Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis by Abu Tayab Moin, Md. Asad Ullah, Jannatul Ferdous Nipa, Mohammad Sheikh Farider Rahman, Afsana Emran, Md. Minhazul Islam, Swapnil Das, Tawsif Al Arian, Mohammad Mahfuz Enam Elahi, Mukta Akter, Umme Sadea Rahman, Arnab Halder, Shoaib Saikat, Mohammad Jakir Hosen

“…Regulatory signatures, including transcription factor and microRNA interactions, were also explored, alongside the identification of potential drug targets.ResultsA total of 275 and 167 DEGs were identified across two datasets, with 67 DEGs common to both. These genes exhibited distinct expression patterns across tissues and were associated with pathways such as extracellular matrix organization, collagen fibril formation, and cell adhesion. …”
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NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled... by Deborah D Stocken, Maureen Twiddy, Hisham Mehanna, Jonathan Wadsley, Neil Corrigan, Katie Gordon, Julie Croft, Neil Sharma, Anna Perry, Mark Strachan, Gemma Ainsworth, Elizabeth Glenister, Sabapathy Prakash P Balasubramanian

“…Introduction Postsurgical hypoparathyroidism (PoSH) is an iatrogenic condition that occurs as a complication of several different procedures with thyroid surgery being the most common. PoSH has significant short- and long-term morbidities. …”
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Comparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective study by Prem Chandra, Vamanjore A Naushad, Nishan K Purayil, Abazar Ahmad M Saeed, Pradeep Radhakrishnan, Irfan Varikkodan, Joe V Mathew, Jaseem Sirajudeen, Riyadh A Hammamy, Ahmad M Badi, Aasir M Suliman, Mohamed N Badawi, Saket Arya, Maryam AlMotawa, Aisha Al-Baker, Rania Alatom, Anand Kartha

“…Patients with a normal chest X-ray and those who had a negative PCR test despite a positive COVID-19 antigen test were excluded.Outcome Length of stay, need for mechanical ventilation, final disposition and mortality were the key outcomes studiedResults Influenza like symptoms (18.5% in the first wave vs 36.1% in the second wave, p 0.001), cough (79.2% vs 87%, p<0.001) and dyspnoea (27.5% vs 38% p<0.001) were more common in the second wave. Second wave patients had significantly higher respiratory rate, lower peripheral oxygen saturation, needed more supplemental oxygen and had higher incidence of pulmonary embolism. …”
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Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis by Chun Zhao, Peng-Cheng Sun, Ke-Jie Fang, Hui-Hui Fu, Li-Feng Wei, Yin-Yun Miao, Xin-Xin Guo, Xiao-Ling Weng

“…IntroductionIncreased intracranial pressure (ICP) is common with viral encephalitis in children which is associated with complications and prognosis. …”
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A Standardized Classification Scheme for Gastroduodenal Disorder Evaluation Using the Gastric Alimetry System: Prospective Cohort Study by Chris Varghese, Gabriel Schamberg, Emma Uren, Stefan Calder, Mikaela Law, Daphne Foong, Vincent Ho, Billy Wu, I-Hsuan Huang, Peng Du, Thomas Abell, Charlotte Daker, Christopher N. Andrews, Armen A. Gharibans, Gregory O’Grady

“…Of the remainder, the most common phenotypes were “continuous pattern” (37, 17.6%), “meal-induced pattern” (28, 13.3%), and “sensorimotor pattern” (15, 7.1%). …”
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Establishment and application of a one-step multiplex real-time PCR assay for detection of A, B, and C subtypes of avian metapneumovirus by Mingjun Su, Jiongze Cheng, Xiangwen Xu, Yijia Liu, Yulin Zhao, Yutao Wang, Xiaoxu Du, Jiale Ying, Junfang Yan, Huihua Zheng, Changyong Cheng, Jing Sun

“…This method demonstrates remarkable specificity, selectively amplifying aMPV-A, aMPV-B, and aMPV-C without cross-reactivity with other common avian pathogens. Furthermore, this method exhibits high sensitivity, with a detection threshold of 8.5 × 102 copies/μL for aMPV-A, aMPV-B, and aMPV-C. …”
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Gestational exposure to environmental chemical mixtures and cognitive abilities in children: A pooled analysis of two North American birth cohorts by Jagadeesh Puvvula, Wei-Ting Hwang, Lawrence McCandless, Changchun Xie, Joseph M. Braun, Ann M. Vuong, Youssef Oulhote, Enrique F. Schisterman, Russell T. Shinohara, Linda Booij, Maryse F. Bouchard, Kristin Linn, Michael M. Borghese, Jean R. Seguin, Angelika Zidek, Christine Till, William Fraser, Kimberly Yolton, Kim M. Cecil, Jillian Ashley-Martin, Tye E. Arbuckle, Bruce Lanphear, Aimin Chen

“…Using quantile g-computation and BKMR methods, we observed that PBDE47, PFHxS, and di-ethyl organophosphates commonly contributed towards a decline in FSIQ scores in males. …”
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The state of combined thoracoabdominal triple-organ transplantation in the United States by Emily G. Dunbar, BS, Ye In Christopher Kwon, BA, Matthew Ambrosio, MS, Inna F. Tchoukina, MD, Keyur B. Shah, MD, David A. Bruno, MD, Walker A. Julliard, MD, Josue Chery, MD, Vigneshwar Kasirajan, MD, Zubair A. Hashmi, MD

“…Background: As triple-organ transplantation (TOT) has become more common, we evaluate patient characteristics, risk factors, and clinical outcomes of patients undergoing thoracoabdominal TOT. …”
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Use and Outcomes of Dexamethasone in the Management of Malignant Small Bowel Obstruction by Frank F. Yang, MD, Elina Serrano, MD, Kyle S. Bilodeau, MD, Michael Weykamp, MD, Caitlin J. Silvestri, MD, Ashleigh C. M. Bull, MD, Brenda Lin, MD, Sara L. Schaefer, MD, Colette Galet, PhD, Luis J. Garcia, MD, FACS, Baraka Gitonga, BS, David T. Kolodziej, BS, Samantha Esposito, BS, Molly Parker-Brigham, BS, Rohan Luhar, BS, Avinash Mamgain, MS, Kendrick C. Brown, BS, Summer Dewdney, MD, Thea P. Price, MD, FACS, Nicole Siparsky, MD, FACS, Sarah Knerr, PhD, Pauline K. Park, MD, FACS, Sabrina Sanchez, MD, FACS, Dionne A. Skeete, MD, FACS, Katherine N. Fischkoff, MD, FACS, David R. Flum, MD, FACS

“…Background:. mSBO is common in patients with advanced abdominal-pelvic cancers. …”
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Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

“…Anxiety and depression emerged as the most commonly-assigned diagnoses for BZRA-users. Conclusion This first Asian population-based study indicates a significant rising trend of BZRA prescriptions, especially among adolescents and young adults. …”
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Dynamic development of gut microbiota and metabolism during and after weaning of kittens by Hong Zhang, Yang Ren, Siyu Wei, Hongli Jin, Yizhen Wang, Mingliang Jin

“…Abstract Background As the pet population grows, there is increasing attention on the health and well-being of companion animals. Weaning, a common challenge for young mammals, often leads to issues such as diarrhea, growth retardation, and in severe cases, even mortality. …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a well-established primate model of MS. …”
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Neoadjuvant chemotherapy combined with antiangiogenic therapy and immune checkpoint inhibitors for the treatment of locally advanced gastric cancer: a real - world retrospective co... by Zhouwei Zhan, Bijuan Chen, Shaohua Xu, Ruyu Lin, Haiting Chen, Xiaohuan Ma, Xuanping Lin, Wanting Huang, Changhua Zhuo, Yu Chen, Zengqing Guo

“…Only one patient experienced a grade 4 TRAE (immune-related hepatitis), while the most common grade 3 TRAEs included thrombocytopenia, elevated aminotransferase levels, and neutropenia.ConclusionsThe combination of neoadjuvant chemotherapy, anti-angiogenic therapy, and ICIs has proven effective in treating LAGC patients, achieving high pCR rates and favorable survival outcomes while maintaining an acceptable safety profile.…”
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Curcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats by Justin Stadler, Justin Stadler, Justin Stadler, Lucas G. Garmo, Lucas G. Garmo, Lucas G. Garmo, David Doyle, David Doyle, David Doyle, Chin-I. Cheng, Garrett Richardson, Garrett Richardson, Zain Waheed, Zain Waheed, Tim Tofan, Bhairavi Srinageshwar, Bhairavi Srinageshwar, Bhairavi Srinageshwar, Ajit Sharma, Robert B. Petersen, Gary L. Dunbar, Gary L. Dunbar, Gary L. Dunbar, Julien Rossignol, Julien Rossignol, Julien Rossignol

“…Polyamidoamine (PAMAM) dendrimers are nanomolecules commonly used in biomedical applications due to their ability to encapsulate small-molecules and improve their pharmacokinetic properties. …”
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Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21 by Henry Chen, Henry Chen, Adam L. Numis, Adam L. Numis, Renée A. Shellhaas, John R. Mytinger, Debopam Samanta, Rani K. Singh, Rani K. Singh, Shaun A. Hussain, Danielle Takacs, Kelly G. Knupp, Li-Rong Shao, Carl E. Stafstrom

“…BackgroundInfantile Epileptic Spasms Syndrome (IESS) is the most common epilepsy syndrome in children with trisomy 21. …”
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Utilisation of ChatGPT and other Artificial Intelligence tools among medical faculty in Uganda: a cross-sectional study [version 2; peer review: 1 approved, 2 approved with reserva... by Job Kuteesa, Faith Oguttu, Ian Guyton Munabi, Aloysius Gonzaga Mubuuke, Sarah Kiguli, Ritah Nantale, David Mukunya, Elizabeth Ajalo, Frank Kayemba, Jonathan Babuya, Kennedy Pangholi, Amelia Margaret Namiiro, Suzan Langoya Akuu, Steven Ekak, Ronald Tweheyo, Kirsten Nantongo, Brenda Nakitto, Milton W. Musaba, Joseph Luwaga Mpagi

“…Over 63% (120/224) of faculty had ever used AI tools. The most commonly used AI tools were ChatGPT (56.3%) and Quill Bot (7.1%). …”
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Serum NLR combined with CA125 and HE4 improves the diagnostic and prognostic efficiency in patients with ovarian cancer by Yun Tian, Yun Tian, Xiabing Li, Xiabing Li, Hongjian Zhang, Hongjian Zhang, Yaping Wang, Yaping Wang, Hongyu Li, Hongyu Li, Qiaohong Qin, Qiaohong Qin

“…BackgroundOvarian cancer (OC) represents a common neoplasm within the female reproductive tract. …”
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Sex differences and determinants of coronary microvascular function in asymptomatic adults with type 2 diabetes by Jian L. Yeo, Abhishek Dattani, Joanna M. Bilak, Alice L. Wood, Lavanya Athithan, Aparna Deshpande, Anvesha Singh, J.Ranjit Arnold, Emer M. Brady, David Adlam, John D. Biglands, Peter Kellman, Hui Xue, Thomas Yates, Melanie J. Davies, Gaurav S. Gulsin, Gerry P. McCann

“…ABSTRACT: Background: Coronary microvascular dysfunction (CMD) is a significant complication in type 2 diabetes (T2D) and may be more common in women. We aimed to evaluate the sex differences and sex-specific clinical determinants of CMD in adults with T2D without prevalent cardiovascular disease. …”
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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…Genetic variants are the most common cause of DEE with KCNQ2 being one of the most frequently identified disease-causing genes. …”
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Impacts of free-roaming dogs on spatiotemporal niches of native carnivores in Taiwan by Hsin-Cheng Ho, Tzung-Su Ding, Hsiao-Wei Yuan, Jo-Szu Tsai, Guo-Jing Weng, Yu-Hsiu Lin, Hsiang Ling Chen, Yu-Bo Huang, Shih-Ching Yen

“…Among animals of the same trophic level, niche partitioning often occurs to facilitate coexistence. However, when a new common predator appears, they may adjust their activity temporally and spatially to avoid the predator. …”
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