Combined Effects of 2-Methoxyestradiol (Hypoxia-Inducible Factor 1α Inhibitor) and Dasatinib (A Second-Generation Tyrosine Kinase Inhibitor) on Chronic Myelocytic Leukemia Cells by Yuexian Zhang, Heng Chen, Yunfeng Shen, Xin Zhou

“…The therapeutic effect of single 2-ME2 was superior to single dasatinib, and the effect of combined therapy of both drugs produced better effectiveness than either of the single drug. …”
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Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials by Ingyu Lee, SeoWon Kang, JinHan Lee, Hyungin Cho, Ki Won Lee, Dongkeun Lim

“…Chemical peels, though slower, are safer for patients prone to adverse effects. Combination therapies and maintenance strategies may improve long-term outcomes in melasma…”
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Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis by Jianhao Bai, Zhongqi Wan, Wanru Zhou, Lijun Wang, Wei Lou, Yao Zhang, Haiying Jin

“…Keyword and co-citation analyses revealed a transition from early focus on BRAF mutations and MAPK pathway activation to recent emphasis on immunotherapy, combination therapies, and non-apoptotic cell death mechanisms like ferroptosis and pyroptosis. …”
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Blockade of TIPE2-Mediated Ferroptosis of Myeloid-Derived Suppressor Cells Achieves the Full Potential of Combinatory Ferroptosis and Anti-PD-L1 Cancer Immunotherapy by Hafiza Kashaf Tariq, Zihao Liang, Lawan Rabiu, Abdulrahman Ibrahim, Nada Mohamady Farouk Abdalsalam, Rong Li, Qiong Yang, Xiaochun Wan, Dehong Yan

“…Recent research suggests that an MDSC blockade can unleash the full therapeutic potential of the combined therapy of ferroptosis and ICB in liver cancer treatment. …”
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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone by Xiongxiong Liu, Tong Zheng, Yanyu Bao, Ping Li, Ting Zhao, Yan Liu, Hui Wang, Chao Sun

“…Future research should focus on dosage optimization and administration, the exploration of combination therapies, and long-term clinical trials to establish genistein benefits in clinical settings. …”
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Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects by Zahid Rafiq, Mingyo Kang, Hampartsoum B. Barsoumian, Gohar S. Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W. Welsh

“…Furthermore, we explore the challenges associated with LDRT’s integration into combination therapies, addressing crucial factors such as optimal dosage, fractionation, treatment frequency, and synergy with other pharmacological agents. …”
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Impact of Tacrolimus, Sirolimus, Age, and Body Mass Index on the Occurrence of Skin Cancer and Islet Dysfunction After Transplantation by Christopher Orr, Jeannette Stratton, Mohamed El-Shahawy, Elena Forouhar, Alice Peng, Gagandeep Singh, Keiko Omori, Meirigeng Qi, Fouad Kandeel

“…High tacrolimus % (>35) resulted in a 4.6-fold increase in skin cancer frequency, whereas sirolimus above 75% of the combined therapy led to a 5.2-fold increase in islet graft dysfunction (IGD) events/year. …”
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Inhibition of NLRP3 enhances pro-apoptotic effects of FLT3 inhibition in AML by Helene Sieberer, Michela Luciano, Diana Amend, Constantin Blöchl, Anna Eglseer, Alina Steinkellner, Sebastian Rieser, Ancuela Andosch, Philip Steiner, Laura Hummer, Peter W. Krenn, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Theresa Neuper, Jutta Horejs-Hoeck

“…While several FLT3 inhibitors have received FDA approval, their use is currently limited to combination therapies with chemotherapy, as resistance occurs, and efficacy decreases when the inhibitors are used alone. …”
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Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial by Marian Majchrzycki, Piotr Kocur, Tomasz Kotwicki

“…To investigate whether chronic low back pain therapy with deep tissue massage (DTM) gives similar results to combined therapy consisting of DTM and non-steroid anti-inflammatory drugs (NSAID). …”
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Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry by Estéfani Alves Asevedo, Estéfani Alves Asevedo, Livia Ramos Santiago, Livia Ramos Santiago, Hyo Jeong Kim, Rony Abdi Syahputra, Moon Nyeo Park, Rosy Iara Maciel Azambuja Ribeiro, Bonglee Kim

“…Particularly noteworthy is C. sappan’s potential in combination therapies, where it may synergistically target multiple cancer pathways, enhance therapeutic outcomes, and mitigate adverse effects. …”
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Hepatocellular carcinoma: signaling pathways and therapeutic advances by Jiaojiao Zheng, Siying Wang, Lei Xia, Zhen Sun, Kui Ming Chan, René Bernards, Wenxin Qin, Jinhong Chen, Qiang Xia, Haojie Jin

“…New trials are investigating combination therapies involving ICIs and TKIs or anti-VEGF (endothelial growth factor) therapies, as well as combinations of two immunotherapy regimens. …”
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Diagnosis dan Penatalaksanaan Tumor Ganas Laring by Dolly Irfandy, Sukri Rahman

“…Management of laryngeal tumour depends on stadium<br />with various modality included surgery, chemotheraphy, radiotheraphy or combined therapy. Reported case of 53<br />years old male with Glottic carcinoma of the larynx stage III (T3N0M0) squamous cell ca keratinized well differentiated<br />is presented. …”
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Melasma management: Unveiling recent breakthroughs through literature analysis by Darshan Kumar R, Richa Sood, Prashant Tiwari

“…Advances in topical formulations, such as combination therapies containing tyrosinase inhibitors, antioxidants, and anti-inflammatory agents, have shown promising results in improving pigmentation and preventing recurrence. …”
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Efficacy of low-dose rituximab versus immunosuppressants in refractory orbital inflammatory pseudotumors with intracranial extension by Yuyu Li, Mingming Sun, Xintong Xu, Biyue Chen, Xiyun Chen, Yuhang Wang, Quangang Xu, Huanfen Zhou, Shihui Wei

“…However, for patients who still experience recurrence or slow reduction of lesions after applying this combined therapy, RTX may be a better option.…”
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Metastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies. by Zeinab Chaharlashkar, Yousof Saeedi Honar, Meghdad Abdollahpour-Alitappeh, Sepideh Parvizpour, Abolfazl Barzegar, Effat Alizadeh

“…The items recognized in the current study can be used as potential biomarkers for diagnostic, predictive, and might helpful to develop targeted combined therapies.…”
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A real-world drug safety surveillance study from the FAERS database of hepatocellular carcinoma patients receiving pembrolizumab alone and plus lenvatinib by Huaxiang Wang, Junjun Li, Xiuling Zhu, Ruling Wang, Yunyan Wan

“…This study aims to meticulously monitor and identify adverse events (AEs) related to this combined therapy, enhance patient safety, and offer evidence-based recommendations for the appropriate use of these drugs. …”
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Computational design of potent dimeric phenylthiazole NS5A inhibitors for hepatitis C virus by Wissal Liman, Mehdi Oubahmane, Nouhaila Ait Lahcen, Ismail Hdoufane, Driss Cherqaoui, Rachid Daoud, Achraf El Allali

“…This significance is highlighted by its inclusion in all existing approved HCV combination therapies. In this study, a quantitative structure–activity relationship (QSAR) was conducted to design new compounds with enhanced inhibitory activity against HCV. …”
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Systemic reviews and meta-analysis of the use of midodrine in hepatorenal syndrome by Prem Balaji Reddy Lankapothu, Shrinidhi B., Satish Kumar M., Magesh Kumar S.

“…This study opens avenues for future research on midodrine's role in HRS treatment, particularly in combination therapies and cost-effectiveness studies.…”
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Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis by Joseph Malinzi, Rachid Ouifki, Amina Eladdadi, Delfim F. M. Torres, K. A. Jane White

“…Numerical simulations show that a successful combinational therapy of the chemotherapeutic drugs and viruses depends mostly on the virus burst size, infection rate, and the amount of drugs supplied. …”
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Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review by Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao

“…However, there is a lack of comprehensive review to explore the efficacy and mechanism of combined therapy with drugs and polyphenols for NAFLD. …”
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