Primary Neuroendocrine Carcinoma of Ocular Adnexa by Daisuke Yamanouchi, Toshiyuki Oshitari, Yosuke Nakamura, Jiro Yotsukura, Kaoru Asanagi, Takayuki Baba, Tomohiro Nizawa, Takashi Kishimoto, Yoko Yonemori, Satoshi Ota, Shuichi Yamamoto

“…Although primary NEC of the ocular adnexa is extremely rare, the tumor has high malignancy and readily metastasizes. Thus, combined therapy including surgery, radiotherapy, and/or chemotherapy is needed for complete management of NEC.…”
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Advancements in cellular immunotherapy: overcoming resistance in lung and colorectal cancer by Lijuan Qin, Yuan Li, Juan Liu, Xiaoqin An

“…The review also explores cutting-edge strategies aimed at overcoming resistance, including combination therapies, gene editing technologies, and nanotechnology for targeted drug delivery. …”
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Pivotal Cytoprotective Mediators and Promising Therapeutic Strategies for Endothelial Progenitor Cell-Based Cardiovascular Regeneration by Hyunyun Kim, Sujin Kim, Sang Hong Baek, Sang-Mo Kwon

“…Additionally, to enhance EPC’s functional capacity at ischemic sites, multiple strategies for cell survival should be considered, that is, preconditioning of EPCs with function-targeting drugs including natural compounds and hormones, virus mediated genetic modification, combined therapy with other stem/progenitor cells, and conglomeration with biomaterials. …”
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Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy by Pavithra Bharathy, Elizabeth Rani E, Punniyakoti V. Thanikachalam

“…Future directions include individualized treatment plans, multifunctional nanoparticles, combination therapies, and improved nanoparticle design. …”
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GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells by Fumiya Ito, Wakiko Iwata, Yoshihiro Adachi, Hiromi Sesaki, Miho Iijima

“…These findings provide a novel mechanism of drug resistance and suggest that combination therapies targeting both GRHL2-HER3 and E-cadherin-mediated pathways may be necessary to overcome erlotinib resistance in lung cancer.…”
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Quantitative estimation of drugs for erectile dysfunction and benign prostatic hyperplasia by high performance liquid chromatography: a review by Shalaka G. Gaonkar, Basavaraj M Dinnimath

“…HPLC is essential for the precise measurement of these drugs, whether assessed individually or within combination therapies. The review thoroughly examines various HPLC methodologies, encompassing both single-drug and simultaneous analysis techniques. …”
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Meta-Analysis on Cognitive Benefit of Exercise after Stroke by Bo Yang, Shuming Wang

“…Higher benefits on cognition were found after combined therapy compared with other exercise programs, and the older the stroke survivors, the less the cognitive benefit of exercise. …”
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Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment by Amy Sarah Benjamin, Sunita Nayak

“…Iron oxide nanoparticles stand out in both therapeutic and diagnostic applications, offering a versatile platform for targeted drug delivery, hyperthermia, magneto-thermal therapy, and combinational therapy using modulation of ferroptosis pathways. …”
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Controversies in the management of anti-TNF therapy in patients with Crohn’s disease: a Delphi consensus by Ignacio Marin-Jimenez, Guillermo Bastida, Daniel Carpio, Fernando Muñoz, Yago González-Lama, Elena Ricart, Daniel Ceballos, Daniel Ginard, Luis Menchen

“…These statements cover: (1) use of first-line non-anti-TNF biological therapy; (2) role of HLA-DQA1*05 in daily practice; (3) attitudes in primary non-response and loss of response to anti-TNF therapy due to immunogenicity; (4) use of ustekinumab or vedolizumab if a change in action mechanism is warranted; (5) anti-TNF drug level monitoring; (6) combined therapy with an immunomodulator.Conclusion This document sought to pull together the best evidence, experts’ opinions, and treating physicians’ attitudes when using anti-TNF therapies in patients with CD.…”
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Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and no... by Zhirui Zhang, Wenhuan Song, Wenyu Chen, Wenze Cui, Wenyi Chen, Qinheng Zhang, Wenwen Ji, Yinglin Wang, Jiayi Wang, Wenhao Yu, Mingkun Yu, Mingkun Yu, Tao Hao, Hong Jiang

“…Future research should focus on miRNA’s role in drug resistance and combination therapies to accelerate its clinical translation.…”
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Silver nanoparticle induced immunogenic cell death can improve immunotherapy by Ara Sargsian, Xanthippi Koutsoumpou, Hermon Girmatsion, Can Egil, Kiana Buttiens, Carla Rios Luci, Stefaan J. Soenen, Bella B. Manshian

“…One particular hot topic is the use of combination therapies. Here, we set out to screen a variety of metallic nanoparticles and explored their in vitro toxicity against a series of tumor and non-tumor cell lines. …”
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Mechanistic insights toward progress in alogliptin beyond glycemic control: translational perspective by Faraha Ahmed, Syed Sufian Ahmad, M. Mumtaz Alam, M. Shaqiquzzaman, Abul Kalam Najmi, Mohammad Ahmed Khan

“…It is administered orally and efficacious as monotherapy as well as combined therapy with other T2DM drugs, such as pioglitazone and metformin. …”
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The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…This narrative review underscores the need for continued research into the molecular mechanisms underlying these interactions and suggests future directions for therapeutic development, including clinical trials, biomarker discovery, and combination therapies that synergistically target aging processes.…”
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Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer by Yixiang Gu, Ruifeng Yang, Yang Zhang, Miaomiao Guo, Kyle Takehiro, Ming Zhan, Linhua Yang, Hui Wang

“…Finally, we discuss current strategies aiming at overcoming chemotherapy resistance, such as combination therapies, targeted treatments, and novel drug delivery systems, while proposing future directions for research in this evolving field. …”
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Coronary Artery Spasm: New Insights by Anthony Matta, Frederic Bouisset, Thibault Lhermusier, Fran Campelo-Parada, Meyer Elbaz, Didier Carrié, Jerome Roncalli

“…Invasive strategies such as PCI (percutaneous coronary intervention) and CABG (coronary artery bypass graft) have shown benefits in CAS with significant atherosclerotic lesions. Combination therapies are proposed for refractory cases.…”
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Photobiomodulation in ocular therapy: current status and future perspectives by Hasan Chichan, Iftkhar Hamzah Aldujaly, Konstantinos Michalakis, Levent Kanal

“…Future prospects of photobiomodulation involve target-specific treatment, combinational therapy to treat complex retinal diseases including gene therapy, and longitudinal studies to predict long-term efficacy and the chance of any recurrence in the patients. …”
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Intravitreal Conbercept Injection with and without Grid Laser Photocoagulation in the Treatment of Diffuse Diabetic Macular Edema in Real-Life Clinical Practice by Yule Xu, Ao Rong, Yanlong Bi, Wei Xu

“…Results. 26 patients (31 eyes) received IVC alone and 25 patients (30 eyes) received combined therapy. At month 12, the mean best-corrected visual acuity (BCVA) letter score improvement was 9.1±4.5 and 7.5±4.2 in the IVC group and the combined group and the mean central retinal thickness (CRT) reduction was 145.1 ± 69.9 μm and 168.5±53.6 μm, respectively. …”
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The Effectiveness of ROMATIF Therapy (Mirror Therapy and Positive Affirmation) on Strength of Muscle and Self-acceptance in Post Stroke Patients by Putu Sintya Arlinda Arsa, Lie Liana Fuadiati, Desy Rinawaty

“…This study aims to determine the effectiveness of a combined therapy, namely mirror therapy and positive affirmations, referred to as ROMATIF therapy(Mirror Therapy and Positive Affirmations). …”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…A mechanism-based precision medicine approach should enhance the clinical efficacy of dietary and related natural products as anticancer agents and decrease toxic side effects for some combination therapies.…”
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Drivers of innovation value: simulation for new drug pricing evaluation based on system dynamics modelling by Qian Xing, Wendi Cheng, Wei Wang, Chunlin Jin, Haiyin Wang

“…Sensitivity analysis highlights that factors like combination therapies, faster mechanisms of action, and novel therapeutic parts notably influence the value dimension. …”
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