Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area by Min-Jeong Jo, Jo-Young Son, Yu-Mi Kim, Jin-Sook Ju, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ahn

“…Although previous studies suggest that Piezo2 regulates chronic pain in the orofacial area, few studies have reported the direct evidence of Piezo2’s involvement in inflammatory and neuropathic pain in the orofacial region. …”
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The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review by Xia-qing Wang, Tahmineh Mokhtari, Yu-xuan Zeng, Lu-peng Yue, Li Hu

“…Chronic pain is considered an economic burden on society as it often results in disability, job loss, and early retirement. …”
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Primary abandon-of-the-sac technique in laparoscopic inguinoscrotal hernia repair: A retrospective comparative study by A. Ramiro Arrechea, Victoria S. Rebzda, José P. Medina, Roberto Cerutti, Daniel E. Pirchi

“…No statistical differences were found in terms of seromas (13.3% vs. 9.5%; P = 0.662), hematomas (6.6% vs. 9.5%; P = 0.727), or hydrocele (13.3% vs. 11.1%; P = 0.808). No recurrence or chronic pain was observed during the study period. Finally, a significantly shorter median operative time was recorded in the PAS group (50 vs. 80 min; P = 0.0026). …”
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Neuronal Plasticity Associated with Burn Injury and Its Relevance for Perception and Management of Pain in Burn Patients by Terence J Coderre, Manon Choinière

“…Second, the progression of knowledge about the basic mechanisms underlying persistent and chronic pain is critically dependent on the increased understanding of the complexity of the symptoms experienced by pain patients. …”
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Effect of 4DryField® PH, a Novel Adhesion Barrier, on Recurrence of Intestinal Adhesions after Extensive Visceral Adhesiolysis by Gerhard Blumhardt, Matthias Haas, Stefanie Polte

“…Adhesions occur after up to 97% of abdominal interventions causing chronic pain, infertility, and intestinal obstruction. …”
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Assessing the Effectiveness of Add-On Therapy of Palmitoylethanolamide to Standard Therapy in Diabetic Peripheral Neuropathy by Velusamy Sivakumar, Thangavelu Saravanan, V.K. Damini

“…Pain was assessed using the Visual Analog Scale (VAS), sensitivity was evaluated via monofilament testing, and quality of life was measured using the American Chronic Pain Association (ACPA) Quality of Life Scale (QOLS). …”
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Varicella-Zoster-Mediated Radiculitis Reactivation following Cervical Spine Surgery: Case Report and Review of the Literature by Doniel Drazin, George Hanna, Faris Shweikeh, Sunil Jeswani, Leah Lovely, Richard Sokolov, John C. Liu

“…The patient was started on a neuromodulating agent for chronic pain. This case adds to the limited literature regarding this rare complication, brings attention to the symptoms for proper diagnosis and treatment, and emphasizes the importance of prompt antiviral therapy. …”
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Macrophage to neuron communication via extracellular vesicles in neuropathic pain conditions by Francesca Picco, Lynda Zeboudj, Silvia Oggero, Vincenzo Prato, Thomas Burgoyne, Nikita Gamper, Marzia Malcangio

“…Neuropathic pain following peripheral nerve injury results from maladaptive changes in neurons and immune cells contribution to mechanisms underlying chronic pain. Specifically, in dorsal root ganglia (DRG), sensory neuron cell bodies release extracellular vesicles (EVs) which promote pro-inflammatory macrophage accumulation that facilitates nociceptive signalling. …”
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Generalized Extension of Referred Trigeminal Pain due to Greater Occipital Nerve Entrapment by Jung-woo Hyung, Byung-chul Son

“…A 42-year-old female patient presented with chronic pain in her gums, jaw angle, submandibular region, retro-auricular suboccipital, and temporo-occipital vertex that had been ongoing for four years. …”
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Chronic prostatitis/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma by Fang-Xing Zhang, Xi Chen, De-Cao Niu, Lang Cheng, Cai-Sheng Huang, Ming Liao, Yu Xue, Xiao-Lei Shi, Zeng-Nan Mo

“…These alterations may be associated with chronic pain, voiding symptoms, reduced fertility, and depression in CP/CPPS. …”
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Medical Cannabis for Chronic Noncancer Pain: A Systematic Review of Health Care Recommendations by Yaping Chang, Meng Zhu, Christopher Vannabouathong, Raman Mundi, Roland S. Chou, Mohit Bhandari

“…All the included publications provided a recommendation supporting medical cannabis for CNCP in general and for the specific conditions of neuropathic pain, chronic pain in people living with Human Immunodeficiency Virus (HIV), and chronic abdominal pain, with detailed information sharing and comprehensive consideration of a patient’s own values and preferences. …”
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Adhesions to Mesh after Ventral Hernia Mesh Repair Are Detected by MRI but Are Not a Cause of Long Term Chronic Abdominal Pain by Odd Langbach, Stein Harald Holmedal, Ole Jacob Grandal, Ola Røkke

“…Adhesions are formed both after open and laparoscopic hernia mesh repair and are not associated with chronic pain.…”
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Bridging the pain gap after cancer surgery – Evaluating the feasibility of transitional pain service to prevent persistent postsurgical pain – A systematic review and meta-analysis... by Raghu S. Thota, S Ramkiran, Aveek Jayant, Koilada Shiv Kumar, Anjana Wajekar, Sadasivan Iyer, M Ashwini

“…Our objective was to evaluate the feasibility of TPS in pain practice among postsurgical cancer patients and its prevention of persistent postsurgical pain (PPSP), culminating in chronic pain catastrophising. Methods: The protocol for this meta-analysis was registered in the International Prospective Register of Systematic Reviews (ID: CRD42023407190). …”
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Users’ views on the use of a smartwatch app to collect daily symptom data in individuals with multiple long-term conditions (Multimorbidity): A qualitative study by Cassandra Kenning, Peter Bower, Nicola Small, Syed Mustafa Ali, Benjamin Brown, Katherine Dempsey, Elaine Mackey, Brian McMillan, Caroline Sanders, Ilina Serafimova, Sabine N Van der Veer, William G Dixon, John McBeth

“…Participants did not seem to consider the management of more than one condition to be a factor in either engagement or use of the app, but the presence of severe or chronic pain was at times a barrier. Conclusion This study has provided preliminary evidence that multimorbidity was not a major barrier to engagement with patient-generated health data via a smartwatch symptom tracking app.…”
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Comparison of Real-world Outcomes Between Patients Treated with Tapentadol ER or Oxycodone CR by Mike Durkin, Jacqueline Pesa, Jessica Lopatto, Rachel Halpern, Damon Van Voorhis, Stephanie Korrer

“…**Background:** The objective of this study was to compare health care utilization and costs between matched cohorts of chronic pain patients treated with the opioids tapentadol extended release (ER) or oxycodone controlled release (CR). …”
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Virally-initiated pain states: phenotypes, mechanisms, and future directions by Sara A. Dochnal, Steven P. Cohen, Mark R. Hutchinson, Mark R. Hutchinson, Mark R. Hutchinson, Yury I. Miller, Tony L. Yaksh

“…Even beyond SARS-CoV-2, common infections with viruses like influenza, HIV, and herpesviruses have profound impacts beyond their typical manifestations, often triggering acute and chronic pain syndromes that can be life-altering. These virally induced pain states can arise through direct viral replication within neurons, or indirectly, via immune responses to infection in both the contexts of afferent signaling in the dorsal root ganglion (DRG) or subsequent higher order integration in intracranial systems. …”
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Perspective of Pain Clinicians in Three Global Cities on Local Barriers to Providing Care for Chronic Noncancer Pain Patients by S. Fatima Lakha, Peri Ballantyne, Hanan Badr, Mubina Agboatwala, Angela Mailis, Peter Pennefather

“…An increasing proportion of the global chronic pain population is managed through services delivered by specialized pain clinics in global cities. …”
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Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation by Rajaram Rajamohan, Perumal Muthuraja, Kuppusamy Murugavel, Murali Krishnan Mani, D. S. Prabakaran, Jeong Hyun Seo, Tabarak Malik, Yong Rok Lee

“…The disease’s pathology is characterized by heightened inflammation and oxidative stress, culminating in chronic pain and the loss of joint functionality. Fenofibric acid (FFA) exhibits notable anti-inflammatory potential. …”
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Mind-Body Exercises for Nurses with Chronic Low Back Pain: An Evidence-Based Review by Pinky Budhrani-Shani, Donna L. Berry, Patricia Arcari, Helene Langevin, Peter M. Wayne

“…The multimodal nature of mind-body exercises has potential to impact physiological and psychological processes associated with chronic pain, affording possible advantages over conventional unimodal therapies. …”
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Evaluation of the efficacy of percutaneous spinal cord stimulation according to the single or double leads by Esra Ertilav, Osman Nuri Aydin

“…Conclusion SCS with single and double lead is an effective method in chronic pain syndromes. SCS with single lead can be preferred in terms of time, cost and labour saving.…”
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