COMBINATION OF ACUPUNCTURE THERAPY AND TURMERICLIQUORICE HERBS FOR CHRONIC COUGHING CASE by Intan Fahdelasari Purwanto, Ario Imandiri, Lusiana Arifanti

“…Conclusion: The combined therapy showed to diminish the chronic coughing within 30 days…”
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Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention by Kashish Azeem, Sadaf Fatima, Asghar Ali, Ayesha Ubaid, Fohad Mabood Husain, Mohammad Abid

“…The exploration of combination therapies, involving antimicrobial agents, biofilm-disrupting enzymes, and immunomodulators, is emphasized to enhance the efficacy of existing treatments and overcome biofilm resilience.…”
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Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model... by Alina Benítez-Castañeda, Verónica Anaya-Martínez, Armando de Jesús Espadas-Alvarez, Ana Luisa Gutierrez-Váldez, Luis Fernando Razgado-Hernández, Patricia Emmanuelle Reyna-Velazquez, Liz Quintero-Macias, Daniel Martínez-Fong, Benjamín Florán-Garduño, Jorge Aceves

“…To restore motor and nonmotor symptoms to normality, we assessed a combined therapy in a bilateral rat Parkinson’s model, with only 30% of surviving neurons. …”
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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…This review discusses the role of DNA methylation in TNBC progression and immune evasion, focusing on recent advances in combination therapies involving DNA methylation inhibitors and ICIs. …”
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MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy by Lihua Chen, Jiaying Yang, Lingyu Jia, Xiaolu Wei, Huijun Wang, Zhuo Liu, Shan Jiang, Pengyue Li, Yanyan Zhou, Hongjie Wang, Nan Si, Baolin Bian, Qinghe Zhao, Haiyu Zhao

“…Therefore, this study provides a new strategy for glucose metabolism-mediated bioenergetic therapy and PTT/CDT/CT combined therapy for tumors. Graphical Abstract…”
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Combating antibiotic resistance: mechanisms, challenges, and innovative approaches in antibacterial drug development by Aiswarya M. Rajesh, Shraddha Subhash Pawar, Kruthi Doriya, Rambabu Dandela

“…Innovative approaches, such as structure-based drug design, combination therapies, and new delivery systems, are highlighted for their potential to create compounds with enhanced action against resistant strains. …”
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Severe Diverticulitis Associated to <i>Clostridioides difficile</i> Infection in a 91 Year Old Patient (Clinical Case) by A. A. Makushina, L.  N. Androsova, K. B. Puzakov, A. V. Okhlobystin, M. A. Tatarkina, O. S. Shifrin

“…However, a few days later, the patient developed a clinic of C. difficile-associated disease, which required the prescription of anticlostridial therapy (vancomycin), until the laboratory confirmation of the accession of this infection was obtained. Combined therapy of exacerbation of diverticular disease and C. difficile-associated disease made it possible to achieve a steady improvement of the condition.Conclusion. …”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…Very recent phase III trials with the leading agent, a humanised anti-CD3 antibody, call into question whether further development of these biologics represents a step forward or more of the same. Combination therapies of one or more of these humanised antibodies are also being considered, and they face identical, if not more serious, impediments and safety issues. …”
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

“…The synergistic effect of inhibiting DNA replication and CHK2 signaling identifies a vulnerability of cancer cells that might be exploited by using clinically approved inhibitors in novel combination therapies.…”
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NVP-2, in combination with Orlistat, represents a promising therapeutic strategy for acute myeloid leukemia by Qing Zhu, Jia Cheng, Yuqing Gao, Zimu Zhang, Jian Pan, Xin Su, Danhong Fei, Linbo Cai, Juanjuan Yu, Yanling Chen, Wanyan Jiao, Di Wu, Xiaolu Li, Peifang Xiao

“…Mechanistically, MCL1, c-Myc, and Akt/mTOR/SREBF1 may be critical factors and pathways in the combined therapy of NVP-2 and Orlistat. In summary, our study revealed that CDK9 and FASN are vital for maintaining AML cell survival and proliferation. …”
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Combined therapeutic option for NDM-producing Serratia Marcescens – an in vitro study from clinical samples by Balbina Chilombo Albano, Leticia Ramos Dantas, Gabriel Burato Ortis, Paula Hansen Suss, Felipe Francisco Tuon

“…Background: Treating NDM-producing bacteria poses a significant challenge, especially for those bacteria inherently resistant to polymyxin, such as Serratia marcescens, necessitating combined therapies. Objective: To assess in vitro the synergistic effect of different antimicrobial combinations against NDM-producing S. marcescens. …”
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Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound: Implications from the Present Clinical Trials by Tinghe Yu, Xiao Fu

“…Based upon evaluable data, the efficacy of HIFU was similar to that of radio frequency, chemoembolization, chemotherapy, radiotherapy, or hormone therapy; a combined therapy did not improve the efficacy. The survival rate of HIFU plus radiotherapy was lower than that of radical surgery in liver cancers. …”
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Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication by Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Roghayeh Jafarian Amiri, Marzieh Pirzadeh, Ali Akbar Moghadamnia

“…Chelator agents such as deferoxamine (DFO) are used in the case of aluminum poisoning. Besides, combination therapies are recommended.…”
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Macrophage Polarisation in the Tumour Microenvironment: Recent Research Advances and Therapeutic Potential of Different Macrophage Reprogramming by Rongqi Guo PhD, Rui Wang PhD, Weisong Zhang PhD, Yangyang Li PhD, Yihao Wang PhD, Hao Wang PhD, Xia Li PhD, Jianxiang Song PhD

“…TAMs play a pivotal role in tumour progression, metastasis, and therapy resistance, making them prime targets for combination therapies. Conclusions Understanding the mechanisms underlying macrophage polarisation and reprogramming offers promising avenues for developing therapies to counteract tumour progression. …”
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Targeting glycolysis: exploring a new frontier in glioblastoma therapy by Lu Yang, Sijia Li, Lei Yu, Jiao Leng, Na Li

“…Future research will aim to address these challenges by improving drug delivery, minimizing side effects, and exploring combination therapies with radiotherapy, chemotherapy, and immunotherapy to develop more precise and effective personalized treatment strategies for GBM.…”
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Topical application of heparin for the correction of ocular surface lesions by V.D. Yartsev

“…Disinfectant properties of heparin were found to be useful for etiotropic treatment of the patients with conjunctivitis or keratitis in mono- or combined therapy. The new drug forms of heparin, such as ocular ointment and eye drops, enable to choose the dose of the drug individually and accurately for the patients with different pathology of ocular surface, thus personifying the treatment.…”
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Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…., sequence and timing of agent administration; drug selectivity; compatibility of combined therapies i.e., adoptive T cell or agents, i.e., MEK inhibitor trametinib, PD-1 and PDL-1 blockers). …”
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Progress and application of intelligent nanomedicine in urinary system tumors by Yingming Xiao, Lei Zhong, Jinpeng Liu, Li Chen, Yi Wu, Ge Li

“…Finally, we have assessed the potential of intelligent nanomedicine in the management of urinary system tumors, emphasizing emerging trends such as personalized nanomedicine and combination therapies. This comprehensive review underscores the substantial contributions of nanomedicine to the field of oncology and offers a promising outlook for more effective and precise treatment strategies for urinary system tumors.…”
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Improved Outcomes with Intensity Modulated Radiation Therapy Combined with Temozolomide for Newly Diagnosed Glioblastoma Multiforme by Noel J. Aherne, Linus C. Benjamin, Patrick J. Horsley, Thomaz Silva, Shea Wilcox, Julan Amalaseelan, Patrick Dwyer, Abdul M. R. Tahir, Jacques Hill, Andrew Last, Carmen Hansen, Craig S. McLachlan, Yvonne L. Lee, Michael J. McKay, Thomas P. Shakespeare

“…In our group, median survival for those receiving 60 Gy with Temozolomide compared favourably to the combined therapy arm of the largest randomised trial of chemoradiation versus radiation to date (17.4 months versus 14.6 months). …”
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The effect of acromegaly on thyroid disease by Caiyan Mo, Liyong Zhong

“…Thyroid-stimulating hormone (TSH) receptor (TSHR) and IGF-1R co-immunoprecipitate in orbital and thyroid tissues to form a functional complex; thus, combined therapy targeting TSHR and IGF-1R may be more effective than single therapy.…”
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