Untangling areas of improvement in secondary prevention of ischemic stroke in patients with atrial fibrillation by F Sánchez-Sáez, CL Rodríguez-Bernal, I Hurtado, J Riera-Arnau, A Garcia-Sempere, Salvador Peiró, G Sanfélix-Gimeno

“…Three ATT strategies were identified: oral anticoagulants (OAC), antiplatelets (APT), or combination therapy (OAC + APT), prescribed to 54%, 23%, and 17% of patients, respectively. …”
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Efficacy of Exenatide Administered Twice Daily in Body Mass Index Reduction in Patients with Type 2 Diabetes Mellitus by Jie Zhang, Tong-Zhang Xian, Yu Teng, Xiuzhi Wang, Ming-Xiao Wu, Chen Li, Weihao Wang, Fuli Man, Xianbo Zhang, Xiaoxia Wang, Li-Xin Guo

“…A total of 27 T2DM patients treated with combination therapy of exenatide twice daily and metformin for 52 weeks were included. …”
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Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report by Shuang Zhao, Shuang Zhao, Qizu Jin, Qi Yang, Jing Liu, Yun Lu, Yun Lu, Haibo Ai

“…This is the first reported case using a multi-target combination therapy for TS. This treatment yielded favorable outcomes and maintained good efficacy during a three-month follow-up period. …”
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Clinical, histopathological and parasitological follow-up of dogs naturally infected by Leishmania infantum before and after miltefosine treatment and associated therapies. by Amábilli de Souza Rosar, Carolina Leite Martins, Álvaro Menin, Carolina Reck, Edmundo Carlos Grisard, Glauber Wagner, Mário Steindel, Patricia Hermes Stoco, Patricia Flavia Quaresma

“…Three dogs were treated exclusively with miltefosine, while eighteen received combination therapy with miltefosine with other treatments such as allopurinol, domperidone and immunotherapy. …”
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Status of the Multidrug Resistance-1 Gene of Plasmodium falciparum in Four Malaria Epidemiological Strata, Two Decades after the Abolition of Chloroquine as First-Line Treatment fo... by David Denis Sofeu-Feugaing, Fabrice Nkengeh Ajonglefac, Marcel Nyuylam Moyeh, Tobias Obejum Apinjoh, Marianne Elodie Essende, Gilchrist Destin Talla Kouam, Stephen Mbigha Ghogomu

“…Chloroquine (CQ) was widely used in Cameroon for decades, but its declining clinical efficacy due to resistance prompted health authorities in 2004 to resort to artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. …”
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Results of a Randomized, Open-Label, Clinical Trial Investigating the Effects of Supplementation with Heracleum persicum Extract as an Adjunctive Therapy for Dyslipidemia by Yunes Panahi, Bahram Pishgoo, Fatemeh Beiraghdar, Zahra Mohammadi Araghi, Amirhossein Sahebkar, Ehsan Abolhasani

“…Apart from HDL-C, the effects of atorvastatin (20 mg/day) on other lipid profile parameters do not appear to be significantly superior to those achieved by combination therapy with H. persicum + atorvastatin (10 mg/day).…”
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Features of therapy selection in patients with glaucoma and “dry eye” syndrome by Zh.G. Oganezova, E.A. Egorov

“…In the presence of contraindications or insufficient effect of the first-choice drugs, it is switched to the second-choice drugs or combination therapy. In this situation, it is preferable to prescribe antiglaucomatous drugs with both pronounced antihypertensive and neuroprotective properties. …”
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Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress by Masoumeh Nouri, Morteza Zarrabi, Safdar Masoumi, Elaheh Khodadoust, Anahita Majmae, Man Amanat, Mahmoud Reza Ashrafi, Massoud Vosough

“…However, there is noconsensus on a standard therapeutic protocol regarding the source of cells, optimal cell dose, timing and frequencyof cell injections, route of administration, or the use of combination therapy. This lack of consensus necessitates acomprehensive investigation to clarify these crucial yet undefined factors in cell-based therapy for CP patients. …”
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Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates by Jersley D. Chirawurah, Felix Ansah, Samuel Blankson, Bridget Adikah, Silas Nkansah Yeboah, Lucas Amenga-Etego, Gordon A. Awandare, Yaw Aniweh

“…These findings suggest that gossypol is effective against P. falciparum and holds potential as part of combination therapy with existing antimalarials. Furthermore, these results may support the identification of new antimalarial agents that are effective against drug-resistant malaria parasites.…”
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New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication by Jennifer H. Gunter, Phoebe L. Sarkar, Amy A. Lubik, Colleen C. Nelson

“…We provide an update on current treatments for advanced prostate cancer and discuss whether metabolic dysfunction, developed during ADT, provides a unique therapeutic window for rapid translation of insulin-sensitising medication as combination therapy with antiandrogen targeting agents for the management of advanced prostate cancer.…”
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Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets by Blatnik Sandra Urek, Dreu Rok, Srčič Stanko

“…The demographic shift toward older population increases the use of combination therapy as polypharmacy. Hydrochlorothiazide (HCTZ), as a model drug, is most commonly used in the treatment of hypertension, congestive heart failure and as a diuretic. …”
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Comparative efficacy of minoxidil alone versus minoxidil combined with low-level laser therapy in the treatment of androgenic alopecia: a systematic review and meta-analysis by Abdulmajeed Alosaimi, Abdullah Algarni, Abdulrahman Alharbi, Abdulmalik Alotaibi, Abdullah Alomairi, Mohannad Alsurayhi, Waleed Alharbi

“…Randomized clinical trials comparing minoxidil monotherapy with minoxidil and LLLT combination therapy were included based on predefined criteria. …”
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Efficacy of Alginate-Antacid Medication in the Treatment of Patients with Gastroesophageal Reflux Disease by O. A. Storonova, A. S. Trukhmanov, V. T. Ivashkin

“…We assess the dynamics of inflammatory process in patients with gastroesophageal reflux disease (GERD) treated with alginate-antacid medication used at conventional dosage, both as a monotherapy and as part of a GERD combination therapy. To this end, we set out to confirm the formation of the layer of unbuffered acidic gastric juice over the gastric chyme after eating, as well as to determine the acidneutralizing effect of alginate-antacid medication upon its interaction with the acidic contents of the stomach.Materials and methods. 36 case records of GERD patients were analyzed (20 women and 16 men, mean age 47.03 years old). …”
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Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade... by Lucie Heinzerling, Michael Fluck, Caroline Robert, Celeste Lebbe, Erika Richtig, Sven D Koch, Ulrike Gnad-Vogt, Tobias Seibel, Thomas Eigentler, Juan Martin-Liberal, Sebastian Ochsenreither, Peter Mohr, Patrick Terheyden, Carsten Weishaupt, Michael Erdmann, Lukas Koch, Ainara Soria, Igor Samoylenko, Jürgen Krauß, Peter Brossart, Franz Georg Bauernfeind, Marina Gonzalez, Peter Wengenmayer, Ioannis Thomas, Artem Poltoratskiy, Marina Sekacheva, Beate Schmitt-Bormann, Gianluca Quintini, Martin Falk, Paula Codó, Arjun Oberoi, Jana Hess, Yulia Semiletova, Casilda Llacer Perez, Oliver Schönborn-Kellenberger

“…No DLTs occurred in the combination therapy dose escalation cohort. The MTD was not formally reached and the RD for expansion was 600 µg. …”
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The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute... by Xiaoxia Wu, Shenqi Lu, Xinhui Zhang, Zhen Yang, Aining Sun, Depei Wu, Huifen Zhou, Miao Miao

“…Blinatumomab in combination with TKIs is safe and effective and hence this combination therapy could be a viable therapeutic option in front‐line treatment of patients with Ph + ALL.…”
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Comparative analysis of real-world data on the efficacy and safety of and adherence to ICS/LABA combinations in asthma management by Hee Sun Park, Jungkuk Lee, Hasung Kim, Seong-Dae Woo

“…Methods Utilizing South Korea’s National Health Insurance Service data, we conducted a population-based cohort study involving patients aged 18–80 years, newly diagnosed with asthma who received ICS/LABA combination therapy between January 2016 and December 2020. …”
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Acute Deterioration of Pulmonary Arterial Hypertension (PAH) in a Patient with Neurofibromatosis Type 1 (NF1) by Seiya Tanaka, Fuko Kawahara, Taro Miyamoto, Satoshi Tsurusaki, Yoshihito Sanuki, Kiyoshi Ozumi, Takashi Harada, Hiromi Tasaki

“…We then administrated upfront combination therapy with macitentan and tadalafil. Mean pulmonary arterial pressure rapidly improved. …”
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Risk Factors for Rebleeding after Emergency Endoscopic Treatment of Dieulafoy Lesion by Yongkang Lai, Jianfang Rong, Zhenhua Zhu, Wangdi Liao, Bimin Li, Yin Zhu, Youxiang Chen, Xu Shu

“…The 30-day rebleeding rate for pure injection therapy (epinephrine, cyanoacrylate, or lauromacrogol injection alone), nonpure injection therapy (argon plasma coagulation, band ligation, and hemoclip application alone), and combination therapy (combination of any >2 methods) was 45.2%, 12.8%, and 11%, respectively. …”
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Cryoablation plus chemotherapy regimen enhance anti-tumor immune response in a mouse model of Lewis lung cancer by Hua Duan, Li Yang, Xueni Fang, Shaohua Yan, Yang Cao, Bingli Qiao, Tian Zhou, Kaiwen Hu

“…Numerous studies have proved that combination therapy based on cryo can activate immunity more effectively and synergistically. …”
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Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Denis Dekugmen Yar

“…Artemether-lumefantrine (AL) is a highly effective and commonly used Artemisinin-based Combination Therapy (ACT) for treating uncomplicated malaria caused by Plasmodium falciparum, including drug-resistant strains. …”
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