The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models by Andrew D. Winters, Dina M. Francescutti, David J. Kracht, Diptaraj S. Chaudhari, Branislava Zagorac, Mariana Angoa-Perez

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Limb Pain as Unusual Presentation of a Parietal Intraparenchymal Bleeding Associated with Crack Cocaine Use: A Case Report by Alan Lucerna, James Espinosa, Taimur Zaman, Risha Hertz, Douglas Stranges

“…Here we present a case of a 65-year-old male with complaints of left arm pain and allodynia (specifically light touch to any part of the left arm produced significant discomfort) who was found to have a right parietal lobe intraparenchymal bleed after smoking crack cocaine. Acute central pain is mainly associated with parietal, thalamic, and brainstem lesions. …”
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Nanoarchitectonics of Biofunctionalized Hydrogen‐Terminated 2D‐Germanane Heterostructures as Highly Sensitive Biorecognition Transducers: The Case Study of Cocaine Drug by Yiming Lei, Ángel Campos‐Lendínez, Xavier Sala, Jordi García‐Antón, Jose Muñoz

“…After an accurate material characterization, the resulting ssDNA/Au@GeH heterostructure is drop‐casted on a fluorine‐doped tin oxide (FTO) electrode for impedimetrically monitoring cocaine as a model drug. Interestingly, the aptamer–cocaine interactions hinder the interfacial electron‐transfer process of the benchmark [Fe(CN)6]3−/4− redox marker with increasing concentration of the cocaine target, leading to a detection limit as low as 4.9 ± 0.1 aM, the lowest one reported in literature by far. …”
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Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats by Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella L. Cruz, Marian T. Sepulveda-Orengo, Richard J. Noel

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Corrigendum to “Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait” by M. Rodríguez-Arias, C. Roger-Sánchez, I. Villanova, N. Revert, C. Manzanedo, J. Miñarro, M. A. Aguilar

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Contemporary decongestant practices of Canadian otolaryngologists for endoscopic sinus surgery by Jonathan W. Reid, Brian W. Rotenberg, Leigh J Sowerby

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The Drug-Trafficking Economy and Its Dynamics in Latin America by Daniel Pontón C.

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Editorial: Pharmacogenetics of psychiatric disorders by Sarah Allegra, Silvia De Francia, Stefano Comità, Maria Grazia Morgese, Thomas M. Polasek

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Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial. by Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John E Walker, Tim Matheson, Matthew McLaughlin, Jennifer Jain, Eric Vittinghoff, Steven L Batki

“…<h4>Objective</h4>To determine if men who have sex with men (MSM) with cocaine use disorder (CUD) and actively-using cocaine could be enrolled and retained in a pharmacologic intervention trial of lorcaserin-a novel 5-HT2cR agonist-and determine the degree to which participants would adhere to study procedures.…”
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Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes by Dasiel O. Borroto-Escuela, Karolina Wydra, Julia Pintsuk, Manuel Narvaez, Fidel Corrales, Magdalena Zaniewska, Luigi F. Agnati, Rafael Franco, Sergio Tanganelli, Luca Ferraro, Malgorzata Filip, Kjell Fuxe

“…Studies with A2AR ligands using cocaine self-administration procedures indicate that antagonistic allosteric A2AR-D2R heterocomplexes of the ventral striatopallidal GABA antireward pathway play a significant role in reducing cocaine induced reward, motivation, and cocaine seeking. …”
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Electrophysiological properties of melanin-concentrating hormone neuron subpopulations defined by anatomical localization and CART expression by Rafiat Damilola Adekunle, Mohammed Sohel Chowdhury, Lisa Z. Fang, Michiru Hirasawa

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Sociodemographic factors of violent deaths related to licit or ilicit psychoactive substances: a cross-sectional study, Ceará, Brazil, 2015-2019 by Wanderley Pinheiro de Holanda Júnior, Raimunda Hermelinda Maia Maceno, Maria Augusta Drago Ferreira

“…Association was found between benzodiazepines (29.5%) and tricyclic antidepressants (15.6%) and suicides; cocaine (28.1%) and cannabis (27.1%) and homicides; and cocaine (28.2%) and tricyclic antidepressants (5.9%) and suspicious deaths. …”
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Ameaça e caráter transnacional do narcotráfico na Amazônia brasileira by Aiala Colares Couto

“…The results of thes cientific research point to the existence of a transnational dynamic of organized crime in the region that incorporates in its networks some strategic cities for the spatial organization of cocaine flows.…”
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Fluorescence‐Based Detector Design Principles for Low Vapor Pressure Analytes by Alex S. Loch, Paul L. Burn, Paul E. Shaw

“…The detection platform is able to detect trace amounts (down to 30 ng) of (±)‐3,4‐methylenedioxyamphetamine hydrochloride (MDA•HCl), along with other common illicit drug salts such as cocaine hydrochloride (cocaine•HCl), fentanyl•HCl, and methamphetamine•HCl (MA•HCl).…”
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Green analysis of illicit drugs on banknote dust by Teresa Cecchi, Arianna Giuliani, Carlo Catini

“…No illicit drugs were found except cocaine in banknote dust. Its concentration ranged only one order of magnitude, from 2.76E+02 to 4.01E+03 mg of cocaine per gram of banknote dust, in agreement with previous results obtained with methanol as an extractant and organic modifier. …”
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Illicit drug use derived from wastewater-based epidemiology in Iran, their removal during wastewater treatment, and occurrence in receiving waters by Anvar Asadi, Shabnam Zarei, Nebile Daglioglu, Evsen Yavuz Guzel, Neda Ravankhah

“…There was no detection of cocaine, its metabolite benzoylecgonine, or 3,4-methylenedioxymethamphetamine in any of the samples. …”
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Coca: The History and Medical Significance of an Ancient Andean Tradition by Amy Sue Biondich, Jeremy David Joslin

“…Coca is also the whole plant from which cocaine is derived. Coca products are thought to be a panacea for health troubles in regions of South America. …”
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The Main Coronary Artery (LMCA) Thrombus Presented as an ST Elevation Myocardial Infarction in a Hypercoagulable Patient by Nithin Gottam, Douglas Stewart, Hiroshi Yamasaki, Mohamad Ajjour

“…Left main coronary artery (LMCA) thrombus is a clinically rare event and is thought to be secondary to plaque rupture with subsequent thrombus formation, persistent hypercoagulable state, cocaine use, or vasospasm. (Klein et al., 2008) here we present a case of LMCA thrombus that presented as an ST elevation myocardial infarction (STEMI) in a hypercoagulable patient.…”
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Astrocytes Control Neuronal Excitability in the Nucleus Accumbens by Tommaso Fellin, Marcello D'Ascenzo, Philip G. Haydon

“…Though accumulating evidence shows that the metabotropic glutamate receptor 5 (mGluR5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood. …”
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Levamisole-Induced immune phenomenon and its various clinical manifestations in children: Two case reports along with review of literature by Anu Punnen Kocheril, T Sathish Kumar, Dharshini Sathishkumar

“…In literature, levamisole-induced immune manifestations were described mostly in association with its use in treatment of rheumatoid arthritis, malignancies, and recently, in relation to the use of illicit cocaine contaminated with levamisole among adults. …”
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