The association of lipid accumulation product with inflammatory parameters and mortality: evidence from a large population-based study by Yi Chi, Yiqing Zhang, Huang Lin, Shanshan Zhou, Genlin Jia, Wei Wen

“…Cox regression model and subgroup analysis were constructed to investigate the associations between AVI and both all-cause and cardiovascular mortality. …”
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Downregulation of Long Noncoding RNA LINC00261 Attenuates Myocardial Infarction through the miR-522-3p/Trinucleotide Repeat-Containing Gene 6a (TNRC6A) Axis by Chaoxin Jiang, Qing Zhao, Chenlong Wang, Minyan Peng, Guoqing Hao, Zhifeng Liu, Wenjin Fu, Kewei Zhao

“…Hypoxic preconditioning in normal cells was used to construct a simulated MI environment to investigate the effect of LINC00261 on apoptosis of cardiac cells. …”
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Realist inquiry into Maternity care @ a Distance (ARM@DA): realist review protocol by Andrew Booth, Catrin Evans, Stephen Timmons, Helen Spiby, Mark Clowes, Nia Jones, Kerry Evans, Benash Nazmeen, Candice Sunney, Georgia Clancy

“…Methods and analysis The review will be conducted in four iterative phases, with embedded stakeholder involvement: (1) refining the review focus and generating initial programme theories, (2) exploring and developing the programme theories in light of evidence, (3) testing/refining the programme theories and (4) constructing actionable recommendations. The review will draw on four sources of evidence: (1) published literature (searching nine bibliographic databases), (2) unpublished (grey) literature, including research, audit, evaluation and policy documents (derived from Google Scholar, website searches and e-thesis databases), (3) expertise contributed by service user and health professional stakeholder groups (n=20–35) and (4) key informant interviews (n=12). …”
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A Transient Conducted EM Disturbances Source Modeling Method for Electromagnetic Launch System Based on the Cascaded Multi-Port Circuit Model by Bailin Mou, Qi-Feng Liu, Zhenya Chen, Xiaowen Wu, Yongming Li, Chen Huang, Huai-Qing Zhang

“…To evaluate the accuracy of this system-level modeling method, an experimental setup is constructed to assess transient conducted EM disturbances in a low-power EML system. …”
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Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study by Simon Thom, Alice Stanton, Jamil Mayet, Amit Kaura, Darrel Francis, Anoop SV Shah, Andrew Sharp, Alun D Hughes, Neil R Poulter, Anenta Ratneswaren, Tong Wu, Somayeh Rostamian, Devan Wasan, PS Sever

“…Unadjusted and adjusted Cox regression survival models were constructed to investigate the association between tissue Doppler echocardiography measurements and long-term cardiovascular mortality.Results Among 506 hypertensive patients (median age 64, interquartile range (58, 69), 87% male), there were 200 (40%) deaths over a 20-year follow-up period. 60 deaths (12%) were cardiovascular-related.A reduction in e′ was independently associated with increased cardiovascular mortality, after adjusting for the ACC/AHA Atherosclerotic Cardiovascular Disease (ASCVD) risk score, with an inverse HR of 1.22 per 1 cm/s decrease (95% CI 1.04–1.43). …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…However, the mechanism underlying the effects of SSA in prostate cancer treatment remains elusive.MethodsIn this study, a network pharmacology approach was applied to identify relevant targets from drug- and disease-related databases, and intersections were analyzed using Venny2.1 to construct a Protein-Protein interaction (PPI) interaction network. …”
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Enhanced AC/DC optimal power flow via nested distributed optimization for AC/VSC-MTDC hybrid power systems by Haixiao Li, Pedro P. Vergara, Robert Dimitrovski, Hongjin Du, Aleksandra Lekić

“…Numerical experiment results finally validate the effectiveness of the proposed enhanced AC/DC OPF. The constructed AC/DC OPF model exhibits acceptable accuracy in terms of power flow calculation, and the developed nested distributed optimization method showcases decent convergence rate and solution optimality performances.…”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…If a suitable PROM was not identified, we planned to (1) construct a draft PROM based on items from existing PROMs, (2) conduct group and individual interviews among members of the target population to ensure comprehensibility, comprehensiveness and relevance, and (3) perform a psychometric validation in a broad sample of patients from primary care. …”
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Development and evaluation of a recombinant monoclonal human antibody with virus-neutralizing activity against the F glycoprotein of respiratory syncytial virus by Sergey A. Klotchenko, Ekaterina A. Romanovskaya-Romanko, Marina A. Plotnikova, Anastasia A. Pulkina, Aram A. Shaldzhyan, Dmitry S. Balabashin, Victoria A. Toporova, Teimur K. Aliev, Natalia E. Gyulikhandanova, Dmitry A. Lioznov

“…Materials and methods. Constructs encoding the recombinant antibody FM1 were designed using genetic engineering. …”
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Predictive value of enhanced CT and pathological indicators in lymph node metastasis in patients with gastric cancer based on GEE model by Ling Yang, Yingying Ding, Dafu Zhang, Guangjun Yang, Xingxiang Dong, Zhiping Zhang, Caixia Zhang, Wenjie Zhang, Youguo Dai, Zhenhui Li

“…Conclusion The predictive model constructed based on lymph node enhancement pattern, Ki67 level, and lymph node long-axis diameter exhibited good performance in predicting LNM in gastric cancer and should aid the lymph node staging of gastric cancer and clinical decision-making.…”
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Kinetic simulation of uranium migration in granite fissure media of beishan, gansu, China: A case study based on the Laplace transform and inverse transform methods by Xianzhe Duan, Cong Du, Nan Li, Jiaxin Duan, Zhenping Tang

“…In this study, the granite rock masses in Beishan, Gansu were selected to construct a physical and mathematical model of U-238 migration using the Laplace transform and inverse transform methods. …”
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Neonatal and perinatal mortality in the urban continuum: a geospatial analysis of the household survey, satellite imagery and travel time data in Tanzania by Lenka Benova, Claudia Hanson, Aliki Christou, Aline Semaan, Peter M Macharia, Jessie Pinchoff, Andrea B Pembe

“…Bivariate and multilevel multivariable logistic regression models were constructed to explore associations between urbanicity and neonatal/perinatal deaths.Results Both neonatal and perinatal mortality rates were highest in core urban and lowest in rural clusters. …”
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Preoperative prediction of lymph node metastasis in intrahepatic cholangiocarcinoma: an integrative approach combining ultrasound-based radiomics and inflammation-related markers by Yu-ting Peng, Jin-shu Pang, Peng Lin, Jia-min Chen, Rong Wen, Chang-wen Liu, Zhi-yuan Wen, Yu-quan Wu, Jin-bo Peng, Lu Zhang, Hong Yang, Dong-yue Wen, Yun He

“…Multivariable logistic regression analysis was used to identify independent risk factors to construct a clinical model. The combined model was established by combining ultrasound-based radiomics and clinical parameters. …”
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Efficient and accurate tobacco leaf maturity detection: an improved YOLOv10 model with DCNv3 and efficient local attention integration by Yi Shi, Hong Wang, Fei Wang, Yingkuan Wang, Jianjun Liu, Long Zhao, Hui Wang, Feng Zhang, Qiongmin Cheng, Shunhao Qing

“…In our study, we have advanced the YOLOv10 framework by integrating DCNv3 with C2f to construct an enhanced neck network, designated as C2f-DCNv3. …”
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Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology by James Johnson, PhD, Ben Gadomski, PhD, Daniel Regan, DVM, PhD, DACVP, Jed Johnson, PhD, Brad Nelson, MS, PhD, DVM, DACVS, Kirk McGilvray, PhD, Kevin Labus, PhD, Anthony Romeo, MD, Jeremiah Easley, DVM, Dipl, ACVS

“…Nondestructive biomechanical testing was conducted to assess the strength of the repair constructs, followed by histological analysis of all tendon samples to evaluate tissue regeneration and integration at the repair site. …”
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Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos by Hong-Ling Zhou, Bei-Bei Wang, Xu-Li Fan, Xiao-Min Zhang, Ying Song

“…PC12 cells were used to construct an oxidative injury model using CPF, and the protective effects and mechanism of action of CAA against CPF-induced oxidative damage were explored in vitro. …”
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Excellent high-temperature strength of (HfZrTiTaNb)C high-entropy carbide diffusion-bonded joint via in-situ alloying of Ni/Nb/Ni composite interlayer by Ruijie Mu, Ying Wang, Shiyu Niu, Kongbo Sun, Zhenwen Yang

“…Starting from a modified Ni/Nb/Ni composite interlayer with a Nb content of > 64 at%, an alloyed Nb2Ni layer was constructed in situ by accelerating the directional diffusion of Ni atoms from the high-entropy interface into the remaining pure Nb through the Ni‒Nb eutectic liquid. …”
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The relationship between college students’ Suicidal ideation and rejection sensitivity: a network analysis by Yang He, Tianqi Yang, Chunyan He, Yuanbei Zhang, Huilin Yang, Shen Huang, Jianjun Liu, Xihong Li, Tao Xu, Shengjun Wu

“…Rejection sensitivity and suicidal ideation networks were constructed using R4.1.1 software to examine the links between the dimensions and to calculate the bridge expected influence (BEI) of each node. …”
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Deciphering the role of miRNA-mRNA interactions in cerebral vasospasm post intracranial hemorrhage by Xiang Chu, Xiang Chu, Xiyan Zhu, Honghao Xu, Wenbing Zhao, Debin Guo, Xing Chen, Jinze Wu, Lei Li, Hao Wang, Jun Fei

“…Additionally, we discovered 19 DEMs associated with CVS and integrated them with mRNA dataset analysis to construct a miRNA-mRNA network, which comprised 8 functionally differentially expressed DEMs and 6 target mRNAs. …”
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shRNA-interfered of Nrf2 reveals a critical role for Keap1-Nrf2 signaling pathway during effects of zearalenone induced oxidative stress in IPEC-J2 cells by Qun Cheng, Shu Zhen Jiang, Li Bo Huang, Wei Ren Yang

“…Objective This study aims to verify the protective effect of the Kelch-like ECH-associated protein1 (Keap1)–nuclear factor erythroid 2–related factor 2 (Nrf2) signaling pathways by studying the effect of plasmids containing Nrf2–small hairpin RNA (shRNA) interference down-regulation of Nrf2 on zearalenone (ZEA)–induced intestinal porcine epithelial cells (IPEC-J2) oxidative stress. Methods We constructed an IPEC-J2 model that interferes with Nrf2 expression, set blank (control), negative control group (Sh-control), positive control group (Sh-Nrf2), and added 10, 20, and 40 μmol/L ZEA experimental group (Sh-Nrf2+ZEA10, Sh-Nrf2+ZEA20, and Sh-Nrf2+ZEA40). …”
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