Transcriptomic resources for Bagrada hilaris (Burmeister), a widespread invasive pest of Brassicales. by Michael E Sparks, David R Nelson, Robert L Harrison, Nicholas R Larson, Daniel Kuhar, Ariela I Haber, Sam D Heraghty, Zarley Rebholz, Dorothea Tholl, Ian M Grettenberger, Donald C Weber, Dawn E Gundersen-Rindal

“…Three gene families involved in xenobiotic detoxification-glutathione S-transferases, carboxylesterases and cytochrome P450 monooxygenases-were phylogenetically characterized. …”
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Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches by Dong Li, Aixin Li, Hairui Zhou, Xi Wang, Peng Li, Sheng Bi, Yang Teng

“…Specifically, the similarity of DIM drugs is more significant than random chance, which shows that the chemical structure could distinguish the DIM-positive drugs from negatives. The cytochrome P450 (CYP) was identified to be shared by DIM drugs, which indicated the important role of metabolism in DIM. …”
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Warfarin Dosing in a Patient with CYP2C9*3*3 and VKORC1-1639 AA Genotypes by Mark Johnson, Craig Richard, Renee Bogdan, Robert Kidd

“…Genetic factors most correlated with warfarin dose requirements are variations in the genes encoding the enzymes cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKOR). …”
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Cyclosporine and Herbal Supplement Interactions by D. Colombo, L. Lunardon, G. Bellia

“…Its bioavailability is affected by many other traditional drugs and herbal extracts. Cytochrome P-450 isoenzymes CYP3A4 and CYP3A5 and protein P-glycoprotein (P-gp) are involved in CyA bioavailability. …”
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Alcohol and cancer: the role of cytochrome P-4502E1 by Helmut K. Seitz, Bernardo Moreira, Manuela Neuman

“…CYP2E1 is one of 57 cytochrome P450 enzymes that are responsible for over 90% of the redox reactions of chemicals, including drugs, vitamins, steroids, chemical carcinogens, and industrial compounds. …”
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Transcriptomic analysis of male diamondback moth antennae: Response to female semiochemicals and allyl isothiocyanate. by Yueqin Zheng, Qianxia Liu, Houjun Tian, Hui Wei

“…The analysis of MAs exposed to FAs and AITC identified 29 and 17 ODEs, respectively, mainly involving aldehyde dehydrogenases (ALDHs), alcohol dehydrogenases (ADs), cytochrome P450s (CYPs), and UDP-glucuronosyltransferases (UGTs). …”
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International Normalized Ratio (INR) Increases amongst Two Patients Living with HIV on Warfarin after Being Switched from a Nevirapine to a Dolutegravir-Based Antiretroviral Regime... by Natalie Sang, Sonak Pastakia, Samuel Nyanje

“…Nevirapine is an enzyme inducer and increases the dosing requirements for cytochrome P450 enzyme substrates including warfarin. …”
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All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia: A Case Report and Literature Review by Dylan Holmes, Prakash Vishnu, Russell K. Dorer, David M. Aboulafia

“…Concomitant administration of medications such as triazole antifungals which influence the cytochrome P-450 system can exacerbate this potential complication of ATRA. …”
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The potential of Mitragyna speciosa leaves as a natural source of antioxidants for disease prevention by Arief Ihsanul, Sunnardianto Gagus Ketut, Khairi Syahrul, Saputri Wahyu Dita

“…This study has been conducted using several computational methods to determine which compounds are the most active in interacting with cytochrome P450, myeloperoxidase, and NADPH oxidase proteins. …”
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Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids by Scott J. Thomson, Ara Askari, David Bishop-Bailey

“…Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs). …”
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Pharmacogenetics of Oral Antidiabetic Drugs by Matthijs L. Becker, Ewan R. Pearson, Ivan Tkáč

“…CYP2C9 encodes sulfonylurea metabolizing cytochrome P450 isoenzyme 2C9, ABCC8 and KCNJ11 genes encode proteins constituting ATP-sensitive K+ channel which is a therapeutic target for sulfonylureas, and TCF7L2 is a gene with the strongest association with type 2 diabetes. …”
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Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics by Ibrahim El-Serafi, Sinclair Steele

“…Cyclophosphamide (Cy) is a prodrug that is mainly bioactivated by cytochrome P450 (CYP) 2B6 enzyme. Several other enzymes are also involved in its bioactivation and affect its kinetics. …”
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Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice by Markus Koponen, Jaana Rysä, Anna-Kaisa Ruotsalainen, Olli Kärkkäinen, Risto O. Juvonen

“…In this study, male LDLr−/−ApoB100/100 mice were fed with Western diet (WD) or a standard diet for five months to reveal the effects on drug metabolism such as cytochrome P450 (CYP) oxidation and conjugation activities in the liver. …”
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Effects of the Maximum Recommended Levels of Fumonisins in the EU on Oxylipin Profiles in the Liver and Brain of Chickens by Philippe Guerre, Elodie Lassallette, Amélie Guerre, Didier Tardieu

“…A total of 96 OLs, derived from seven polyunsaturated fatty acids (PUFAs) via the cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (P450), and non-enzymatic pathways, were measured using HPLC-MS/MS. …”
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Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin by Michał Biernacki, Elżbieta Skrzydlewska

“…Phospholipids are subject to continuous transformation, including enzymatic hydrolysis (with the participation of phospholipases A, C, and D) to free polyunsaturated fatty acids (PUFAs), which under the influence of cyclooxygenases (COX1/2), lipoxygenases (LOXs), and cytochrome P450 (CYPs P450) are metabolized to various classes of oxylipins, depending on the type of PUFA being metabolized and the enzyme acting. …”
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The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and me... by Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu

“…The transcriptome data revealed the involvement of many differentially expressed genes in chemical carcinogenesis, drug metabolism, and metabolism of xenobiotics by cytochrome P450. The metabolome analysis revealed that TLMPS significantly regulated specific metabolites in the liver, including organic acids, lipids, nucleosides, and organic oxygen compounds. …”
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Transcriptional regulation of suberin and its response to the environment by ZHOU Yue, AN Yongping, MA Rong, WANG Pei

“…[Reviews] The regulation of suberin involves various factors, including key enzymes such as β-ketoacyl-CoA synthase (KCS), fatty acyl reductase (FAR), cytochrome P450 enzymes (CYP family), and transcription factors such as MYB, NAC, WRKY. …”
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Green chemistry approaches in the analytical validation of fosravuconazole using UV spectrophotometry and HPLC by Jeswin Maliyakal, Mital Patel

“…Its mild inhibition of the cytochrome P450 enzyme, which plays a role in adverse effects during polypharmacy, allows for the safe use of fosravuconazole alongside other medications, making it suitable for elderly patients. …”
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The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer by Guomin Gu, Chunling Liu, Yan Yang, Yan Zhao, Xiaodan Zhu, Gang Sun

“…A total of 1323 DEGs were predominantly enriched in the PI3K-Akt signalling pathway, cell adhesion molecules, and metabolism of xenobiotics by cytochrome P450. Additionally, most immune cell infiltration levels in KRAS mutations were lower than in KRAS wild type. …”
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Ciprofloxacin and Clozapine: A Potentially Fatal but Underappreciated Interaction by Jonathan M. Meyer, George Proctor, Michael A. Cummings, Laura J. Dardashti, Stephen M. Stahl

“…Clozapine provides a 50%–60% response rate in refractory schizophrenia but has a narrow therapeutic index and is susceptible to pharmacokinetic interactions, particularly with strong inhibitors or inducers of cytochrome P450 (CYP) 1A2. Case Report. We report the case of a 28-year-old nonsmoking female with intellectual disability who was maintained for 3 years on clozapine 100 mg orally twice daily. …”
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