Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications by Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

“…Elevated cerebrospinal fluid (CSF) levels of CHI3L1 have been linked to disease severity and cognitive decline, particularly in AD and MS, highlighting its potential for clinical diagnostics. …”
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ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation by Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huang

“…Abstract Delayed radiation-induced brain injury (RIBI) characterized by progressive cognitive decline significantly impacts patient outcomes after radiotherapy. …”
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Association between retinal markers and cognition in older adults: a systematic review by Gerald Liew, Bamini Gopinath, Joyce Chan, Joyce Siette, Varshanie Jeevakumar, Rebekah Sefton, Tejal M Shah

“…Longitudinal studies (n=6) using OCT also mostly identified significant reductions in retinal nerve fibre layer thickness with cognitive decline. Study quality was overall moderate.Conclusion Retinal nerve fibre layer thickness is linked with cognitive performance and therefore may have the potential to detect cognitive impairment in older adults. …”
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Psychosocial, physical, cognitive and quality of life aspects in primary restless legs syndrome by I. Jarašiūnaitė, R. Kaladytė-Lokominienė

“…There is a number of studies on relationship between RLS and cognitive decline, however, their results are controversial. …”
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Playful brains: a possible neurobiological pathway to cognitive health in aging by Yulia Golland, Yulia Golland, Boaz M. Ben-David, Boaz M. Ben-David, Boaz M. Ben-David, Mara Mather, Mara Mather, Mara Mather, Shoshi Keisari, Shoshi Keisari, Shoshi Keisari

“…In older adults, where LC-NA functionality may decline with age, social playfulness could counteract cognitive decline by upregulating this system. We review evidence linking LC-NA integrity to cognitive health and explore how playfulness might mitigate the deterioration of cognitive functioning by training executive functions and promoting novelty and exploration. …”
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The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases by Rojin Sarallah, Shima Jahani, Alireza Soltani Khaboushan, Amir Kian Moaveni, Maryam Amiri, Masoumeh Majidi Zolbin

“…In AD, dysregulation of this axis contributes to amyloid-β accumulation and tau hyperphosphorylation, leading to synaptic dysfunction and cognitive decline. PD studies reveal that CXCL12/CXCR4 signaling influences dopaminergic neuron survival and microglial activation, affecting cognitive function. …”
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Detection of Alzheimer Disease in Neuroimages Using Vision Transformers: Systematic Review and Meta-Analysis by Vivens Mubonanyikuzo, Hongjie Yan, Temitope Emmanuel Komolafe, Liang Zhou, Tao Wu, Nizhuan Wang

“… BackgroundAlzheimer disease (AD) is a progressive condition characterized by cognitive decline and memory loss. Vision transformers (ViTs) are emerging as promising deep learning models in medical imaging, with potential applications in the detection and diagnosis of AD. …”
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Inflammatory and immunological markers and risk for mortality and cognitive impairment in a longitudinal study of older adults from the longevous project by M.R. Caldeira, C.M. Almada-Filho, M.C. Brunialti, R. Salomão, M.S. Cendoroglo

“…However, even slight changes in inflammatory markers can be associated with increased risk for mortality and cognitive decline.…”
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Role of Cannabis in the Management of Chronic Non-Cancer Pain: A Narrative Review by Lou’i Al-Husinat, Shrouq Obeidat, Saif Azzam, Yara Al-Gwairy, Fatima Obeidat, Sarah Al Sharie, Deema Haddad, Fadi Haddad, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Giustino Varrassi

“…Short-term cannabis use can impair cognition and motor skills, while long-term use may lead to dependency and cognitive decline, especially if used from an early age. …”
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Early characterization and prediction of glioblastoma and brain metastasis treatment efficacy using medical imaging-based radiomics and artificial intelligence algorithms by Noémie N. Moreau, Noémie N. Moreau, Samuel Valable, Cyril Jaudet, Loïse Dessoude, Leleu Thomas, Romain Hérault, Romain Modzelewski, Romain Modzelewski, Dinu Stefan, Juliette Thariat, Juliette Thariat, Alexis Lechervy, Aurélien Corroyer-Dulmont, Aurélien Corroyer-Dulmont

“…Even with intensive treatment involving radiotherapy and surgery, which frequently leads to cognitive decline due to doses on healthy brain tissue, the median survival is 15 months for GBM and about 6 to 9 months for BM. …”
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Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults by Hao Shu, Gangyu Ding, Xiaona Xu, Xuerong Huang, Ruqian He

“…Stratified analyses indicated that, in CI participants, higher CSF sTREM1 levels were associated with a more accelerated rate of hippocampal atrophy, whereas no such association was observed in CU participants.ConclusionThese results underscore the complex interplay between neuroinflammation, as reflected by CSF sTREM1 levels, hippocampal atrophy, and cognitive decline. The data suggest that neuroinflammation may contribute differently to hippocampal atrophy rates in CI versus CU individuals, highlighting the potential for targeted anti-inflammatory interventions in the prevention and treatment of AD.…”
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Relevance of anxiety in clinical practice of Guillain-Barré syndrome: a cohort study by Raphaël Porcher, Djillali Annane, Andrea Polito, Tarek Sharshar, Takoua Merhbene, Morgane Blanc, Marion Antona, Marie-Christine Durand, Diane Friedman, David Orlikowski, Marie-Hélène Marcadet

“…Either language barrier or cognitive decline that precluded understanding was considered as exclusion criteria.Primary outcome Acute respiratory failure.Interventions At admission, anxiety and clinical factors (including known predictors of respiratory failure: delay between GBS onset and admission, inability to lift head, vital capacity (VC)) were assessed and related to subsequent need for mechanical ventilation (MV). …”
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Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease by Wen Wu, Yubai Zhao, Xin Cheng, Xiaoru Xie, Yixiu Zeng, Quan Tao, Yishuai Yang, Chuan Xiao, Zhan Zhang, Jiahui Pang, Jian Jin, Hongbo He, Yangyang Lin, Boxing Li, Junxian Ma, Xiaojing Ye, Wei-Jye Lin

“…Abstract Alzheimer’s disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms and treatments remain elusive. …”
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Fatal toxoplasmic encephalitis triggered by anti-TNF therapy by Rodrigo A. Montoro, Michael Moran, Katherine A. Overmyer, Andrew Periaccante, Joshua J. Coon, Swapnil Lanjewar, Laura J. Knoll, Rob Striker

“…Lumbar puncture ruled out bacterial or viral meningitis. With continued cognitive decline, magnetic resonance imaging of the head revealed an increased number of lesions with T. gondii-associated ring-enhancing lesions. …”
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Relationship between Obesity and Cognitive Function in Young Women: The Food, Mood and Mind Study by Rebecca L. Cook, Nicholas J. O’Dwyer, Cheyne E. Donges, Helen M. Parker, Hoi Lun Cheng, Katharine S. Steinbeck, Eka P. Cox, Janet L. Franklin, Manohar L. Garg, Kieron B. Rooney, Helen T. O’Connor

“…This may indicate early cognitive decline, but longitudinal research confirming these findings is warranted.…”
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Correlation between depressive symptoms and cognitive function in middle-aged and elderly population in China: an analysis of CHARLS baseline data by Yuchao SUN, Jing FENG, Zihui LEI, Ge QU, Xinyan LI, Yong GAN

“…The results of multiple linear stepwise regression showed that being female (B = – 0.31), being older (B60 – 69 years = – 0.19; B70 – 79 years = – 1.18; B80 – 89 years = – 2.12; B ≥ 90 years = – 3.66), living in central and western regions (Bcentral = – 0.36; Bwestern = – 0.57), smoking (B = – 0.15), and having depressive symptoms (Bmild to moderate = – 0.90; Bsevere = – 1.51) were risk factors for cognitive decline; further stratified analysis revealed that depressive symptoms had a significant negative impact on cognitive function in middle-aged and older adults across gender, residential area, and region of life, with higher levels of depression associated with poorer cognitive function. …”
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Neurofilament Light Chain Levels in Serum and Cerebrospinal Fluid Do Not Correlate with Survival Times in Patients with Prion Disease by Mika Shimamura, Kong Weijie, Toshiaki Nonaka, Koki Kosami, Ryusuke Ae, Koji Fujita, Taiki Matsubayashi, Tadashi Tsukamoto, Nobuo Sanjo, Katsuya Satoh

“…This accumulation disrupts neuronal functions, leading to the rapid onset of psychiatric symptoms, ataxia, and cognitive decline. The urgency of timely diagnosis for effective treatment necessitates the identification of strongly correlated biomarkers in bodily fluids, which makes our research crucial. …”
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Static and dynamic brain functional connectivity patterns in patients with unilateral moderate-to-severe asymptomatic carotid stenosis by Junjun Wang, Junjun Wang, Linfeng Song, Binlin Tian, Li Yang, Xiaoyu Gu, Xu Chen, Lei Gao, Lin Jiang

“…Further imaging-behavior associations identified static and dynamic functional connectivity patterns that reflect cognitive decline.ResultsACS patients showed altered functional connectivity in multiple brain regions and networks compared to controls. …”
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Multisensory Stimulation in Rehabilitation of Dementia: A Systematic Review by Andrea Calderone, Angela Marra, Rosaria De Luca, Desirèe Latella, Francesco Corallo, Angelo Quartarone, Francesco Tomaiuolo, Rocco Salvatore Calabrò

“…<b>Background/Objectives</b>: Dementia leads to cognitive decline, affecting memory, reasoning, and daily activities, often requiring full-time care. …”
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Age-related changes in DNA methylation in a sample of elderly Brazilians by Hayley Welsh, Caio M. P. F. Batalha, Weili Li, Nadja C. Souza-Pinto, Yeda A. O. Duarte, Michel S. Naslavsky, Esteban J. Parra

“…The enrichment of these sites could provide evidence for age-related neurodegeneration and cognitive decline in elderly populations.…”
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