Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study by Paul Ewings, Emma Dures, Sarah Hewlett, Joanna Thorn, Mwidimi Ndosi, Siobhan Creanor, Jo Adams, Lance M McCracken, Joe Lomax, Susan Bridgewater, Bryan Abbott, Alice Berry, Marie Urban

“…The Fatigue - Reducing its Effects through individualised support Episodes in Inflammatory Arthritis (FREE-IA) study tested the feasibility of RHP training, intervention delivery and outcome collection ahead of a potential trial of clinical and cost-effectiveness.Methods In this single-arm feasibility study, eligible patients were ≥18 years, had a clinician-confirmed diagnosis of an inflammatory arthritis and scored ≥6/10 on the Bristol Rheumatoid Arthritis Fatigue (BRAF) Numerical Rating Scale (NRS) Fatigue Effect. …”
Get full text

Estimating the Need for Sedation in Patients with Dental Anxiety and Medical Complexities Reporting to Tertiary Care Dental Hospital Using the IOSN Tool by Beenish Abbas, Ayesha Maqsood, Syeda Rabia Rahat Geelani, Madeeha Sattar, Majida Rahim, Zohaib Khurshid

“…A simple assessment tool can enable clinicians in their decision making to identify patients in need for dental treatment under sedation based on patient-specific risk factors such as past traumatic dental experiences. …”
Get full text

Knowledge translation initiatives at the Transitional Pain Service: insights from healthcare provider outreach and patient education by Anna M. Lomanowska, Rabia Tahir, Christina Choo, Sabrina Zhu, Dora Y. Wang, P. Maxwell Slepian, Joel Katz, Hance Clarke

“…Guided by the Knowledge to Action (KTA) framework, knowledge translation activities undertaken by our TPS team include clinician training, resources and outreach activities for providers, and patient education. …”
Get full text

Concurrent Intracranial and Spinal Subdural Hematoma in a Teenage Athlete: A Case Report of This Rare Entity by Daniel S. Treister, Sara E. Kingston, Gabriel Zada, Manu Singh, Jesse G. A. Jones, Jena N. Mills, Alexander Lerner, Orest B. Boyko, Meng Law, Anandh Rajamohan, Mark S. Shiroishi

“…Viral meningitis was suspected by the primary clinician, and treatment with corticosteroids was initiated. …”
Get full text

Real-world clinical experience with secukinumab in psoriatic arthritis: an observational study and a literature review by Eleonora Celletti, Giulio Gualdi, Emanuela Sabatini, Francesco Cipollone, Fabio Lobefaro, Paolo Amerio

“…Both patient-oriented and clinician-oriented outcomes showed a significant improvement with this treatment. …”
Get full text

Virtual online consultations: advantages and limitations (VOCAL) study by Trisha Greenhalgh, Joe Wherton, Sara Shaw, Charles Gutteridge, Emma Byrne, Isabel Hodkinson, Shanti Vijayaraghavan, Desirée Campbell-Richards, Satya Bhattacharya, Philippa Hanson, Seendy Ramoutar, Anna Collard, Joanne Morris

“…Introduction Remote video consultations between clinician and patient are technically possible and increasingly acceptable. …”
Get full text

Automated process assessment of primary healthcare for hyperlipidemia: preliminary findings and implications form Anhui, China by Ningjing Yang, Yuning Wang, Ying Li, Dongying Xiao, Ruirui Cui, Nana Li, Rong Liu, Jing Chai, Xingrong Shen, Debin Wang

“…Results The study revealed interesting findings including: low and varied rates of visits for HL(from 0.01 to 1.43%) and visits by patients with EDHL/CNHL(from 0.13 to 20.54% or from 0.02 to 2.99%) between regions; large differences (5.14 to 22.20 times) between the mean or cumulative proportions of visits by patients with EDHL versus CNHL among clinician groups; consistent increase in the ratio of visits for HL in all cause visits over the study period (from 0.087 to 1.000%) accompanied with relatively stable proportions of patients with CNHL/EDHL; Relatively low scores in the procedure-based measures (ranged from 0.00 to 36.08% for specific procedures by seasons). …”
Get full text

A novel interpretable deep learning model for diagnosis in emergency department dyspnoea patients based on complete data from an entire health care system. by Ellen T Heyman, Awais Ashfaq, Ulf Ekelund, Mattias Ohlsson, Jonas Björk, Ardavan M Khoshnood, Markus Lingman

“…For each unique patient visit, the model selected the most important variables, analysed them and presented them to the clinician interpretably by taking event time and clinical context into account. …”
Get full text

Impact of Order Set on Exocrine Pancreatic Insufficiency in Chronic Pancreatitis, Pancreatic Cancer, and Pancreatic Resection by Michael Ladna, Ishaan Madhok, Adnan Bhat, Nicole Ruiz, Jackson Brown, Jake Wilson, Peter Jiang, Robert Taylor, Mark Radetic, John George, Christopher Forsmark

“…The BPA fired if the patient was already on PERT or if an order for PERT was placed and directed the clinician to the smart set which provided PERT formulations each prefilled to the minimum therapeutic dose of 40,000 units of lipase. …”
Get full text

The Potential Clinical Utility of the Customized Large Language Model in Gastroenterology: A Pilot Study by Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee, Jonghyung Park, Eunsil Kim, Subeen Kim, Minjae Kimm, Seoung-Ho Choi

“…However, RAG capabilities by enabling real-time retrieval of external data not included in the training dataset, appear essential for managing complex, specialized content, and clinician oversight will remain crucial to ensure safe and effective use in clinical practice.…”
Get full text

Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials by Igho J Onakpoya, Elizabeth T Thomas, Joseph J Lee, Ben Goldacre, Carl J Heneghan

“…Our secondary outcomes were sleep disturbance, quality of life, Patient Global Impression of Change, Clinician Global Impression scale, anxiety and depression scores, overall discontinuations and discontinuations because of adverse events.Results We included 28 trials comprising 6087 participants. …”
Get full text

Current state and promise of user-centered design to harness explainable AI in clinical decision-support systems for patients with CNS tumors by Eric W. Prince, Eric W. Prince, Eric W. Prince, David M. Mirsky, David M. Mirsky, Todd C. Hankinson, Todd C. Hankinson, Carsten Görg, Carsten Görg

“…Explainable AI (XAI) methods aim to improve trustworthiness and informativeness, but their success depends on considering end-users’ (clinicians') specific context and preferences. User-Centered Design (UCD) prioritizes user needs in an iterative design process, involving users throughout, providing an opportunity to design XAI systems tailored to clinical neuro-oncology. …”
Get full text

mHealth-Augmented Care for Reducing Depression Symptom Severity Among Patients With Chronic Pain: Exploratory, Retrospective Cohort Study by Dan Holley, Amanda Brooks, Matthew Hartz, Sudhir Rao, Thomas Zaubler

“…We evaluated changes in depression severity between treatment cohorts via longitudinal analyses of both clinician- and mHealth-administered Patient Health Questionnaire-9 (PHQ-9) assessments. …”
Get full text

Improvement of a MALDI-TOF database for the reliable identification of Candidozyma auris (formally Candida auris) and related species by Hui-Hui Zhu, Miao-Miao Liu, Teun Boekhout, Qi-Ming Wang

“…Thus, MALDI-TOF MS may help expedite laboratory diagnosis and treatment of C. auris and related species of clinical importance and help the clinician to decide on early treatment.…”
Get full text

AI Interventions to Alleviate Healthcare Shortages and Enhance Work Conditions in Critical Care: Qualitative Analysis by Nadine Bienefeld, Emanuela Keller, Gudela Grote

“… BackgroundThe escalating global scarcity of skilled health care professionals is a critical concern, further exacerbated by rising stress levels and clinician burnout rates. Artificial intelligence (AI) has surfaced as a potential resource to alleviate these challenges. …”
Get full text

E-HEART score: A novel scoring system for undifferentiated chest pain in the emergency department by V. Yuvaraj, Sachin Sujir Nayak, S. Vimal Krishnan

“…CONCLUSION: The E-HEART score gives the clinician a quick and accurate forecast of outcomes in undifferentiated chest pain presenting to the ED. …”
Get full text

Intricacies of human–AI interaction in dynamic decision-making for precision oncology by Dipesh Niraula, Kyle C. Cuneo, Ivo D. Dinov, Brian D. Gonzalez, Jamalina B. Jamaluddin, Jionghua Judy Jin, Yi Luo, Martha M. Matuszak, Randall K. Ten Haken, Alex K. Bryant, Thomas J. Dilling, Michael P. Dykstra, Jessica M. Frakes, Casey L. Liveringhouse, Sean R. Miller, Matthew N. Mills, Russell F. Palm, Samuel N. Regan, Anupam Rishi, Javier F. Torres-Roca, Hsiang-Hsuan Michael Yu, Issam El Naqa

“…Abstract AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals’ cancer progression for effective personalized care. …”
Get full text

Ketamine effects on resting state functional brain connectivity in major depressive disorder patients: a hypothesis-driven analysis based on a network model of depression by Kasper Recourt, Joop Van Gerven, Joop Van Gerven, Nadieh Drenth, Jeroen van der Grond, Kantaro Nishigori, Nic J. Van Der Wee, Gabriël E. Jacobs, Gabriël E. Jacobs

“…We applied resting-state functional magnetic resonance imaging (rs-fMRI) to explore changes in functional brain connectivity directly at 50, 80 and 165 min (acute) and 24 h (delayed) following ketamine administration. A clinician-rated 10-item scale (MADRS) was administered at 165 min and 24 h after ketamine administration. …”
Get full text

Defining the Need for Causal Inference to Understand the Impact of Social Determinants of Health: A Primer on Behalf of the Consortium for the Holistic Assessment of Risk in Transp... by Nrupen A. Bhavsar, PhD, Rachel E. Patzer, PhD, David J. Taber, PharmD, Katie Ross-Driscoll, PhD, Rhiannon Deierhoi Reed, PhD, Juan C. Caicedo-Ramirez, MD, Elisa J. Gordon, PhD, MPH, Roland A. Matsouaka, PhD, Ursula Rogers, BS, Wendy Webster, MBA, Andrew Adams, MD, PhD, Allan D. Kirk, MD, Lisa M. McElroy, MD

“…We illustrate that biases can arise due to socioeconomic status, race/ethnicity, and incongruencies in language between the patient and clinician. Conclusions:. Progress towards an equitable transplant system requires establishing causal pathways between psychosocial risk factors, access, and outcomes. …”
Get full text

Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…The findings arising from the Delphi process provide valuable insights into the unmet needs in the management of moderate-to-severe ulcerative colitis from the clinician’s perspective, while emphasising the benefits of therapeutic individualization and suggesting areas that need additional study with the aim of optimising the treatment of patients with ulcerative colitis.…”
Get full text