Synthesis of Diazacyclic and Triazacyclic Small-Molecule Libraries Using Vicinal Chiral Diamines Generated from Modified Short Peptides and Their Application for Drug Discovery by Mukund P. Tantak, Ramanjaneyulu Rayala, Prakash Chaudhari, Chhanda C. Danta, Adel Nefzi

Subjects: Get full text

Meeting Report: High-Throughput Technologies for In Vivo Imaging Agents by Robert J. Gillies, John M. Hoffman, Kit S. Lam, Anne E. Menkens, David R. Piwnica-Worms, Daniel C. Sullivan, Ralph Weissleder

“…Combinatorial chemistry and high-throughput screening have become standard tools for discovering new drug candidates with suitable pharmacological properties. …”
Get full text

Problems of creating antibody phage libraries and their solutions by V. S. Aripov, N. V. Volkova, A. A. Ilyichev, D. N. Shcherbakov

“…The diversity, whether natural or obtained by combinatorial chemistry, is the basis of any library. The choice of molecular techniques is critical to ensure that this diversity is maintained during the phage library preparation step and during the transformation of E. coli cells. …”
Get full text