Adverse health effects after breast cancer up to 14 years after diagnosis by Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling, Joke C. Korevaar, Annette Berendsen, Daan Brandenbarg, Anneriet Dassen, Agnes Jager, Jacqueline Hugtenburg, Gerda van der Weele

“…Methods: We retrieved data on 11,495 women diagnosed with breast cancer in 2000–2016 and 23,242 age and sex matched controls from the PSCCR-Breast Cancer, a database containing data about cancer diagnosis, treatment and primary healthcare. We built Cox regression models for 685 health effects, with time until the health effect as the outcome and survivor/control and cancer treatment as predictors. …”
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Real-World Experience with AGA Guidelines in the Management of Crohn’s Disease following Ileocolonic Resection: A Retrospective Cohort Study by Shasha Tang, Wei Liu, Weilin Qi, Tunan Yu, Qian Cao, Xiaolong Ge, Wei Zhou

“…The PER rate in patients treated with nitroimidazole, thiopurines, infliximab, or a combination of thiopurines and infliximab for postoperative prophylaxis was 88.1%, 34.1%, 20.5%, and 0%, respectively. Cox regression showed that smoking at the time of surgery and AGA guideline adherence were independent factors associated with PER (HR: 3.75, 95% CI: 1.36-10.33, P=0.01; HR: 0.36, 95% CI: 0.15-0.86, P=0.02). …”
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Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort by Fern FitzHenry, Svetlana K. Eden, Jason Denton, Hui Cao, Aize Cao, Ruth Reeves, Guanhua Chen, Glenn Gobbel, Nancy Wells, Michael E. Matheny

“…The association of time to constipation with opioid use was analyzed using Cox proportional hazard regression adjusted for patient characteristics, concomitant medications, laboratory tests, and comorbidities. …”
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Serum Cystatin S (CST4): A Novel Prognostic Marker for Gastric Cancer by Chao Gu, Shan Chen, Lining Huang, Chenliang Cao, Renshun Yuan, Zhongyang Kou, Weiwei Chen, Haihua Shi, Xiaodong Gu

“…The cohort was divided into training and test sets at a ratio of 3:1 for Cox regression analyses, which identified CST4 as an independent risk factor for overall survival (OS) and disease-free survival (DFS). …”
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Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort by Sarah Damanti, Sarah Damanti, Rebecca De Lorenzo, Rebecca De Lorenzo, Lorena Citterio, Laura Zagato, Elena Brioni, Cristiano Magnaghi, Marco Simonini, Maria Pia Ruggiero, Simona Santoro, Eleonora Senini, Marco Messina, Francesca Farina, Costanza Festorazzi, Giordano Vitali, Paolo Manunta, Paolo Manunta, Angelo Andrea Manfredi, Chiara Lanzani, Chiara Lanzani, Patrizia Rovere-Querini, Patrizia Rovere-Querini

“…Concordance was assessed using Cohen’s Kappa coefficients. Age-and sex-adjusted Cox regression analyses were conducted to evaluate the association with mortality.ResultsOut of 1,114 participants (median age 72 years, IQR 69–77), 186 were classified as frail by the FI, 13 by the FP and 48 by both definitions. …”
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SECTM1 acts as an immune-related biomarker of poor prognosis and promotes cancer progression by modulating M2 macrophage polarization in esophageal squamous cell carcinoma by Pengzhou Kong, Pengzhou Kong, Pengzhou Kong, Ye Jiao, Ye Jiao, Meng Sun, Meng Sun, Zhinan Zhou, Zhinan Zhou, Yingying Zhang, Yingying Zhang, Xin Yang, Xin Yang, Jing Ren, Jing Ren, Mengyuan Yang, Mengyuan Yang, Yanyan Dong, Yanyan Dong, Yanyan Dong, Bin Song

“…Performed with univariate and multivariate Cox regression, a novel prognostic prediction model was developed based on three immune-related genes (MAP3K8, SECTM1, IGLV7-43), which has been identified as a relatively accurate, independent, and specific prognostic risk model for ESCC patients in different ESCC cohorts. …”
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Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 by Pingping Huang, Hongwei Zhang, Gaocan Ren, Yifei Wang, Shuangqing Fu, Yicheng Liu, Zhibo Zhang, Lijun Guo, Xiaochang Ma

“…Multivariate logistic regression models indicated significant associations between TyG and obesity-related indices with hypertension. Using Cox regression analysis, we examined the relationship between TyG and obesity-related indices in relation to hypertensive prognosis, employing threshold effect analysis and fitted smoothed curves for consistency. …”
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Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus by Yu-Ling Lin, Sheng-Hsiang Lin, Hsi-Hao Wang, Wan-Chia Hsu, Shih-Yuan Hung, Yuan-Yow Chiou, Hung-Hsiang Liou, Min-Yu Chang, Li-Chun Ho, Ching-Fang Wu, Yi-Che Lee

“…<b>Results</b>: The multivariable Cox survival model showed that metformin users had significantly better renal outcomes, with a notably lower risk of sustained eGFR of <60 mL/min/1.73 m² (hazard ratio (HR), 0.71; 95% confidence interval (CI), 0.56–0.90) and new CKD onset (HR, 0.78; 95% CI, 0.65–0.94). …”
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Examined lymph node counts affected the staging and survival in cervical cancer: a retrospective study using the SEER and Chinese cohort by Tao Guo, Yuxi Zhao, Jia Zeng, Jian Li, Enyu Tang, Lingying Wu

“…Multivariable logistic and Cox regression models assessed LN positivity detection and overall survival (OS), respectively. …”
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HLA-G high-expressor 3’UTR markers are linked to gastric cancer development and survival by Christian Vaquero-Yuste, Ignacio Juarez, Marta Molina-Alejandre, Elisa María Molanes-López, Alberto Gutiérrez-Calvo, Adela López-García, Inmaculada Lasa, Remedios Gómez, Antonio Arnaiz-Villena, Jose Manuel Martín-Villa

“…Survival analysis was conducted using Kaplan–Meier curves and multivariate Cox regression models. High-expressor HLA-G 3’UTR haplotypes (UTR-1 and UTR-6) were significantly associated with gastric cancer susceptibility, indicating a potential role in tumor immune evasion. …”
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Pien Tze Huang Attenuates Neuro-inflammatory Injury in BV2 Microglial Cells Induced by Lipopolysaccharide via Inhibition of TLR4/MAPK Signaling Pathway by Zhenwei HUANG, Qing ZHANG, Lili HUANG, Xiaoqin ZHANG, Mingqing HUANG

“…Then the protein expression of TLR4, ERK1/2, p-ERK1/2, p38, p-p38, JNK, p-JNK, COX-2, iNOS in BV2 microglial cells were detected by Western blot.Results:1) The result of MTT assay showed that PZH at 0.05-0.15 mg/mL concentration and LPS at 100 ng/mL concentration had no significant cytotoxicity on BV2 microglial cells (<italic>P</italic>&gt; 0.05).2) The result of ELISA showed that the secretion of IL-6 was significantly increased in BV2 microglial cells induced by LPS compared with the normal control group (<italic>P</italic>&lt; 0.001); compared with the LPS group, different concentrations of PZH significantly decreased the expression level of IL-6 in LPS-induced BV2 microglial cells (<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01).3) The result of RT-qPCR showed that the transcriptional levels of IL-1β(<italic>P</italic>&lt; 0.001), IL-6(<italic>P</italic>&lt; 0.001) and TNF-α(<italic>P</italic>&lt; 0.01) were significantly increased after the induction of LPS compared with normal controal group; different concentrations of PZH significantly inhibited the LPS-induced IL-1β(<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.001), IL-6(<italic>P</italic>&gt; 0.05, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.001) and TNF-α(<italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.001) mRNA upregulation.4) The result of Western blot showed that PZH significantly inhibited the LPS-induced TLR4/MAPK signaling pathway activation, and decreased the protein expressions of TLR4(<italic>P</italic>&gt; 0.05, <italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.05), p-ERK1/2(<italic>P</italic>&gt; 0.05, <italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01), p-p38(<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01), COX-2(<italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.001) and iNOS(<italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01), but not p-JNK.Conclusion:PZH can significantly improve the LPS-induced neuro-inflammatory injury, which may be related to the inhibition of the activation of TLR4/MAPK signaling pathway.…”
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Association of early versus late care seeking for sport-related concussion in adolescent athletes in Canada: a historical cohort study by Sheilah Hogg-Johnson, Carolina Cancelliere, Cameron Marshall, Darrin Germann, Mohsen Kazemi, David Youngwoo Oh

“…Propensity scores were first derived from logistic regression with early versus late clinical presentation as the outcome. Cox proportional hazards regression analysis was then used to model the relationship between early versus late clinical presentation and time to recovery, while including the propensity score to adjust for confounding. …”
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Prognostic Impact of Adjuvant Immunotherapy in Patients With Resectable NSCLC After Neoadjuvant Chemoimmunotherapy: A Brief Report by Yichen Dong, MD, Long Xu, MD, Jialiang Wen, MD, Haojie Si, MD, Juemin Yu, MD, Tao Chen, MD, Huikang Xie, MD, Xinjian Li, MD, Minglei Yang, MD, Junqiang Fan, MD, Junqi Wu, MD, Yunlang She, MD, Deping Zhao, MD, Chang Chen, MD, PhD

“…Recurrence-free survival (RFS) and overall survival (OS) were estimated using Kaplan-Meier methods and tested by log-rank test. Unstratified Cox proportional hazards models were fitted to the subgroups. …”
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A novel histone acetylation-associated gene signature with prognostic value in Ewing sarcoma by Anshun Wu, Fayin Liu, Lei Zhou, Runyi Jiang, Shangjiang Yu, Zihuan Zhou, Qi Zhang, Qian Zhang, Dongjie Jiang, Shaohui He, Haifeng Wei

“…After collecting EWS patients with mRNA sequencing data from the Gene Expression Omnibus (GEO) database and a list of HARGs from previous studies, Cox regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression were performed to construct a prognostic gene signature based on HARGs. …”
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Liraglutide and GLP-1(9–37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway by Chenqi Lu, Cong Xu, Shanglin Li, Haiqiang Ni, Jun Yang

“…Besides, both of them increased GPX4 expression and decreased COX2 expression. These effects were reversed by a High-Iron Diet. …”
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Unconventional use of injectable long-acting cabotegravir and rilpivirine against HIV-1 in PWH in clinical need: 52 weeks real-world data by Valentina Iannone, Roberto Rossotti, Nicholas Brian Bana, Gabriele Cavazza, Federico D’Amico, Francesca Lombardi, Pierluigi Francesco Salvo, Gianmaria Baldin, Simona Di Giambenedetto, Dario Bernacchia, Gabriele Pagani, Alberto Borghetti, Stefano Rusconi

“…Kaplan-Meier (KM) was used to assess the probability of CAB/RPV discontinuation. Cox regression analysis was used to evaluate potential predictors of discontinuation. …”
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Repurposing of Metformin to Improve Survival Outcomes in Patients With Upper Tract Urothelial Carcinoma by Hsiang Ying Lee, Po‐Hung Lin, See‐Tong Pang, Jen‐Kai Fang, Chung‐You Tsai, Yao‐Chou Tsai, Yung‐Tai Chen, Wei‐Chieh Chen, Hsin‐Chih Yeh, Wei‐Ming Li

“…Statistical analysis involved the use of Student's t‐test, Mann–Whitney test, Chi‐squared test, Fisher's exact test, and Cox proportional hazard regression. Results Significant differences were observed between the two groups in BMI, preoperative creatinine, eGFR, tumor location, tumor laterality, tumor size, and pathological grade and T stage. …”
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Predicting cardiovascular disease and all-cause mortality using the lymphocyte-to-monocyte ratio: Insights from explainable machine learning models by Jichao Wu, Die Huang, Jiefang Li, Jingxing Yi, Yu Lei, Jun Yin

“…We employed various statistical methods, including weighted Cox proportional hazards models, restricted cubic spline models, and time-varying receiver operating characteristic curves, to examine the association between LMR and mortality risk. …”
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Worst pattern of invasion: A prognostic indicator in early-stage oral tongue cancer: A single-center cohort study by Bhargav Ram, LM Chandra Sekara Rao S, Daphne Fonseca, Sravan Kumar Ch, Johnathan Gondi, Anil Kumar Akula, Hemantkumar Nemade

“…Statistical analysis was done using chi-square, cox multivariate analysis and Kaplan-Meier survival analysis. …”
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Trends in Survival for Adult Organ Transplantation by Grant Patrick, BS, Brian Hickner, MD, Karthik Goli, BS, Liam D. Ferreira, MBA, John Goss, MD, Abbas Rana, MD

“…Univariable and multivariable Cox regression analyses were used to analyze factors contributing to intent-to-treat survival in 813,862 adults listed for kidney, liver, heart, and lung transplants. …”
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