Correlation between neutrophil percentage-to-albumin ratio and all-cause and cerebrovascular mortality among hypertension patients by You Li, Cheng Yu

“…In order to assess the independent risk contribution of the NPAR in all-cause and cerebrovascular mortality, weighted Cox proportional hazards models were employed. Concordance index and receiver operating characteristic (ROC) curve were employed to assess how effectively the NPAR predicted the mortality risk at different times. …”
Get full text

SLC35A2 is a novel prognostic biomarker and promotes cell proliferation and metastasis via Wnt/β-catenin/EMT signaling pathway in breast cancer by Rushu Yan, Tianwen Chen

“…Kaplan-Meier survival curves and Cox regression analysis confirmed the independent and significant prognostic value of SLC35A2 in overall survival. …”
Get full text

Predicting the Clinical Outcome of Triple-Negative Breast Cancer Based on the Gene Expression Characteristics of Necroptosis and Different Molecular Subtypes by Peng Luo, Zhaoqi Shi, Changshou He, Guojun Chen, Ji Feng, Linghua Zhu, Xiangyang Song

“…Then, the weighted gene coexpression network analysis (WGCNA) assisted in determining key modules, and we selected the genes exhibiting obvious association with necroptosis prognosis through the relationship with prognosis. The univariate Cox regression analysis together with least absolute shrinkage and selection operator (LASSO) techniques served for the construction of the necroptosis-related prognostic risk score (NPRS) model, and the pathway characteristics of NPRS model grouping were further studied. …”
Get full text

The Impact of C-Peptide and Diabetes Mellitus on Coronary Ectasia and Effect of Coronary Ectasia and C-Peptide on Long-Term Outcomes: A Retrospective Cohort Study by Kenan Toprak, Mustafa Kaplangoray, Ali Palice

“…The Kaplan–Meier cumulative survival curves showed that the risks for MACE increased as the C-peptide levels increased. The Cox regression analysis for 5-years MACE related to the plasma C-peptide levels and presence of CAE, C-peptide, and CAE were found to be independent predictors of MACE (HR = 1.255, 95% CI: 1.164–1.336, p<0.001 and HR = 1.012, 95% CI: 1.002–1.023, p=0.026, respectively). …”
Get full text

Correlation of triglyceride glucose index with all cause mortality in acute myocardial infarction patients following percutaneous coronary intervention by Guang Yang, Zilun Huang, Shanjie Wang, Shuang Yang

“…To discern the link between the TyG index and the 30-day and 12-month ACM, we employed a multivariate Cox proportional hazard regression model and K-M survival curve. …”
Get full text

A Retrospective Database Cohort Study Evaluating the Association Between Immune Suppressive Therapy and the Development of Cancer in Patients with Atopic Dermatitis Within UK Prima... by Simon Wan Yau Ming, Yi Zhou, Mike Smith, Jay Were

“…Cohorts were propensity matched 1:1, resulting in 17,556 patients per cohort. Cox proportional hazard models were used to model the hazard of a cancer diagnosis. …”
Get full text

The weight-adjusted-waist index predicts all-cause and cardiovascular mortality in hypertension by Yu Zheng, Zixing Nie, Yifan Zhang, Tao Sun

“…The relationship between WWI and mortality was assessed using a weighted Cox proportional risk model; the nonlinear relationship was explored using restricted cubic splines. …”
Get full text

Development and validation of a nomogram to predict the probability of death after surgical evacuation for traumatic intracranial hemorrhage by Yan-Chao Zheng, Jun-Wei Qian, An-Ni Li, Yi-Nuo Yuan, Sen-Lin Ma, Mingquan Chen

“…The nomogram was developed using Cox regression models. The predictive performance of the nomogram was assessed by concordance index (C index) and calibration in the primary and validation cohorts. …”
Get full text

Time to First-Line Antiretroviral Treatment Failure and Its Predictors among HIV-Positive Children in Shashemene Town Health Facilities, Oromia Region, Ethiopia, 2019 by Endale Zenebe, Assefa Washo, Abreham Addis Gesese

“…Data were extracted using a checklist, entered into EpiData version 3.1, and exported to SPSS version 20 for data analysis. Cox proportional hazard regression was used to determine the predictors of time to first-line treatment failure. …”
Get full text

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes by Kexin Wang, Hongyan Li, Hongxing Wang, Jun-hui Wang, Feng Song, Yu Sun

“…Also, we found that irisin could attenuate the release of IL-6 and IL-1β from cultured astrocytes and decrease the expression level of COX-2 and phosphorylation of AKT. Last, we found that irisin could reduce NFκB activation in astrocyte exposed to Aβ by preventing the phosphorylation and the loss of IκBα. …”
Get full text

Sex differences in the association between fasting glucose and ischemic stroke incidence in people without diabetes: a 19-year prospective cohort study in Korea by Hyun Yi Kook, U Chul Ju, Yong Soo Cho, Eujene Jung, Hyun Ho Ryu

“…The main outcome was the occurrence of IS in the biennial follow-up surveys. Cox proportional regression analysis was performed to estimate the effects of high FBG on IS incidence. …”
Get full text

IGFBP-3的表达水平对食管鳞癌放疗疗效和预后的影响

“…我们又应用western blot技术检测10对食管鳞癌新鲜手术标本及癌旁无瘤组织标本IGFBP-3的表达水平,然后联合食管鳞癌临床病理参数,用χ2检验探讨其表达与放疗疗效关系,用分析Kaplan-Meier方法和Cox回归法分析其与预后的关系? 【结果】 在食管鳞癌活检组织中IGFBP-3呈现高表达的比例为45.7%(32/70)?…”
Get full text

Early postoperative bevacizumab for preventing neovascular glaucoma in phacovitrectomy for proliferative diabetic retinopathy by Sunjin Hwang, Eun Hee Hong, Min Ho Kang, Yong Un Shin

“…Multivariate analysis with the Cox proportional hazards model identified risk factors associated with NVG postphacovitrectomy. …”
Get full text

Development and validation of a five-year cardiovascular risk assessment tool for Asian adults aged 75 years and older by Meng-Chen Hsu, Yu-Hua Fu, Chi-Chuan Wang, Chau-Chung Wu, Fang-Ju Lin

“…A sex-specific CV risk assessment tool was developed to predict major adverse cardiovascular events (MACE) using Cox regression modeling. Results During a median follow-up period of 8.6 years for men and 8.5 years for women in the derivation cohort, MACE occurred in 3.62% of men and 3.02% of women. …”
Get full text

Effect of acute pancreatitis on the risk of developing osteoporosis: A nationwide cohort study. by Shih-Yi Lin, Wu-Huei Hsu, Cheng-Chieh Lin, Cheng-Li Lin, Chung-Hao Tsai, Chia-Hung Kao

“…We applied age-, sex-, and comorbidities-adjusted variable Cox proportional hazard models for assessing the association between AP and osteoporosis. …”
Get full text

Contralateral Prophylactic Mastectomy among Women with Pathogenic Variants in BRCA1/2: Overall Survival, Racial, and Ethnic Differences by Sukh Makhnoon, Angelica M. Gutierrez Barrera, Roland Bassett, Aimaz Afrough, Isabelle Bedrosian, Banu K. Arun

“…Of the 63 patients who did not undergo CPM, there is no racial/ethnic difference in overall survival (p = 0.61). In multivariable cox regression, adjusted for demographic and clinical characteristics, OS was significantly lower among non-Whites than in Whites (HR = 0.39, p = 0.04). …”
Get full text

Exclusive Breastfeeding and Its Determinants in Yaoundé, Cameroon: A Retrospective Survival Analysis by Gloria Akah Ndum Okwen, Esron Daniel Karimuribo, Helena Aminiel Ngowi, Edith Nig Fombang

“…Data was collected between November 2019 and May 2020. A Cox proportional hazard modelling and Kaplan-Meier analysis were employed to identify prognostic factors affecting survival time defined as the duration, in months, from birth until the time of stopping EBF. …”
Get full text

Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo by Chien-Wei Feng, Nan-Fu Chen, Te-Fu Chan, Wu-Fu Chen

“…It could significantly attenuate the interferon-gamma-induced upregulation of proinflammatory cytokines, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). …”
Get full text

Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening. by Francis Michael Sullivan, Frances S Mair, William Anderson, Cindy Chew, Alistair Dorward, John Haughney, Fiona Hogarth, Denise Kendrick, Roberta Littleford, Alex McConnachie, Colin McCowan, Nicola McMeekin, Manish Patel, Petra Rauchhaus, Fergus Daly, Lewis Ritchie, John Robertson, Joseph Sarvesvaran, Herbert Sewell, Thomas Taylor, Shaun Treweek, Kavita Vedhara, Stuart Schembri

“…Outcomes were ascertained from Register of Deaths and Cancer Registry. Cox proportional hazards models were used to estimate the hazard ratio of the rate of deaths from all causes and lung cancer. …”
Get full text

Exploration and Verification of Prognostic Value of Endothelial Cells in Glioblastoma by Hengchao MA, Yuyang LIU, Jun XU, Bingyan TAO, Jun ZHANG

“…MethodsThrough bioinformatics analysis of the TCGA and CGGA databases, we screened endothelial cell-related markers in GBM single-cell data according to a series of criteria. Moreover, univariate Cox regression analysis was performed to obtain and screen endothelial cell prognosis-related markers and construct endothelial cell-related prognostic risk score. qPCR experiments was used to verify the differences in the expression of prognostic markers in GBM tissues and peritumoral normal brain tissues. …”
Get full text