First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours by Michael Smith, Aung Naing, Todd Bauer, Kyriakos P Papadopoulos, Osama Rahma, Elena Garralda, Glenn J Hanna, Michael J Pishvaian, Xuejun Chen, Sven Gogov, Omar Saavedra, Howard Kallender, LuLu Cheng, Emil Kuriakose

“…The most common INCB001158-related AEs were fatigue (n=10/107 (9.3%)) and nausea (n=10/107 (9.3%)) with monotherapy and diarrhoea (n=24/147 (16.3%)) and fatigue (n=22/147 (15.0%)) with combination therapy. The highest response rate was seen in the anti–PD-1/PD-L1–naive combination therapy group with head/neck squamous cell carcinoma (overall response rate, 19.2%; 4/26 partial responses, 1/26 complete response). …”
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Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…The improvement of effect may be due to the decrease of MMP-3 and MMP-9 expression in combination therapy.Keywords: bone marrow mesenchymal stem cell, fractional carbon dioxide laser, photoaging, matrix metalloproteinase, mouse model…”
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The effect of repetitive transcranial magnetic stimulation on sleep quality in patients with more than mild depressive mood: a systematic review and meta-analysis by Yu’ang Liu, Silang Huang, Xinxin Zhang, Huangying Liao, Weiguo Liu, Zhi Zhang, Xianhui Qu, Ziwen Wang

“…In terms of whether combination therapy was used or not, compared with the combination therapy group (I2 = 29%, MD = −1.39, 95%CI = −2.30 to −0.48, p = 0.003), the non-combination therapy group had a better treatment effect (I2 = 0%, MD = −2.93, 95%CI = −3.36 to −2.50, p < 0.00001).ConclusionrTMS significantly improves sleep quality in patients with more than mild depression. …”
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National Trends of Antiparkinsonism Treatment in Taiwan: 2004–2011 by Weng-Ming Liu, Ruey-Meei Wu, Chia-Hsuin Chang, Jou-Wei Lin, Ying-Chun Liu, Chin-Hsien Lin

“…Levodopa monotherapy or combination therapy was the mainstay. Levodopa monotherapy comprised 37.4% of prescriptions in 2004 and 44.2% in 2011, with an annual increase rate of 18.14%. …”
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COMBINATION OF ULTRASOUND THERAPY, MUSCLE ENERGY TECHNIQUE, AND SUSTAINED NATURAL APOPHYSEAL GLIDES IN NON-SPECIFIC NECK PAIN – A CASE SERIES by Ni Komang Ayu Juni Antari, Anak Agung Gede Angga Puspa Negara, Made Hendra Satria Nugraha

“…Purpose: To find out the efficacy of the combination therapy in individuals with non-specific neck pain. …”
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IVIG plus Glucocorticoids versus IVIG Alone in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Systematic Review and Meta-Analysis by Robin Rauniyar, Aman Mishra, Sanjeev Kharel, Subarna Giri, Rohit Rauniyar, Shikha Yadav, Gajendra Chaudhary

“…This study supports the use of IVIG with glucocorticoids compared to IVIG alone, as the combination therapy significantly lowered the risk of treatment failure and the need for adjunctive immunomodulatory therapy.…”
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Trends in prescribing sodium‐glucose cotransporter 2 inhibitors for individuals with type 2 diabetes with and without cardiovascular‐renal disease in South Korea, 2015–2021 by Kyoung Hwa Ha, Soyoung Shin, EunJi Na, Dae Jung Kim

“…However, the proportion of individuals receiving monotherapy or dual combination therapy decreased by 9.2 percentage points, whereas the proportion prescribed triple or more combination therapy increased. …”
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Montelukast Use and Patterns of Ambulatory Care among Asian versus Non-Asian Adult Patients with Asthma and/or Allergic Rhinitis in the United States by Joseph Vasey, Shalini Bagga, Huan Huang, Tongsheng Wang, David Thompson

“…**Results:** Overall patterns of use of montelukast were similar for Asian and non-Asian patients, but Asians were more likely to receive it as part of a combination therapy regimen. Changes in treatment regimen followed similar patterns for both groups. …”
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Multidrug-Resistant <i>Acinetobacter baumannii</i>: Risk Factors for Mortality in a Tertiary Care Teaching Hospital by Kristina Černiauskienė, Astra Vitkauskienė

“…Infections caused by <i>A. baumannii</i> strains producing two types of <i>β</i>-lactamases were significantly more often treated with combination therapy than infections caused by strains producing one type of <i>β</i>-lactamase (78.9% vs. 60.0%, <i>p</i> = 0.019). …”
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Edoxaban Monotherapy in Nonvalvular Atrial Fibrillation Patients with Coronary Artery Disease by Daisuke Fukamachi, Yasuo Okumura, Naoya Matsumoto, Eizo Tachibana, Koji Oiwa, Makoto Ichikawa, Hironori Haruta, Kazumiki Nomoto, Ken Arima, Atsushi Hirayama

“…Between March 2018 and June 2020, 147 patients from 8 institutions in Japan were randomized to receive either an edoxaban monotherapy (n = 74) or combination therapy (edoxaban plus clopidogrel, n = 73). …”
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Multimodal Surgical and Medical Treatment for Extensive Rhinocerebral Mucormycosis in an Elderly Diabetic Patient: A Case Report and Literature Review by Paola Di Carlo, Roberto Pirrello, Giuliana Guadagnino, Pierina Richiusa, Antonio Lo Casto, Caterina Sarno, Francesco Moschella, Daniela Cabibi

“…These interventions may include combination therapy. Finally, a judicious multimodal treatment approach can improve appearance and optimize outcome in elderly patients.…”
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Photobiomodulation Can Enhance Stem Cell Viability in Cochlea with Auditory Neuropathy but Does Not Restore Hearing by So-Young Chang, Eunjeong Kim, Nathaniel T. Carpena, Jae-Hun Lee, Doo Hee Kim, Min Young Lee

“…An animal model for secondary neurodegeneration was achieved by KM treatment and was treated by a combination therapy of GFP-mESC and NIR-PBM at 8 weeks of KM treatment. …”
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Trichloroacetic Acid Peeling for Treating Photoaging: A Systematic Review by Irma Bernadette S. Sitohang, Lili Legiawati, Lis Surachmiati Suseno, Fadhila Dea Safira

“…Medium-depth peels using a higher concentration of TCA or as combination therapy are effective as skin resurfacing agents to reduce wrinkles. …”
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Enhanced bacteriostatic effects of phage vB_C4 and cell wall-targeting antibiotic combinations against drug-resistant Aeromonas veronii by Xin Cao, Yanqiong Tang, ZhenZhang Lu, Xiang Ma, Hong Li, Xue Chi, Juanjuan Li, Zhu Liu

“…Additionally, this combination therapy demonstrates significant therapeutic effects on clinical infections mediated by biofilms. …”
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GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury. by Xin Zhang, Xinyu Liu, Qianxi Li, Chenyu Li, Xinyan Li, Jinghua Qian, Jianjun Li, Xuemei Li

“…Results indicate the combination therapy effectively improves histopathology of spinal cord and soleus muscle in SCI rats, enhancing motor function. …”
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Addition of Sildenafil in Patients with Pulmonary Arterial Hypertension with Inadequate Response to Bosentan Monotherapy by Nancy R Porhownik, Hassan Al-Sharif, Zoheir Bshouty

“…BACKGROUND: Pulmonary arterial hypertension (PAH) remains a progressive disease despite improvement when using one of three medication classes: prostanoids, endothelin receptor antagonists or phosphodiesterase-5 inhibitors. Combination therapy has been proposed for patients with unsatisfactory response to monotherapy.…”
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Nursing of a lung cancer patient with cough treated by Traditional Chinese Medicine ointment combined with acupoint sticking therapy (中药膏摩联合穴位贴敷疗法治疗1例肺癌相关性咳嗽患者的护理体会)... by WANG Xingyuan (王兴元), LIU Shuhong (刘书红), ZHANG Zhonghua (张中华)

“…The clinical symptoms of cough were obviously relieved after treatment. The combination therapy of Traditional Chinese Medicine ointment and acupoint sticking therapy can effectively relieve the cough symptoms, enhance clinical treatment and nursing efficacy and improve patient’s quality of life. …”
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Capivasertib enhances chimeric antigen receptor T cell activity in preclinical models of B cell lymphoma by Hui-Ju Hsieh, Ryan Urak, Mary C. Clark, Larry W. Kwak, Stephen J. Forman, Xiuli Wang

“…Since PTEN deficiency is common in cancer and is the main mechanism for capivasertib function, combination therapy may provide an alternative solution for the challenges of CAR T cell therapy.…”
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Symptomatic vigabatrin‐associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms by Rujuta Sathe, Gyaneshwar Shrestha, Aria Terango, David Tabibzadeh, Rajsekar R. Rajaraman, Hiroki Nariai, Shaun A. Hussain

“…However, we have not proven that combination therapy actually causes sVABAM. Further study is needed to clarify the nature of sVABAM and risk factors thereof.…”
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Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity by Eman Aly Khalifa, Ahmed Nabil Ahmed, Khalid Shaaban Hashem, Ahmad Gad Allah

“…Creatinine clearance was significantly higher with combination therapy (group V compared to other groups). …”
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