Protocol of the TransformUs SecondaryTeachers’ perceptions of the program reach, effectiveness,adoption, implementation and maintenance schools program: a type II hybrid implementa... by Harriet Koorts, Anna Timperio, Jo Salmon, David Revalds Lubans, Gavin Abbott, Nicola D Ridgers, Natalie Lander, Ana María Contardo Ayala, Emiliano Mazzoli

“…TransformUs, an effective and cost-effective whole-of-school programme for promoting primary school children’s physical activity and reducing sedentary behaviour, has been adapted for secondary schools (TransformUs Secondary). …”
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Risk factors affecting polygenic score performance across diverse cohorts by Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L Walunas, Iftikhar J Kullo, Wei-Qi Wei, Hemant Tiwari, Josh F Peterson, Wendy K Chung, Brittney H Davis, Atlas Khan, Leah C Kottyan, Nita A Limdi, Qiping Feng, Megan J Puckelwartz, Chunhua Weng, Johanna L Smith, Elizabeth W Karlson, Regeneron Genetics Center, Penn Medicine BioBank, Gail P Jarvik, Marylyn D Ritchie

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Characterization of Shigella flexneri serotype 6 strains from geographically diverse low- and middle-income countries by Caitlin E. Gabor, Charlotte E. Chong, Jose M. Lemme-Dumit, Tracy H. Hazen, Kate S. Baker, Karen L. Kotloff, Irene N. Kasumba, Sharon M. Tennant, Henry Badji, M. Jahangir Hossain, Richard Omore, Benjamin Ochieng, Alex O. Awuor, Billy Ogwel, Jane Juma, Eileen M. Barry, David A. Rasko

“…This level of conservation has not been noted for other S. flexneri serotypes and is promising for vaccine and diagnostic assays to provide global Sf6-specific coverage.IMPORTANCEShigellosis is an ongoing global public health crisis with >270 million annual episodes among all age groups; however, the greatest disease burden is among children in low- and middle-income countries (LMIC). …”
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Rare and common single nucleotide variants in childhood-onset systemic lupus erythematosus by Elisabet Svenungsson, Iva Gunnarsson, Lars Rönnblom, Ingrid E Lundberg, Andreas Jönsen, Niklas Hagberg, Leonid Padyukov, Marie Wahren-Herlenius, Christopher Sjöwall, Solbritt Rantapää-Dahlqvist, Sule Yavuz, Øyvind Molberg, Dag Leonard, Andrei Alexsson, Maija-Leena Eloranta, Ann-Christine Syvänen, Johanna K Sandling, Gunnel Nordmark, Roland Jonsson, Roald Omdal, Christine Bengtsson, Anders A Bengtsson, Pascal Pucholt, Kerstin Lindblad-Toh, Sergey V Kozyrev, Peter Söderkvist, Johanna Dahlqvist, Jonas Carlsson Almlöf, Daniel Eriksson, Ahmed Sayadi, Åsa Karlsson, Gerli Rosengren Pielberg, Anna Lobell, Eva Murén, Kerstin M Ahlgren, Nils Landegren, Olle Kämpe, Fabiana HG Farias, Argyri Mathioudaki, Jennifer Meadows, Jessika Nordin

“…A PRS analysis showed that patients with cSLE with any of these gene variants had a similar average PRS as control individuals.Conclusion RD SNVs were observed in a small proportion of cSLE and carriers of these RD SNVs had a PRS similar to healthy individuals, suggesting the importance of rare coding heterozygous variants in driving disease risk in a subset of children with SLE.…”
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Editorial by Lindsay B. Flynn

“…If progress is about ensuring that younger generations today have accessible housing paths so that one day they can help their own children launch, the intergenerational justice framework should push us to act even more quickly.   …”
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Genetic characteristics involving the PD-1/PD-L1/L2 and CD73/A2aR axes and the immunosuppressive microenvironment in DLBCL by Tingting Zhang, Zhenzhen Zhang, Xiubao Ren, Jin He, Zhengzi Qian, Bin Meng, Lei Jiao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Wenchen Gong, Huilai Zhang, Xianhuo Wang

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A Systematic Review of the Cost-Effectiveness of Nurse Practitioners and Clinical Nurse Specialists: What Is the Quality of the Evidence? by Faith Donald, Kelley Kilpatrick, Kim Reid, Nancy Carter, Ruth Martin-Misener, Denise Bryant-Lukosius, Patricia Harbman, Sharon Kaasalainen, Deborah A. Marshall, Renee Charbonneau-Smith, Erin E. Donald, Monique Lloyd, Abigail Wickson-Griffiths, Jennifer Yost, Pamela Baxter, Esther Sangster-Gormley, Pamela Hubley, Célyne Laflamme, Marsha Campbell–Yeo, Sheri Price, Jennifer Boyko, Alba DiCenso

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Three-dimensional aortic arch geometry and blood flow in neonates after surgical repair for aortic coarctation by Katrin Fricke, Katrin Fricke, Lea Christierson, Lea Christierson, Lea Christierson, Einar Heiberg, Einar Heiberg, Pia Sjöberg, Pia Sjöberg, Erik Hedström, Erik Hedström, Erik Hedström, Erik Hedström, Kristoffer Steiner, Constance G. Weismann, Constance G. Weismann, Constance G. Weismann, Johannes Töger, Johannes Töger, Petru Liuba, Petru Liuba

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The use of patient-generated health data in the management of low anterior resection syndrome: a qualitative study by Olivia Monton, Olivia Monton, Allister Smith, Sarah Sabboobeh, Marie Demian, Julie Cornish, Steven D. Wexner, Peter Christensen, Peter Christensen, Amandeep Ghuman, Liliana G. Bordeianou, Liliana G. Bordeianou, Liliana G. Bordeianou, Celia Keane, Celia Keane, Syed Husain, Alessandra Gasior, Alessandra Gasior, Natalie Leon, Julie Savard, Lieba R. Savitt, Margit Majgaard, Gitte Kjær Sørensen, Melanie Mills, Fateme Rajabiyazdi, Marylise Boutros, Marylise Boutros

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Campylobacter colonization and undernutrition in infants in rural eastern Ethiopia — a longitudinal community-based birth cohort study by Dehao Chen, Dehao Chen, Sarah Lindley McKune, Sarah Lindley McKune, Yang Yang, Ibsa Aliyi Usmane, Ibsa Abdusemed Ahmed, Jafer Kedir Amin, Abdulmuen Mohammed Ibrahim, Abadir Jemal Seran, Nurmohammad Shaik, Amanda Ojeda, Bahar Mummed Hassen, Loic Deblais, Belisa Usmael Ahmedo, Kedir Abdi Hassen, Mussie Bhrane, Xiaolong Li, Nitya Singh, Kedir Teji Roba, Nigel P. French, Gireesh Rajashekara, Mark J. Manary, Jemal Yusuf Hassen, Arie Hendrik Havelaar, on behalf of the CAGED Research Team

“…BackgroundCampylobacter is associated with environmental enteric dysfunction (EED) and malnutrition in children. Campylobacter infection could be a linchpin between livestock fecal exposure and health outcomes in low-resource smallholder settings.MethodsWe followed a birth cohort of 106 infants in rural smallholder households in eastern Ethiopia up to 13 months of age. …”
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homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort studyResearch in... by Fang Yun Lim, Hannah G. Lea, Ashley M. Dostie, Soo-Young Kim, Tammi L. van Neel, Grant W. Hassan, Meg G. Takezawa, Lea M. Starita, Karen N. Adams, Michael Boeckh, Joshua T. Schiffer, Ollivier Hyrien, Alpana Waghmare, Erwin Berthier, Ashleigh B. Theberge

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Challenges and enablers for scaling up interventions targeting non-communicable diseases: a qualitative study applying the Consolidated Framework for Implementation Research to 19... by Josefien van Olmen, Peter Delobelle, Meena Daivadanam, Hassan Haghparast-Bidgoli, Maria Lazo-Porras, J Jaime Miranda, Yuan Li, Rohina Joshi, Amanda G Thrift, Rajesh Vedanthan, Gina Agarwal, Mark D Huffman, Kerstin Klipstein-Grobusch, Naomi Levitt, Dike Ojji, Feng J He, Kamran Siddiqi, Pascal Geldsetzer, Puhong Zhang, Milena Soriano Marcolino, Lal B Rawal, Brian Oldenburg, Helena Teede, Josephine Birungi, Edwin Wouters, Abha Shrestha, Ari Probandari, Mayowa Owolabi, Vilma Irazola, Andrea Beratarrechea, Keiko Nakamura, Gindo Tampubolon, Zulma Ortiz, Violet Naanyu, Jaap Koot, Anusha Ramani-Chander, Stephen Sherwood, Monika Martens, Gade Waqa, Maria Eugenia Esandi, Sujarwoto Sujarwoto, Laura Antonietti, Jan-Walter De Neve, Sayoki G Mfinanga, Antonio Luiz Pinho Ribeiro

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Photoaging smartphone app promoting poster campaign to reduce smoking prevalence in secondary schools: the Smokerface Randomized Trial: design and baseline characteristics by Michael Kreuter, Fabian N Fries, Titus J Brinker, Ute Mons, David A Groneberg, Anil Batra, Werner Seeger, Felix Herth, Julia Holzapfel, Tanja G Baudson, Katharina Sies, Lena Jakob, Hannah Maria Baumert, Marlene Heckl, Ana Cirac, Janina L Suhre, Verena Mathes, Hannah Spielmann, Nancy Rigotti, Tobias Raupach, Henning Gall, Claudia Bauer, Pat Marek, Chase H Harrison, Lava Taha, Andreas Owczarek, Felix J Hofmann, Roger Thomas

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Simulation-based training program effect on pediatric nurses’ knowledge and performance regarding heel-prick during newborn blood screening test by Abdulaziz Asiri, Abeer A. Almowafy, Shimaa M. Moursy, Hanan A. Abd-Elhay, Shimaa Abdelrahim Khalaf Ahmed, Aml S. Abdelrahem, Marim T. Abo Seif, Faransa A. Ahmed

“…The sample consisted of 50 nurses recruited from the Maternity & Children Hospital Bisha, Al-Namas General Hospital in the Kingdom of Saudi Arabia, and Pediatric Assiut University Hospital in Egypt; they were randomly divided into two groups of 25 nurses, intervention and control. …”
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Safety, Tolerability, and Immunogenicity of the Invaplex_AR-Detox <i>Shigella</i> Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protoc... by Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D’Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan R. Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg

“…A challenge to effective Shigella vaccine development has been the low immunogenicity and protective efficacy of candidate Shigella vaccines in infants and young children. Additionally, a new vaccine might be less immunogenic in a highly endemic setting compared to a low endemic setting (“vaccine hyporesponsiveness”). …”
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Recombinase-based amplification coupled with lateral flow chromatography for the specific and sensitive detection and identification of Leishmania major in cutaneous leishmaniasis... by Insaf Bel Hadj Ali, Yusr Saadi-Ben Aoun, Imen Khammeri, Hejer Souguir, Emna Harigua-Souiai, Hamed Chouaieb, Ahmed S. Chakroun, Meryem Lemrani, Aicha Kallel, Kalthoum Kallel, Nabil Haddad, Oussaima El Dbouni, Rhea N. Coler, Rhea N. Coler, Rhea N. Coler, Steven G. Reed, Akila Fathallah-Mili, Akila Fathallah-Mili, Ikram Guizani

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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

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Inflammation severity, rather than respiratory failure, is strongly associated with mortality of ARDS patients in high-altitude ICUs by Daniel Molano-Franco, Daniel Molano-Franco, Daniel Molano-Franco, Daniel Molano-Franco, Daniel Molano-Franco, Joan Ramon Masclans Enviz, Joan Ramon Masclans Enviz, Antonio Viruez-Soto, Antonio Viruez-Soto, Antonio Viruez-Soto, Antonio Viruez-Soto, Mario Gomez, Harvey Rojas, Edgar Beltran, Victor Nieto, Fernanda Aliaga-Raduan, Fernanda Aliaga-Raduan, Pablo Iturri, Christian Arias-Reyes, Christian Arias-Reyes, Christian Arias-Reyes, Jorge Soliz, Jorge Soliz

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IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3 by Huiyue Dong, Huiyue Dong, Ling Zhu, Ling Zhu, Jingjing Sun, Jingjing Sun, Qiuyan Chen, Qiuyan Chen, Pengyang Liu, Pengyang Liu, Wei Zhang, Huajing Zeng, Rong Lin, Rong Lin, Zongyang Yu, Zongyang Yu, Jun Lu, Jun Lu, Jun Lu, Jun Lu

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A study on the interaction of family function of parents of premature infants on home care preparation (早产儿父母家庭功能对家庭护理准备的交互作用研究) by JIANG Canhui (江灿慧), CHEN Yingfang (陈樱芳), YE Yanli (叶严丽)

“…The actor-partner interdependence model (APIM) was used to explore the interaction between parental family function and home care preparation of the children. Results The premature infants of mother had higher home care readiness than fathers, and the difference was statistically significant (P＜0. 05), but there was no statistically significant difference in family function between the parents of premature infants (P＞0. 05). …”
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