Showing 301 - 320 results of 328 for search '"cognitive decline"', query time: 0.06s Refine Results
  1. 301

    Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease by Yanan Sun, Cao Ma, Hui Sun, Huan Wang, Wei Peng, Zibo Zhou, Hongwei Wang, Chenchen Pi, Yingai Shi, Xu He

    Published 2020-01-01
    “…Multiple studies have identified an increased risk for AD in some diabetic populations, but it is still unclear which diabetic patients will develop dementia and which biological characteristics can predict cognitive decline. Although few mechanistic metabolic studies have shown clear pathophysiological links between DM and AD, there are several plausible ways this may occur. …”
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  2. 302

    Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice by Xiaohang Wang, Xiaohang Wang, Xiaohang Wang, Qianqian Wang, Zhensheng Cai, Chengming Ni, Huan Wang, Hui Liu, Yusong Zhao, Jinbang Wang, Subo Liu, Xueying Wang

    Published 2025-01-01
    “…We showed that the fluorescence intensities of IL-1β, IL-6, TNF-α, and TGF-β1 in hippocampus were decreased after the Pdpn knocking down in astrocytes of T2DM mice.ConclusionIn summary, this study demonstrates that Pdpn exerts a novel player in T2DM-induced neuroinflammation and cognitive decline. Knocking down Pdpn in astrocytes shows a protective effect in hippocampal inflammation and VaD.…”
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  3. 303

    Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice by Yingbin Lin, Xinqun Luo, Fangyu Wang, Huange Cai, Yuanxiang Lin, Dezhi Kang, Wenhua Fang

    Published 2025-01-01
    “…Results Male aged apoE4-TR mice are more vulnerable to cognitive decline than females. Metformin improves the spatial memory of female, but not male apoE3-TR mice and female apoE4-TR mice while aggravating the cognitive impairment of male apoE4-TR mice. …”
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  4. 304

    Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG by Xin Xin, Qing Liu, Shuqi Jia, Shufan Li, Peng Wang, Xingze Wang, Xing Wang

    Published 2025-01-01
    “…The EEG-specific indicators (B = 0.019, 95% CI: 0.003, 0.047) and information processing speed (B = 0.137, 95% CI: 0.096, 0.292) were found to partially mediate the relationship between grip strength and MoCA scores, with information processing speed exerting a stronger mediating effect.ConclusionSpecific patterns were observed in the EEG of elderly individuals with cognitive impairments, which could objectively assess the risk of cognitive decline in this population. Muscle strength, information processing speed, and EEG-specific biomarkers were closely associated with cognitive function in elderly individuals. …”
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  5. 305

    Diet restriction and exercise alleviate cognitive reduction of high fat diet (HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway throug... by Hu Zhang, Ye Zhang, Jiling Liang, Jiahang Li, Miao He, Xin Liu, Jielun Huang, Minghui Wang, Jingjing Fan, Ning Chen

    Published 2024-11-01
    “…However, further exploration is needed to understand the specific mechanisms of high fat diet (HFD)-induced cognitive decline in obesity. In the present study, 4-month-old mice were subjected to HFD feeding for 18 weeks, followed by aerobic exercise and high-intensity intermittent exercise, regular diet feeding, and intermittent fasting for 8 weeks, and then used to evaluate cognitive capacity, inflammation, compromised insulin signaling pathway, and apoptosis in hippocampal tissue, as well as AMPK/SIRT1 and TLR4 signal pathways. …”
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  6. 306

    Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study by Mark Monane, Demetrius M. Maraganore, Robert M. Carlile, Kim G. Johnson, David A. Merrill, Darren R. Gitelman, Kenneth S. Sharlin, Lawren A. VandeVrede, Kristi K. George, Jimin Wang, Tim West, Leslie Jacobs, Philip B. Verghese, Joel B. Braunstein

    Published 2025-01-01
    “…<b>Methods</b>: The Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey (NCT06025877) study evaluated the clinical utility of the PrecivityAD2™ blood test in a prospective, single cohort of 203 patients presenting with symptoms of Alzheimer’s disease (AD) or other causes of cognitive decline across 12 memory specialists. The PrecivityAD2 blood test (C2N Diagnostics, St. …”
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  7. 307

    Age-related differences in long-term potentiation-like plasticity and short-latency afferent inhibition and their association with cognitive function by Tong Wang, Ying Shen, Tianjiao Zhang, Chuan He, Qian Lu, Jie Song, Manyu Dong, Yilun Qian, Sisi Huang, Jing Teng

    Published 2024-02-01
    “…Thus, the cholinergic system may play a vital role in preventing cognitive decline during normal ageing. In younger individuals, LTP-like plasticity might represent a potential neurophysiological marker for language function.…”
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  8. 308

    Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study by Xiyu Wei, Chao Li, Dongyu Liu, Jieyi Chen, Yumeng Ju, Jin Liu, Bangshan Liu, Yan Zhang

    Published 2025-02-01
    “…However, evidence is lacking in determining the appropriate physical health indicators for early screening of cognitive decline in each domain. Therefore, the current study aimed to establish a comprehensive physical health indicators profile in association with cognitive performance. …”
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  9. 309

    The role of inflammatory system genes in individual differences in nonverbal intelligence by R. F. Enikeeva, A. V. Kazantseva, Yu. D. Davydova, R. N. Mustafin, Z. R. Takhirova, S. B. Malykh, Y. V. Kovas, E. K. Khusnutdinova

    Published 2022-04-01
    “…Within the framework of the present study, we conducted the association analysis of six SNPs in the genes that encode proteins involved in inf lammatory response regulation in the central nervous system (CRP rs3093077, IL1А rs1800587, IL1B rs16944, TNF/ LTA rs1041981, rs1800629, and P2RX7 rs2230912), with nonverbal intelligence in mentally healthy young adults aged 18– 25 years without cognitive decline with inclusion of sex, ethnicity and the presence of the “risky” APOE ε4 allele as covariates. …”
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  10. 310

    Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study by Serena Tagliente, Brigida Minafra, Simona Aresta, Simona Aresta, Paola Santacesaria, Andrea Buccoliero, Cinzia Palmirotta, Gianvito Lagravinese, Davide Mongelli, Christian Gelao, Luigi Macchitella, Stefania Pazzi, Domenico Scrutinio, Paola Baiardi, Petronilla Battista

    Published 2025-01-01
    “…Significant differences were also observed when comparing the HB-CCT with Standard Care, with improved performance in TMT-A (p = 0.02), Phonemic Fluency (p &lt; 0.01), and Digit Span Forward (p &lt; 0.01).DiscussionThese findings suggest that HB-CCT via Neurotablet can effectively enhance specific cognitive abilities in PD, supporting the role of digital, home-based interventions as feasible strategies to mitigate cognitive decline.…”
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  11. 311

    Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors by Shudong Lin, Guanghua Zhu, Juan Xie, Xuanwei Wen, Limin Deng, Sijing Li, Guozhi Liu, Feiyan Wang, Shuangxi Chen, Zijian Xiao

    Published 2025-01-01
    “…ABSTRACT Background and Purpose Cerebral amyloid angiopathy (CAA) is recognized as a major contributor to progressive cognitive decline and cerebral hemorrhages in the elderly population. …”
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  12. 312

    Enriched environment rescues bisphenol A induced anxiety-like behavior and cognitive impairment by modulating synaptic plasticity by Jiong Li, Guangyin Yu, Laijian Wang, Wenjun Zhang, Wenya Ke, Yifei Li, Danlei Liu, Keman Xie, Yuanyuan Xu, Caihui Cha, Guoqing Guo, Jifeng Zhang

    Published 2025-01-01
    “…The findings of this study provide proof that EE has a neuroprotective effect in reducing anxiety-related behavior and cognitive decline caused by BPA.…”
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  13. 313
  14. 314

    Altered regional brain activity and functional connectivity in relation to blood lead levels by Yi Shi, Linfeng Yan, Yang Yang, Fenfen He, Wenhao Li, Jianbin Zhang, Fang Zhao, Diya Wang, Wen Wang, Zaihua Zhao, Xuefeng Shen

    Published 2025-01-01
    “…Abstract Background Lead is a prevalent heavy metal pollutant in the environment, and chronic lead exposure in occupational settings has been linked to cognitive decline. Our objective was to delineate lead-induced changes in brain functional activity through the assessment of regional homogeneity (ReHo), degree centrality (DC) and seed-based functional connectivity (FC) using resting-state functional magnetic resonance imaging (rs-fMRI). …”
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  17. 317

    Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

    Published 2025-02-01
    “…Being on antipsychotics, antidepressants and antidiabetic drugs was associated with increased risk of higher anticholinergic burden.ConclusionIn conclusion, the anticholinergic burden might play a significant role as a risk factor for developing more severe BPSD in patients with cognitive decline, independently from their degree of cognitive impairment.…”
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  18. 318

    Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment by Kai Zhang, Xiaoxia Liu, Siyu Huang, Xinrui Liu, Meiqi Zhao, Chao Xue, Shijun Xia, Jianzeng Dong, Yu Kong, Changsheng Ma

    Published 2025-02-01
    “…Conclusions General CVD patients with abnormal echocardiographic LV diastolic dysfunction and IVST were associated with cognitive decline, suggesting further cognitive assessment for MCI. …”
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  20. 320

    Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF by Shuhei Yamamoto, Saeko Yamasaki, Satoko Higuchi, Kentaro Kamiya, Hiroshi Saito, Kazuya Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Kentaro Jujo, Hiroshi Wada, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Naoki Aizawa, Akihiro Makino, Kazuhiro Oka, Shin‐ichi Momomura, Nobuyuki Kagiyama, Yuya Matsue

    Published 2022-06-01
    “…Abstract Aims Although evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated with prognosis, the impact of concurrent physical frailty and cognitive impairment, that is, cognitive frailty, on prognosis has yet to be fully investigated. …”
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