What do ultrasound vocalizations really mean in rats with different origins of pain? by Yang Yu, Chun-Li Li, Rui Du, Xiao-Liang Wang, Jun Chen

“…Emissions of both 22 kHz and 50 kHz spontaneous calls were impaired by acute and chronic pain conditions regardless of inflammatory and neuropathic or somatic and visceral origins.…”
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Psychometric Properties of the Abdominal Pain Index (API) in the Iranian Adolescent Population by Sepideh Hoseini, Mahdi Jafari, Zahra Asl Soleimani, Kaveh Qaderi Bagajan, Meysam Sadeghi, Shadi Zolfaghari

“…This study showed that API could be used with considerable confidence for Iranian children and adolescents with chronic pain.…”
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Transanal Hemorrhoidal Dearterialization (THD): A Single Center Experience on 100 Consecutive Cases by Aleksandar Mitevski, Vladko Cvetanovski, Petar Markov, Ilija Milev

“…If the THD technique is used according to the established standards, postoperative complications in patients in the form of fecal incontinence and chronic pain have not been described, which is also confirmed in our series. …”
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Experiences of general practitioners explaining central sensitisation to patients with persistent physical symptoms: a focus group study by Henriëtte E van der Horst, Johannes C van der Wouden, Berend Terluin, Annette H Blankenstein, Carine den Boer

“…Central sensitisation (CS) is an explanatory model for PPS and chronic pain that has been broadly applied in the context of pain medicine, but, until recently, not by general practitioners (GPs). …”
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The Impact of Chronic Low-Back Pain on Quality of Life among Samples of Iraqi Patients: A Cross-Sectional Study by Nadia Ayad Mohammed Jawad, Mohammad Hadi Alosami, Zainab Fadhil Mahdi

“…Background: The term “chronic pain” refers to discomfort that lasts longer than 3–6 months. …”
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Dissemination of Evidence-Based Recommendations for Sickle Cell Disease to Primary Care and Emergency Department Providers in North Carolina: A Cost Benefit Analysis by Paula Tanabe, Audrey L. Blewer, Emily Bonnabeau, Hayden B. Bosworth, Denise H. Clayton, Nancy Crego, Marian F. Earls, Kern Eason, Grayson Forlines, Gary Rains, Matthew Young, Nirmish Shah

“…Individuals with SCD are at high likelihood of high acute care utilization and chronic pain episodes. The multiple complications seen in SCD contribute to significant morbidity and premature mortality, as well as substantial costs to the healthcare system. …”
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The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials by Mark C. Kendall, Lucas J. Alves, Kristi Pence, Taif Mukhdomi, Daniel Croxford, Gildasio S. De Oliveira

“…Methadone is commonly used in chronic pain, but it is not frequently used as an intraoperative analgesic. …”
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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord by Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhang

“…Collectively, the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for exploring the cellular basis of spinal cord-related illnesses, including chronic pain, amyotrophic lateral sclerosis, and multiple sclerosis.…”
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Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres by Wei Xiong, Yue-kun Shen, Peng Dong, Ying Xiao, Xiong-qing Huang, Wen-qi Huang, Lu Yang, Xia Feng

“…Sustained release of anesthesia has shown great promise in the treatment of chronic pain in patients. In this research, we used neutralized ropivacaine as an anesthesia and poly(ε-caprolactone) (PCL) with different architectures to systematically study how these architectures affect the release of ropivacaine. …”
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Skin Closure Technique and Postprocedural Pain after Spinal Cord Stimulator Implantation: A Retrospective Review by Markus A. Bendel, Ryan S. D’Souza, Taylor J. North, Thomas P. Pittelkow, Jonathan M. Hagedorn

“…Spinal cord and dorsal root ganglion stimulation are minimally invasive surgical techniques used to treat an array of chronic pain disorders. There is a paucity of data related to defining best practices in these specific patient populations, and historically, providers have relied on consensus committees to opine on the best techniques for patient safety and experience. …”
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Antiallodynic effect of propoxazepam at monoiodoacetate-induced osteoarthritis in rats by M.Ya. Golovenko, I.P. Valivodz, A.S. Reder, V.B. Larionov

“…However, further studies are required to explore the long-term efficacy and safety profile of propoxazepam in chronic pain management related to OA.…”
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Artificial Intelligence-Powered Cognitive Behavioral Therapy Chatbots, a Systematic Review by Maryam Farzan, Hamid Ebrahimi, Maryam Pourali, Fatemeh Sabeti

“…Woebot showed remarkable reductions in depression and anxiety with high user engagement; Wysa demonstrated similar improvements, especially in users with chronic pain or maternal mental health challenges; Youper also presented a significant symptom reduction, including a 48% decrease in depression and a 43% decrease in anxiety. …”
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Differential Gene Expression Analysis in a Lumbar Spinal Stenosis Rat Model via RNA Sequencing: Identification of Key Molecular Pathways and Therapeutic Insights by Jin Young Hong, Wan-Jin Jeon, Hyunseong Kim, Changhwan Yeo, Hyun Kim, Yoon Jae Lee, In-Hyuk Ha

“…Background/Objectives: Lumbar spinal stenosis (LSS) is a degenerative condition characterized by the narrowing of the spinal canal, resulting in chronic pain and impaired mobility. However, the molecular mechanisms underlying LSS remain unclear. …”
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Using a Two-Steps Clustering and PCA Analysis for Stratified Chronic Non-Cancer Pain Care: A Retrospective Cross-Sectional Study by Peiró AM, Barrachina J, Escorial M, Aguado I, Margarit C, Grimby-Ekman A

“…Ana M Peiró,1,2 Jordi Barrachina,1 Mónica Escorial,1 Isidro Aguado,1 César Margarit,1,3 Anna Grimby-Ekman4 1Neuropharmacology Applied to Pain (NED), Clinical Pharmacology Unit, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, 03010, Spain; 2Institute of Bioengineering, University Miguel Hernández, Elche, 03202, Spain; 3Pain Unit, Alicante Department of Health -General Hospital, Alicante, 03010, Spain; 4School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenCorrespondence: Ana M Peiró, Alicante Institute for Health and Biomedical Research (ISABIAL), Hospital General Universitario Doctor Balmis, c/Pintor Baeza, 12, Alicante, 03010, Spain, Email apeiro@umh.esPurpose: Given the number of people who suffer from chronic pain and the impact on healthcare resources, it is imperative that the people with pain receive an appropriate matched treatment due and stratified care. …”
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A comparison of kinesiophobia, pain-activity patterns and fear-avoidance beliefs in patients with chronic low back pain by Egemen Kızılay, Fatma Kızılay, Betül Ergün

“…Chronic pain affects individuals’ activity levels. Three activity patterns are observed among individuals with chronic pain: avoidance, overdoing, and regularization. …”
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Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review by Natasha Cox, Christian D. Mallen, Ian C. Scott

“…Abstract Background Pain is a major challenge for patients with rheumatoid arthritis (RA), with many people suffering chronic pain. Current RA management guidelines focus on assessing and reducing disease activity using disease-modifying anti-rheumatic drugs (DMARDs). …”
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The Brain Waves During Reaching Tasks in People With Subacute Low Back Pain: A Cross-Sectional Study by Hsin-Hui Hsu, Yea-Ru Yang, Li-Wei Chou, Yung-Cheng Huang, Ray-Yau Wang

“…Subacute low back pain (sLBP) is a critical transitional phase between acute and chronic stages and is key in determining the progression to chronic pain. While persistent pain has been linked to changes in brain activity, studies have focused mainly on acute and chronic phases, leaving neural changes during the subacute phase—especially during movement—under-researched. …”
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Effectiveness of supracondylar dome osteotomy in reducing lateral condylar prominence and enhancing functional outcomes in pediatric cubitus varus: a retrospective study by Yam Prakash Gurung, Sabin Pokharel, Rajan Bhusal, Tarun Rajbhandari, Ashok Kumar Banskota, Bibek Banskota

“…While primarily considered a cosmetic concern, it can lead to significant complications, including chronic pain, ulnar nerve palsy, and posterolateral elbow instability. …”
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Mechanism of Tai Chi Chuan in Improving Knee Osteoarthritis from the Perspective of Sports Biomechanics by LIU Longcheng, ZHANG Feng, GAO Pengyi, ZHAO Tianlin, WANG Honghao, LI LIU Yinuo, WANG Jiaying, ZHU Xiangyu

“…Exercise therapy, represented by Tai Chi Chuan, has been proven to have good effective in relieving chronic pain caused by KOA. Long-term practice of Tai Chi Chuan can effectively improve knee and ankle proprioception, enhance dynamic stability and reduce the risk of falls in patients with KOA. …”
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Effect of a Novel Training Program in Patients With Chronic Shoulder Pain Based on Implicit Motor Learning: Pilot and Feasibility Study. by Annelies Maenhout, Wieger Heijenk, Peter Glashouwer, Lore Quatacker, Luna Praet, Dorien Borms

“…Especially in patients with chronic pain conditions like shoulder pain this approach might benefit over traditional exercise programs…”
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