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The symbiont Wolbachia increases resistance to bifenthrin in Ectropis grisescens by regulating the host detoxification function
Published 2025-01-01“…Transcriptome analysis showed a significant down-regulation of two cytochrome P450 genes in E. grisescens population without Wolbachia. …”
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42
Cloning and functional verification of Geraniol-10-Hydroxylase gene in Lonicera japonica
Published 2025-01-01“…Background Geraniol 10-hydroxylase (G10H) is a cytochrome P450 monooxygenase involved in regulation, which is involved in the biosynthesis of monoterpene. …”
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43
Determination of mutagenicity of chemical compounds, physical factors and environmental pollutants by the Drosophila melanogaster wing somatic mutation and recombination test
Published 2016-03-01“…The Drosophila and mammalian detoxication system is arranged on similar principles, which are based on the action of cytochrome P450. There are modifications to SMART, based on elevated cytochrome P450 expression, allowing more reliable extrapolation of the test results to mammals. …”
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44
Neuroprotective Potentials Of Extracts From Moringa Oleifera And Musa Sapientum Against Cadmium Chloride-Induced Neurotoxicity In Rats Cerebri
Published 2025-02-01“…Tissue concentrations of catalase, superoxide dismutase, cyclo-oxygenase-2 and cytochrome P450 in rats’ cerebri were determined using ELISA. …”
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45
Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?
Published 2020-01-01“…These metabolites may inhibit cytochrome P450 2C19 (CYP2C19) and cytochrome P450 3A4 (CYP3A4) reversibly, but as recent evidence suggests, they may also be involved in causing kidney disease. …”
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46
Paracetamol metabolism by endothelial cells – Potential mechanism underlying intravenous paracetamol-induced hypotension
Published 2025-01-01“…In this study, we examine the hypothesis that APAP is metabolized by cytochrome P450 enzymes within the endothelium, which may be accelerated in critically ill patients by the presence of elevated myeloperoxidase (MPO). …”
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47
Myopathy with Concurrent Tadalafil and Simvastatin
Published 2009-01-01“…Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.…”
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48
A Computational Approach towards the Development of Newer Anticancer Agents
Published 2010-01-01“…In silico molecular docking analyses of the novel 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-aryl-propane-1, 3-diones were performed in the active sites of enzyme cytochrome P450 reductase to obtain new anticancer agents computationally. 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-(4"-methoxy-phenyl)-propane-1, 3-dione (3f) was found to have maximum affinity for the active sites of enzyme.…”
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49
iTRAQ-based quantitative proteomic analysis of herbicide stress in Avena ludoviciana Durieu
Published 2025-01-01“…The function of DEPs indicated that some proteins, such as cytochrome P450, play a direct role in herbicide detoxification. …”
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50
Hepatic changes during a carrageenan induced granuloma in rats
Published 1993-01-01“…The continuous increase in hepatic cAMP observed during acute and chronic phases could be related to adenylate cyclase stimulation by mediators, and could be an initial step in the hepatocyte adaptation leading to the increased level of hepatic caeruloplasmin, to the reduction of cytochrome P-450 level and to the modifications of Ca2+ sequestration by microsomes.…”
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51
Treatment of Severe Acetaminophen–Induced Hepatocellular Injury with Prostaglandin E: Two Case Reports
Published 1995-01-01“…Acetaminophen hepatotoxicity is mediated by a toxic reactive metabolite formed from the parent compound by the cytochrome P450 mixed-function oxidase system of the hepatocyte. …”
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52
Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy
Published 2024-12-01“…Abstract Warfarin is the most widely used oral anticoagulant in clinical practice. The cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) genotypes are associated with warfarin dose requirements in China. …”
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53
Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application
Published 2015-01-01“…Various clinical and in vivo studies have been undertaken to evaluate the effects of foods and food-derived components on the activity of detoxification pathways, including phase I cytochrome P450 enzymes, phase II conjugation enzymes, Nrf2 signaling, and metallothionein. …”
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54
The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity
Published 2025-01-01“…The six pathways related to energy metabolism driven by L. reuteri, including the citrate cycle, ascorbate and alderate metabolism, proximal tube bicarbonate metabolism, glycolysis/gluconeogenesis, ferroptosis, drug metabolism–cytochrome P450, are important mechanisms.…”
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55
Metabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya
Published 2025-01-01“…A synergist assay using piperonyl butoxide (PBO) (4%) was conducted to determine cytochrome P450s’ role in pyrethroid resistance. RNA-seq was conducted on a combined pool of specimens that were resistant and unexposed, and the results were compared with those of the FANG susceptible reference strain. …”
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56
Sorafenib-Induced Liver Failure: A Case Report and Review of the Literature
Published 2011-01-01“…We hypothesize that an underlying cytochrome P450 dysfunction with the presence of reactive drug metabolites might lead to this potentially fatal Sorafenib-induced severe liver dysfunction.…”
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57
How to Make the Right Choice of Proton Pump Inhibitor for Patients with Gastroesophageal Reflux Disease?
Published 2023-06-01“…Pantoprazole is distinguished from other PPIs by its persistent high bioavailability, long-term antisecretory effect, and very low affinity for cytochrome P450.…”
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Current Trends in Treatment for Acid-Dependent Diseases: Clinical Efficacy and Safety of Rabeprazole
Published 2021-12-01“…A lower rabeprazole metabolic dependence on cytochrome P-450 enzyme system renders its antisecretory effect predictable and reduces the risk of interactions with other drugs metabolised through this system. …”
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59
Pathway and molecular mechanisms for malachite green biodegradation in Exiguobacterium sp. MG2.
Published 2012-01-01“…Furthermore, our molecular biology experiments suggested that both triphenylmethane reductase gene tmr and cytochrome P450 participated in MG degradation, consistent with their roles in the proposed pathway. …”
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Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration
Published 2015-01-01“…This is particularly true for drugs that are extensively metabolized by cytochrome P450 (CYP)3A4. We describe a particularly severe case of rhabdomyolysis after the introduction of ciprofloxacin, a weak CYP3A4 inhibitor, in a patient who previously tolerated the simvastatin-amlodipine combination.…”
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