Aetiological, seasonal and antibiotic susceptibility patterns of diarrhoeal diseases in Bhutan (2016–2022): a retrospective study of surveillance data by Sangay Dorji, Kinley Gyem, Sonam Pelden, Dorji Tshering, Kinley Penjor, Rinzin Wangchuk, Jigme Tenzin, Birdi Lal Phuyel

“…Multidrug resistance was prevalent, with β-lactamase production contributing to resistance rates of 80.7% to penicillin and 65.4% to fluoroquinolones groups. Cephalosporin resistance was also notable, with rates of 34.4% for cephalexin, 40.0% for cefazolin and 16.9% for ceftriaxone.Conclusions DEC and Rotavirus were identified as the leading causes of diarrhoea, with significant resistance patterns observed in common bacterial isolates. …”
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Comparative Analysis of Adverse Drug Reactions Associated with Fluoroquinolones and Other Antibiotics: A Retrospective Pharmacovigilance Study by Alshareef H, Alenzi KA, Albalawi BR, Alanazi RM, Albalawi NS, Alasoufi WS, Alqifari S, Ahmed R, Ali MAS

“…ADRs caused by FQs use were the most frequently reported (177; 29.3%), followed by penicillin (100; 23.4%) and cephalosporin (90; 21%). There was no significant difference in ADRs caused by FQs between men (104; 58%) and women (OR 1.17, 95% CI 0.82– 1.67, p=0.386). …”
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Effects of аntimicrobials on <i>Pseudomonas aeruginosa</i> biofilm formation by U. M. Nemchenko, K. O. Sitnikova, N. L. Belkova, E. V. Grigorova, N. M. Voropaeva, M. V. Sukhоreva, E. S. Sukhareva, E. D. Savilov

“…Carbapenems and cephalosporins did not affect the mature biofilms of the tested P. aeruginosa strains in more than 60 % of cases. …”
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Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection by Simone Giuliano, Jacopo Angelini, Floriana Campanile, Paola Conti, Sarah Flammini, Alberto Pagotto, Francesco Sbrana, Luca Martini, Denise D’Elia, Mohd H. Abdul-Aziz, Menino O. Cotta, Jason A. Roberts, Robert A. Bonomo, Carlo Tascini

“…Abstract Enterococcus faecalis is responsible for numerous serious infections, and treatment options often include ampicillin combined with an aminoglycoside or dual beta-lactam therapy with ampicillin and a third-generation cephalosporin. The mechanism of dual beta-lactam therapy relies on the saturation of penicillin-binding proteins (PBPs). …”
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Isolation of Extended-Spectrum β-lactamase- (ESBL-) Producing Escherichia coli and Klebsiella pneumoniae from Patients with Community-Onset Urinary Tract Infections in Jimma Univer... by Mengistu Abayneh, Getnet Tesfaw, Alemseged Abdissa

“…Enhanced inhibition zone of any of the cephalosporin discs on the side facing amoxicillin + clavulanic acid was considered as ESBL producer. …”
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In Vitro Antibacterial Activity of Crude Extracts of Artocarpus heterophyllus Seeds against Selected Diarrhoea-Causing Superbug Bacteria by Asio Eve, Adamu Almustapha Aliero, Doreen Nalubiri, Rasheed Omotayo Adeyemo, Saheed Adekunle Akinola, Theophilus Pius, Saphurah Nabaasa, Susan Nabukeera, Bashir Alkali, Ibrahim Ntulume

“…Ethanolic and hexanolic seed crude extracts of the plant were screened for antidiarrhoeal activity against bacteria isolated from clinical samples (methicillin-resistant and susceptible Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, ciprofloxacin-resistant Salmonella typhimurium, and third-generation cephalosporin-resistant Escherichia coli). Plant phytochemical screening was conducted using standard methods. …”
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Antimicrobial susceptibilities of oral Neisseria from men on HIV pre-exposure prophylaxis in Hanoi, Vietnam by Huan Vinh Dong, Paul Adamson, Dieu Hoa Pham, Quynh Hoa Pham, Hai Ha Long Le, Loc Quang Pham, Hao Thi Minh Bui, Giang Minh Le, Jeffrey D. Klausner

“…Conclusions: A High frequency of azithromycin resistance, moderate doxycycline resistance, and low cephalosporin resistance was found in oropharyngeal Neisseria isolates from men who have sex with men (MSM) in a pre-exposure prophylaxis (PrEP) program in Hanoi, Vietnam. …”
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Tackling the unyielding: testing two novel approaches against NDM-producing Enterobacterales and Pseudomonas aeruginosa isolates collected in India by Yamuna Devi Bakthavatchalam, Bijayini Behera, Anand Shah, Purva Mathur, Raja Ray, Bashir Ahmed Fomda, Kamini Walia, Balaji Veeraraghavan

“…In this study, we tested siderophore cephalosporin, cefiderocol, which utilizes an unconventional iron uptake pathway for efficient cellular penetration, and cefepime/zidebactam that utilizes novel β-lactam enhancer mechanisms for overcoming diverse carbapenemases. …”
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Treatment of autonomous intestinal neuropathy in critical care by prucalopride and multistrain probiotic by A. L. Kovaleva, A. I. Ulyanin, O. Yu. Kiselyova, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, V. T. Ivashkin

“…In postoperative period antibacterial treatment was prescribed that included first-generation cephalosporin. At the 4thday after onset of antibiotic treatment the patient developed chronic abdominal pain that increased progressively, diarrhea up to 10 times per day and fever of 39 °C. …”
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Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort stud... by Jian Chen, Jian Chen, Haixin Huang, Ruichen Zhang, Yueqiang Fu, Chunmei Jing

“…The detection rates of extended-spectrum cephalosporin resistance (ECR) and fluoroquinolone resistance (FQR) in Escherichia coli (E. coli) were higher than those in Klebsiella pneumoniae.ConclusionIn the PICU, higher mortality was observed in children with BSI-induced severe sepsis who presented with elevated pSOFA scores and low P/F values. …”
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Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients by Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam

“…Two third-generation cephalosporin-resistant [wubC-blaCTX-M-15-ISEcp1 and blaTEM-1] and two macrolide-resistant mobile genomic islands (GIs) [mphA-mrx-mph(R)A-IS6100 and mphE-msrE-IS482-IS6] had emerged in Shigella in Bangladesh. …”
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A Case of Alveolar Bleeding from Clotting Abnormality by Cefmetazole by Eri Nakano, Tsubasa Fukuoka, Nao Takeuchi, Tomoyuki Seki, Michihiro Tamai, Makoto Araki

“…Cephalosporins are one of the most commonly used first-line antibiotics. …”
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Containing Cefoxitin Costs through a Program to Curtail Use in Surgical Prophylaxis by Geoffrey Taylor, Edith Blondel-Hill, Pamela Kibsey, Erwin Friesen, Ronald Tisdell, Wendy Vaudry

“…Objective: To reduce drug costs attributable to anti-anaerobic cephalosporins – specifically to reduce cefoxitin use in surgical prophylaxis.…”
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Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children by Hideaki Kikuta, Mutsuo Shibata, Shuji Nakata, Tatsuru Yamanaka, Hiroshi Sakata, Kouji Akizawa, Kunihiko Kobayashi

“…Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. …”
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Search for new antimicrobials against extended spectrum β-lactamase-positive Escherichia coli: Potential of fungi from the phylum Ascomycota by Walter Oliva Pinto Filho Segundo, Luciana Aires de Oliveira, Ana Cláudia Alves Cortez, Érica Simplício de Souza, Hagen Frickmann, João Vicente Braga de Souza

“…Some isolates of this species are capable of producing extended-spectrum β-lactamase (ESBL) enzymes, which mediate resistance against penicillin derivates and cephalosporins. Fungi of the Ascomycota phylum are known to produce antibiotics from different classes with activity against various bacterial agents. …”
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MONITORING OF ANTIMICROBIAL RESISTANCE OF AVIBACTERIUM (HAEMOPHILUS) PARAGALLINARUM ISOLATES RECOVERED IN THE TERRITORY OF THE RUSSIAN FEDERATION AND THE REPUBLIC OF BELARUS IN 201... by V. A. Danilova, A. V. Potekhin, I. A. Stepanova

“…Most of the isolates were sensitive to aminopenicillins (55.5%), III-IV generation cephalosporins (100%), and florfenicol (100%). Most of the isolates were resistant to gentamycine, erythromycin, chlortetracycline and sulfamethoxazole with trimethoprim. …”
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Monitoring of antibiotic resistance of Acinobacillus pleuropneumoniae isolated in the Russian Federation in 2012-2014 by A. V. Potekhin, V. S. Rusaleyev

“…Most of them proved to be sensitive to penicillins (85,7%), aminopenicillins (92,9%), III-IV-generation cephalosporins (100%), enrofloxacin (81,0%), erythromycin (85,7%) and florfenicol (95,2%). …”
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Extended Spectrum β-Lactamases among Gram-Negative Bacterial Isolates from Clinical Specimens in Three Major Hospitals in Northern Jordan by Raymond G. Batchoun, Samer F. Swedan, Abdullah M. Shurman

“…The DDD test demonstrated some variations in the efficacy of the different cephalosporins in detecting all the ESBL producers. The inclusion of ceftizoxime discs increased the efficacy of the test. …”
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Chromobacterium violaceum: A Rare Cause of Urinary Tract Infection by Ujjwal Laghu, Manami Yanagawa, Konosuke Morimoto, Bhim Gopal Dhoubhadel

“…The isolate was resistant to cephalosporins, while it was sensitive to ofloxacin, gentamicin, and imipenem. …”
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Evaluation of resistance rates of enterobacterales to beta-lactam drugs and interpretation of their minimum inhibitory concentrations relative to clinical breakpoints by Uma BM, Neelesh Naik, Rama N.K

“…There has been an escalation of resistance among cephalosporins, and carbapenems in the recent days. Evaluation of resistance rates and careful selection of drugs based on Minimum Inhibitory Concentration (MIC) aids in effective therapy of infections caused by these resistant strains. …”
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