Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis by Bong-Ki Hong, Sungyong You, Jung Gon Kim, Jung Gon Kim, Minhyung Kim, Naeun Lee, Kijun Lee, Kijun Lee, In-Pyo Baek, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju, Wan-Uk Kim, Wan-Uk Kim, Ho-Youn Kim

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Evaluation of a new biomarker 14-3-3 Eta protein in diagnosis of rheumatoid arthritis by Lakshmi Deepika Yarlagadda, Rachel Jacob, D Liza Rajasekhar, Krishna Mohan Iyyapu, Sai Baba S S. Kompella, Vijaya Bhaskar Madrol, N N Sreedevi, Siraj Ahmed Khan, Noorjahan Mohammed

Subjects: “…anti-citrullinated peptide antibodies…”
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Revisiting the Link Between HLA‐DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non‐Shared Epitope Alleles *09 and *15 With High Levels of Anti–Citrullinated Peptide/Protein Antibodies by Denis Lagutkin, Luis Panaifo, Ahmad‐Fauzi Nurul‐Aain, Lena Israelsson, Monika Hansson, Karin Lundberg, Lars Alfredsson, Johan Askling, RACI consortium, Lars Klareskog, Chun‐Lai Too, Leonid Padyukov

“…We focused on a quantitative analysis of the levels of anti–cyclic citrullinated peptide IgG antibodies, including those falling below the diagnostic threshold. …”
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Enhancing newborn screening sensitivity and specificity for missed NICCD using selected amino acids and acylcarnitines by Peiyao Wang, Lingwei Hu, Yuhe Chen, Duo Zhou, Shasha Zhu, Ting Zhang, Ziyan Cen, Qimin He, Benqing Wu, Xinwen Huang

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Establishment and evaluation of a method for measuring ornithine transcarbamylase activity in micro blood of neonates by Zhilei Zhang, Xin Wang, Jingjing Zhang, Xianwei Guan, Yanyun Wang, Dongyang Hong, Yahong Li, Peiying Yang, Yun Sun, Tao Jiang

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Prognostic importance of human leukocyte antigen DRβ1 gene and protein tyrosine phosphatase nonreceptor Type 22 gene polymorphism in rheumatoid arthritis by Pramod Kumar Verma, Usha Singh, Shyam Kumar Saraf, Narendra Kumar Singh

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Factors predicting early discontinuation of methotrexate as a first-line treatment for rheumatoid arthritis in Italy: Results from the GISEA registry by Andreina Manfredi, Marco Sebastiani, Florenzo Iannone, Elisa Gremese, Alessandra Bortoluzzi, Ennio Favalli, Roberto Gorla, Fausto Salaffi, Enrico Fusaro, Rosario Foti, Luca Cantarini, Roberto Caporali, Alberto Cauli, Stefano Alivernini, Francesco Paolo Cantatore, Antonio Carletto, Fabrizio Conti, Salvatore D'Angelo1, Oscar Epis, Roberta Ramonda, Antonio Marchesoni, Gianfranco Ferraccioli, Giovanni Lapadula

Subjects: “…anti-citrullinated protein antibodies…”
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Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils by Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey, Robert Bucki

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The PerioGene North study reveals that periodontal inflammation and advanced jawbone loss in periodontitis associate with serum gingipain antibodies but not with systemic autoimmun... by Elin Kindstedt, Elin Kindstedt, Charlotte de Vries, Magnus Wänman, Barbara Aleksandra Potempa, Jan Potempa, Jan Potempa, Susanne Lindquist, Anders Esberg, Karin Lundberg, Pernilla Lundberg

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A study of serum YKL-40 and its correlation with traditional biomarkers in rheumatoid arthritis patients by Vinod Narayan, Vasanthi Pallinti, Nalini Ganesan

Subjects: “…anti-cyclic citrullinated peptide…”
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SLC7A5 is required for cancer cell growth under arginine-limited conditions by Kyle N. Dunlap, Austin Bender, Alexis Bowles, Alex J. Bott, Joshua Tay, Allie H. Grossmann, Jared Rutter, Gregory S. Ducker

“…Our screen identified the SLC-family transporter SLC7A5 as required for growth, and we hypothesized that this protein functions as a high-affinity citrulline transporter. Using isotope tracing experiments, we show that citrulline uptake and metabolism into arginine are dependent upon expression of SLC7A5. …”
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Deciphering of differences in gut microbiota and plasma metabolites profile between non-obese and obese Golden Retrievers dogs by Yazhen Cai, Huayu Tang, Guilin Xiang, Hongyu Yi, Jie Zhong, Zhaoxi Xie, Qinfeng Hu, Romaissaa El Bouhi, Pan Zhou, Yong Zhang, Honglin Yan

“…Plasma concentrations of citrulline and 11-dehydrocorticosterone were significantly higher in the Obe group than those in the Ctrl group (p < 0.05). …”
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The role of Ashwagandha in modulating gut parameters in dogs—a randomized double-blind placebo-controlled trial by Kala Kumar Bharani, Ashok Kumar Devarasetti, Rajendar Bobbili, Amit Khurana, Donga Durga Veera Hanuman, Roupesh Gudepu, Swapna Guda

“…In addition, the levels of L-citrulline were significantly modulated by ARE intervention, whereas the intervention did not affect intestinal-type alkaline phosphatase (I-ALP), lactate, and carbamoyl-phosphate synthase (CPS). …”
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Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis by Judith Giroud-Gerbetant, Fernando Sotillo, Gonzalo Hernández, Irene Ruano, David Sebastián, Joana Fort, Mayka Sánchez, Günter Weiss, Neus Prats, Antonio Zorzano, Manuel Palacín, Susanna Bodoy

“…Given the limitations of current citrulline-based treatments and the unknown role of SLC7A7 in red blood cell production, there is an urgent need to investigate the pathways affected by SLC7A7 deficiency. …”
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Oxidized Lipoproteins Suppress Nitric Oxide Synthase in Macrophages: Study of Glucocorticoid Receptor Involvement by K. E. Matthys, P. G. Jorens, B. Marescau, M. Rosseneu, H. Bult, A. G. Herman

“…Loading with oxLDL caused a small induction of NOS activity in unstimulated cells, as indicated by nitrite and citrulline accumulation in the supernatant. However, it suppressed the iNOS activity resulting from stimulation of the cells with lipopolysaccharide with or without interferon-γ. …”
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Modulation of nitric oxide synthase activity in macrophages by P. G. Jorens, K. E. Matthys, H. Bult

“…L-Arginine is converted to the highly reactive and unstable nitric oxide (NO) and L-citrulline by an enzyme named nitric oxide synthase (NOS). …”
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Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. by Monica G Ferrini, Andrea Abraham, Revecca Millán, Leslie Graciano, Sriram V Eleswarapu, Jacob Rajfer

“…The nutraceutical COMP-4 -consisting of L-citrulline, ginger extract, and herbal components Paullinia cupana and muira puama-has been shown previously to stimulate the production of nitric oxide (NO) in a variety of tissue types. …”
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Anticholinesterase Toxicity and Oxidative Stress by Dejan Milatovic, Ramesh C. Gupta, Michael Aschner

“…OPs and CMs cause excessive formation of F2-isoprostanes and F4-neuroprostanes, in vivo biomarkers of lipid peroxidation and generation of reactive oxygen species (ROS), and of citrulline, a marker of NO/NOS and reactive nitrogen species (RNS) generation. …”
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Evaluation of Plasma Amino Acid Levels in Preterm Infants and Their Potential Correlation with Retinopathy of Prematurity by Yasin Ozcan, Gumus Huseyin, Kenan Sonmez

“…No significant differences were determined between the groups in terms of alanine, asparagine, valine, leucine, phenylalanine, tyrosine, serine, proline, citrulline, cysteine, ornithine, tryptophan, methionine, threonine, taurine, and isoleucine amino acids (p>0.05, respectively). …”
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Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms by Amaia Rodríguez, Javier Gómez-Ambrosi, Victoria Catalán, Ana Fortuño, Gema Frühbeck

“…NO and NO synthase (NOS) activity were assessed by the Griess and 3H-arginine/citrulline conversion assays, respectively. Inducible NOS (iNOS) and NADPH oxidase subutnit Nox2 expression was determined by Western-blot. …”
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