Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover tr... by Xiexiong Zhao, Tao Liu, Qiong Yang, Guoping Yang, Xingli Li, Xiaohong Tang, Jingle Li, Zhongshu Liang, Anying Li, Lixiong Zeng, Juan Wen, Xiaoyan Wang, Liping Peng, Wenjuan Wang, Jingjing Cai, Ye Chen, Miao Huang, Ruixuan Li, Ru Fu, Lin Zhao, Xiaogang Li, Weihong Jiang

“…Conclusions Initiating treatment with half-dose quadruple combination therapy was more effective in lowering blood pressure than standard-dose dual therapy. …”
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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…The therapeutic use of these Nb-Fc fusion proteins was evaluated, either as monotherapy or as combination therapy with anti-programmed cell death protein-1 (anti-PD-1), in both the LLC-OVA and MC38 mouse models.Results We were able to discern two ti-Treg populations, one of which is characterized by the unique expression of Ccr8 in conjunction with Treg activation markers. …”
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Stenotrophomonas maltophilia bacteremia in adult patients with hematological diseases: clinical characteristics and risk factors for 28-day mortality by Wenjing Guo, Qingsong Lin, Jia Li, Xiaomeng Feng, Sisi Zhen, Yingchang Mi, Yizhou Zheng, Fengkui Zhang, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng

“…The preferred treatment is TMP/SMX rather than fluoroquinolones, with combination therapy of TMP/SMX and CSL considered a feasible treatment option.IMPORTANCEThis study, representing the largest cohort of adult hematological patients with SM bacteremia to date, strengthens the validity of existing findings and provides new insights into its clinical management. …”
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Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line by Faeze Vali, Vahid Changizi, Majid Safa

“…However, these methods could only improve the living survival. Nowadays the combined therapy including herbals such as crocin is to study for improving breast cancer treatment. …”
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Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective study by Lucia Scaramella, Stefania Chetcuti Zammit, Reena Sidhu, Maurizio Vecchi, Gian Eugenio Tontini, Nicoletta Nandi, Matilde Topa, Luca Elli

“…Results In total, 957 patients (1,052 VCEs) underwent VCE for SBB (DY 50.6%, no retention); 27 patients (27 VCEs) received direct oral anticoagulants, 87 (88 VCEs) received other anticoagulants, 115 (135 VCEs) received antiplatelet therapy, 198 (218 VCEs) received monotherapy, and 31 (32 VCEs) received combined therapy. There were no differences in the completion rate, findings, and DYs between each subgroup or between monotherapy and combined therapy. …”
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Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…New combination therapies, such as CAR-T therapy modified with TGF-βRII, are also emerging in clinical research. …”
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Percutaneous Vertebroplasty and Facet Blocking for Treating Back Pain Caused by Osteoporotic Vertebral Compression Fracture by Yongquan Cheng, Xiaoliang Wu, Jiawei Shi, Hui Jiang

“…Percutaneous vertebroplasty (PVP) and facet blocking (FB) combined therapy would relieve pain better, but it has not been elucidated. …”
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The Role of Pulmonary Metastasectomy in Breast Cancer with Limited Progression Following CDK4/6 Inhibitor Therapy: A Case Report by Yu-Ting Su, Shang-Hung Chen

“…Due to the progression of pulmonary metastasis following combined therapy with ribociclib and fulvestrant for advanced disease, she underwent PM, which histologically confirmed breast cancer metastasis. …”
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SARS-CoV-2 drug resistance and therapeutic approaches by Sania Batool, Santosh Chokkakula, Ju Hwan Jeong, Yun Hee Baek, Min-Suk Song

“…By examining the complex interactions between the virus and its host, the review advocates for a multifaceted approach, including combination therapies, targeted drug development, and continuous surveillance of viral mutations. …”
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Taking Sides: An Integrative Review of the Impact of Laterality and Polarity on Efficacy of Therapeutic Transcranial Direct Current Stimulation for Anomia in Chronic Poststroke Ap... by Margaret Sandars, Lauren Cloutman, Anna M. Woollams

“…Recommendations for future research to help determine optimal protocols for combined therapy and tDCS are outlined.…”
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Identification of glutamine as a potential therapeutic target in dry eye disease by Xiaoniao Chen, Chuyue Zhang, Fei Peng, Lingling Wu, Deyi Zhuo, Liqiang Wang, Min Zhang, Zhaohui Li, Lei Tian, Ying Jie, Yifei Huang, Xinji Yang, Xiaoqi Li, Fengyang Lei, Yu Cheng

“…In situ metabolomics through matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased glutamine levels in cornea following MSC + Tβ4 combined therapy. Inhibition of glutamine reversed the anti-inflammatory, anti-apoptotic, and homeostasis-preserving effects observed with combined therapy, highlighting the critical role of glutamine in dry eye therapy. …”
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Structural insights into antibody-based immunotherapy for hepatocellular carcinoma by Masaud Shah, Muhammad Hussain, Hyun Goo Woo

“…This review delves into the epitope-paratope interactions of structurally unresolved mAbs and bsAbs, and discusses the potential for combination therapies based on their non-overlapping epitopes. …”
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Periodontal Therapy as an Adjunct to Pulmonary Rehabilitation in Chronic Respiratory Diseases: A Randomized Controlled Trial by Anuj S. Parihar, Neha Khare, Sneha Bayyapu, Maninderjit Kaur, Deepak Kochar, Rashmi Laddha

“…Secondary outcomes included quality of life, inflammatory markers, and periodontal health parameters. Results: The combined therapy group showed significantly greater improvements in FEV1 (P < 0.001), quality of life (P < 0.05), and inflammatory markers (P < 0.01) compared to the PR-only group. …”
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The Potential for Cellular Therapy Combined with Growth Factors in Spinal Cord Injury by Jack Rosner, Pablo Avalos, Frank Acosta, John Liu, Doniel Drazin

“…This paper reviews and discusses the most promising new SCI research including combination therapies.…”
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Multifunctional drug delivery nanoparticles for combined chemotherapy/chemodynamic/photothermal therapy against colorectal cancer through synergistic cuproptosis/ferroptosis/apopto... by Xiuzhang Yan, Heshi Liu, Lei Guo, Chang Liu, Shichen Zhang, Xue Wang, Yixin Tang, Rui Zhou, Xin Jiang, Erlei Wang, Shuohui Gao, Caina Xu

“…The use of combination therapies that employ a variety of cell death mechanisms has emerged as a promising avenue of research in the treatment of cancer. …”
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Effectiveness of Repetitive Facilitative Exercise Combined with Electrical Stimulation Therapy to Improve Very Severe Paretic Upper Limbs in with Stroke Patients: A Randomized Cont... by Hitoshi Ohnishi, Hiroyuki Miyasaka, Naoki Shindo, Kazuki Ito, Shiori Tsuji, Shigeru Sonoda

“…We investigated the effect of combined therapy with RFE and NMES on stroke patients with severe upper paresis. …”
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Combination of dapagliflozin and pioglitazone lacks superiority against monotherapy in streptozotocin-induced nephropathy by Aneta Cinakova, Diana Vavrincova-Yaghi, Peter Krenek, Jan Klimas, Eva Kralova

“…Both dapagliflozin and pioglitazone exert protective character in kidneys when used in monotherapy. The combined therapy does not exhibit an expected additive effect within modulating oxidative stress, NO signalling or apoptosis.…”
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Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology by Emile Youssef, Brandon Fletcher, Dannelle Palmer

“…To overcome these barriers, novel approaches like dual-targeting, armored CAR-T cells, and combination therapies with immune checkpoint inhibitors and ferroptosis inducers are being explored. …”
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Comparing Cisplatin Dosing Schedules in Concurrent Chemoradiotherapy for Locally Advanced Head-and-Neck Cancer: A Comprehensive Review of Weekly Versus 3-Weekly Regimens by Oscar Chi-Yu Yang, Nai-Wen Su, Yi-Shing Leu, Yi-Fang Chang

“…Further randomized controlled trials are required to confirm the optimal cisplatin schedule and efficacy of combinational therapies with novel agents. These findings underline the importance of exploring treatment protocols that balance therapeutic benefits with reduced adverse effects and improved compliance.…”
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Efficacy of daclatasvir and asunaprevir for viral hepatitis С in two donor lung recipients by D. T. Abdurakhmanov, Ye. . Sidorova, I. N. Tikhonov, N. A. Mukhin, V. T. Ivashkin

“…The first cases in Russian literature and one of the first-ever cases of hepatitis C treatment by direct antiviral agents in lung transplant recipients are presented. Combined therapy by asunaprevir and daclatasvir for 24 weeks resulted in sustained virologic response. …”
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