. …”
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Noninvasive Evaluation of Liver Function in Morbidly Obese Patients by Patrick H. Alizai, Isabella Lurje, Andreas Kroh, Sophia Schmitz, Tom Luedde, Julia Andruszkow, Ulf P. Neumann, Florian Ulmer

“…Liver function capacity was determined by the LiMAx® test (enzymatic capacity of cytochrome P450 1A2). Liver biopsy specimens were obtained intraoperatively and classified according to the NAFLD Activity Score (NAS). …”
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Ossification Vesicles with Calcium Phosphate in the Eyes of the Insect Copium teucrii (Hemiptera: Tingidae) by Javier Garcia-Guinea, Alberto Jorge, Laura Tormo, Marta Furio, Elena Crespo-Feo, Virgilio Correcher, Pedro Prado-Herrero, Ana C. Soria, Jesus Sanz, Jose L. Nieves-Aldrey

“…., peptides, amide-S, amide-II, amide-III, and cytochrome P-450scc. The chemical composition of both galls and leaves of T. gnaphalodes was determined by gas chromatography – mass spectrometry (GC-MS) of their extracts. …”
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THE BIOSYNTHESIS REGULATION OF POTATO STEROIDAL GLYCOALKALOIDS by K. A. Ivanova, S. V. Gerasimova, E. K. Khlestkina

“…As a promising target for reducing SGA levels in tubers, the genes encoding PGA enzymes (belonging to the CYP72 subfamily cytochrome-P450-dependent monooxygenases catalyzing the conversion of hydrocholesterol to trihydrocholesterol) and SGT (SGA glycosyltransferases that catalyze the conversion of solanidine to its toxic glycosylated derivatives α-solanine and α-chaconine) are considered. …”
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Expression of a Splice Variant of CYP26B1 in Betel Quid-Related Oral Cancer by Ping-Ho Chen, Ka-Wo Lee, Cheng-Chieh Hsu, Jeff Yi-Fu Chen, Yan-Hsiung Wang, Ker-Kong Chen, Hui-Min David Wang, Hurng-Wern Huang, Bin Huang

“…Arecoline is the primary alkaloid in the AN and can be metabolized through the cytochrome P450 (CYP) superfamily by inducing reactive oxygen species (ROS) production. …”
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Effects of Aerobic Exercise on Rats with Hyperandrogenic Polycystic Ovarian Syndrome by Na Li, Chenghao Yang, Huiyu Xie, Yinghong Liu, Yuanpeng Liao

“…In addition, compared with the NC group, the levels of adiponectin (ADP) were significantly decreased (p<0.05), and the expression of aromatase cytochrome P450 (P450arom) in ovarian tissue was significantly elevated in the PC group (p<0.05). …”
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Integrating in vitro and in silico techniques for evaluating the antioxidant activity of Chrysanthemum indicum L by Fatimawali, Billy J. Kepel, Linda W. A. Rotty, Trina E. Tallei, Fahrul Nurkolis

“…Additionally, the detected compounds present in chrysanthemum flowers were computationally docked to the key macromolecular receptors involved in reactive oxygen species (ROS) production, namely Cytochrome P450 (CP450) and NADPH oxidase (NO). The findings revealed that the ethanolic extract in chrysanthemum flowers displayed inhibitory activity against 2,2-dyphenyl-1-picrylhydrazyl (DPPH) radicals at a concentration of 1.35 µg/mL, which is comparable to that of vitamin C (0.7 µg/mL). …”
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Expression of CSTF2 in oral squamous cell carcinoma and its relationship with immune infiltration and poor prognosis by Zumulaiti Aierken, Muertiza Muhetaer, Zhang Lei, Ainiwaerjiang Abudourousuli, Ainiwaerjiang Abudourousuli

“…Functional enrichment analysis indicated that CSTF2 plays a role in epidermal development and differentiation, immunoglobulin complexes, peptidases and endopeptidase inhibitor activity, and cytochrome P450 metabolic processes. Additionally, the overexpression of CSTF2 exhibited a negative correlation with the infiltration of immature dendritic cells (iDCs), cytotoxic cells, and plasmacytoid dendritic cells (pDCs). …”
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Antitoxic Effects of Chicory Herb Extract Fractions in Rats with Toxic Hepatitis by I. A. Lupanova, O. L. Saybel, E. N. Kurmanova, E. V. Ferubko, I. A. Martynchik, P. G. Mizina

“…The changes in the activity of biotransformation enzymes (cytochrome P450 [cytР450] and glutathione transferase [GT]) in hepatocytes and serum liver enzymes (AST, ALT and AP) were assessed.Results. …”
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