Diabetes Treatment with Dapagliflozin and Its Combinations: Insights from Clinical Practice by Akshay Bafna, Ajit Mehta, Rajeev Garg, Jayagopal Pathiyil Balagopalan, Rajesh Rajput, Nitin Zalte, Preethi Naik, Amarnath Sugumaran, Senthilnathan Mohanasundaram

“…Abstract Objective: To evaluate the perception of clinicians about the association of heart failure (HF) and type 2 diabetes mellitus (T2DM) and the utilization of dapagliflozin-based combination therapies for cardiorenal protection in Indian patients with T2DM. …”
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Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium by Eileen S. Kim, Jennifer E. Kim, Mira A. Patel, Antonella Mangraviti, Jacob Ruzevick, Michael Lim

“…The review will provide an overview of the existing preclinical and clinical data, antitumor efficacy, and clinical applications for each checkpoint with respect to GBM, as well as a summary of combination therapies with chemotherapy and radiation.…”
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Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects by Zhe Cheng, Huichao Huang, Meilong Yin, Huaizheng Liu

“…In this review, we focus on targeted liposomes, stimuli-responsive strategy and combined therapy in cancer treatment. We also summarize advances of liposome and lipid nanoparticle applications in nucleic acid delivery and tumor vaccination. …”
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The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis by Beibei Wu, Beibei Wu, Beibei Wu, Ding Luo, Ding Luo, Xuejie Wang, Xuejie Wang, Chen Qiao, Chen Qiao, Rui Li, Jian Liu, Jian Liu

“…Keyword and reference analyses further indicate that “adoptive cell therapy,” “the prognostic value of TILs,” and “immune checkpoint inhibitors and TILs” are central themes in current and future research. Combination therapies; tumor neoantigens; gene editing; dominant population selection of TILs therapy; TILs in Tumor microenvironment; emerging predictive biomarkers; TILs in predicting the efficacy of neoadjuvant chemotherapy and immunotherapy; the relationship between TILs and PD-L1; TIL-based patient stratification; tertiary lymphoid structures; and TIL evaluation through digital pathology and artificial intelligence are identified as key areas of interest.ConclusionsThis analysis highlights the increasing academic focus on tumor-infiltrating lymphocyte research and identifies key recent themes in the field such as prognostic value of TILs, personalized treatments, and combination therapies.…”
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The biological and functional restoration of spinal cord injury by JIAN Feng‐zeng, YANG Qi‐qi, DUAN Wan‐ru

“…Functional restoration can be achieved by boosting neuroplasticity with activity‐based therapy or electrical stimulation, or by implanting interfaces that allowed accessibility to interactive devices. Combined therapy showed potentially better outcomes.…”
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Concomitant Transverse Myelitis and Acute Axonal Sensory-Motor Neuropathy in an Elderly Patient by L. M. Oliveira, R. G. Cury, L. H. Castro, R. Nitrini

“…Intravenous methylprednisolone, plasma exchange, cyclophosphamide, or combination therapies are usually used, although there are no randomized controlled studies regarding treatment choices.…”
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One-Stage Hybrid Repair of Multiple Degenerative Aneurysms by George N. Kouvelos, Nektario K. Papa, Eleni M. Arnaoutoglou, Christina Bali, Miltiadis I. Matsagkas

“…This case illustrates the prospect to combine classic open surgical and endovascular techniques for the optimal management of multileveled arterial pathology. Combined therapy simplifies management and allows the one-stage treatment of these patients, while minimizing the overall operative risk.…”
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Local controllability and optimal control for\newline a model of combined anticancer therapy with control delays by Jerzy Klamka, Helmut Maurer, Andrzej Swierniak

“…The optimized protocols of the combined therapy for the model, considered as solutions to an optimal control problem with delays in control, are found using necessary conditions of optimality and numerical computations. …”
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Mirvetuximab Soravtansine in solid tumors: A systematic review and meta-analysis. by Shamsnur Rehim, Shuang Yuan, Hongjing Wang

“…The pooled ORRs of MIRV monotherapy and MIRV+BEV combined therapy were 25% (95% CI 21%-29%, I2 = 25.20%) and 43% (95% CI 36%-50%, I2 = 0.01%), respectively. …”
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Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma by Song Y, Tian S, Li Z, Miao J, Wu M, Xu T, Wu X, Qiao J, Zhang X, Zhao H, Kang L, Cao L, Zhu P, Miao M

“…Through the analysis, it is proposed that intratumor organisms can be used as markers for liver cancer diagnosis and treatment, drug carrier materials for targeting liver cancer tissues, and the research prospects of developing new combination therapies based on the in-depth understanding of the interactions between intratumor microorganisms and the tumor microenvironment, immune cells, liver cancer cells, etc. as well as exploring the prospects of developing new combination therapies based on these interactions. …”
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Evaluating the Efficacy of Combined Intravaginal Estriol Therapy and Kegel Exercises in Managing Menopausal Atrophic Vulvovaginitis by Lucian Șerbănescu, Vadym Rotar, Dragoș Brezeanu, Sebastian Mirea, Elena-Valentina Ionescu, Paris Ionescu

“…In the mild VVA group, 81.82% achieved complete remission with combined therapy compared to 68.18% with estriol alone. …”
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Precision oncology through next generation sequencing in hepatocellular carcinoma by Sayali Shinde, Carola Maria Bigogno, Ana Simmons, Nikita Kathuria, Aruni Ghose, Vedika Apte, Patricia Lapitan, Shania Makker, Aydin Caglayan, Stergios Boussios

“…The knowledge gained from sequencing is then utilised to develop countermeasures against these mutants through different combination therapies. Advances in NGS have led to sequencing with higher accuracy and throughput, thereby enabling personalized and effective treatments. …”
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Cosmetic filler-induced hair loss: case series and literature review by Yutong Xie, Xi Chen, Aihua Wei

“…The third case described another female who experienced alopecia areata-like hair loss after autologous fat grafting, and received combined therapies including corticosteriod, 5% minoxidil and microneedling.Results All patients got gradual hair regrowth with treatments.Conclusions Early recognition and intervention are crucial to prevent permanent hair follicle damage. …”
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Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival by Gil-Ran Kim, Kyung-Ho Nam, Je-Min Choi

“…Additionally, it discusses the potential benefits of combining therapies that boost Treg cells with belatacept to increase the effectiveness of immunosuppression and improve graft outcomes.…”
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CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity by Yaojie Kong, Jingyao Li, Xueyao Zhao, Yanwei Wu, Liang Chen

“…Also, key innovations were discussed including specialized CAR-T, combination therapies and the novel use of CAR-Treg, CAR-NK and CAR-M cells. …”
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Phototherapy in vitiligo by Anuradha Bishnoi, Iltefat Hamzavi

“…Additionally, combination therapies involving phototherapy and topical and systemic agents (such as psoralens, corticosteroids, calcineurin inhibitors, azathioprine, and other systemic immunomodulators, basic fibroblast growth factor/decapeptide and Janus kinase inhibitors) and surgical management have demonstrated enhanced repigmentation outcomes. …”
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Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes by P. J. Simpson-Haidaris, S. J. Pollock, S. Ramon, N. Guo, C. F. Woeller, S. E. Feldon, R. P. Phipps

“…This paper has two objectives: first to highlight the potential uses for PPARγ agonists in anticancer therapy with special emphasis on their role when used as adjuvant or combined therapy in the treatment of hematological malignancies found in the vasculature, marrow, and eyes, and second, to review the potential role PPARγ and/or its ligands may have in modulating cancer-associated angiogenesis and tumor-stromal microenvironment crosstalk in bone marrow.…”
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Two ways to one goal: new strategy of antiviral therapy for chronic hepatitis C by S. N. Batskikh

“…To analyze data of the clinical studies on chronic hepatitis C (CHC) treatment with application of new modes of combined therapy, including selective inhibitor of viral protease.Key points. …”
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Neoadjuvant pembrolizumab-carboplatin-paclitaxel in locally advanced squamous cell carcinoma of the oral cavity: A case report and literature review by Abdulrahman Hesham, Fawaz AlOtaibi, D. David Kim, Yousef Alshamrani, Joao Hyppolito, Katie Jubala

“…Clinical trials are essential to investigate the viability of this potentially less toxic and more convenient combined therapy in patients with advanced squamous cell carcinoma of the oral cavity.…”
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Dual-drug loaded chondroitin sulfate embolization beads enhance TACE therapy for HCC by integrating embolization, chemotherapy, and anti-angiogenesis by Jin-Xin Huang, Rui Yang, Huan Long, Jie Kong, Guo-Qiang Shao, Fei Xiong

“…In clinical practice, combined therapy for liver cancer using TACE and oral targeted drugs often encounters the limitation that targeted drugs cannot efficiently reach the tumor site following TACE. …”
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