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301
Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease
Published 2020-01-01“…Multiple studies have identified an increased risk for AD in some diabetic populations, but it is still unclear which diabetic patients will develop dementia and which biological characteristics can predict cognitive decline. Although few mechanistic metabolic studies have shown clear pathophysiological links between DM and AD, there are several plausible ways this may occur. …”
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302
Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice
Published 2025-01-01“…We showed that the fluorescence intensities of IL-1β, IL-6, TNF-α, and TGF-β1 in hippocampus were decreased after the Pdpn knocking down in astrocytes of T2DM mice.ConclusionIn summary, this study demonstrates that Pdpn exerts a novel player in T2DM-induced neuroinflammation and cognitive decline. Knocking down Pdpn in astrocytes shows a protective effect in hippocampal inflammation and VaD.…”
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303
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice
Published 2025-01-01“…Results Male aged apoE4-TR mice are more vulnerable to cognitive decline than females. Metformin improves the spatial memory of female, but not male apoE3-TR mice and female apoE4-TR mice while aggravating the cognitive impairment of male apoE4-TR mice. …”
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304
Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG
Published 2025-01-01“…The EEG-specific indicators (B = 0.019, 95% CI: 0.003, 0.047) and information processing speed (B = 0.137, 95% CI: 0.096, 0.292) were found to partially mediate the relationship between grip strength and MoCA scores, with information processing speed exerting a stronger mediating effect.ConclusionSpecific patterns were observed in the EEG of elderly individuals with cognitive impairments, which could objectively assess the risk of cognitive decline in this population. Muscle strength, information processing speed, and EEG-specific biomarkers were closely associated with cognitive function in elderly individuals. …”
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305
Diet restriction and exercise alleviate cognitive reduction of high fat diet (HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway throug...
Published 2024-11-01“…However, further exploration is needed to understand the specific mechanisms of high fat diet (HFD)-induced cognitive decline in obesity. In the present study, 4-month-old mice were subjected to HFD feeding for 18 weeks, followed by aerobic exercise and high-intensity intermittent exercise, regular diet feeding, and intermittent fasting for 8 weeks, and then used to evaluate cognitive capacity, inflammation, compromised insulin signaling pathway, and apoptosis in hippocampal tissue, as well as AMPK/SIRT1 and TLR4 signal pathways. …”
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306
Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study
Published 2025-01-01“…<b>Methods</b>: The Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey (NCT06025877) study evaluated the clinical utility of the PrecivityAD2™ blood test in a prospective, single cohort of 203 patients presenting with symptoms of Alzheimer’s disease (AD) or other causes of cognitive decline across 12 memory specialists. The PrecivityAD2 blood test (C2N Diagnostics, St. …”
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307
Age-related differences in long-term potentiation-like plasticity and short-latency afferent inhibition and their association with cognitive function
Published 2024-02-01“…Thus, the cholinergic system may play a vital role in preventing cognitive decline during normal ageing. In younger individuals, LTP-like plasticity might represent a potential neurophysiological marker for language function.…”
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308
Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study
Published 2025-02-01“…However, evidence is lacking in determining the appropriate physical health indicators for early screening of cognitive decline in each domain. Therefore, the current study aimed to establish a comprehensive physical health indicators profile in association with cognitive performance. …”
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309
The role of inflammatory system genes in individual differences in nonverbal intelligence
Published 2022-04-01“…Within the framework of the present study, we conducted the association analysis of six SNPs in the genes that encode proteins involved in inf lammatory response regulation in the central nervous system (CRP rs3093077, IL1А rs1800587, IL1B rs16944, TNF/ LTA rs1041981, rs1800629, and P2RX7 rs2230912), with nonverbal intelligence in mentally healthy young adults aged 18– 25 years without cognitive decline with inclusion of sex, ethnicity and the presence of the “risky” APOE ε4 allele as covariates. …”
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310
Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study
Published 2025-01-01“…Significant differences were also observed when comparing the HB-CCT with Standard Care, with improved performance in TMT-A (p = 0.02), Phonemic Fluency (p < 0.01), and Digit Span Forward (p < 0.01).DiscussionThese findings suggest that HB-CCT via Neurotablet can effectively enhance specific cognitive abilities in PD, supporting the role of digital, home-based interventions as feasible strategies to mitigate cognitive decline.…”
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311
Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors
Published 2025-01-01“…ABSTRACT Background and Purpose Cerebral amyloid angiopathy (CAA) is recognized as a major contributor to progressive cognitive decline and cerebral hemorrhages in the elderly population. …”
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312
Enriched environment rescues bisphenol A induced anxiety-like behavior and cognitive impairment by modulating synaptic plasticity
Published 2025-01-01“…The findings of this study provide proof that EE has a neuroprotective effect in reducing anxiety-related behavior and cognitive decline caused by BPA.…”
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313
START—the Swiss tele-assisted rehabilitation and training program to support transition from inpatient to outpatient care in the subacute phase after a stroke: feasibility, safety...
Published 2025-01-01“…IntroductionEffective rehabilitation is essential to prevent physical and cognitive decline, but many stroke patients face challenges to maintain rehabilitation efforts after hospital discharge. …”
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314
Altered regional brain activity and functional connectivity in relation to blood lead levels
Published 2025-01-01“…Abstract Background Lead is a prevalent heavy metal pollutant in the environment, and chronic lead exposure in occupational settings has been linked to cognitive decline. Our objective was to delineate lead-induced changes in brain functional activity through the assessment of regional homogeneity (ReHo), degree centrality (DC) and seed-based functional connectivity (FC) using resting-state functional magnetic resonance imaging (rs-fMRI). …”
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315
Hippocampal connectivity dynamics and volumetric alterations predict cognitive status in migraine: A resting-state fMRI study
Published 2025-01-01“…The etiology of cognitive decline linked to migraine remains unclear, with a growing recurrence rate and potential increased dementia risk among sufferers. …”
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316
Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Multicenter Randomiz...
Published 2020-01-01“…Longitudinal studies are required to determine whether CT may also attenuate cognitive decline in the long term. This trial is registered with DRKS00010186.…”
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317
Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment
Published 2025-02-01“…Being on antipsychotics, antidepressants and antidiabetic drugs was associated with increased risk of higher anticholinergic burden.ConclusionIn conclusion, the anticholinergic burden might play a significant role as a risk factor for developing more severe BPSD in patients with cognitive decline, independently from their degree of cognitive impairment.…”
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318
Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment
Published 2025-02-01“…Conclusions General CVD patients with abnormal echocardiographic LV diastolic dysfunction and IVST were associated with cognitive decline, suggesting further cognitive assessment for MCI. …”
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319
Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease
Published 2025-01-01“…Abstract Cognitive resilience (CR) describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer’s disease neuropathology. …”
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320
Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF
Published 2022-06-01“…Abstract Aims Although evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated with prognosis, the impact of concurrent physical frailty and cognitive impairment, that is, cognitive frailty, on prognosis has yet to be fully investigated. …”
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