Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL by Willem P. J. Cox, Noël M. M. Dautzenberg, Linde Dekker, Tesa Klenovsek, Annelisa M. Cornel, Marliek van Hoesel, Dorette S. van Ingen Schenau, Reno S. Bladergroen, Roland P. Kuiper, Laurens T. van der Meer, Friso G. Calkoen, Stefan Nierkens, Frank N. van Leeuwen

“…We observed a significantly worse overall survival after CD19-targeting CAR T therapy in children with TP53-mutated (TP53Mut) compared with TP53–wild-type (TP53WT) BCP-ALL. …”
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CircRNA-miRNA-mRNA regulatory network in high-altitude hypobaric hypoxia-induced hearing impairment and hearing acclimatization by Danzeng Awang, Kanzi Danzeng, Tianheng Wang, Quzong Deji, Mengting Huang, Hailong Ren, Xinzhu Liu, Binghan Zhao, Lanzi Gongga

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The multiple uses of artificial intelligence in exercise programs: a narrative review by Alberto Canzone, Alberto Canzone, Giacomo Belmonte, Antonino Patti, Domenico Savio Salvatore Vicari, Domenico Savio Salvatore Vicari, Fabio Rapisarda, Valerio Giustino, Patrik Drid, Antonino Bianco

“…The findings suggest that artificial intelligence holds promise in promoting physical activity across diverse populations, including children, adolescents, adults, older adult, and individuals with disabilities.ConclusionOur research found that artificial intelligence, machine learning and deep learning techniques were used: (a) as part of applications to generate automatic messages and be able to communicate with users; (b) as a predictive approach and for gesture and posture recognition; (c) as a control system; (d) as data collector; and (e) as a guided trainer.…”
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University students’ ambition levels and vocational tendencies associated with common culture by H. A. Danaa, M. M. Al-mzary, W. N. Halasa, L. M. Obeidat, M. A. Rababah, M. Kh. Al-Alawneh

“…Besides, universities are recommended to focus on ways of developing the ambition level among students by raising parents’ awareness to set a good example to their children, bring them up from an early age to be ambitious and promote their ambition level.…”
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Discharge against Medical Advice (DAMA) from an Emergency Department of a Tertiary Care Hospital in Saudi Arabia by Ashraf El-Metwally, Nesreen Suliman Alwallan, Ali Amin Alnajjar, Nida Zahid, Khalid Alahmary, Paivi Toivola

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The newborn behavioural observations (NBO) system embedded in routine postpartum care in at-risk families in Iceland: a randomised controlled trial by Lisbeth Valla, Kari Slinning, Tore Wentzel-Larsen, Gun-Mette Røsand, Stefanía Birna Arnardóttir

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Sources analysis and risk assessment of heavy metals in soil in a polymetallic mining area in southeastern Hubei based on Monte Carlo simulation by Jing Wang, Bo Wang, Qibin Zhao, Jinnan Cao, Xiao Xiao, Di Zhao, Zhenya Chen, Di Wu

“…The main findings are as follows: (1) Among the heavy metals present in the soil, copper (Cu) has the highest average concentration at 278.54 mg/kg, followed by zinc (Zn) at 161.16 mg/kg, chromium (Cr) at 75.23 mg/kg, nickel (Ni) at 30.38 mg/kg, arsenic (As) at 22.53 mg/kg, cadmium (Cd) at 0.76 mg/kg, and mercury (Hg) at 0.14 mg/kg; (2) The distribution of heavy metal concentrations exhibits significant regional variations, with the spatial pattern of pollution indicating that TLS is more affected than JLS, as evidenced by the Pollution Load Index (PLI) values; (3) Three potential sources of heavy metals were identified: natural sources, anthropogenic activities (including industrial production and agricultural practices), and atmospheric deposition (both dry and wet); (4) While severe contamination levels of specific metals such as copper and cadmium are observed in JLS and TLS soils, the overall contamination is mild, suggesting complex contamination dynamics; (5) Cadmium poses a moderate to high ecological risk, being the most sensitive factor in the comprehensive ecological risk assessment with a contribution rate of 65.2 %; (6) The concentrations of heavy metals in the soil present certain health risks, with children being more vulnerable than adults. This study helps to identify the hot spots and pollution patterns of heavy metal pollution in polymetallic mining areas and provides a theoretical basis for the study of local countermeasures against pollution. …”
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Specific and sensitive detection of bovine coronavirus using CRISPR-Cas13a combined with RT-RAA technology by Zili Liang, Ruxing Luo, Qifu He, Cheng Tang, Zhidong Zhang, Yanmin Li, Zijing Guo

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Inactivation of glutathione S-transferase alpha 4 blocks Enterococcus faecalis-induced bystander effect by promoting macrophage ferroptosis by Yuanyuan Ju, Chunhua Ma, Lin Huang, Yumei Tao, Tianqi Li, Haibo Li, Mark M. Huycke, Yonghong Yang, Xingmin Wang

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Respiratory pathogen spectrum and epidemiological trends in Hainan Province: a retrospective analysis from 2017 to 2023 by Lvying Wu, Jianan Zhang, Zhiming Wu, Hua Pei, You Zhang

“…However, the infection rate for M. pne was significantly decrease, and the infection rate for Flu-B and Flu-A were a notable increased in NPI and COVID-19 pandemic. Children aged 0–5 years account for the largest proportion of all RTI patients with the highest infection rate, especially in NPI and COVID-19 pandemic. …”
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Screening and evaluation of key technologies for non-bioartificial liver care: an empirical study by Yunzhi Zhang, Han Zhang, Ling Luo, Zhen Liu, Anlin Liu, Lin Shi, Lin Shi, Luwen Liang, Jing Zhao, Pu Chen, Yanli Yang

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Food taboo practices and associated factors among pregnant women in Sub-Sahara Africa: a systematic review and meta-analysis by Aysheshim Kassahun Belew, Berhanu Mengistu, Ayenew Molla Lakew, Esmeal Ali Muhammad

“…Abstract Background Even though maternal nutrition has improved, food taboos and poor dietary practices during pregnancy can still lead to nutrient deficiencies, increasing the risk of complications for both mothers and children. Therefore, this study aimed to generate pooled evidence from across different countries in Sub-Saharan Africa to inform effective prevention actions. …”
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Efficacy of Esophageal Protector in Treating Gastroesophageal Reflux Disease with Extraesophageal Symptoms: a Multicenter, Open-Label, Observational Study by Yu. A. Kucheryavy, D. N. Andreyev, E. Yu. Eryomina, A. A. Gilmanov, O. V. Nazarova, Ye. A. Sidneva, Yu. G. Topalova

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Comparing the Effectiveness of Self-determination Skills Training and Affect Phobia Therapy on the Meta-Emotional and Mental Toughness in Adolescent Girls with Sexual Abuse Experie... by Fatemeh Dafeian, Zahra Yousefi

“…Introduction: The sexual abuse of children and adolescents is a significant public health issue that leads to a variety of detrimental social, cultural, and familial consequences. …”
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A study on sexual violence among women in Northern Ethiopia's 2022 conflict: mixed methods by Atitegeb Abera Kidie, Seteamlak Adane Masresha, Birtukan Gizachew Ayal, Kindie Mekuria, Tsion Kokeb Kodo, Abayneh Tunta Boye, Misganaw Guadie Tiruneh, Fassikaw Kebede Bizuneh, Eneyew Talie Fenta

“…Ethiopia faces this issue extensively despite its preventable nature, persisting as a significant challenge within the country.ObjectiveThe study aimed to identify the extent and factors associated with sexual violence among women, children, and adolescent girls during the 2022 armed conflict in Northern Ethiopia.MethodA community-based cross-sectional study combined quantitative and phenomenological methods. …”
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Knowledge, Attitudes, and Practices of HIV-Positive Adolescents Related to HIV/AIDS Prevention in Abidjan (Côte d’Ivoire) by Azagoh-Kouadio Richard, Yeboua Kossonou Roland, Yao Kouassi Christian, Kouassi-Kouadio Amenan Cécile, Aholi Jean Michel, Cissé Lacina, Asse Kouadio Vincent

“…The active queue was 349 children, including 210 adolescents. Fifty adolescents (22 boys and 28 girls) participated in the study, a participation rate of 24%. …”
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Individual-level and community-level factors associated with the family planning use among pastoralist community of Ethiopia: a community-based cross-sectional study by Mussie Alemayehu, Araya Abrha Medhanyie, Elizabeth Reed, Afework Mulugeta

“…Women who need to walk 1 hour and more to the nearest health facility (AOR 0.14, 95% CI 0.05 to 0.3), have ANC visit of 4 and above (AOR 6.02, 95% CI 1.74 to 20.8), had their last birth at a health facility (AOR 2.71 95% CI 1.27 to 5.81), have five and more children (AOR 4.71, 95% CI 1.86 to 11.9), have high knowledge on FP (AOR 2.74, 95% CI 1.11 to 6.74) and had high intentions to use FP (AOR 10.3, 95% CI 3.85 to 27.6) were more likely to report FP use. …”
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Community Integration of Disability: A Bibliometric and Knowledge-Map Analysis by Wang S, Li D, Liu C, Sun X, Shi Y, Wang H, Zhang H

“…Research on community integration related to traumatic brain injury (TBI), stroke, children, and spinal cord injuries is current focus of community integration. …”
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Determinant of unmet need for family planning among adolescent and young women in Kenya: multilevel analysis using recent Kenyan demographic health survey by Beyene Sisay Damtew, Hinsermu Bayu Abdi, Beker Ahemed Hussien, Getahun Tiruye, Nafyad Tolossa Urgie, Beniam worku Yigezu, Sifan Ahmed Mohammed, Bezawit Melak Fente

“…Determinants of Unmet need for family planning are age 15–19 (AOR: 3.4, 95%CI (1.3–11), undecided desire number of children (AOR: 2.3, 95%CI: 1.4–2.1), age at first sex 15–29 (AOR: 2.7, 95%CI: 1.2–6.2), rural residency (AOR: 3.9, 95%CI: 1.1–14), high community level poverty (AOR: 2.1, 95%CI: 1.1–4.5).ConclusionThe study finds that 25% of young women in Kenya lack access to family planning. …”
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Potentialities and critical issues of liquid biopsy in clinical practice: An umbrella review by Nicola Veronese, Claudio Luchini, Stefano Ciriminna, Katia Spinelli, Santo Fruscione, Paola Mattiolo, Miriam Belluzzo, Veronica Messina, Lee Smith, Mario Barbagallo, Walter Mazzucco

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