PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression by Marion Haas, Sabrina Cherfa, Léa Nguyen, Maxence Bourgoin, Gersende Caron, Elise Dessauge, Tony Marchand, Laurent Delpy, Patrick Auberger, Jérôme Moreaux, Arnaud Jacquel, Thierry Fest

“…Abstract Our study explores the complex dynamics of the integrated stress response (ISR) axis, highlighting PIM2 kinase’s critical role and its interaction with the BCL2 protein family, uncovering key mechanisms of cell survival and tumor progression. …”
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Exploring novel solitary wave phenomena in Klein–Gordon equation using $$\phi ^{6}$$ ϕ 6 model expansion method by Yasir A. Madani, Khidir Shaib Mohamed, Sadia Yasin, Sehrish Ramzan, Khaled Aldwoah, Mohammed Hassan

“…Our findings highlight the $$\phi ^{6}$$ ϕ 6 model as a powerful tool to study nonlinear wave equations, improve our understanding of their complex dynamics, and increase the scope for theoretical exploration. …”
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An empirical study on logistic service quality, customer satisfaction, and cross-border repurchase intention by Guan Hui, Abdullah Al Mamun, Mohammad Nurul Hassan Reza, Wan Mohd Hirwani Wan Hussain

“…This study contributes to the literature by providing new insights into the complex dynamics of LSQ in CBEC and highlighting the nuanced role of customer satisfaction as a mediator in different market contexts. …”
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Karhunen–Loeve orthogonal decomposition method for problems of EEG assessment of patients with migraine by Egorov, Evgenij Nikolaevich, Zhuravlev, Maksim Olegovich, Runnova, Anastasia Evgenevna, Evstropov, Maksim Arkad`evich, Redzhepova, Alena Садуллаевна

“…The obtained data were processed using the Karhunen–Loeve transformation, which allows one to interpret the complex dynamics of the system from the point of view of the coexistence and interaction of coherent orthogonal space-time structures. …”
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Functional segregation and dynamic integration of the corticotectal descending signal in rat by Hikaru Sugino, Sho Tanno, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira

“…These findings suggest a spatial gradient in SC integration, with a division of labor between simple relay circuits and those integrating complex dynamics.…”
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Regional disparities and dynamic adaptation in the forest health-based industry and ecological environment: A case study of Fujian Province, China by Wenyu Chen, Shuhan Yu, Xuwang Jiang, Liyu Zhan

“…In contrast, regions like Nanping and Xiamen show lower indices, suggesting a need for greater policy support and resource allocation to improve adaptability. (2)The adaptability index’s spatial distribution and migration patterns reveal cyclical spatial dispersion changes from 2013 to 2023, closely associated with economic development strategies, environmental protection policies, and climate change. (3) A spatial cluster analysis of the adaptability index reveals significant shifts in adaptability levels across most regions, especially between 2015 and 2018, reflecting the complex dynamics of ecological adaptability. (4) Sanming City and Fuzhou District demonstrate effective coordination between the forest health-based industry and the ecological environment. …”
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Nationwide guideline implementation: a qualitative study of barriers and facilitators from the perspective of guideline organizations by Andrea C. Thoonsen, Anika Gans, Toby T. Broeders, Ilse van Beusekom, Diana M. J. Delnoij, Martine C. de Bruijne, Hanneke Merten

“…Conclusions We obtained valuable insights into the complex dynamics of barriers and facilitators perceived by guideline organizations in nationwide guideline implementation. …”
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Opening a career door!: The role of ChatGPT adoption in digital entrepreneurial opportunity recognition and exploitation by Cong Doanh Duong, Thi Thanh Hoa Phan, Bich Ngoc Nguyen, Thanh Van Pham, Ngoc Diep Do, Anh Trong Vu

“…The findings of the study unravel the complex dynamics within the extended SOR model, showcasing positive relationships between ChatGPT adoption in entrepreneurship and digital entrepreneurial identity aspiration, digital entrepreneurial opportunity exploration, and exploitation. …”
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Mixed pastures and biological efficiency in buffalo production systems: determinants for a sustainable livestock by Juan Pablo Uzcátegui-Varela, Martha Gloribet Ceballos Ramírez

“…The analysis of biological systems is characterized by the use of basic calculations during the production process that define the complex dynamics of natural capital, which is directly managed by human activities with a simplification and selection of biodiversity to support ecosystem function while generating products of agri-food interest. …”
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Stock price prediction with attentive temporal convolution-based generative adversarial network by Ying Liu, Xiaohua Huang, Liwei Xiong, Ruyu Chang, Wenjing Wang, Long Chen

“…Traditional prediction models such as ARIMA and classic linear regression models are often inadequate for capturing the complex dynamics of stock prices. The advent of deep learning has led to substantial improvements in prediction accuracy, with various recurrent neural networks widely employed for representation learning from stock sequences. …”
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Insights into host-pathogen interaction based on the comparison of genomes of Leptospira interrogans isolated from dogs, humans, and a rodent in the same epidemiological context: A... by Lucas Nogueira Paz, Laise de Moraes, Luciane Amorim Santos, Camila Hamond, Melissa Hanzen Pinna

“…The present findings highlight the necessity of One Health-based collaborative interventions to address the complex dynamics of leptospirosis transmission, involving both common hosts such as rodents and dogs, as well as less-recognized hosts.…”
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Water scarcity in semi-arid California compromises perennial alfalfa’s high yield and carbon sinking potentials by Tianxin Wang, Kanishka Mallick, Joseph Verfaille, Daphne Szutu, Dennis Baldocchi

“…This highlights the complex dynamics between high yield and water consumption in alfalfa cultivation, especially under conditions of water scarcity. …”
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Privacy-preserving approach for IoT networks using statistical learning with optimization algorithm on high-dimensional big data environment by Fatma S. Alrayes, Mohammed Maray, Asma Alshuhail, Khaled Mohamad Almustafa, Abdulbasit A. Darem, Ali M. Al-Sharafi, Shoayee Dlaim Alotaibi

“…Additionally, it needs to adequately account for the complex dynamics of the IoT environment. In a large-sized big data environment, privacy protection challenges are additionally enlarged. …”
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Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer by Elena Lastraioli, Jessica Iorio, Francesco Piazza, Chiara Capitani, Michele Santillo, Claudia Duranti, Simonetta Bianchi, Icro Meattini, Scott P. Fraser, Mustafa B. A. Djamgoz, Andrea Becchetti, Annarosa Arcangeli

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Progress in phase field research of dead lithium in lithium batteries by Jing LIU, Huiyi CHEN, Huiyu LIU, Shu LI

“…This study focuses on analyzing these mechanisms and influencing factors from the perspective of the phase field, which is a powerful computational method to simulate microstructure evolution, providing insights into the complex dynamics of lithium deposition and the conditions and influencing factors for the formation of lithium dendrites and dead Lithium. …”
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Single-cell RNA sequencing elucidates cellular plasticity in esophageal small cell carcinoma following chemotherapy treatment by Qinkai Zhang, Qinkai Zhang, Qinkai Zhang, Ziyu Gao, Ru Qiu, Jizhao Cao, Chunxiao Zhang, Wei Qin, Wei Qin, Meiling Yang, Meiling Yang, Xinyue Wang, Ciqiu Yang, Jie Li, Jie Li, Dongyang Yang, Dongyang Yang

“…This study elucidates the complex dynamics of cellplasticity in SCCE following chemotherapy, providing new insights and identifyingpotential therapeutic targets to enhance treatment efficacy.…”
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Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation by Chang Dong Yeo, Dong Won Park, Seong Hoon Yoon, Eun Young Kim, Jeong Eun Lee, Shin Yup Lee, Chang‐Min Choi, In‐Jae Oh, Do Jin Kim, Jeong Seon Ryu, Jae Cheol Lee, Young‐Chul Kim, Tae Won Jang, Kye Young Lee, Seung Hun Jang, Seung Joon Kim, for the Korean EGFR Registry Investigators

“…The Korean EGFR Registry will contribute significantly to the understanding of the complex dynamics of EGFR‐mutated NSCLC, aiding in the development of more effective and personalized treatment strategies.…”
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Evaluation of the resistome and gut microbiome composition of hospitalized patients in a health unit of southern Brazil coming from a high animal husbandry production region by Elisa Pires Coltro, Elisa Pires Coltro, Lucas Cafferati Beltrame, Lucas Cafferati Beltrame, Lucas Cafferati Beltrame, Caroline Ribeiro da Cunha, Caetana Paes Zamparette, Clarissa Feltrin, Vilmar Benetti Filho, Patrícia de Almeida Vanny, Sérgio Beduschi Filho, Taíse Costa Ribeiro Klein, Mara Cristina Scheffer, Jussara Kasuko Palmeiro, Jussara Kasuko Palmeiro, Glauber Wagner, Thaís Cristine Marques Sincero, Thaís Cristine Marques Sincero, Carlos Rodrigo Zárate-Bladés, Carlos Rodrigo Zárate-Bladés

“…These findings underscore the substantial impact of antimicrobial use on resistance development and the complex dynamics of the resistome in hospital settings. …”
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The Mediating Role of Cash Flow Statement Indicators in the Relationship between Stock Mispricing and Corporate Cash Holding by Ali Majid Akaleh, Hamzeh Didar, Gholamreza Mansourfar

“…These findings contribute to the understanding of how companies navigate the complex dynamics of stock valuation and cash management in their strategic decision-making.…”
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Function Projective Synchronization of Two Complex Networks with Unknown Sector Nonlinear Input and Multiple Time-Varying Delay Couplings by Na Fang, Da Wei, Nan-nan Yin, Dan-ying Xu, Hua Liu, Jie Fang

“…This paper deals with the function projective synchronization of two complex dynamic networks with unknown sector nonlinear input, multiple time-varying delay couplings, model uncertainty, and external interferences. …”
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