Potential benefits of GLP-1 analogues and metformin in patients with osteoarthritis by Anna Skowronek, Martyna Piekarska, Katarzyna Dąbek, Michał Ochwat, Maria Sudoł, Gabriela Mierzwa, Aleksandra Kajtel, Tomasz Skowronek

“…It is the primary cause of chronic pain. Known risk factors for OA include obesity and type 2 diabetes mellitus (T2DM). …”
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Moxibustion for Herpes Zoster and Postherpetic Neuralgia: A Meta-Analysis by Yuanen Huang, Jingping Wu, Hongbin Cheng, Yanling Liu

“…At the same time, more than 9 to 34 percent of patients have postherpetic neuralgia (PHN) present with chronic pain for months or even years. Moxibustion has been used to treat herpes zoster and postherpetic neuralgia for many years; however, there has been no comprehensive study to evaluate the efficacy and safety of moxibustion in the treatment of herpes zoster and postherpetic neuralgia. …”
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Comparative effectiveness of manual therapy, pharmacological treatment, exercise therapy, and education for neck pain (COMPETE study): protocol of a systematic review with network... by Ana Izabela Sobral de Oliveira-Souza, Jordana Barbosa-Silva, Douglas P. Gross, Bruno R. da Costa, Nikolaus Ballenberger, Tiago V. Pereira, Liz Dennett, Susan Armijo-Olivo

“…., medication) to manage all types of neck pain based on the chronicity of the disease (acute, subacute, and chronic pain). However, there is scarce evidence to determine which interventions constitute the most effective strategy for this condition. …”
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A Retrospective Case Series of a Novel Spinal Cord Stimulator Trial Technique with Less Displacement and Migration of the Trial Leads by N. Shaparin, K. Gritsenko, P. Agrawal, S. Kim, S. Wahezi, A. Gitkind, J. Hascalovici, A. Vydyanathan, J. Bernstein, A. Dizdarevic, N. Mehta, A. Kaufman

“…Spinal cord stimulation is an established treatment option for certain chronic pain conditions which have been previously unresponsive to conservative therapies or potentially for a subset of patients who have not improved following spine surgery. …”
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Abord laparoscopique d’un volumineux kyste hépatique simple : à propos d’un cas [A laparoscopic approach to a large simple hepatic cyst : a case report] by Meriem Bouzida, Mustapha Zeggane, Noura Zahi, Benyahia Boukhatem, Noureddine Ait Benamer

“…A 54-year-old wo­man with no pathological history who consulted for chronic pain in the right hypo­chondrium. The radiological explorations had objectified a large hepatic cyst and an uncomplicated gall bladder lithiasis. …”
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Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats by Pei-Ran Lv, Yang-Shuai Su, Wei He, Xiao-Yu Wang, Hong Shi, Xiao-Ning Zhang, Bing Zhu, Yu Kan, Li-Zhen Chen, Qiao-Feng Wu, Shu-Guang Yu, Xiang-Hong Jing

“…Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. Herein, we sought to determine whether spinal LTP contributes to the referral hyperalgesia in colitis rats and particularly whether electroacupuncture (EA) is effective to alleviate somatic hyperalgesia via suppressing spinal LTP. …”
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A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats by Sabrina Salberg, Matthew Macowan, Angela Doshen, Glenn R. Yamakawa, Marissa Sgro, Benjamin Marsland, Luke A. Henderson, Richelle Mychasiuk

“…Research suggests that specific microbiome components are important for brain development and function, with recent studies demonstrating that chronic pain results in changes to the microbiome. Consumption of a high fat, high sugar (HFHS) diet can drastically alter composition of the microbiome and is a modifiable risk factor for many neuroinflammatory conditions. …”
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An assessment of burden associated with problem joints in children and adults with moderate or severe haemophilia A: analysis of the CHESS-Paediatrics and CHESS II cross-sectional... by Paul McLaughlin, Hortensia De la Corte-Rodriguez, Tom Burke, Francis Nissen, Martynas Aizenas, Katya Moreno, Jamie O’Hara

“…Around two-thirds (67%) of CHESS-Paediatrics and 39% of CHESS II participants received prophylactic factor VIII replacement therapy. The presence of chronic pain was greater in severe HA with ‘ ≥ 2’ problem joints in both cohorts. …”
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Physical activity patterns following major lower limb amputation by Katarzyna Wójtowicz, Agata Walczak, Wiktoria Gajek-Flanczewska, Małgorzata Wirkijowska, Paulina Woźniak, Sebastian Flanczewski, Jakub Wirkijowski, Ewa Wietrzykowska, Martyna Śliwińska, Anna Podraza, Dominika Sobolewska, Katarzyna Michalczyk-Fraszka

“…The post-amputation care is crucial and requires a multidisciplinary team approach. Chronic pain restricts physical activity significantly. …”
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The Economic Analysis of the Overlooked Recurrent Low Back Pain: Three Years Retrospective Observational Study by Szyszka J, Matuska J, Szyszka BG, Walkowiak D, Skorupska E

“…We aimed to compare the cost per visit for LBP and recurrent LBP, including the impact of gender and type of medical service, estimating the approximate annual cost of recurrent LBP.Patients and Methods: Data on LBP categorized according to ICD-10 codes (G54, G55, M45, M46, M47, M48, M49, M51, M53, and M54) from the Polish National Health Fund (NHF) and Opolskie Rehabilitation Center (OCR) were analyzed based on the recurrent state as outlined in the new chronic pain definition.Results: In OCR, a recurrent LBP was confirmed for 22.78% of patients, of which 59.72% were female (p< 0.001). …”
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Exploratory study on the ascending pain pathway in patients with chronic neck and shoulder pain based on combined brain and spinal cord diffusion tensor imaging by Zhiqiang Qiu, Tianci Liu, Chengxi Zeng, Maojiang Yang, HongYing Yang, Xiaoxue Xu

“…These findings contribute a novel neuroimaging perspective to the evaluation and elucidation of the pathophysiological mechanisms underlying chronic pain in the ascending conduction pathways.…”
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Study protocol: an observational study of distress, immune function and persistent pain in HIV by John A Joska, Mark R Hutchinson, Maia Lesosky, Victoria J Madden, Ncumisa Msolo, Luyanduthando Mqadi, Gillian J Bedwell, Jonathan Grant Peter, Romy Parker, Andrew Schrepf, Robert R Edwards

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Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain by Binglin Chen, Jiabao Guo, Chan Gong, Chenchen Zhu, Yang Wu, Shengbo Wang, Yili Zheng, Haixia Lu

“…Abstract Neuropathic pain (NP) is a complex and prevalent chronic pain condition that affects millions of individuals worldwide. …”
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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…Pain is a hypersensitivity state caused by peripheral and central sensitization, with the latter considered the culprit for chronic pain. This study summarizes the pathogenesis of central sensitization from the perspective of neuroglial crosstalk and synaptic plasticity and underlines the related analgesic mechanisms of acupuncture. …”
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Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approv... by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

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The state of apoptosis factor system in mitochondria of skin and tumor cells in standard and stimulated growth of B16/F10 melanoma in female C57BL/6 mice by E. M. Frantsiyants, I. V. Neskubina, E. I. Surikova, A. I. Shikhlyarova, I. V. Kaplieva, L. A. Nemashkalova, L. K. Trepitaki

“…In general, the growth of melanoma stimulated by chronic pain and the standard melanoma growth were characterized by the opposite dynamics of levels of apoptosis factor both in mitochondria of skin cells and in mitochondria of tumor cells, with the exception of cytochrome C. …”
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Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos by Anne E. Sanders, Jianwen Cai, Martha L. Daviglus, Olga Garcia-Bedoya, Gary D. Slade

“… ABSTRACT Objective: Omega-6 and omega-3 long-chain polyunsaturated fatty acids (PUFAs) play opposing roles in inflammation, anxiety, and nociception, all of which are closely associated with chronic pain. We hypothesized that diets high in omega-6 arachidonic acid (C20:4n-6, AA) and low in combined omega-3 eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:6n-3, DHA) would be associated with higher odds of painful temporomandibular disorder (TMD). …”
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Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia by Sabrina Grundtner, Julia R. Sondermann, Feng Xian, Daniel Malzl, Daniel Segelcke, Esther M. Pogatzki-Zahn, Jörg Menche, David Gómez-Varela, Manuela Schmidt

“…Our understanding of how sex and age influence chronic pain at the molecular level is still limited with wide-reaching consequences for adolescent patients. …”
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Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine by Anna Konarska, Artur Fabijański, Adriana Dukacz, Wojciech Firlej, Joanna Rychlewska-Duda, Justyna Lisiecka, Michał Nowak, Mateusz Janik, Barbara Ufnalska, Anna Machowiak

“…Due to its role as an NMDA receptor antagonist, magnesium has garnered significant attention in pain management research, particularly for its potential to modulate both acute and chronic pain. This article provides an overview of magnesium's therapeutic applications in neuropathic pain, migraine, and perioperative pain, drawing on research from PubMed and Google Scholar published between 1988 and 2025. …”
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Clinical characteristics of patients with the hardware failure after surgical stabilization of rib fractures in Korea: a case series by Na Hyeon Lee, Sun Hyun Kim, Seon Hee Kim, Dong Yeon Ryu, Sang Bong Lee, Chan Ik Park, Hohyun Kim, Gil Hwan Kim, Youngwoong Kim, Hyun Min Cho

“…Nine patients (11.3%) experienced wound infection, and 35 patients (43.8%) experienced chronic pain. A total of 21 patients (26.3%) underwent reoperation for plate removal. …”
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