Pentavalent Antimonials Combined with Other Therapeutic Alternatives for the Treatment of Cutaneous and Mucocutaneous Leishmaniasis: A Systematic Review by Taisa Rocha Navasconi Berbert, Tatiane França Perles de Mello, Priscila Wolf Nassif, Camila Alves Mota, Aline Verzignassi Silveira, Giovana Chiqueto Duarte, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verziganassi Silveira

“…In general, the combined therapy resulted in high rates of clinical cure and when relapse or recurrence was reported, it was higher in the groups treated with pentavalent antimonials alone. …”
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Antimicrobial susceptibility and epidemiological types of Legionella pneumophila human isolates from Italy (1987–2020) by Maria Scaturro, Alessio Lanni, Fabiola Mancini, Antonietta Girolamo, Silvia Fillo, Andrea Ciammaruconi, Florigio Lista, Clementina Elvezia Cocuzza, Rosario Musumeci, Christophe Ginevra, Ghislaine Descours, Sophie Jarraud, Jessica Iera, Paolo Visca, Maria Luisa Ricci

“…Conclusions: The presence of L. pneumophila strains with reduced susceptibility or resistance to azithromycin should be monitored to predict future trends and suggest to physicians a combined therapy with fluoroquinolones when a poor response to azithromycin is observed. © 2025 The Author(s). …”
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Involvement of HLADQA1*05 in Patients with Inflammatory Bowel Disease Treated with Anti-TNF Drugs by Anna Pau, Ilaria Galliano, Elisa Barnini, Maddalena Dini, Antonio Pizzol, Alice Ponte, Stefano Gambarino, Pier Luigi Calvo, Massimiliano Bergallo

“…However, immunogenicity—where anti-drug antibodies diminish effectiveness—remains an issue, often requiring dose changes or combination therapies. Pharmacogenomics is increasingly applied in IBD to personalise treatment, especially since genetic factors like the HLA-DQA1*05 variant heighten the immunogenicity risk with IFX. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Advanced nano-delivery systems and combination therapies further enhance oridonin's therapeutic potential. …”
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Combination of ataxia telangiectasia and Rad3-related inhibition with ablative radiotherapy remodels the tumor microenvironment and enhances immunotherapy response in lung cancer by Jenny Ling-Yu Chen, Chun-Kai Pan, Li-Cheng Lin, Yu-Sen Huang, Tsung-Hsuan Huang, Shu-Jyuan Yang, Sung-Hsin Kuo, Yu-Li Lin

“…These findings underscore the importance of combination therapies for enhancing systemic antitumor immune responses and outcomes.…”
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Axial Length Shortening after Combined Repeated Low-Level Red-Light Therapy in Poor Responders of Orthokeratology in Myopic Children by Mengting Yu, Xianghua Tang, Jinyun Jiang, Fengqi Zhou, Lili Wang, Chuqi Xiang, Yin Hu, Xiao Yang

“…Those who respond poorly to ortho-k with elder age might benefit more from combined therapy.…”
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Results of the ORION open comparative randomized trial: evaluation of efficacy of the Russian drugs Altevir and Phosphogliv in combined treatment of chronic hepatitis C by V. T. Ivashkin, M. V. Mayevskaya, P. O. Bogomolov, I. G. Nikitin, A. O. Buyeverov, A. V. Lapshin

“…To estimate efficacy and safety of application of «Phosphogliv»® (glycyrrhizinic acid) within combined therapy of patients with chronic hepatitis C (CHC) who received no previous antiviral therapy (AVT).Material and methods. …”
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P-glycoprotein and/or Histone Deacetylase 2 Regulates Steroid Responsiveness in Childhood Nephrotic Syndrome by Harshit Singh, Narayan Prasad, Durga Prasanna Misra, Akhilesh Kumar Jaiswal, Vikas Agarwal

“…Conclusion: The expression and function of P-gp and HDAC2 may affect steroid response in NS patients. Combined therapy of steroids with P-gp inhibitor and/or HDAC2 inducers may have a rationale in management of SRNS patients.…”
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Efficacy and safety of repetitive transcranial magnetic stimulation in the treatment of male smokers with tobacco use disorder: a randomized controlled trial by Salma W. Mousa, Adel A. Badawy, Gehan F. Attia, Wesam A. Ghareeb

“…Further research is needed to optimize treatment protocols, explore combined therapies, and assess long-term outcomes to improve smoking cessation in diverse populations.…”
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A literature review of recent advances in gastric cancer treatment: exploring the cross-talk between targeted therapies by Reza Panahizadeh, Padideh Panahi, Vahid Asghariazar, Shima Makaremi, Ghasem Noorkhajavi, Elham Safarzadeh

“…Challenges include resistance mechanisms, immunosuppressive tumor environments, and inconsistent results from combination therapies. Biomarker-driven approaches and further research into emerging modalities like CAR-T cells and cancer vaccines are critical for optimizing treatments. …”
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Pancreatic Cancer: Molecular, Biochemical, Chemopreventive, and Therapeutic Aspects by Juan Iovanna, José Luis Neira

“…For a clinically significant effect to be achieved, treatment strategies should either be in the form of (1) a horizontal approach, in which several oncogenic pathways (as those described in this series of reviews) are inhibited; or (2) a vertical approach, whereby multiple levels of a major pathway are targeted. Combination therapies, together with improved diagnostic tools and predictive markers, are ultimately desired in order to improve the bleak outlook for patients diagnosed with PC.…”
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Antimicrobial and Antibiofilm Activity of Monolaurin against Methicillin-Resistant Staphylococcus aureus Isolated from Wound Infections by Shimaa Salah Hassan Abd El-Ghany, Ahmed Farag Azmy, Ahmed Osama EL-Gendy, Rehab Mahmoud Abd El-Baky, Ahmad Mustafa, Mohammed A. S. Abourehab, Mohamed E. El‐Beeh, Reham Ali Ibrahem

“…The assessment of combined therapy involving monolaurin and antibiotics was conducted using fractional inhibitory concentration (FIC). …”
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Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia by Juan Li, Chunmei Ye, Hui Li, Jun Li

“…In vivo studies with cell line-derived xenograft (CDX) and patient-derived xenograft (PDX) models demonstrated that CX-4945 and venetoclax combined therapy provided superior therapeutic efficacy, reducing tumor burden and prolonging survival compared to single-agent treatments.Conclusions IKZF1 represses BCL-2 in T-ALL, and targeting the CK2-IKZF1 axis with CX-4945 and venetoclax offers a promising therapeutic strategy, showing enhanced efficacy and potential as a novel treatment approach for T-ALL.…”
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Efficacy of high-dose steroids versus low-dose steroids in the treatment of immune checkpoint inhibitor-associated myocarditis: a case series and systematic review by Xiuyue Man, Hong Wang, Chen Chen, Xiaofeng Cong, Lemeng Sun, Xueru Sun, Chen Chen, Jing Zhang, Lei Yang

“…In cases of steroid resistance, combination therapies may provide additional benefit.…”
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Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma by Z.M. Nagornova, A.V. Kuroyedov, A.V. Seleznev

“…<br> <br> <b>Keywords</b>: primary open-angle glaucoma, fixed-dose combination, glaucoma, combined therapy, treatment efficacy.<br> <b>For citation:</b> Nagornova Z.M., Kuroyedov A.V., Seleznev A.V. …”
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Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: trial protocol of the phase-II randomised placebo controlled PROSPER trial by Phillip Knebel, Thilo Hackert, Markus W Büchler, Ilse Rooman, Markus K Diener, Felix J Hüttner, André L Mihaljevic, Oliver Strobel, Gauthier Bouche, Johannes Hüsing

“…The clinical trial is accompanied by a translational study investigating the mechanisms of action of the combined therapy on a molecular basis.Ethics and dissemination The PROSPER-trial has been approved by the German Federal Institute for Drugs and Medical Devices (reference number 4042875) and the Ethics Committee of the Medical Faculty of the University of Heidelberg (reference number AFmo-385/2018). …”
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EFFECT OF IRRIGATION INTERVAL ON GROWTH AND ARTEMISININ CONTENT OF WORMWOOD (Artemisia annua L.) CHEN YOUNG VARIETY IN SOKOTO by Lawal Gandi ABDULKADIR, Adamu Aliyu ALIERO, Hassan Muhammad MAISHANU, Abdullahi Yahaya ABBAS

“…Artemisinin is the main antimalarial compound in Artemisia annua, used in the formulation of artemisinin-based combined therapies (ACT) to treat malaria. Artemisinin is largely obtained from A. annua plant but the content is very low and its production commercially is not cost effective worldwide. …”
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Curative Effect of Wearable Back Trainer Combined with Massage on Patients of Chronic Nonspecific Low Back Pain by An CAO, Guozhi HUANG, Qing ZENG, Peichen HE, Rihui LI

“…There were statistical differences among the three groups in ODI score two weeks after treatment respectively (<italic>P</italic>&lt; 0.05); the score showed a downward trend with time in the treatment group and the control group, the decreasing amplitude of ODI score in the treatment group was higher than that of control group two weeks after treatment (<italic>P</italic>&lt; 0.05), and the ODI value in the blank group was decreased one week after treatment and increased two weeks after treatment.Conclusion:The clinical efficacy of the wearable back trainer combined with massage has good effect on patients of chronic nonspecific low back pain, and the effect of the combined therapy is better than simple massage therapy especially in pain relief.…”
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Mesenchymal Stem Cell-Derived Neuron-Like Cell Transplantation Combined with Electroacupuncture Improves Synaptic Plasticity in Rats with Intracerebral Hemorrhage via mTOR/p70S6K S... by Guoqiang Yang, Jiayi Zhu, Guwen Zhan, Guangbi Fan, Li Deng, Huajun Tang, Xiaoqian Jiang, Bo Chen, Chaoxian Yang

“…The BWC increased in rats after ICH and decreased significantly in ICH rats treated with MSC-dNLC transplantation, EA stimulation, or combined therapy. Meanwhile, after ICH, the number of blood vessels increased more evidently, but only the combined treatment reduced the number of blood vessels among rats receiving the three treatments. …”
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Development and Validation of an Ion-Pair HPLC-UV Method for the Quantitation of Quinoline and Indoloquinoline Alkaloids in Herbal and Pharmaceutical Antimalarial Formulations by Samuel Oppong Bekoe, Emmanuel Orman, Samuel Awenteka Adjabui, Abena Amponsaa Brobbey, James Oppong-Kyekyeku, Kwabena Frimpong-Manso Opuni, Noble Kuntworbe, Samuel Asare-Nkansah

“…Quinine- and cryptolepine-based antimalarials serve as valuable alternatives to artemisinin-based combination therapies (ACTs) in Ghana. Their use, however, is associated with adulteration and substandard quality challenges. …”
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